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The map label for this gene is luxQ [H]

Identifier: 116625119

GI number: 116625119

Start: 7580049

End: 7581905

Strand: Direct

Name: luxQ [H]

Synonym: Acid_6056

Alternate gene names: 116625119

Gene position: 7580049-7581905 (Clockwise)

Preceding gene: 116625117

Following gene: 116625120

Centisome position: 76.06

GC content: 57.08

Gene sequence:

>1857_bases
ATGAACGAACGATCCTTAGCCCGCCGGGGCGTGCGAAGTGTGCTCCTCGCTTTGCGTTTGCGCGGACCTCTATCGGCCGA
TCCCACGGCGCAGATCCTGCACGCTTTGGTTTTGGCTCTGACCATCTGGTCTGCGATCTGGACTATATTCACGCTGCCTC
TTTACCCGAATCTAATGGCCAGATTGGTCAGGCTGCGATTCATTATGGTTGCCGACCTGGTCCCGGTGACCACTTTGATT
CTTCTTCGCCTCGGTCATTTTCGGCAAGCCACCTATGTGTACCTGACCGGCCAATGGGCGCAAGCCACGTATAACATCGC
CATCAACGGTTCGATCGAGATCACCAGCACAGCTTTCTACATCACGTTGCCAATTTTGGCAACGTGGCTGTTGGGGTTCA
GAGAAGCGTTCTGGACTGCCGGTGTATGCCTTGGCAGTGCGCTGATTTTAGCATTGCGGCAAGGGCCGACCAGCGTTTTT
CTTCCAACCGCGCCGCTGAGACCGCCCCTGCTCATATGGGCTAATCTCGTGCAACTCACACTTACCGCGGCGGCTCCGGT
GGCCCACATTTTGCAGACCCTGCAGCAATACAAGGAGCATTTGGAGCAAGTGGTGGAGCAGCGCACCGCTGAGCTAGTGA
TAGCCCGTGACCAGGCGGATTCCGCCAACCGGGCCAAGAGCACGTTCCTGGCCAACATGAGTCACGAACTTCGCACGCCC
CTCAGCGTCATCCTCGCATCATCCGACCTCCTGAACGAGAGTGACCCAACACCCGATCAGCGTGAAGACATCGACAGGAT
CAGCCACAGCGGCAAGCATCTCTTGGGACTGATCGACAACGTGCTGGATGTCGCGAAAATCGAGTCAGGCAAACAGGAAC
TCGCGATCGCAGCCAGCGATTTGCTCTCCACTGTGCGAATGGTCATTGAAATGATGCGGGGCCGGGCGGAGGATAAGCAT
CTGGCGCTCATTTACTATCAAGCTCCTGACGTGCCGCGATACGTCCGCGTAGATGCGCCGAAGCTGCGGCAAATCCTCAT
CAACCTGCTTGGCAACGCCATTAAATTCACAAGAGAAGGAGCCGTAGAGCTACGGTTGAGCGCCAAGCCGGGTGACGAAC
CCGGATACGCGCAGTTTTGTTTCGATATTAACGACACTGGCGTGGGGATGCCACAACACGACCTGGACCGCATATTCGAA
CCGTTCCAACAGGTGGGCAATCCGAGTCAACAGGCTGGCACAGGTCTCGGCCTGACGATTACTCGCCGATTTGTAGAACT
GATGGGCGGGACGCTGCTAGTTGAGAGCGAGGTGGGCCGGGGATCATGTTTCGTGGTCAAGTTGCCGTTGGAACTAGCAA
GGGCGTCGGAGACTTACGGTGTAGAACTTGCCGCAGGATATCCTTTCATTTTGGAATCGGGCCAACCGGACTGGCGCGTT
CTGATTGTCGAAGACGACCCTGAAAGCGCCACGGTCTTGCAGAAGATGCTCACTCGCGCCGGCTTTCAGGTGAGGGTCGC
GGAGAATGGGGTACTCGCGGTTGAGGCGTTCCAGCACTGGCAGCCGCACTTTATTTGGATGGATCTGGGTTTGCCGCAGT
TGAGTGGCACGGAAGCGACACGGCGGATTCGCCAGTTGGACGGCGGGGCGGAGACAAAGATTGCTGCCATAACCGCGGCT
GCAGATGCTTCGGGGTATGACGGGATGAGGTGTGCAGGCTTTGACGACATTGCCTTCAAGCCATTTCGCCAGACAGAAAT
CTTCTTCTGTATGGCGCGCCACCTGGGTGTGTGCTATTCATCTTCGGAAGGAGAGGGAAAGAATTCGCACCAGCAAGCCG
GGGGGCGTCCGTCGTGA

