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The map label for this gene is napA [H]

Identifier: 116624606

GI number: 116624606

Start: 6934729

End: 6935967

Strand: Reverse

Name: napA [H]

Synonym: Acid_5530

Alternate gene names: 116624606

Gene position: 6935967-6934729 (Counterclockwise)

Preceding gene: 116624607

Following gene: 116624605

Centisome position: 69.6

GC content: 61.82

Gene sequence:

>1239_bases
ATGAATATCCCGGCCATTCCGCCGCTGGCTCTCATGTTGGATACCAGCGGTTCCGCCCACATTCCGTTATCGATGTTGAT
CATCTTCGTCTCCGCCAAACTCATGGCGGAGTTGTTCGAGCGCGTCAACCAGCCGGGCATCGTAGGCGAGATTCTTGCCG
GCGTGCTGATTGGCCCCAGCGTGTTGGGGCTGATCGGGCCGAGCGAATTCCTCACTGCACTTGCGGATTTGGGCGCGATG
TTTCTCCTGTTCCGGGTGGGATTGGACGTGCGCTCCTCTGAATTATTGCAAGTGGGCGGCACGGCGACGGTGGTGGCCTG
TTCGGGCGTGGTGGTTCCCTTTCTGTTTGGCTGGGGAATCCTGACGGCCTGGGGCGCTTCCGCCAACGAAGCCATCTTCG
TGGGAGCCTCGATGGTGGCAACCAGTGTCGGAATCACGGCGCAGGTGCTCTCGGCCAAAGGACTGCTGCACGCGATTTCG
AGCAAGATCATTTTGGCCGCGGCGGTGATCGACGACGTCCTCGGGTTGTTGGTGCTGGCAGTGGTGAGCAGCCTGACTCA
CGGGCAGCTAAATATTCCGGCGCTGGCCTTGACCGCCGTAATGGCGGTGGGATTCACGTTAGTGATTGCGAAATGGGGCA
CGCATGCGATGGGGCGTGTGGTGCCGCACGTGGATCAGAAATTGCGCGTAGGCGAAGCGCAGTTCGCGCTGGCGATGAGC
GTACTTTTTGCGCTGTCTGTAGCCGCAGTCTATATCGGTGTAGCGGCAATCGTGGGCGCGTTCCTGGCCGGCTTGGCGCT
GGCGGAAAGCACCGGACAGCGGGTGCGGGATCTGGCGCACGGGGTGACCGAGTTACTAGTGCCGTTTTTCCTGGCGGGAA
TCGGCCTGCACGTCAGCCTGGCGGCGTTTTCCAGCCCGCGCAACGCGCTCCTGGCGGTGGTGATTCTGCTGGCCGCAGTG
GTCTCCAAATTCATCGGGTGCGGCCTGGGCGCGTTGGGCCTTGGCAAGGCCGACGCCCTGCGTGTAGGTGTAGGGATGAT
CCCGCGCGGCGAGGTGGGGATGGTGGTTGCGCAAATCGGGCTGGGATTCGGAATCATCACGCAGAATGTTTACGGCGTGG
TGGTGTTCATGTCTGTCGCCACCACGATTGTGGCGCCGCCGCTGATCAAGATCGCTTTCCGCGGCTTGCTCAAAACCGGA
CAGGCGGAAGCGCCGGAGGAAGTCTTCCGGATCGGTTAG

Upstream 100 bases:

>100_bases
CTGATTACGCACGGGGCACCCCCTCTGGCGGTGGCCGCCGGTATCGGATTCGGGGCCCTGTTGACGGTGCGCTCCACGCG
TTCCGCGTGAAGCTGCGGTC

Downstream 100 bases:

>100_bases
GGTGAGAGCGCGCGGCCCCTGCGATTTTACCTCTCGACACTCGTGTATACTTTTCTGCATGAATCGAAGGGCATTCGTTT
CCACGTCGGGCGCCGCAGCG

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MNIPAIPPLALMLDTSGSAHIPLSMLIIFVSAKLMAELFERVNQPGIVGEILAGVLIGPSVLGLIGPSEFLTALADLGAM
FLLFRVGLDVRSSELLQVGGTATVVACSGVVVPFLFGWGILTAWGASANEAIFVGASMVATSVGITAQVLSAKGLLHAIS
SKIILAAAVIDDVLGLLVLAVVSSLTHGQLNIPALALTAVMAVGFTLVIAKWGTHAMGRVVPHVDQKLRVGEAQFALAMS
VLFALSVAAVYIGVAAIVGAFLAGLALAESTGQRVRDLAHGVTELLVPFFLAGIGLHVSLAAFSSPRNALLAVVILLAAV
VSKFIGCGLGALGLGKADALRVGVGMIPRGEVGMVVAQIGLGFGIITQNVYGVVVFMSVATTIVAPPLIKIAFRGLLKTG
QAEAPEEVFRIG

