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The map label for this gene is prlC [H]

Identifier: 116624892

GI number: 116624892

Start: 7282805

End: 7284853

Strand: Reverse

Name: prlC [H]

Synonym: Acid_5816

Alternate gene names: 116624892

Gene position: 7284853-7282805 (Counterclockwise)

Preceding gene: 116624900

Following gene: 116624888

Centisome position: 73.1

GC content: 64.42

Gene sequence:

>2049_bases
ATGATGGATCAGAGCCCGGACACTAACCCGTTACTCCGCGTAGAGTTCCGCATTCCGTTCGATCGTATTCGCGCCGAGCA
TGTGCAGCCCGCCGCGACCCAGCTGCTGAACGAAGCCCGCGCCCGGCTGGCCGCGCTGGCGGCGCCTAATGGCGAGCGGA
CTTTCGAAAACACAATGCGCGCGCTGGACGATTTGACGGAGCCGCTGGATTGGGCGATGGCCGTGGTCCGGCACTTGGAG
AGCGTAGCCACCTATCCGGACCTGCGCGCGGCGTTCAATGCCGCGCAGCCCGAGGTGAGCGCGTTCTATAGCGGTATCCC
TCTGAACGCGGACCTGTGGAACAACGTGAAGGCCTTCGCCGCCACACCGGAGGCAGCCGCGCTCTCGGGCGAGCGGCGCC
GCTTCCTGCACAAGACCGTGGACACCTTTCGACGCCATGGCGCGGACCTGGATCCGGCCGGGAAGAAGCGCCTGGAAGCG
ATCGACGTGGAGCTGACGCAGATCACGACCAAGTTCGCGGAGAATGTTCTGGATTCGACCAACGCCTTCGAACTGGTGTT
GACCAAAGAGAGCGACCTCGCCGGATTGCCGCCCACCGCGGTGGCGAGCGCACGCGAAAGCGCGCAGCGCAAGGGCCTCG
AAGGCTGGCGCTTCACCCTGCAGGCGCCCGATTATACGGCGGTGATGACGTACCTGGACGACGTCGCGATCCGCCGTCAG
ATGTACGAGGCATTCGCCGTGCGCGCCACCAAAGGCGAGCGCGATAACCGGCCGATCATCGTGCGCATTCTGGAACTGCG
GCGCGAGAAGGCGGCGCTGCTGGGCTTCGCCAACTTCGCCGACCTGGTGCTGGAAGATCGCATGGCGCACACGGGCGAGC
GCGCCTTGCACTTCCTGGAAGACCTGAAGAGCAAAACCGAGCGGCGTTTCCACGAGGAGAATCAGGAGCTGTTCGAGTAC
CGCCGCGGCTTGGAAGGTCCGGCCGCCGCACCGCTGGCGCCGTGGGATGTGGCTTATTACGCGGAGAAGCAGCGCGCCGC
GCTCTACGATTTCGACGAAGAGGCGCTGCGCCCTTACTTTCCGATGGAGCGCGTGGAGGCCGGCCTTTTCGAACTGGTCC
ACCGCCTTTACGGCATTAAGGTGGAGGAAGAAAAGGGCGTACCGGCATGGGATCCCGAGGTCCACTATTACAACGTCCGC
GATGAGAACGGCCTGTACCTGGGCGGGTTCTACGCCGATTGGTACCCGCGCGAAAACAAGCGCGGCGGCGCGTGGATGGA
TGGGTTGATCACTGGTGGTCCGGCGCCGGTCGGCTTCCGTCCCCACCTGGGCTTGATCTGCGGAAACCTCACCCCGCCGG
TGGGCGGCAAGCCCGCGCTGTTGACGCATCGCGAAGTGGAGACGATCTTTCACGAGTTCGGCCACCTGCTGCATCATTTA
TTAAGCCGCGTGGAGACGCGCTCGCTGGCGGGCACAAACGTGGCCTGGGACTTCGTGGAACTGCCGAGCCAGATCATGGA
GAACTGGTGCTGGGAGCGCGACGCGCTGGATCTGTTCGCCTGCCACTACGAGACCGGCGCGCCGATTCCGGACGACTTGT
TCCAGAAGATGAAGCGAGCGCGCAATTTCCGCGCGGCCAACGGCCAGATGCGCCAGCTCGGCTTTGGCTTTATCGACCTG
AACGTCCACGTGCGCTACGATGCCGCGCGCGACGGCGACCCGGTGCAGTACACCCGGAATATTTTGCAGGAGTTCAGCGC
CGCCCCCCTGCCGGCGGATCACGCGATGATCGCCGCGTTCACCCACTTGTTCGCGAGTCCGGTAGGTTACGGCGCGGGAT
ATTACTCCTATAAGTGGGCCGAGGTGCTGGAGGCCGACGCCTTCACCCGCTTCCGCGACGGCGGCATCTTCAGCCGCGAG
ATTGGCGCTTCGTTCCGCGGCGAGATCCTGTCCAAGGGCGACAGCGAAGATCCGGCCGAGTTATACCGCCATTTCATGGG
CCGAGACCCGGACCCCAACGCCTTGCTACAGAGATCCGGACTGGCGTAG

