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The map label for this gene is 116625046

Identifier: 116625046

GI number: 116625046

Start: 7496952

End: 7499018

Strand: Reverse

Name: 116625046

Synonym: Acid_5976

Alternate gene names: NA

Gene position: 7499018-7496952 (Counterclockwise)

Preceding gene: 116625047

Following gene: 116625045

Centisome position: 75.25

GC content: 61.64

Gene sequence:

>2067_bases
ATGCGTTCCGTAATTGCCTTCGCCCTATTTTGTTGCGCCGCATTCTCGCAGACTCCGCCGCCGGCGAGGACCCAGCAGCG
CGATCTCAAGGTGGAGAAGCTCGATGAGCCCGCAGGCGCGCCCAAGCCGCCGCGGATTCCGCGCAGCTACGCCGTCATCG
TCGGCGTCTCGAAGTATCGCAACCTGGAATCCAAACTCCAGTTGCAGTTCGCCGAGCGCGACGCCCAAGCCATCTTCACC
GCGCTGATCAGCCCCGAGGGCGGAAATTTCCGCGTCGAGAATGTTCACGTCCTGACCAACGAAAAGGCTACGCTGGCCGC
GCTCCGCAAGGAGATCGATACCTGGCTGCCCGGCGTGGCACAGGAAGACGATCGCGTGCTGATCTACTTCGCCGGCCACG
GCTTCATGTACCAGGGCAAGGGCTACCTGGCGCCGCACGATTTCGACCGCAACCGCATCGCCGAGACCGGCTTCCCGATG
GATGAGCTGGGCTCCGTGATCGGCGCCAAGATCAAGGCGAAATCGAAAATCCTGTTCACCGACGCCTGCCATTCCGGCGC
CATCACGCCCGAGGAAACCGAGAGCATCAACGGTACCCTCGGCGATCTCAACAAGAGCCTCTTCTCGCTCACCGCCAGCC
GCGCCCGCGAGCAATCCTTCGAAGACCCCGGGCTCAAAGGCGGCCACGGCGTCTTCACTTACTACGTGGTGGAAGGCATG
CAGGGCGAGGCCGATGTCAGCGGCGATGGCGTGGTCACGGCCGATGAGCTGGCCGAGTACGTACATACTCAAGTCCGCGA
GTATACTTCCAACAAGCAGAACCCGACCTCCGACAAATCCAACTTCGATCCCAACATGTTCCTCGCCTGGGTGCCTTCCC
GGGCGAAGCCCGCCGCCGGCGCCGCGCCGAAATTCGGCGGCATGGTGATCGAAAGCAACATGGATGGCGTGGAGGTCTTC
GTGGACGGCAAAACTATCGGCGTGCTGGATAAAGGCAAGAGCACCTCGGTCCCCGGACTCACTCCCGGGGAGCACACCGT
GCAGGGCGTGAAAATGGGCTACGAGCCGGATGGCCCGCGGCAGGAGACCGTCTACCCCGGGCAGGATTCCACGGTGCGCA
TTCGCATCCTGATTCCGCGCCGCCGAAACAAGGCCGCGCTCGATCTCTTGCAGCAGGGGCTCCGCGAGTACCACAAGGGC
GCCGAACAGGATTACAAGAAGGCCGCCGCGATCTTCGAAAACGCGCTCGCCGCCGACCCAAGTTACAGTCAGGCGGCCTT
CTACTTGGGCCTAACCTACAGCGCCCTCTTCGATTACGAAAAGGCTGGCGCGGCTTACAAACGCGCCATCCAGCTCGACC
CGGACTATCTGGAAGCGCATGCCAATTACGGCGGCATGCTGCTCGATACCGGCGACGTGGATGAAGCCATCCGCCAGCTC
AATACCGTGCTCCAGCGCGAGCCGAAACATGCGGTCGCGCTCACGCTGATCGCGCAGGCTTACCGCTTCAAAGAGCTCTA
TCCGCAATCCATCGACAGCGCCCGCAACGCCATCCTCCAAAACCCGAAGACCGCCGAACCCCATCTCTGGCTGGCCGACA
GCCTGCGCCTGAGCGGCAAGTTCGCCGATGCCAAGCCCGAATACGGCGAGTATCTCAAGCTCAGCGATTTCGATAGCAAG
CTCGGCGGGCAATTGAACTATTACGTGCTCGGCTCGTTATTCGGCTTCGGCCGCCGGAAGCGCGTCGCCGAGCGTGACAT
CTGGAACGACTTCCACAACATGGCCTGGTTCGGCATGTGCGAATGCGAGCGCAAGACTTCCAACCTGGATGCCGCCATCG
CGGATTGCCAGAAGGCCCTCACTTACGATTCCAAGGATCCCTTCGCGCACTACAATCTGGGTCTCGCTTTCATGACCAAG
GCCGTCAACTCCGGCAGCATCGCCGAACTCGACCCCGCGGTGCAGCACTTTCAGAAGATGATCGAAATCAACCCCGATAT
CCCCGAAGCCGCCAACGCCAAAAAGAACATCGCCAACATCCAGCAGTTCCTCAAGCAGCCCCACTAA

