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The map label for this gene is cpg2 [H]

Identifier: 116625256

GI number: 116625256

Start: 7778991

End: 7780088

Strand: Reverse

Name: cpg2 [H]

Synonym: Acid_6201

Alternate gene names: 116625256

Gene position: 7780088-7778991 (Counterclockwise)

Preceding gene: 116625263

Following gene: 116625255

Centisome position: 78.07

GC content: 65.76

Gene sequence:

>1098_bases
ATGATGATGACGCTGCGCCGCTTCGTGGAGTGCGAATCGCCGAGTGACGATGCCTCCGCCGTCAACCGGTTTGTCGATCT
TGTTTCGGAAACCGTCGCGCCGTATGCCAAGGTCAAGACCTTTCGCGGCGGAAAGTTCGGCCGCCTCATGGTGGCCGAGA
TGCAATTGCCCGGACGCCGCAAGAGCGGACAGGTGCTGGCGCTCGGACACTCCGACACCGTGTGGCCCCTCGGCACCTTG
CGCACCATGCCTTTTCGCGAGGCTGAAGGCCGCGTCTGGGGACCCGGCGCGCTCGATATGAAGGCCGGCATCGTGTTCTT
CCTGTTCGCCGTCCGCGCGCTGCGCGAGCTGGATATCACGGCGCCTTCCAAGGTGCTCTTGCAACTCAATCCCGATGAAG
AGGTGGGCAGCGAAAGCTCGCGCGGTCTCACCGAAAAGAATGCCGCCAAAAGCAAGGCTGTCCTGGTCCTGGAGCCCGGC
ACCGGGCTCACCGGCAAGCTGAAGACGGCGCGCAAGGGGGTCGGCGACTTCACCGTGACTGTGAAAGGCCGCGCCTCGCA
TTCCGGCGTGGATTTTCAAGCCGGCGCCAGCGCCGTCCTGGAACTGGCGCGCCAGCTCGACCGCATCTCCGGTTTCACGA
ACCTGGCCCGCGGGATTACAGTGAACCCGGGTGTGATCGCGGGGGGCACTCGCTCCAACGTGGTCGCCGCCGAGGCCCAC
GCCGAAGTCGATATCCGCGTGCTGCGCCTGCGCGACGCTCCCGCGCTCGAGAAGAAATTCCGCGCGCTCAAGCCGGTCGA
TAAGCGGTGCACCATCGAGATCACCGGCGGCTTAAACCGTCCGCCGATGGAACGCTCGGCGGGCATCGTGAAGCTCTTCC
GGCTGGCGCAGAAGTTGGGCCGCGAGATCGGCGTGGAGGTAGAAGAATCGCTCACCGGCGGCGGCTCGGACGGGAACTTC
ACCGCGGCCCTCGGCATCCCGACCCTCGATGGCCTTGGCGCCGTCGGCGAAGGCGCGCACGCCGTCAACGAAAGCCTCCT
GGTGGACCGCATGGCCGATCGCACGGCACTCATCGGCAAATTGCTGGCGACGCTGTAA

Upstream 100 bases:

>100_bases
AATTGCACGGATCTCGTTGATGTCCAGAATTGCCATGGAAGCCTGTATTATAACAGCCGTGGACTCTATTCTCTCTTTTG
CGCGCGCTCACCAGGCCGAA

Downstream 100 bases:

>100_bases
GAGGTATTCTGAAGATCGAGGAGGCGTCGAAGATGAACGAGCTTTTGAGCAGGATTTTGGTAGATCCTAATATTTGCTTC
GGCAAACCCTGTATTCGGGG

Product: peptidase dimerisation domain-containing protein

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MMMTLRRFVECESPSDDASAVNRFVDLVSETVAPYAKVKTFRGGKFGRLMVAEMQLPGRRKSGQVLALGHSDTVWPLGTL
RTMPFREAEGRVWGPGALDMKAGIVFFLFAVRALRELDITAPSKVLLQLNPDEEVGSESSRGLTEKNAAKSKAVLVLEPG
TGLTGKLKTARKGVGDFTVTVKGRASHSGVDFQAGASAVLELARQLDRISGFTNLARGITVNPGVIAGGTRSNVVAAEAH
AEVDIRVLRLRDAPALEKKFRALKPVDKRCTIEITGGLNRPPMERSAGIVKLFRLAQKLGREIGVEVEESLTGGGSDGNF
TAALGIPTLDGLGAVGEGAHAVNESLLVDRMADRTALIGKLLATL