Upstream 100 bases:

>100_bases
GAATCAAAACCCATTCTCCCCTCCATAGTAACTGTTTTGTGGCTTTTGTCACGCAGGCGTCGTACCGGTTCCGCAGTGCC
TGTACCTGATACGCTTAGTG

Downstream 100 bases:

>100_bases
AAGAATTGCTTTCAGCACCGCGCCGATATTCATGAATTCGTCGAGCCGCGAGGGCTTCTGAATGAACAGATCGGCGCCCA
GGCGATGGCTCTCGGATTTG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MMDQSPDTNPLLRVEFRIPFDRIRAEHVQPAATQLLNEARARLAALAAPNGERTFENTMRALDDLTEPLDWAMAVVRHLE
SVATYPDLRAAFNAAQPEVSAFYSGIPLNADLWNNVKAFAATPEAAALSGERRRFLHKTVDTFRRHGADLDPAGKKRLEA
IDVELTQITTKFAENVLDSTNAFELVLTKESDLAGLPPTAVASARESAQRKGLEGWRFTLQAPDYTAVMTYLDDVAIRRQ
MYEAFAVRATKGERDNRPIIVRILELRREKAALLGFANFADLVLEDRMAHTGERALHFLEDLKSKTERRFHEENQELFEY
RRGLEGPAAAPLAPWDVAYYAEKQRAALYDFDEEALRPYFPMERVEAGLFELVHRLYGIKVEEEKGVPAWDPEVHYYNVR
DENGLYLGGFYADWYPRENKRGGAWMDGLITGGPAPVGFRPHLGLICGNLTPPVGGKPALLTHREVETIFHEFGHLLHHL
LSRVETRSLAGTNVAWDFVELPSQIMENWCWERDALDLFACHYETGAPIPDDLFQKMKRARNFRAANGQMRQLGFGFIDL
NVHVRYDAARDGDPVQYTRNILQEFSAAPLPADHAMIAAFTHLFASPVGYGAGYYSYKWAEVLEADAFTRFRDGGIFSRE
IGASFRGEILSKGDSEDPAELYRHFMGRDPDPNALLQRSGLA

Sequences:

>Translated_682_residues
MMDQSPDTNPLLRVEFRIPFDRIRAEHVQPAATQLLNEARARLAALAAPNGERTFENTMRALDDLTEPLDWAMAVVRHLE
SVATYPDLRAAFNAAQPEVSAFYSGIPLNADLWNNVKAFAATPEAAALSGERRRFLHKTVDTFRRHGADLDPAGKKRLEA
IDVELTQITTKFAENVLDSTNAFELVLTKESDLAGLPPTAVASARESAQRKGLEGWRFTLQAPDYTAVMTYLDDVAIRRQ
MYEAFAVRATKGERDNRPIIVRILELRREKAALLGFANFADLVLEDRMAHTGERALHFLEDLKSKTERRFHEENQELFEY
RRGLEGPAAAPLAPWDVAYYAEKQRAALYDFDEEALRPYFPMERVEAGLFELVHRLYGIKVEEEKGVPAWDPEVHYYNVR
DENGLYLGGFYADWYPRENKRGGAWMDGLITGGPAPVGFRPHLGLICGNLTPPVGGKPALLTHREVETIFHEFGHLLHHL
LSRVETRSLAGTNVAWDFVELPSQIMENWCWERDALDLFACHYETGAPIPDDLFQKMKRARNFRAANGQMRQLGFGFIDL
NVHVRYDAARDGDPVQYTRNILQEFSAAPLPADHAMIAAFTHLFASPVGYGAGYYSYKWAEVLEADAFTRFRDGGIFSRE
IGASFRGEILSKGDSEDPAELYRHFMGRDPDPNALLQRSGLA
>Mature_682_residues
MMDQSPDTNPLLRVEFRIPFDRIRAEHVQPAATQLLNEARARLAALAAPNGERTFENTMRALDDLTEPLDWAMAVVRHLE
SVATYPDLRAAFNAAQPEVSAFYSGIPLNADLWNNVKAFAATPEAAALSGERRRFLHKTVDTFRRHGADLDPAGKKRLEA
IDVELTQITTKFAENVLDSTNAFELVLTKESDLAGLPPTAVASARESAQRKGLEGWRFTLQAPDYTAVMTYLDDVAIRRQ
MYEAFAVRATKGERDNRPIIVRILELRREKAALLGFANFADLVLEDRMAHTGERALHFLEDLKSKTERRFHEENQELFEY
RRGLEGPAAAPLAPWDVAYYAEKQRAALYDFDEEALRPYFPMERVEAGLFELVHRLYGIKVEEEKGVPAWDPEVHYYNVR
DENGLYLGGFYADWYPRENKRGGAWMDGLITGGPAPVGFRPHLGLICGNLTPPVGGKPALLTHREVETIFHEFGHLLHHL
LSRVETRSLAGTNVAWDFVELPSQIMENWCWERDALDLFACHYETGAPIPDDLFQKMKRARNFRAANGQMRQLGFGFIDL
NVHVRYDAARDGDPVQYTRNILQEFSAAPLPADHAMIAAFTHLFASPVGYGAGYYSYKWAEVLEADAFTRFRDGGIFSRE
IGASFRGEILSKGDSEDPAELYRHFMGRDPDPNALLQRSGLA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=637, Percent_Identity=32.182103610675, Blast_Score=322, Evalue=8e-88,
Organism=Homo sapiens, GI14149738, Length=639, Percent_Identity=31.4553990610329, Blast_Score=298, Evalue=2e-80,
Organism=Homo sapiens, GI156105687, Length=645, Percent_Identity=24.8062015503876, Blast_Score=159, Evalue=8e-39,
Organism=Escherichia coli, GI1789913, Length=682, Percent_Identity=40.4692082111437, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1787819, Length=683, Percent_Identity=32.6500732064422, Blast_Score=319, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI32565901, Length=654, Percent_Identity=20.9480122324159, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71999758, Length=670, Percent_Identity=22.5373134328358, Blast_Score=83, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319793, Length=603, Percent_Identity=28.0265339966833, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6322715, Length=684, Percent_Identity=23.6842105263158, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21356111, Length=644, Percent_Identity=26.7080745341615, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20129717, Length=454, Percent_Identity=27.0925110132159, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77023; Mature: 77023

