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The map label for this gene is ywrD [H]

Identifier: 116625440

GI number: 116625440

Start: 8001050

End: 8002735

Strand: Reverse

Name: ywrD [H]

Synonym: Acid_6385

Alternate gene names: 116625440

Gene position: 8002735-8001050 (Counterclockwise)

Preceding gene: 116625442

Following gene: 116625435

Centisome position: 80.3

GC content: 64.47

Gene sequence:

>1686_bases
ATGTATCATTTCGGAATCATGAGGCTGCTCGTTATCTTTCTTCTCGCATCGCTGGGATCGGCGCAGGACCGTTCGCAGGC
GCGATCGATGGTGTTATCGGATCGCGGGATTGCGGCGACTTCGCAGACGCTGGCATCGCAGGCCGGGGCGCAGGTGCTGG
CGCGCGGTGGGTCGGCAATCGACGCGGCGATCGCGGCCAACGCCACGCTGGGCGTGGTGGAGCCGGAGCGCGGCGGGATC
GGCGGCGACCTCTTCGTGATTTACTGGGAGGCCAAGACCGGGAAGCTCACGGGCATCAACGCCAGCGGGTGGGCGCCGAA
GGGACTGACCATCGACGCCCTGAAGGCGATGGGCAACACCAGCATGCCGCAGACCGGGATTCACGCGGTCACGGTGCCGG
GGTGCGTGGACGGGTGGGCGAAGCTGCACCAGAAATTCGGCAAGCTGCCGTGGAAGGACCTGTTCGCGCCGGCGATCTAT
TACGCGAAGAACGGCTTCCCGGTCACCGAGATCATTCACGAGACGTGGCACGAGGAATCGGCCAAGCTGGCGGCCGACGT
GAACGGACGGCGCGTGTACATGAAGAATGGAGAGACGCCGAAGCTGGGCGAGATCGCGCGCAATCCGGAGCTGGCGGCTG
CCTACGAACTGATCGCGGCGCAGGGAGCGGCGGCGTTCTACAAGGGCGCGATCGCGAAGGCTATCGTCAAGACCAGCGAG
CGGCTGGGCGGGAAGATGTCGGCGGCGGATTTGAGCGAGTTCGCGAGCGAGTGGGTGACGCCGGTCTCCACCGAATATCG
CGGCTGGAAAGTCTACGAGTTGCCGCCCAACAGCCAGGGCATCGGGCCGCTGGAGATGCTGAACATCATGTCGGCCTTCC
CAATGGGCAGCTATGCGCCGCGCGGCGTGGAGGAGTTGCACGCGCAGATCGAAGCGCAGAAGCTGACCTTCGCCGATCTG
CATCGCTACCTGGCCGATCCGCGGGTGAGCAAAGTACCGGTGGAAGGCCTGATCGCTCCGGCCTTCGGGCGCGAGCGCGC
CAAGCTGATCGATGCCAACCGCGCGCGCTGCGAGGAGACGCCGGGTGCGCCGGATACCGTCGCCGGCAACACGGTGTACC
TCTCGGTGGTGGATCGCGAGGGCAATATCGCGTCGTTGATCCAGAGCGTCTACCAGCACTTCGGGTCGGGCGTGGTGGTG
GATGATTACGGCTTCGCCCTGCAGAATCGCGGCGCGCTATTCGAGCTGGATCCGGCGCACCCGAACGCGCTGGCGCCGCG
CAAACGGCCGTACCAGACGATCATCCCGGCCTTCATGGAGAAGGGCGATGTGCACATCGGGTTCGGCATCATGGGCGGGA
TGAATCAGACTCCGGCGCACGGGCAGTTCGTCAGCAACGTGGTGGATCACGGAATGAGCATTCAGATGGCGCTCGAAGCG
CCGCGCTTCACGAAGCTCAAATTTTCCGGCTGCGACATTCTGATGGAGAACCGGGTGCGGAAGGAAGTCCGCGACGCGCT
GGCAGCGAAGGGACACGAGATTAAGGTGGTGGGCGATTTTTCGAATCAGATGGGCGGCGGGCAGGCGGTGATTTATAACT
CGGCGACGGGGGTAAAGTACGGGGCGTCGGATCCGCGCAAGGATGGCTCGGCGGTGCCGGAGCCGCATCCTTATTTCAAG
CCGTAA

Upstream 100 bases:

>100_bases
CTGCGGGTCGATGGCAGCTTGAGGCTGGGGAGAGCACCCGACGAGGAGGAGGAATAAGGCGGGTAAGAAGAGGAGTCGGC
GGTCGGGCATGTGAAAAACA

Downstream 100 bases:

