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The map label for this gene is degP [H]

Identifier: 116624799

GI number: 116624799

Start: 7169574

End: 7170416

Strand: Direct

Name: degP [H]

Synonym: Acid_5723

Alternate gene names: 116624799

Gene position: 7169574-7170416 (Clockwise)

Preceding gene: 116624798

Following gene: 116624801

Centisome position: 71.94

GC content: 62.4

Gene sequence:

>843_bases
ATGAAACTCAGTCTGGGTATTCTCTTAGCTTCCCTTGCGGCCTCGTCCGCCTTCGGCCAGGTGGCCCTTCCGCGTTCGCG
TAATGCGCAGGCCCTGATCATCACCAAGGGCGGCAGTTATCTCGGCATCGGCGGCCTCGATATCACTTCCGAGCGCGCCA
AAGCCCTCAACCTCAAAGAGGAGCGCGGCGTCGAAGTCTCCAGCGTCGCCGAAGATGGCCCCGCCGCCAAAGCCGGCATC
AAGGCCGGTGACGTCGTTCTCGAATTCGATGGCCAGCCCGTCCAGGGCACTACGCAGTTCCAACGCATGGTCCGTGAAAC
TCCCGTCGGCCGCCAGGTCAAAATCACCGTCTGGCGCGGCGGCGCCCTTCAAACCGTCACCGCCACCGTCGGCGAAAACA
AGGGCAACATGATCTCCTCCGACGACGGCAACTGGAACTTTTCCATGCCCACCATGCCGCCCATGCCTCCCATGGCCGAT
ATGAACATGCCGCGCATGCAGATCTTCTCGCAGAACCCCATGCTCGGCATCGAAGGCGAATCGCTCGGCCAGCAGGAGCA
GCTCGCCGAATTCTTCGGCGTCCAGGATGGCGTCCTCGTCCGCCTGGTGAAGAAGGGCTCCCCCGCCGAAAAGGCCGGCC
TCAAAGCCGGCGACGTCATCACCAAAATCGACGATTCCAAGGTCGCCAGCACCGCCGAAATCACCCGCACCCTCCGCACC
CTCAAGTCGAAGAAGTCCTTCACCCTGACCATCACCCGCAACAAAAAGGAAATGCCCCTGACCGTCACCATGGATACCAC
CGGTGCCGCCCCCCGCGCCGCCCTCGAAATCGTCAACTGCTGA

Upstream 100 bases:

>100_bases
ATCGTCGCGGAAGGCCCCGTGAACGGCGGAGGACCGCTGCTTCAGATTTCCGCGACCGTGGGCACCATCTTCATCAGAAA
ACAACAATAGAGGTTTGAAC

Downstream 100 bases:

>100_bases
CCATCGACGAGCCGCGACCGTAATGTAAGGGAGCGCAACGAACTCCTGCTCCTGTCTCAGCGCCGCCATCAGAAGCCGCG
ACCGTGACGGTCGCGGCTCG

Product: PDZ/DHR/GLGF domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKLSLGILLASLAASSAFGQVALPRSRNAQALIITKGGSYLGIGGLDITSERAKALNLKEERGVEVSSVAEDGPAAKAGI
KAGDVVLEFDGQPVQGTTQFQRMVRETPVGRQVKITVWRGGALQTVTATVGENKGNMISSDDGNWNFSMPTMPPMPPMAD
MNMPRMQIFSQNPMLGIEGESLGQQEQLAEFFGVQDGVLVRLVKKGSPAEKAGLKAGDVITKIDDSKVASTAEITRTLRT
LKSKKSFTLTITRNKKEMPLTVTMDTTGAAPRAALEIVNC

Sequences:

>Translated_280_residues
MKLSLGILLASLAASSAFGQVALPRSRNAQALIITKGGSYLGIGGLDITSERAKALNLKEERGVEVSSVAEDGPAAKAGI
KAGDVVLEFDGQPVQGTTQFQRMVRETPVGRQVKITVWRGGALQTVTATVGENKGNMISSDDGNWNFSMPTMPPMPPMAD
MNMPRMQIFSQNPMLGIEGESLGQQEQLAEFFGVQDGVLVRLVKKGSPAEKAGLKAGDVITKIDDSKVASTAEITRTLRT
LKSKKSFTLTITRNKKEMPLTVTMDTTGAAPRAALEIVNC
>Mature_280_residues
MKLSLGILLASLAASSAFGQVALPRSRNAQALIITKGGSYLGIGGLDITSERAKALNLKEERGVEVSSVAEDGPAAKAGI
KAGDVVLEFDGQPVQGTTQFQRMVRETPVGRQVKITVWRGGALQTVTATVGENKGNMISSDDGNWNFSMPTMPPMPPMAD
MNMPRMQIFSQNPMLGIEGESLGQQEQLAEFFGVQDGVLVRLVKKGSPAEKAGLKAGDVITKIDDSKVASTAEITRTLRT
LKSKKSFTLTITRNKKEMPLTVTMDTTGAAPRAALEIVNC

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Escherichia coli, GI1786356, Length=200, Percent_Identity=31, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789629, Length=201, Percent_Identity=29.3532338308458, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 29794; Mature: 29794

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSLGILLASLAASSAFGQVALPRSRNAQALIITKGGSYLGIGGLDITSERAKALNLKE
CEEHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHCCCHH
ERGVEVSSVAEDGPAAKAGIKAGDVVLEFDGQPVQGTTQFQRMVRETPVGRQVKITVWRG
HHCCCHHHHCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEEC
GALQTVTATVGENKGNMISSDDGNWNFSMPTMPPMPPMADMNMPRMQIFSQNPMLGIEGE
CCEEEEEEEECCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCHHEEECCCCEEEECCC
SLGQQEQLAEFFGVQDGVLVRLVKKGSPAEKAGLKAGDVITKIDDSKVASTAEITRTLRT
CCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHH
LKSKKSFTLTITRNKKEMPLTVTMDTTGAAPRAALEIVNC
HHCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHEEEECC
>Mature Secondary Structure
MKLSLGILLASLAASSAFGQVALPRSRNAQALIITKGGSYLGIGGLDITSERAKALNLKE
CEEHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHCCCHH
ERGVEVSSVAEDGPAAKAGIKAGDVVLEFDGQPVQGTTQFQRMVRETPVGRQVKITVWRG
HHCCCHHHHCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEEC
GALQTVTATVGENKGNMISSDDGNWNFSMPTMPPMPPMADMNMPRMQIFSQNPMLGIEGE
CCEEEEEEEECCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCHHEEECCCCEEEECCC
SLGQQEQLAEFFGVQDGVLVRLVKKGSPAEKAGLKAGDVITKIDDSKVASTAEITRTLRT
CCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHH
LKSKKSFTLTITRNKKEMPLTVTMDTTGAAPRAALEIVNC
HHCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]