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The map label for this gene is ampC [H]

Identifier: 116624681

GI number: 116624681

Start: 7019549

End: 7021174

Strand: Direct

Name: ampC [H]

Synonym: Acid_5605

Alternate gene names: 116624681

Gene position: 7019549-7021174 (Clockwise)

Preceding gene: 116624680

Following gene: 116624684

Centisome position: 70.44

GC content: 63.84

Gene sequence:

>1626_bases
ATGAGCCCTTCCCTTGCCTTCCTGCTCCTCGCGCTCGCACCCGCCTTCGCGCAAAACGACACCGCCGCGCGGCTCGCCCG
CGCCTTTGCAGCCATCGATCGCGCCGCCACCGCGTCCACCGCTCCAGGAATGGTCGTCGGCATCACCGACCGCACCCGCA
CGCTCAAAATCGGCGCCTACGGATATGCCAACCTGAATTCCAAAACGCGCATCACTCCCGAGACGCTCTTTGAGATCGGT
TCCGTGAGCAAATCATTCACCGCCATATCCCTGATGGAATTGTTCGACGAGGACCGCTTCGATCCTCAGGAGCCGGTTGC
CAAATATCTGCCCTGGTTCGCACTCAAATCCAGGTACCGGGCGATCACCGGCCACGATCTCCTCACCCACACTTCCGGCC
TGCAAAACTACCGCCCGGATCTCGCCTCCATGCCCTTCGCCGCGCTCTCCCTGCGTGACTTCGAGCCATCGTACGCCCCC
GGCGAGCACTACTGGTATTCGAATCTCGGCTTCCAGGTTCTCGGCTACGTGCTCGAACATATCGACGCGGCAAAGTACGA
CACCATCGTCCAGCGGCGTATCCTCAACCGCCTCGGCATGAGCGCCACACATGCCGCCATCGACGATGCCCTTCGCGCCC
GGCTGCCGCAAAGCTACAGCCACTGGCCCTACACCGGCGAATTCACCGAGGAGCCCTGGTTTGAGTACCTCGCAGCCGAC
GGCAGCATCGCTTCCACCGCCGGCGATATGACCGCCTACGCCCGCCTCATCCTCAACCGCGGCGTCGCACCGTCGGGCCG
CCTGCTCTCCGAGCGTGCCTTCGCGCAGCTCACCAGGCCCACGCTCAACTCCTATGCCTACGGCCTGTTCGTCCGCCAGG
ACGATGGCGACACCGTCATCCAGCACGGCGGCGGCATCGCCGGCTTCCAGACGCTGCTCGAAATGCATATGCAGGATGGC
TTCGGCATCATCGCCATGGGAAACGGAGGCCTCGACCGTGAGCTGGTGCAGTTTGCGATCGCGTCCGTCAAGGCCGCGCT
CCGCGACAAGCCGCTGCCCGATCCGCCCGCTCGGCCATCCTCCGCCGCCATCACCAACTCCGGCGATTTTGCCGGCCTGT
TCTCCAGCGGCGCCAGGTCGCTTGAGTTTTCCGCCGCCGGCAATCGCCTCACTTTGAAACAAAGCGGAGCCTCAATTCCC
CTCCTCCGCGTGCAAGGCGATACGTTCCGCGTCGAATCAGGCATCCTGGCCGAGTACTACTTTGTCTTCACCCGCAACGC
GGGTAAGGTCACCGAGCTCTCGTACGGACCCGACTGGTACACCAGCAAGGCCTATACCGGGCCGAAGCAGTTCGACACTC
CGCCCGAATTCGCCGCCTACGCCGGACGCTACGTGAATCACAATCCCGAAGAAGGCGCCGTTCATGTCTTCGTGCGCAAA
GGCCAGCTCTTCCTCGCCACCGGAACGGGCCCCGGACAACGCCTCCTTCCCGCCGGCCCGGCAACCTTCCGCCCTGGCGC
TCCCGAGTTCAACCCCGAACGCATTTCTTTCGATTCGATTGTTGAAGGCCACGCCCTGCGCCTGCTCCGCTCCGGCATGC
CCATGTACCGCATGGACCTCCGTTAG