>100_bases
GAGTCCGGAAAAACCAAAGGGGCAAACCGTGAGGCTTGCCCCGTGAGTGCAGGCTCTTTAACCCAGCATTTTCCAAAGAA
GAAACAGCATCCCGGCCAGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MYHFGIMRLLVIFLLASLGSAQDRSQARSMVLSDRGIAATSQTLASQAGAQVLARGGSAIDAAIAANATLGVVEPERGGI
GGDLFVIYWEAKTGKLTGINASGWAPKGLTIDALKAMGNTSMPQTGIHAVTVPGCVDGWAKLHQKFGKLPWKDLFAPAIY
YAKNGFPVTEIIHETWHEESAKLAADVNGRRVYMKNGETPKLGEIARNPELAAAYELIAAQGAAAFYKGAIAKAIVKTSE
RLGGKMSAADLSEFASEWVTPVSTEYRGWKVYELPPNSQGIGPLEMLNIMSAFPMGSYAPRGVEELHAQIEAQKLTFADL
HRYLADPRVSKVPVEGLIAPAFGRERAKLIDANRARCEETPGAPDTVAGNTVYLSVVDREGNIASLIQSVYQHFGSGVVV
DDYGFALQNRGALFELDPAHPNALAPRKRPYQTIIPAFMEKGDVHIGFGIMGGMNQTPAHGQFVSNVVDHGMSIQMALEA
PRFTKLKFSGCDILMENRVRKEVRDALAAKGHEIKVVGDFSNQMGGGQAVIYNSATGVKYGASDPRKDGSAVPEPHPYFK
P

Sequences:

>Translated_561_residues
MYHFGIMRLLVIFLLASLGSAQDRSQARSMVLSDRGIAATSQTLASQAGAQVLARGGSAIDAAIAANATLGVVEPERGGI
GGDLFVIYWEAKTGKLTGINASGWAPKGLTIDALKAMGNTSMPQTGIHAVTVPGCVDGWAKLHQKFGKLPWKDLFAPAIY
YAKNGFPVTEIIHETWHEESAKLAADVNGRRVYMKNGETPKLGEIARNPELAAAYELIAAQGAAAFYKGAIAKAIVKTSE
RLGGKMSAADLSEFASEWVTPVSTEYRGWKVYELPPNSQGIGPLEMLNIMSAFPMGSYAPRGVEELHAQIEAQKLTFADL
HRYLADPRVSKVPVEGLIAPAFGRERAKLIDANRARCEETPGAPDTVAGNTVYLSVVDREGNIASLIQSVYQHFGSGVVV
DDYGFALQNRGALFELDPAHPNALAPRKRPYQTIIPAFMEKGDVHIGFGIMGGMNQTPAHGQFVSNVVDHGMSIQMALEA
PRFTKLKFSGCDILMENRVRKEVRDALAAKGHEIKVVGDFSNQMGGGQAVIYNSATGVKYGASDPRKDGSAVPEPHPYFK
P
>Mature_561_residues
MYHFGIMRLLVIFLLASLGSAQDRSQARSMVLSDRGIAATSQTLASQAGAQVLARGGSAIDAAIAANATLGVVEPERGGI
GGDLFVIYWEAKTGKLTGINASGWAPKGLTIDALKAMGNTSMPQTGIHAVTVPGCVDGWAKLHQKFGKLPWKDLFAPAIY
YAKNGFPVTEIIHETWHEESAKLAADVNGRRVYMKNGETPKLGEIARNPELAAAYELIAAQGAAAFYKGAIAKAIVKTSE
RLGGKMSAADLSEFASEWVTPVSTEYRGWKVYELPPNSQGIGPLEMLNIMSAFPMGSYAPRGVEELHAQIEAQKLTFADL
HRYLADPRVSKVPVEGLIAPAFGRERAKLIDANRARCEETPGAPDTVAGNTVYLSVVDREGNIASLIQSVYQHFGSGVVV
DDYGFALQNRGALFELDPAHPNALAPRKRPYQTIIPAFMEKGDVHIGFGIMGGMNQTPAHGQFVSNVVDHGMSIQMALEA
PRFTKLKFSGCDILMENRVRKEVRDALAAKGHEIKVVGDFSNQMGGGQAVIYNSATGVKYGASDPRKDGSAVPEPHPYFK
P