Sequences:

>Translated_412_residues
MNIPAIPPLALMLDTSGSAHIPLSMLIIFVSAKLMAELFERVNQPGIVGEILAGVLIGPSVLGLIGPSEFLTALADLGAM
FLLFRVGLDVRSSELLQVGGTATVVACSGVVVPFLFGWGILTAWGASANEAIFVGASMVATSVGITAQVLSAKGLLHAIS
SKIILAAAVIDDVLGLLVLAVVSSLTHGQLNIPALALTAVMAVGFTLVIAKWGTHAMGRVVPHVDQKLRVGEAQFALAMS
VLFALSVAAVYIGVAAIVGAFLAGLALAESTGQRVRDLAHGVTELLVPFFLAGIGLHVSLAAFSSPRNALLAVVILLAAV
VSKFIGCGLGALGLGKADALRVGVGMIPRGEVGMVVAQIGLGFGIITQNVYGVVVFMSVATTIVAPPLIKIAFRGLLKTG
QAEAPEEVFRIG
>Mature_412_residues
MNIPAIPPLALMLDTSGSAHIPLSMLIIFVSAKLMAELFERVNQPGIVGEILAGVLIGPSVLGLIGPSEFLTALADLGAM
FLLFRVGLDVRSSELLQVGGTATVVACSGVVVPFLFGWGILTAWGASANEAIFVGASMVATSVGITAQVLSAKGLLHAIS
SKIILAAAVIDDVLGLLVLAVVSSLTHGQLNIPALALTAVMAVGFTLVIAKWGTHAMGRVVPHVDQKLRVGEAQFALAMS
VLFALSVAAVYIGVAAIVGAFLAGLALAESTGQRVRDLAHGVTELLVPFFLAGIGLHVSLAAFSSPRNALLAVVILLAAV
VSKFIGCGLGALGLGKADALRVGVGMIPRGEVGMVVAQIGLGFGIITQNVYGVVVFMSVATTIVAPPLIKIAFRGLLKTG
QAEAPEEVFRIG

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=428, Percent_Identity=26.1682242990654, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 42043; Mature: 42043

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPAIPPLALMLDTSGSAHIPLSMLIIFVSAKLMAELFERVNQPGIVGEILAGVLIGPS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VLGLIGPSEFLTALADLGAMFLLFRVGLDVRSSELLQVGGTATVVACSGVVVPFLFGWGI
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHH
LTAWGASANEAIFVGASMVATSVGITAQVLSAKGLLHAISSKIILAAAVIDDVLGLLVLA
HHHCCCCCCCEEEECHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSSLTHGQLNIPALALTAVMAVGFTLVIAKWGTHAMGRVVPHVDQKLRVGEAQFALAMS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHH
VLFALSVAAVYIGVAAIVGAFLAGLALAESTGQRVRDLAHGVTELLVPFFLAGIGLHVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFSSPRNALLAVVILLAAVVSKFIGCGLGALGLGKADALRVGVGMIPRGEVGMVVAQIG
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHH
LGFGIITQNVYGVVVFMSVATTIVAPPLIKIAFRGLLKTGQAEAPEEVFRIG
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure
MNIPAIPPLALMLDTSGSAHIPLSMLIIFVSAKLMAELFERVNQPGIVGEILAGVLIGPS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VLGLIGPSEFLTALADLGAMFLLFRVGLDVRSSELLQVGGTATVVACSGVVVPFLFGWGI
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHH
LTAWGASANEAIFVGASMVATSVGITAQVLSAKGLLHAISSKIILAAAVIDDVLGLLVLA
HHHCCCCCCCEEEECHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSSLTHGQLNIPALALTAVMAVGFTLVIAKWGTHAMGRVVPHVDQKLRVGEAQFALAMS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHH
VLFALSVAAVYIGVAAIVGAFLAGLALAESTGQRVRDLAHGVTELLVPFFLAGIGLHVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFSSPRNALLAVVILLAAVVSKFIGCGLGALGLGKADALRVGVGMIPRGEVGMVVAQIG
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHH
LGFGIITQNVYGVVVFMSVATTIVAPPLIKIAFRGLLKTGQAEAPEEVFRIG
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]