Upstream 100 bases:

>100_bases
GACGCTGGCCAGGCCGGGCGTTCCAATCCGGTGCTCAAGCCCCCGCCCGTGGCTTCGACCTTTCCGGTCAAACTGTTCAA
TCCCGCGACGGACTACTGAT

Downstream 100 bases:

>100_bases
ATCCTGCACAACGGCACGGCACCTGCTTCTCCTTACGACCATGCAGGTTCCCCGTTGGCTTCTTCCGGCGGCTTTAGCGG
GCGTGCTCGCAATCGCGGCC

Product: beta-lactamase

Products: NA

Alternate protein names: Cephalosporinase [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MSPSLAFLLLALAPAFAQNDTAARLARAFAAIDRAATASTAPGMVVGITDRTRTLKIGAYGYANLNSKTRITPETLFEIG
SVSKSFTAISLMELFDEDRFDPQEPVAKYLPWFALKSRYRAITGHDLLTHTSGLQNYRPDLASMPFAALSLRDFEPSYAP
GEHYWYSNLGFQVLGYVLEHIDAAKYDTIVQRRILNRLGMSATHAAIDDALRARLPQSYSHWPYTGEFTEEPWFEYLAAD
GSIASTAGDMTAYARLILNRGVAPSGRLLSERAFAQLTRPTLNSYAYGLFVRQDDGDTVIQHGGGIAGFQTLLEMHMQDG
FGIIAMGNGGLDRELVQFAIASVKAALRDKPLPDPPARPSSAAITNSGDFAGLFSSGARSLEFSAAGNRLTLKQSGASIP
LLRVQGDTFRVESGILAEYYFVFTRNAGKVTELSYGPDWYTSKAYTGPKQFDTPPEFAAYAGRYVNHNPEEGAVHVFVRK
GQLFLATGTGPGQRLLPAGPATFRPGAPEFNPERISFDSIVEGHALRLLRSGMPMYRMDLR

Sequences:

>Translated_541_residues
MSPSLAFLLLALAPAFAQNDTAARLARAFAAIDRAATASTAPGMVVGITDRTRTLKIGAYGYANLNSKTRITPETLFEIG
SVSKSFTAISLMELFDEDRFDPQEPVAKYLPWFALKSRYRAITGHDLLTHTSGLQNYRPDLASMPFAALSLRDFEPSYAP
GEHYWYSNLGFQVLGYVLEHIDAAKYDTIVQRRILNRLGMSATHAAIDDALRARLPQSYSHWPYTGEFTEEPWFEYLAAD
GSIASTAGDMTAYARLILNRGVAPSGRLLSERAFAQLTRPTLNSYAYGLFVRQDDGDTVIQHGGGIAGFQTLLEMHMQDG
FGIIAMGNGGLDRELVQFAIASVKAALRDKPLPDPPARPSSAAITNSGDFAGLFSSGARSLEFSAAGNRLTLKQSGASIP
LLRVQGDTFRVESGILAEYYFVFTRNAGKVTELSYGPDWYTSKAYTGPKQFDTPPEFAAYAGRYVNHNPEEGAVHVFVRK
GQLFLATGTGPGQRLLPAGPATFRPGAPEFNPERISFDSIVEGHALRLLRSGMPMYRMDLR
>Mature_540_residues
SPSLAFLLLALAPAFAQNDTAARLARAFAAIDRAATASTAPGMVVGITDRTRTLKIGAYGYANLNSKTRITPETLFEIGS
VSKSFTAISLMELFDEDRFDPQEPVAKYLPWFALKSRYRAITGHDLLTHTSGLQNYRPDLASMPFAALSLRDFEPSYAPG
EHYWYSNLGFQVLGYVLEHIDAAKYDTIVQRRILNRLGMSATHAAIDDALRARLPQSYSHWPYTGEFTEEPWFEYLAADG
SIASTAGDMTAYARLILNRGVAPSGRLLSERAFAQLTRPTLNSYAYGLFVRQDDGDTVIQHGGGIAGFQTLLEMHMQDGF
GIIAMGNGGLDRELVQFAIASVKAALRDKPLPDPPARPSSAAITNSGDFAGLFSSGARSLEFSAAGNRLTLKQSGASIPL
LRVQGDTFRVESGILAEYYFVFTRNAGKVTELSYGPDWYTSKAYTGPKQFDTPPEFAAYAGRYVNHNPEEGAVHVFVRKG
QLFLATGTGPGQRLLPAGPATFRPGAPEFNPERISFDSIVEGHALRLLRSGMPMYRMDLR

