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The map label for this gene is pgsA [H]

Identifier: 116625359

GI number: 116625359

Start: 7922216

End: 7922917

Strand: Reverse

Name: pgsA [H]

Synonym: Acid_6304

Alternate gene names: 116625359

Gene position: 7922917-7922216 (Counterclockwise)

Preceding gene: 116625361

Following gene: 116625357

Centisome position: 79.5

GC content: 62.25

Gene sequence:

>702_bases
ATGAACCTTCCGAATGCGCTGACCATTCTCCGGATCTTCTTCGTACCGCTGCTGGTGGCGGCGCTGGTCCAGGAGAACGT
CGGCTTCCAGGTCGGGGCAGTAAAGGTTACCAACGAATGGCTCTCATTAGCCATCTTCCTGGTCGCCGCCGCTACCGATC
TGCTCGATGGCTATTTGGCACGTCGATGGAAGCAGGTCACCACCATCGGCACCCTGCTGGACCCCATCGCCGATAAGCTG
CTGGTCTCGGCCGCGCTGATTTCGCTGGTGCAGGTGCGCTCGCTGCCGGGCTGGATGGCGGTGCTGATCATCGGCCGTGA
ATTCGCGGTATCCGGCTTGCGCAGCATCGCGGCGACGGAAGGCTACACGATCAAGGCCAGCGACCTGGGCAAGACGAAGA
TGTTTTGCCAGGTGGTGGCGATTTCGGTCATGATGCTGGCGGTGCGGCATCCCGGGCTGCGGACTACGGGGCTGGCGCTC
ATGTGGGGCGTAGTTTTCTTCGCAATGGCCTCGGCGATCAGCTACTTCTCGAAGTTCTGGCACAAAGTGGACGAGGGCAT
CAAGAATCGCCGCCGGCGCGAGTTGCTGGTACTGGATCGAAAACGGCGTCGCGCACTGCGCCGTCAGAGGCGATCGAGCG
GATCGATGGGCGCCGCGGGCGGCTTGGCGGGGACGATCTGGAAACCGCCGGAAGTCAATTGA

Upstream 100 bases:

>100_bases
AAATGACGGCGGGTGAAGTTCATGGCTTGAATTTCCAGTATAAGCCCGGTCCTGGATTCGAGCCCGAGCCGGCGGACTCT
TGTTATAGTTGGGTTGGACG

Downstream 100 bases:

>100_bases
ACGGTTCGCGTCTGGCCCTTGGGTCCCACCGAACCCACTGGTTTTCCATTCAGTGAAATCGAAACGCCGCCGGCATTCCC
CAGCCGCAGCACCACATCCT

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MNLPNALTILRIFFVPLLVAALVQENVGFQVGAVKVTNEWLSLAIFLVAAATDLLDGYLARRWKQVTTIGTLLDPIADKL
LVSAALISLVQVRSLPGWMAVLIIGREFAVSGLRSIAATEGYTIKASDLGKTKMFCQVVAISVMMLAVRHPGLRTTGLAL
MWGVVFFAMASAISYFSKFWHKVDEGIKNRRRRELLVLDRKRRRALRRQRRSSGSMGAAGGLAGTIWKPPEVN

Sequences:

>Translated_233_residues
MNLPNALTILRIFFVPLLVAALVQENVGFQVGAVKVTNEWLSLAIFLVAAATDLLDGYLARRWKQVTTIGTLLDPIADKL
LVSAALISLVQVRSLPGWMAVLIIGREFAVSGLRSIAATEGYTIKASDLGKTKMFCQVVAISVMMLAVRHPGLRTTGLAL
MWGVVFFAMASAISYFSKFWHKVDEGIKNRRRRELLVLDRKRRRALRRQRRSSGSMGAAGGLAGTIWKPPEVN
>Mature_233_residues
MNLPNALTILRIFFVPLLVAALVQENVGFQVGAVKVTNEWLSLAIFLVAAATDLLDGYLARRWKQVTTIGTLLDPIADKL
LVSAALISLVQVRSLPGWMAVLIIGREFAVSGLRSIAATEGYTIKASDLGKTKMFCQVVAISVMMLAVRHPGLRTTGLAL
MWGVVFFAMASAISYFSKFWHKVDEGIKNRRRRELLVLDRKRRRALRRQRRSSGSMGAAGGLAGTIWKPPEVN

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI10092647, Length=107, Percent_Identity=33.6448598130841, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI188536108, Length=107, Percent_Identity=33.6448598130841, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1788220, Length=185, Percent_Identity=34.5945945945946, Blast_Score=80, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24650130, Length=138, Percent_Identity=35.5072463768116, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650126, Length=138, Percent_Identity=35.5072463768116, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650128, Length=138, Percent_Identity=35.5072463768116, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 25651; Mature: 25651

Theoretical pI: Translated: 11.65; Mature: 11.65

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPNALTILRIFFVPLLVAALVQENVGFQVGAVKVTNEWLSLAIFLVAAATDLLDGYLA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
RRWKQVTTIGTLLDPIADKLLVSAALISLVQVRSLPGWMAVLIIGREFAVSGLRSIAATE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GYTIKASDLGKTKMFCQVVAISVMMLAVRHPGLRTTGLALMWGVVFFAMASAISYFSKFW
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HKVDEGIKNRRRRELLVLDRKRRRALRRQRRSSGSMGAAGGLAGTIWKPPEVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLPNALTILRIFFVPLLVAALVQENVGFQVGAVKVTNEWLSLAIFLVAAATDLLDGYLA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
RRWKQVTTIGTLLDPIADKLLVSAALISLVQVRSLPGWMAVLIIGREFAVSGLRSIAATE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GYTIKASDLGKTKMFCQVVAISVMMLAVRHPGLRTTGLALMWGVVFFAMASAISYFSKFW
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HKVDEGIKNRRRRELLVLDRKRRRALRRQRRSSGSMGAAGGLAGTIWKPPEVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]