Upstream 100 bases:

>100_bases
GCCGCTCGGACTTTATAACACACGTTGCCTTTCTGCCGGATGGTGACAAGGATTATAATGTCTGCGAATCAGCCCTCCTT
AAAAATGGCATCGAGGCGCG

Downstream 100 bases:

>100_bases
TTTTTGGGCAGCTGCTTAGCTTTCGCTCAGCATCACTCTGATGTTCGACTCTAGTAAAAAGAATCGAACACTTTTAGGTC
AGAAGCCGTTCTGCAAACGA

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MNERSLARRGVRSVLLALRLRGPLSADPTAQILHALVLALTIWSAIWTIFTLPLYPNLMARLVRLRFIMVADLVPVTTLI
LLRLGHFRQATYVYLTGQWAQATYNIAINGSIEITSTAFYITLPILATWLLGFREAFWTAGVCLGSALILALRQGPTSVF
LPTAPLRPPLLIWANLVQLTLTAAAPVAHILQTLQQYKEHLEQVVEQRTAELVIARDQADSANRAKSTFLANMSHELRTP
LSVILASSDLLNESDPTPDQREDIDRISHSGKHLLGLIDNVLDVAKIESGKQELAIAASDLLSTVRMVIEMMRGRAEDKH
LALIYYQAPDVPRYVRVDAPKLRQILINLLGNAIKFTREGAVELRLSAKPGDEPGYAQFCFDINDTGVGMPQHDLDRIFE
PFQQVGNPSQQAGTGLGLTITRRFVELMGGTLLVESEVGRGSCFVVKLPLELARASETYGVELAAGYPFILESGQPDWRV
LIVEDDPESATVLQKMLTRAGFQVRVAENGVLAVEAFQHWQPHFIWMDLGLPQLSGTEATRRIRQLDGGAETKIAAITAA
ADASGYDGMRCAGFDDIAFKPFRQTEIFFCMARHLGVCYSSSEGEGKNSHQQAGGRPS

Sequences:

>Translated_618_residues
MNERSLARRGVRSVLLALRLRGPLSADPTAQILHALVLALTIWSAIWTIFTLPLYPNLMARLVRLRFIMVADLVPVTTLI
LLRLGHFRQATYVYLTGQWAQATYNIAINGSIEITSTAFYITLPILATWLLGFREAFWTAGVCLGSALILALRQGPTSVF
LPTAPLRPPLLIWANLVQLTLTAAAPVAHILQTLQQYKEHLEQVVEQRTAELVIARDQADSANRAKSTFLANMSHELRTP
LSVILASSDLLNESDPTPDQREDIDRISHSGKHLLGLIDNVLDVAKIESGKQELAIAASDLLSTVRMVIEMMRGRAEDKH
LALIYYQAPDVPRYVRVDAPKLRQILINLLGNAIKFTREGAVELRLSAKPGDEPGYAQFCFDINDTGVGMPQHDLDRIFE
PFQQVGNPSQQAGTGLGLTITRRFVELMGGTLLVESEVGRGSCFVVKLPLELARASETYGVELAAGYPFILESGQPDWRV
LIVEDDPESATVLQKMLTRAGFQVRVAENGVLAVEAFQHWQPHFIWMDLGLPQLSGTEATRRIRQLDGGAETKIAAITAA
ADASGYDGMRCAGFDDIAFKPFRQTEIFFCMARHLGVCYSSSEGEGKNSHQQAGGRPS
>Mature_618_residues
MNERSLARRGVRSVLLALRLRGPLSADPTAQILHALVLALTIWSAIWTIFTLPLYPNLMARLVRLRFIMVADLVPVTTLI
LLRLGHFRQATYVYLTGQWAQATYNIAINGSIEITSTAFYITLPILATWLLGFREAFWTAGVCLGSALILALRQGPTSVF
LPTAPLRPPLLIWANLVQLTLTAAAPVAHILQTLQQYKEHLEQVVEQRTAELVIARDQADSANRAKSTFLANMSHELRTP
LSVILASSDLLNESDPTPDQREDIDRISHSGKHLLGLIDNVLDVAKIESGKQELAIAASDLLSTVRMVIEMMRGRAEDKH
LALIYYQAPDVPRYVRVDAPKLRQILINLLGNAIKFTREGAVELRLSAKPGDEPGYAQFCFDINDTGVGMPQHDLDRIFE
PFQQVGNPSQQAGTGLGLTITRRFVELMGGTLLVESEVGRGSCFVVKLPLELARASETYGVELAAGYPFILESGQPDWRV
LIVEDDPESATVLQKMLTRAGFQVRVAENGVLAVEAFQHWQPHFIWMDLGLPQLSGTEATRRIRQLDGGAETKIAAITAA
ADASGYDGMRCAGFDDIAFKPFRQTEIFFCMARHLGVCYSSSEGEGKNSHQQAGGRPS

