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The map label for this gene is aphA [H]

Identifier: 116624890

GI number: 116624890

Start: 7280899

End: 7282398

Strand: Direct

Name: aphA [H]

Synonym: Acid_5814

Alternate gene names: 116624890

Gene position: 7280899-7282398 (Clockwise)

Preceding gene: 116624889

Following gene: 116624891

Centisome position: 73.06

GC content: 58.13

Gene sequence:

>1500_bases
ATGAGATTATCTGAGAACCGCGAAGCTTCTTCGGCCCTAACCGCGCACTACGATCTCCTGGGTCCCGAGGAAGAGCTGAC
CGATTTCATCGAGAAAGTCGCGATCCCCCTGCATTGGGTCGCCGAGGATGGCACCATCCTATGGGCGAATGCCGCGGAAC
TGGAACTCCTGGGCTACACTCGCGAGGAATATATCGGCCGCAACATTCGGGATTTCCACGTGGATGCGGCGGTCATTGAA
GACATTCTCCAACGCCTCAGTAACGACGACTCTTTGAGCGCTTTCGAGGCGCGCCTGCGCCGTAAAGACGGCTCGATCCG
CGATGTTTCCATCAGCTCGAACGTCCTGCGCACGGGCGGAAAGTTCGTTCACACCCGCTGCGTCACCGTCGATATCACCG
AGAAGAAGAACGCCTCCGAACTGCAAGAGCGCATGGCCGCGATCGTCGAGTCTTCAGACGATGCCATTCTGAGCAAGGAC
CTGAACGGCATCATCCAAAGCTGGAACCGCGGCGCCGAACGCATCTTCGGCTATAAGGCCGATGAAATCGTGGGAAAGCA
CATTTCGACCCTCGCGGCTCCGGACGCTGTGGACGAAATTCCGAACATCCTGGACCGTCTCCGCCGCGGCGAGCGGGTAG
ATCACTATCAGACCAGGCGGATGACCAAAGACGGCCGCATACTCACTGTTTCACTCACCGTTTCACCCATCAGGGACTCA
TCCGGCGTCATCGTTGGCGCATCCAAGGTGGCTCGCGACATCACCGAGCGCCACCAGCACGAGCGGGCGATTTGCGAGGC
GAATGCCGCCCTCACCAGGGCTAACTCGGATTTGCAGCAGTTTGTCTACTCGGCATCGCACGATCTTCAGGAGCCGCTTC
GCATGATCGCTGCTTTCAGCGGCATGCTGAAGAAGAAGTTTGAAGGTAAGTTGGGACCTGAGGCCGATCAATACATCGAG
CTGACCCTGGAGGGCGCCCTGCGCATGGAGCAGCTCTTGAAGGACCTGCGATCGTTCGCACAAATCTCGATAGGAGGCGA
GGAACCGGTTGAGGATGTGGACGCGGGAGCCACACTCGATAAGACGATGGATAACCTGGCCGTCCTCATCCGCGACAGCG
GCGCCCGTATCACCCGCACGACTCTTCCCCACGTTCGGATTCACAAGTTTCAGCTGGAGCAGCTTTTTCAAAACCTCATA
GGAAATTCGATTCGGTATCGGAGCAGCGCTCCGCCGCGGATTCATGTCGCCGCGGAGCTTGGGGACAAGGAATGGGTCTT
CTCGGTCGCTGACAACGGGATCGGGATCGAGACTCAGTTTAAGGAGCAGATCTTTGGCATGTTTAAGCGTCTTCACAGCA
CGGCCGAGTACCCCGGCACCGGGATGGGTCTTGCCATCTGCCAGCGCATTGTCGATCGCGTGGGAGGTCGGATCTGGGTC
GAGTCAGAACCCGGACAAGGTTCAAAATTTTTCTTCACCGTCCCCCGGCAGCAGAACTGA

Upstream 100 bases:

>100_bases
AAACATGTCCCCTCCTGCCCGTTCGCGCCACTGTTAGGAGAGGCCTATAATATGAGCAAGTAATCCTCCCCAGATCTCAA
GAGTGCCTGGGCTGTGTCTT

Downstream 100 bases:

>100_bases
TCAAGCGCGTGCCAGCTCCGTATCGATCGTTCTGATCGAAGATAATCCCGGCGATGTGCTCCTTATCCGCGAAGCGCTCG
ACTTACATGGAGTCACCGCT

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MRLSENREASSALTAHYDLLGPEEELTDFIEKVAIPLHWVAEDGTILWANAAELELLGYTREEYIGRNIRDFHVDAAVIE
DILQRLSNDDSLSAFEARLRRKDGSIRDVSISSNVLRTGGKFVHTRCVTVDITEKKNASELQERMAAIVESSDDAILSKD
LNGIIQSWNRGAERIFGYKADEIVGKHISTLAAPDAVDEIPNILDRLRRGERVDHYQTRRMTKDGRILTVSLTVSPIRDS
SGVIVGASKVARDITERHQHERAICEANAALTRANSDLQQFVYSASHDLQEPLRMIAAFSGMLKKKFEGKLGPEADQYIE
LTLEGALRMEQLLKDLRSFAQISIGGEEPVEDVDAGATLDKTMDNLAVLIRDSGARITRTTLPHVRIHKFQLEQLFQNLI
GNSIRYRSSAPPRIHVAAELGDKEWVFSVADNGIGIETQFKEQIFGMFKRLHSTAEYPGTGMGLAICQRIVDRVGGRIWV
ESEPGQGSKFFFTVPRQQN