Sequences:

>Translated_365_residues
MMMTLRRFVECESPSDDASAVNRFVDLVSETVAPYAKVKTFRGGKFGRLMVAEMQLPGRRKSGQVLALGHSDTVWPLGTL
RTMPFREAEGRVWGPGALDMKAGIVFFLFAVRALRELDITAPSKVLLQLNPDEEVGSESSRGLTEKNAAKSKAVLVLEPG
TGLTGKLKTARKGVGDFTVTVKGRASHSGVDFQAGASAVLELARQLDRISGFTNLARGITVNPGVIAGGTRSNVVAAEAH
AEVDIRVLRLRDAPALEKKFRALKPVDKRCTIEITGGLNRPPMERSAGIVKLFRLAQKLGREIGVEVEESLTGGGSDGNF
TAALGIPTLDGLGAVGEGAHAVNESLLVDRMADRTALIGKLLATL
>Mature_365_residues
MMMTLRRFVECESPSDDASAVNRFVDLVSETVAPYAKVKTFRGGKFGRLMVAEMQLPGRRKSGQVLALGHSDTVWPLGTL
RTMPFREAEGRVWGPGALDMKAGIVFFLFAVRALRELDITAPSKVLLQLNPDEEVGSESSRGLTEKNAAKSKAVLVLEPG
TGLTGKLKTARKGVGDFTVTVKGRASHSGVDFQAGASAVLELARQLDRISGFTNLARGITVNPGVIAGGTRSNVVAAEAH
AEVDIRVLRLRDAPALEKKFRALKPVDKRCTIEITGGLNRPPMERSAGIVKLFRLAQKLGREIGVEVEESLTGGGSDGNF
TAALGIPTLDGLGAVGEGAHAVNESLLVDRMADRTALIGKLLATL

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 38837; Mature: 38837

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMTLRRFVECESPSDDASAVNRFVDLVSETVAPYAKVKTFRGGKFGRLMVAEMQLPGRR
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCEEEEEEECCCCCC
KSGQVLALGHSDTVWPLGTLRTMPFREAEGRVWGPGALDMKAGIVFFLFAVRALRELDIT
CCCCEEEECCCCCCCCCHHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
APSKVLLQLNPDEEVGSESSRGLTEKNAAKSKAVLVLEPGTGLTGKLKTARKGVGDFTVT
CCCEEEEEECCCHHHCCCCCCCCCHHCCCCCCEEEEECCCCCCCCCHHHHHCCCCCEEEE
VKGRASHSGVDFQAGASAVLELARQLDRISGFTNLARGITVNPGVIAGGTRSNVVAAEAH
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECC
AEVDIRVLRLRDAPALEKKFRALKPVDKRCTIEITGGLNRPPMERSAGIVKLFRLAQKLG
CCEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
REIGVEVEESLTGGGSDGNFTAALGIPTLDGLGAVGEGAHAVNESLLVDRMADRTALIGK
HHHCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLATL
HHHHC
>Mature Secondary Structure
MMMTLRRFVECESPSDDASAVNRFVDLVSETVAPYAKVKTFRGGKFGRLMVAEMQLPGRR
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCEEEEEEECCCCCC
KSGQVLALGHSDTVWPLGTLRTMPFREAEGRVWGPGALDMKAGIVFFLFAVRALRELDIT
CCCCEEEECCCCCCCCCHHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
APSKVLLQLNPDEEVGSESSRGLTEKNAAKSKAVLVLEPGTGLTGKLKTARKGVGDFTVT
CCCEEEEEECCCHHHCCCCCCCCCHHCCCCCCEEEEECCCCCCCCCHHHHHCCCCCEEEE
VKGRASHSGVDFQAGASAVLELARQLDRISGFTNLARGITVNPGVIAGGTRSNVVAAEAH
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECC
AEVDIRVLRLRDAPALEKKFRALKPVDKRCTIEITGGLNRPPMERSAGIVKLFRLAQKLG
CCEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
REIGVEVEESLTGGGSDGNFTAALGIPTLDGLGAVGEGAHAVNESLLVDRMADRTALIGK
HHHCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLATL
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]