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDQSPDTNPLLRVEFRIPFDRIRAEHVQPAATQLLNEARARLAALAAPNGERTFENTMR
CCCCCCCCCCEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALDDLTEPLDWAMAVVRHLESVATYPDLRAAFNAAQPEVSAFYSGIPLNADLWNNVKAFA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHCCCCCCCHHHCCCHHEE
ATPEAAALSGERRRFLHKTVDTFRRHGADLDPAGKKRLEAIDVELTQITTKFAENVLDST
CCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
NAFELVLTKESDLAGLPPTAVASARESAQRKGLEGWRFTLQAPDYTAVMTYLDDVAIRRQ
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
MYEAFAVRATKGERDNRPIIVRILELRREKAALLGFANFADLVLEDRMAHTGERALHFLE
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKSKTERRFHEENQELFEYRRGLEGPAAAPLAPWDVAYYAEKQRAALYDFDEEALRPYF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCC
PMERVEAGLFELVHRLYGIKVEEEKGVPAWDPEVHYYNVRDENGLYLGGFYADWYPRENK
CHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCEEECEEECCCCCCCC
RGGAWMDGLITGGPAPVGFRPHLGLICGNLTPPVGGKPALLTHREVETIFHEFGHLLHHL
CCCCCCCCEECCCCCCCCCCCCCHHEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
LSRVETRSLAGTNVAWDFVELPSQIMENWCWERDALDLFACHYETGAPIPDDLFQKMKRA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHH
RNFRAANGQMRQLGFGFIDLNVHVRYDAARDGDPVQYTRNILQEFSAAPLPADHAMIAAF
HCCCCCCCCHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
THLFASPVGYGAGYYSYKWAEVLEADAFTRFRDGGIFSREIGASFRGEILSKGDSEDPAE
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHCCCCCCCHHH
LYRHFMGRDPDPNALLQRSGLA
HHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MMDQSPDTNPLLRVEFRIPFDRIRAEHVQPAATQLLNEARARLAALAAPNGERTFENTMR
CCCCCCCCCCEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALDDLTEPLDWAMAVVRHLESVATYPDLRAAFNAAQPEVSAFYSGIPLNADLWNNVKAFA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHCCCCCCCHHHCCCHHEE
ATPEAAALSGERRRFLHKTVDTFRRHGADLDPAGKKRLEAIDVELTQITTKFAENVLDST
CCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
NAFELVLTKESDLAGLPPTAVASARESAQRKGLEGWRFTLQAPDYTAVMTYLDDVAIRRQ
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
MYEAFAVRATKGERDNRPIIVRILELRREKAALLGFANFADLVLEDRMAHTGERALHFLE
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKSKTERRFHEENQELFEYRRGLEGPAAAPLAPWDVAYYAEKQRAALYDFDEEALRPYF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCC
PMERVEAGLFELVHRLYGIKVEEEKGVPAWDPEVHYYNVRDENGLYLGGFYADWYPRENK
CHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCEEECEEECCCCCCCC
RGGAWMDGLITGGPAPVGFRPHLGLICGNLTPPVGGKPALLTHREVETIFHEFGHLLHHL
CCCCCCCCEECCCCCCCCCCCCCHHEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
LSRVETRSLAGTNVAWDFVELPSQIMENWCWERDALDLFACHYETGAPIPDDLFQKMKRA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHH
RNFRAANGQMRQLGFGFIDLNVHVRYDAARDGDPVQYTRNILQEFSAAPLPADHAMIAAF
HCCCCCCCCHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
THLFASPVGYGAGYYSYKWAEVLEADAFTRFRDGGIFSREIGASFRGEILSKGDSEDPAE
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHCCCCCCCHHH
LYRHFMGRDPDPNALLQRSGLA
HHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]