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=365, Percent_Identity=34.2465753424658, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788713, Length=375, Percent_Identity=34.1333333333333, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=39.4736842105263, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI48994928, Length=375, Percent_Identity=31.4666666666667, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=37.984496124031, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=31.0483870967742, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1786600, Length=260, Percent_Identity=29.6153846153846, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=27.5555555555556, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=30.0429184549356, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=204, Percent_Identity=30.3921568627451, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789808, Length=235, Percent_Identity=25.1063829787234, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68114; Mature: 68114

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERSLARRGVRSVLLALRLRGPLSADPTAQILHALVLALTIWSAIWTIFTLPLYPNLMA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLVRLRFIMVADLVPVTTLILLRLGHFRQATYVYLTGQWAQATYNIAINGSIEITSTAFY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECEEEEEEEEEEECEEEEECEEHH
ITLPILATWLLGFREAFWTAGVCLGSALILALRQGPTSVFLPTAPLRPPLLIWANLVQLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHH
LTAAAPVAHILQTLQQYKEHLEQVVEQRTAELVIARDQADSANRAKSTFLANMSHELRTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCHHHHHCC
LSVILASSDLLNESDPTPDQREDIDRISHSGKHLLGLIDNVLDVAKIESGKQELAIAASD
HHHHHHCHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LLSTVRMVIEMMRGRAEDKHLALIYYQAPDVPRYVRVDAPKLRQILINLLGNAIKFTREG
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCC
AVELRLSAKPGDEPGYAQFCFDINDTGVGMPQHDLDRIFEPFQQVGNPSQQAGTGLGLTI
CEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCHHH
TRRFVELMGGTLLVESEVGRGSCFVVKLPLELARASETYGVELAAGYPFILESGQPDWRV
HHHHHHHHCCEEEEEECCCCCCEEEEEECHHHHCCCCCCCEEEECCCCEEEECCCCCEEE
LIVEDDPESATVLQKMLTRAGFQVRVAENGVLAVEAFQHWQPHFIWMDLGLPQLSGTEAT
EEEECCCCHHHHHHHHHHHCCCEEEEECCCEEEEEHHHCCCCEEEEEECCCCCCCCHHHH
RRIRQLDGGAETKIAAITAAADASGYDGMRCAGFDDIAFKPFRQTEIFFCMARHLGVCYS
HHHHHCCCCCCCEEEEEEEECCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCEEEC
SSEGEGKNSHQQAGGRPS
CCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MNERSLARRGVRSVLLALRLRGPLSADPTAQILHALVLALTIWSAIWTIFTLPLYPNLMA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLVRLRFIMVADLVPVTTLILLRLGHFRQATYVYLTGQWAQATYNIAINGSIEITSTAFY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECEEEEEEEEEEECEEEEECEEHH
ITLPILATWLLGFREAFWTAGVCLGSALILALRQGPTSVFLPTAPLRPPLLIWANLVQLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHH
LTAAAPVAHILQTLQQYKEHLEQVVEQRTAELVIARDQADSANRAKSTFLANMSHELRTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCHHHHHCC
LSVILASSDLLNESDPTPDQREDIDRISHSGKHLLGLIDNVLDVAKIESGKQELAIAASD
HHHHHHCHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LLSTVRMVIEMMRGRAEDKHLALIYYQAPDVPRYVRVDAPKLRQILINLLGNAIKFTREG
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCC
AVELRLSAKPGDEPGYAQFCFDINDTGVGMPQHDLDRIFEPFQQVGNPSQQAGTGLGLTI
CEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCHHH
TRRFVELMGGTLLVESEVGRGSCFVVKLPLELARASETYGVELAAGYPFILESGQPDWRV
HHHHHHHHCCEEEEEECCCCCCEEEEEECHHHHCCCCCCCEEEECCCCEEEECCCCCEEE
LIVEDDPESATVLQKMLTRAGFQVRVAENGVLAVEAFQHWQPHFIWMDLGLPQLSGTEAT
EEEECCCCHHHHHHHHHHHCCCEEEEECCCEEEEEHHHCCCCEEEEEECCCCCCCCHHHH
RRIRQLDGGAETKIAAITAAADASGYDGMRCAGFDDIAFKPFRQTEIFFCMARHLGVCYS
HHHHHCCCCCCCEEEEEEEECCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCEEEC
SSEGEGKNSHQQAGGRPS
CCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]