Upstream 100 bases:

>100_bases
TCCTCTTCATGCGCCAGAAAAACACCGCGGTGATCTCGTCCCAGGAGCCGCTCACCGGCCCCATCGTGTACGAGTTCCGC
CTCGCCCACAGGTGACCGCC

Downstream 100 bases:

>100_bases
GCAGCCCCCATTAGCGCGCCTGCGCTATCATTTTTCTAAATGCGCTCCGTAACCCTTCCTGCCCTCGCTGTGCTTTTTGT
GTTCCAGGCCCGGCCGGCCA

Product: peptidase C14, caspase catalytic subunit p20

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MRSVIAFALFCCAAFSQTPPPARTQQRDLKVEKLDEPAGAPKPPRIPRSYAVIVGVSKYRNLESKLQLQFAERDAQAIFT
ALISPEGGNFRVENVHVLTNEKATLAALRKEIDTWLPGVAQEDDRVLIYFAGHGFMYQGKGYLAPHDFDRNRIAETGFPM
DELGSVIGAKIKAKSKILFTDACHSGAITPEETESINGTLGDLNKSLFSLTASRAREQSFEDPGLKGGHGVFTYYVVEGM
QGEADVSGDGVVTADELAEYVHTQVREYTSNKQNPTSDKSNFDPNMFLAWVPSRAKPAAGAAPKFGGMVIESNMDGVEVF
VDGKTIGVLDKGKSTSVPGLTPGEHTVQGVKMGYEPDGPRQETVYPGQDSTVRIRILIPRRRNKAALDLLQQGLREYHKG
AEQDYKKAAAIFENALAADPSYSQAAFYLGLTYSALFDYEKAGAAYKRAIQLDPDYLEAHANYGGMLLDTGDVDEAIRQL
NTVLQREPKHAVALTLIAQAYRFKELYPQSIDSARNAILQNPKTAEPHLWLADSLRLSGKFADAKPEYGEYLKLSDFDSK
LGGQLNYYVLGSLFGFGRRKRVAERDIWNDFHNMAWFGMCECERKTSNLDAAIADCQKALTYDSKDPFAHYNLGLAFMTK
AVNSGSIAELDPAVQHFQKMIEINPDIPEAANAKKNIANIQQFLKQPH

Sequences:

>Translated_688_residues
MRSVIAFALFCCAAFSQTPPPARTQQRDLKVEKLDEPAGAPKPPRIPRSYAVIVGVSKYRNLESKLQLQFAERDAQAIFT
ALISPEGGNFRVENVHVLTNEKATLAALRKEIDTWLPGVAQEDDRVLIYFAGHGFMYQGKGYLAPHDFDRNRIAETGFPM
DELGSVIGAKIKAKSKILFTDACHSGAITPEETESINGTLGDLNKSLFSLTASRAREQSFEDPGLKGGHGVFTYYVVEGM
QGEADVSGDGVVTADELAEYVHTQVREYTSNKQNPTSDKSNFDPNMFLAWVPSRAKPAAGAAPKFGGMVIESNMDGVEVF
VDGKTIGVLDKGKSTSVPGLTPGEHTVQGVKMGYEPDGPRQETVYPGQDSTVRIRILIPRRRNKAALDLLQQGLREYHKG
AEQDYKKAAAIFENALAADPSYSQAAFYLGLTYSALFDYEKAGAAYKRAIQLDPDYLEAHANYGGMLLDTGDVDEAIRQL
NTVLQREPKHAVALTLIAQAYRFKELYPQSIDSARNAILQNPKTAEPHLWLADSLRLSGKFADAKPEYGEYLKLSDFDSK
LGGQLNYYVLGSLFGFGRRKRVAERDIWNDFHNMAWFGMCECERKTSNLDAAIADCQKALTYDSKDPFAHYNLGLAFMTK
AVNSGSIAELDPAVQHFQKMIEINPDIPEAANAKKNIANIQQFLKQPH
>Mature_688_residues
MRSVIAFALFCCAAFSQTPPPARTQQRDLKVEKLDEPAGAPKPPRIPRSYAVIVGVSKYRNLESKLQLQFAERDAQAIFT
ALISPEGGNFRVENVHVLTNEKATLAALRKEIDTWLPGVAQEDDRVLIYFAGHGFMYQGKGYLAPHDFDRNRIAETGFPM
DELGSVIGAKIKAKSKILFTDACHSGAITPEETESINGTLGDLNKSLFSLTASRAREQSFEDPGLKGGHGVFTYYVVEGM
QGEADVSGDGVVTADELAEYVHTQVREYTSNKQNPTSDKSNFDPNMFLAWVPSRAKPAAGAAPKFGGMVIESNMDGVEVF
VDGKTIGVLDKGKSTSVPGLTPGEHTVQGVKMGYEPDGPRQETVYPGQDSTVRIRILIPRRRNKAALDLLQQGLREYHKG
AEQDYKKAAAIFENALAADPSYSQAAFYLGLTYSALFDYEKAGAAYKRAIQLDPDYLEAHANYGGMLLDTGDVDEAIRQL
NTVLQREPKHAVALTLIAQAYRFKELYPQSIDSARNAILQNPKTAEPHLWLADSLRLSGKFADAKPEYGEYLKLSDFDSK
LGGQLNYYVLGSLFGFGRRKRVAERDIWNDFHNMAWFGMCECERKTSNLDAAIADCQKALTYDSKDPFAHYNLGLAFMTK
AVNSGSIAELDPAVQHFQKMIEINPDIPEAANAKKNIANIQQFLKQPH

Specific function: Unknown

COG id: COG4249

COG function: function code R; Uncharacterized protein containing caspase domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 13 WD repeats [H]

Homologues:

Organism=Homo sapiens, GI32307150, Length=284, Percent_Identity=23.5915492957746, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI32307148, Length=284, Percent_Identity=23.5915492957746, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020472
- InterPro:   IPR011600
- InterPro:   IPR015943
- InterPro:   IPR001680
- InterPro:   IPR011046
- InterPro:   IPR019782
- InterPro:   IPR019775
- InterPro:   IPR017986
- InterPro:   IPR019781 [H]

Pfam domain/function: PF00656 Peptidase_C14; PF00400 WD40 [H]