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-C beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=171, Percent_Identity=27.4853801169591, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=296, Percent_Identity=25.6756756756757, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001586
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 59194; Mature: 59062

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00336 BETA_LACTAMASE_C

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSLAFLLLALAPAFAQNDTAARLARAFAAIDRAATASTAPGMVVGITDRTRTLKIGAY
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECE
GYANLNSKTRITPETLFEIGSVSKSFTAISLMELFDEDRFDPQEPVAKYLPWFALKSRYR
EEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHH
AITGHDLLTHTSGLQNYRPDLASMPFAALSLRDFEPSYAPGEHYWYSNLGFQVLGYVLEH
EECCCHHHHHHCCCHHCCCCHHHCCHHHEEEECCCCCCCCCCCCEECCCHHHHHHHHHHH
IDAAKYDTIVQRRILNRLGMSATHAAIDDALRARLPQSYSHWPYTGEFTEEPWFEYLAAD
HCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCC
GSIASTAGDMTAYARLILNRGVAPSGRLLSERAFAQLTRPTLNSYAYGLFVRQDDGDTVI
CCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEE
QHGGGIAGFQTLLEMHMQDGFGIIAMGNGGLDRELVQFAIASVKAALRDKPLPDPPARPS
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SAAITNSGDFAGLFSSGARSLEFSAAGNRLTLKQSGASIPLLRVQGDTFRVESGILAEYY
CCEECCCCCCHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCEEEECCCCEEEEE
FVFTRNAGKVTELSYGPDWYTSKAYTGPKQFDTPPEFAAYAGRYVNHNPEEGAVHVFVRK
EEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHCCCCCCCCEEEEEEEC
GQLFLATGTGPGQRLLPAGPATFRPGAPEFNPERISFDSIVEGHALRLLRSGMPMYRMDL
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
R
C
>Mature Secondary Structure 
SPSLAFLLLALAPAFAQNDTAARLARAFAAIDRAATASTAPGMVVGITDRTRTLKIGAY
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECE
GYANLNSKTRITPETLFEIGSVSKSFTAISLMELFDEDRFDPQEPVAKYLPWFALKSRYR
EEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHH
AITGHDLLTHTSGLQNYRPDLASMPFAALSLRDFEPSYAPGEHYWYSNLGFQVLGYVLEH
EECCCHHHHHHCCCHHCCCCHHHCCHHHEEEECCCCCCCCCCCCEECCCHHHHHHHHHHH
IDAAKYDTIVQRRILNRLGMSATHAAIDDALRARLPQSYSHWPYTGEFTEEPWFEYLAAD
HCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCC
GSIASTAGDMTAYARLILNRGVAPSGRLLSERAFAQLTRPTLNSYAYGLFVRQDDGDTVI
CCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEE
QHGGGIAGFQTLLEMHMQDGFGIIAMGNGGLDRELVQFAIASVKAALRDKPLPDPPARPS
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SAAITNSGDFAGLFSSGARSLEFSAAGNRLTLKQSGASIPLLRVQGDTFRVESGILAEYY
CCEECCCCCCHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCEEEECCCCEEEEE
FVFTRNAGKVTELSYGPDWYTSKAYTGPKQFDTPPEFAAYAGRYVNHNPEEGAVHVFVRK
EEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHCCCCCCCCEEEEEEEC
GQLFLATGTGPGQRLLPAGPATFRPGAPEFNPERISFDSIVEGHALRLLRSGMPMYRMDL
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2125210; 10984043; 8012497; 8405939 [H]