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=540, Percent_Identity=28.1481481481481, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI73915090, Length=540, Percent_Identity=28.1481481481481, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI73915096, Length=540, Percent_Identity=28.1481481481481, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI73915094, Length=540, Percent_Identity=28.1481481481481, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI113429324, Length=528, Percent_Identity=28.219696969697, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI113429326, Length=534, Percent_Identity=28.2771535580524, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI109148539, Length=510, Percent_Identity=25.2941176470588, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI153266885, Length=542, Percent_Identity=24.9077490774908, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI153266901, Length=543, Percent_Identity=25.2302025782689, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI153266907, Length=543, Percent_Identity=24.1252302025783, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789856, Length=535, Percent_Identity=31.4018691588785, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17542894, Length=558, Percent_Identity=26.1648745519713, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI193208245, Length=496, Percent_Identity=26.4112903225806, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193208247, Length=496, Percent_Identity=26.4112903225806, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI212646519, Length=482, Percent_Identity=27.1784232365145, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI72000294, Length=482, Percent_Identity=27.1784232365145, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17506189, Length=560, Percent_Identity=24.6428571428571, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17564448, Length=419, Percent_Identity=26.2529832935561, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI161077878, Length=569, Percent_Identity=27.0650263620387, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642670, Length=569, Percent_Identity=27.0650263620387, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24642666, Length=569, Percent_Identity=27.0650263620387, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45551474, Length=569, Percent_Identity=27.0650263620387, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI161077880, Length=569, Percent_Identity=27.0650263620387, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI161077496, Length=543, Percent_Identity=26.5193370165746, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI18859893, Length=492, Percent_Identity=27.6422764227642, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18859741, Length=508, Percent_Identity=25.1968503937008, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 60254; Mature: 60254

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHFGIMRLLVIFLLASLGSAQDRSQARSMVLSDRGIAATSQTLASQAGAQVLARGGSAI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHH
DAAIAANATLGVVEPERGGIGGDLFVIYWEAKTGKLTGINASGWAPKGLTIDALKAMGNT
HHHHHCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHCCCC
SMPQTGIHAVTVPGCVDGWAKLHQKFGKLPWKDLFAPAIYYAKNGFPVTEIIHETWHEES
CCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
AKLAADVNGRRVYMKNGETPKLGEIARNPELAAAYELIAAQGAAAFYKGAIAKAIVKTSE
CCEEECCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RLGGKMSAADLSEFASEWVTPVSTEYRGWKVYELPPNSQGIGPLEMLNIMSAFPMGSYAP
HHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCC
RGVEELHAQIEAQKLTFADLHRYLADPRVSKVPVEGLIAPAFGRERAKLIDANRARCEET
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCCCHHHHHCCCHHHHCCC
PGAPDTVAGNTVYLSVVDREGNIASLIQSVYQHFGSGVVVDDYGFALQNRGALFELDPAH
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCC
PNALAPRKRPYQTIIPAFMEKGDVHIGFGIMGGMNQTPAHGQFVSNVVDHGMSIQMALEA
CCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECC
PRFTKLKFSGCDILMENRVRKEVRDALAAKGHEIKVVGDFSNQMGGGQAVIYNSATGVKY
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCEE
GASDPRKDGSAVPEPHPYFKP
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYHFGIMRLLVIFLLASLGSAQDRSQARSMVLSDRGIAATSQTLASQAGAQVLARGGSAI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHH
DAAIAANATLGVVEPERGGIGGDLFVIYWEAKTGKLTGINASGWAPKGLTIDALKAMGNT
HHHHHCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHCCCC
SMPQTGIHAVTVPGCVDGWAKLHQKFGKLPWKDLFAPAIYYAKNGFPVTEIIHETWHEES
CCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
AKLAADVNGRRVYMKNGETPKLGEIARNPELAAAYELIAAQGAAAFYKGAIAKAIVKTSE
CCEEECCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RLGGKMSAADLSEFASEWVTPVSTEYRGWKVYELPPNSQGIGPLEMLNIMSAFPMGSYAP
HHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCC
RGVEELHAQIEAQKLTFADLHRYLADPRVSKVPVEGLIAPAFGRERAKLIDANRARCEET
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCCCHHHHHCCCHHHHCCC
PGAPDTVAGNTVYLSVVDREGNIASLIQSVYQHFGSGVVVDDYGFALQNRGALFELDPAH
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCC
PNALAPRKRPYQTIIPAFMEKGDVHIGFGIMGGMNQTPAHGQFVSNVVDHGMSIQMALEA
CCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECC
PRFTKLKFSGCDILMENRVRKEVRDALAAKGHEIKVVGDFSNQMGGGQAVIYNSATGVKY
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCEE
GASDPRKDGSAVPEPHPYFKP
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]