Sequences:

>Translated_499_residues
MRLSENREASSALTAHYDLLGPEEELTDFIEKVAIPLHWVAEDGTILWANAAELELLGYTREEYIGRNIRDFHVDAAVIE
DILQRLSNDDSLSAFEARLRRKDGSIRDVSISSNVLRTGGKFVHTRCVTVDITEKKNASELQERMAAIVESSDDAILSKD
LNGIIQSWNRGAERIFGYKADEIVGKHISTLAAPDAVDEIPNILDRLRRGERVDHYQTRRMTKDGRILTVSLTVSPIRDS
SGVIVGASKVARDITERHQHERAICEANAALTRANSDLQQFVYSASHDLQEPLRMIAAFSGMLKKKFEGKLGPEADQYIE
LTLEGALRMEQLLKDLRSFAQISIGGEEPVEDVDAGATLDKTMDNLAVLIRDSGARITRTTLPHVRIHKFQLEQLFQNLI
GNSIRYRSSAPPRIHVAAELGDKEWVFSVADNGIGIETQFKEQIFGMFKRLHSTAEYPGTGMGLAICQRIVDRVGGRIWV
ESEPGQGSKFFFTVPRQQN
>Mature_499_residues
MRLSENREASSALTAHYDLLGPEEELTDFIEKVAIPLHWVAEDGTILWANAAELELLGYTREEYIGRNIRDFHVDAAVIE
DILQRLSNDDSLSAFEARLRRKDGSIRDVSISSNVLRTGGKFVHTRCVTVDITEKKNASELQERMAAIVESSDDAILSKD
LNGIIQSWNRGAERIFGYKADEIVGKHISTLAAPDAVDEIPNILDRLRRGERVDHYQTRRMTKDGRILTVSLTVSPIRDS
SGVIVGASKVARDITERHQHERAICEANAALTRANSDLQQFVYSASHDLQEPLRMIAAFSGMLKKKFEGKLGPEADQYIE
LTLEGALRMEQLLKDLRSFAQISIGGEEPVEDVDAGATLDKTMDNLAVLIRDSGARITRTTLPHVRIHKFQLEQLFQNLI
GNSIRYRSSAPPRIHVAAELGDKEWVFSVADNGIGIETQFKEQIFGMFKRLHSTAEYPGTGMGLAICQRIVDRVGGRIWV
ESEPGQGSKFFFTVPRQQN

Specific function: Photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=356, Percent_Identity=25.561797752809, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI48994928, Length=365, Percent_Identity=26.3013698630137, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693157, Length=283, Percent_Identity=25.4416961130742, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789149, Length=354, Percent_Identity=24.2937853107345, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=26.530612244898, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=269, Percent_Identity=23.7918215613383, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=380, Percent_Identity=24.7368421052632, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789808, Length=238, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55839; Mature: 55839

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSENREASSALTAHYDLLGPEEELTDFIEKVAIPLHWVAEDGTILWANAAELELLGYT
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCCEEEECCC
REEYIGRNIRDFHVDAAVIEDILQRLSNDDSLSAFEARLRRKDGSIRDVSISSNVLRTGG
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCC
KFVHTRCVTVDITEKKNASELQERMAAIVESSDDAILSKDLNGIIQSWNRGAERIFGYKA
CEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
DEIVGKHISTLAAPDAVDEIPNILDRLRRGERVDHYQTRRMTKDGRILTVSLTVSPIRDS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCC
SGVIVGASKVARDITERHQHERAICEANAALTRANSDLQQFVYSASHDLQEPLRMIAAFS
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHH
GMLKKKFEGKLGPEADQYIELTLEGALRMEQLLKDLRSFAQISIGGEEPVEDVDAGATLD
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCHHH
KTMDNLAVLIRDSGARITRTTLPHVRIHKFQLEQLFQNLIGNSIRYRSSAPPRIHVAAEL
HHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEC
GDKEWVFSVADNGIGIETQFKEQIFGMFKRLHSTAEYPGTGMGLAICQRIVDRVGGRIWV
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEE
ESEPGQGSKFFFTVPRQQN
ECCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MRLSENREASSALTAHYDLLGPEEELTDFIEKVAIPLHWVAEDGTILWANAAELELLGYT
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCCEEEECCC
REEYIGRNIRDFHVDAAVIEDILQRLSNDDSLSAFEARLRRKDGSIRDVSISSNVLRTGG
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCC
KFVHTRCVTVDITEKKNASELQERMAAIVESSDDAILSKDLNGIIQSWNRGAERIFGYKA
CEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
DEIVGKHISTLAAPDAVDEIPNILDRLRRGERVDHYQTRRMTKDGRILTVSLTVSPIRDS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCC
SGVIVGASKVARDITERHQHERAICEANAALTRANSDLQQFVYSASHDLQEPLRMIAAFS
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHH
GMLKKKFEGKLGPEADQYIELTLEGALRMEQLLKDLRSFAQISIGGEEPVEDVDAGATLD
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCHHH
KTMDNLAVLIRDSGARITRTTLPHVRIHKFQLEQLFQNLIGNSIRYRSSAPPRIHVAAEL
HHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEC
GDKEWVFSVADNGIGIETQFKEQIFGMFKRLHSTAEYPGTGMGLAICQRIVDRVGGRIWV
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEE
ESEPGQGSKFFFTVPRQQN
ECCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]