EC number: NA

Molecular weight: Translated: 75954; Mature: 75954

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00018 EF_HAND_1 ; PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVIAFALFCCAAFSQTPPPARTQQRDLKVEKLDEPAGAPKPPRIPRSYAVIVGVSKYR
CHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCEEEEEECHHHH
NLESKLQLQFAERDAQAIFTALISPEGGNFRVENVHVLTNEKATLAALRKEIDTWLPGVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCC
QEDDRVLIYFAGHGFMYQGKGYLAPHDFDRNRIAETGFPMDELGSVIGAKIKAKSKILFT
CCCCEEEEEEECCCEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCEECCCEEEEE
DACHSGAITPEETESINGTLGDLNKSLFSLTASRAREQSFEDPGLKGGHGVFTYYVVEGM
ECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECC
QGEADVSGDGVVTADELAEYVHTQVREYTSNKQNPTSDKSNFDPNMFLAWVPSRAKPAAG
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
AAPKFGGMVIESNMDGVEVFVDGKTIGVLDKGKSTSVPGLTPGEHTVQGVKMGYEPDGPR
CCCCCCCEEEECCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHEEECCCCCCCC
QETVYPGQDSTVRIRILIPRRRNKAALDLLQQGLREYHKGAEQDYKKAAAIFENALAADP
CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
SYSQAAFYLGLTYSALFDYEKAGAAYKRAIQLDPDYLEAHANYGGMLLDTGDVDEAIRQL
CCCCEEEEEHHHHHHHHHHHHHCHHHHHEECCCHHHHHHHCCCCCEEEECCCHHHHHHHH
NTVLQREPKHAVALTLIAQAYRFKELYPQSIDSARNAILQNPKTAEPHLWLADSLRLSGK
HHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCEEECCC
FADAKPEYGEYLKLSDFDSKLGGQLNYYVLGSLFGFGRRKRVAERDIWNDFHNMAWFGMC
CCCCCCCCCCEEEECCCCHHHCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEE
ECERKTSNLDAAIADCQKALTYDSKDPFAHYNLGLAFMTKAVNSGSIAELDPAVQHFQKM
EHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHCHHHHHHHHCCCCCCHHCCHHHHHHHHH
IEINPDIPEAANAKKNIANIQQFLKQPH
HHCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRSVIAFALFCCAAFSQTPPPARTQQRDLKVEKLDEPAGAPKPPRIPRSYAVIVGVSKYR
CHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCEEEEEECHHHH
NLESKLQLQFAERDAQAIFTALISPEGGNFRVENVHVLTNEKATLAALRKEIDTWLPGVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCC
QEDDRVLIYFAGHGFMYQGKGYLAPHDFDRNRIAETGFPMDELGSVIGAKIKAKSKILFT
CCCCEEEEEEECCCEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCEECCCEEEEE
DACHSGAITPEETESINGTLGDLNKSLFSLTASRAREQSFEDPGLKGGHGVFTYYVVEGM
ECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECC
QGEADVSGDGVVTADELAEYVHTQVREYTSNKQNPTSDKSNFDPNMFLAWVPSRAKPAAG
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
AAPKFGGMVIESNMDGVEVFVDGKTIGVLDKGKSTSVPGLTPGEHTVQGVKMGYEPDGPR
CCCCCCCEEEECCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHEEECCCCCCCC
QETVYPGQDSTVRIRILIPRRRNKAALDLLQQGLREYHKGAEQDYKKAAAIFENALAADP
CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
SYSQAAFYLGLTYSALFDYEKAGAAYKRAIQLDPDYLEAHANYGGMLLDTGDVDEAIRQL
CCCCEEEEEHHHHHHHHHHHHHCHHHHHEECCCHHHHHHHCCCCCEEEECCCHHHHHHHH
NTVLQREPKHAVALTLIAQAYRFKELYPQSIDSARNAILQNPKTAEPHLWLADSLRLSGK
HHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCEEECCC
FADAKPEYGEYLKLSDFDSKLGGQLNYYVLGSLFGFGRRKRVAERDIWNDFHNMAWFGMC
CCCCCCCCCCEEEECCCCHHHCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEE
ECERKTSNLDAAIADCQKALTYDSKDPFAHYNLGLAFMTKAVNSGSIAELDPAVQHFQKM
EHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHCHHHHHHHHCCCCCCHHCCHHHHHHHHH
IEINPDIPEAANAKKNIANIQQFLKQPH
HHCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]