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The map label for this gene is ppi [H]

Identifier: 116624576

GI number: 116624576

Start: 6895645

End: 6896700

Strand: Direct

Name: ppi [H]

Synonym: Acid_5500

Alternate gene names: 116624576

Gene position: 6895645-6896700 (Clockwise)

Preceding gene: 116624575

Following gene: 116624577

Centisome position: 69.19

GC content: 60.42

Gene sequence:

>1056_bases
ATGCGATTCCTTCCGCTTCTACTCTGTTCGGTCGCGTTCGCGCAATCGCCCGCGGATCTCGAGGCCGTCGTGACCACGGA
CCTCGGTGTCTTCCGTTTCGAGTTTGCTGCCGATAAGGCGCCGAAGCACGTACAGCATTTCATCCAGCTCGCCCGCGAAG
GCTTCTACGATGGCAGCGCCTTCCATCGCGTGGTGGCCTACGGCATCATACAAGGCGGTGACCCGCTCCTCAAGGAACCC
AAGACCCCGCGCAAACTCTGGGGCACCGGCGGACTGAACCAGCTCGCCGGCGAATTCAGCGATATGAAGCACGAGCGCGG
CGTGGTCTCCACCGTCAGCATTCCCAACAAGCTCGATAGCGATGGCTCGCAGTTCTTCATCTGTATCTCGCCGCAGCCTC
CGCTCGATGGAAAGTTCTCCGCCTTCGGCCGCGTTAGCGAGGGCATGGACGTGGTGGAGAAGATCTCGCAATCTCCCAAC
AACGCCGATGGCATGGTGGAAAAGCCGGTTCGCATTCTCAAGGTGGTGATCGAAAGGAAAAAGGTCGAACCTTTCGTCAA
CGAGCCCGTGGAGCAGCTGAAGCGCACCGTGACCATGAAGACCACGCTCGGCACGTTGAAGATCAAGATGGAGCCAGACT
GGGCGCCCAACCACGTGCGCAACTTCCTCAAGCTGGCTGAGACCGGATGGCTGAACGGCACCAGCTTTCACCGAATTGTA
AAGGGCTTCGTAGTGCAGGGAGGGATGGAGAACTCGCGCGTGAACGGCGCCGCGCATCCGGCCGACCGCTGGGTGCGCCC
ACTGAACGGCGAGTTCCGCAAGGACGTGCAGCACGTTCGCGGCATCGTCAGCATGGCGCGCTCCGACGATCCGAACTCGG
CGACCACGTCTTTTTTCCTCATGCTCGCCCCCGCCCCTCACCTGGACGGCCAATACTCGGCGTTCGGCCGGATCGTCGAA
GGCATGGAAGTATTGGACCTGTTCGAAAAGGAAGAGCTGACCGGCGAGACTCCAAAACGCCGTCTGGAAATCATCGAAGC
GACCATAGACAAGTAG

Upstream 100 bases:

>100_bases
CTTCGGAACGGGGACCGTTACCCTGAGGGCCACGTCTGAGAGCGCCCCCGCGAGGTCGGTAACCGCGACCTGCAGGAGAT
AACCAGTTAGGATGAAATTG

Downstream 100 bases:

>100_bases
GACAGATCGAGACGTACAATACCGCACTCCTCAACGCCATGTTGTCGGTATCGATGAGTAAGTCAGAGTCACGTACTAAC
TAAGTGCTTTCTGGCACTCT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MRFLPLLLCSVAFAQSPADLEAVVTTDLGVFRFEFAADKAPKHVQHFIQLAREGFYDGSAFHRVVAYGIIQGGDPLLKEP
KTPRKLWGTGGLNQLAGEFSDMKHERGVVSTVSIPNKLDSDGSQFFICISPQPPLDGKFSAFGRVSEGMDVVEKISQSPN
NADGMVEKPVRILKVVIERKKVEPFVNEPVEQLKRTVTMKTTLGTLKIKMEPDWAPNHVRNFLKLAETGWLNGTSFHRIV
KGFVVQGGMENSRVNGAAHPADRWVRPLNGEFRKDVQHVRGIVSMARSDDPNSATTSFFLMLAPAPHLDGQYSAFGRIVE
GMEVLDLFEKEELTGETPKRRLEIIEATIDK

Sequences:

>Translated_351_residues
MRFLPLLLCSVAFAQSPADLEAVVTTDLGVFRFEFAADKAPKHVQHFIQLAREGFYDGSAFHRVVAYGIIQGGDPLLKEP
KTPRKLWGTGGLNQLAGEFSDMKHERGVVSTVSIPNKLDSDGSQFFICISPQPPLDGKFSAFGRVSEGMDVVEKISQSPN
NADGMVEKPVRILKVVIERKKVEPFVNEPVEQLKRTVTMKTTLGTLKIKMEPDWAPNHVRNFLKLAETGWLNGTSFHRIV
KGFVVQGGMENSRVNGAAHPADRWVRPLNGEFRKDVQHVRGIVSMARSDDPNSATTSFFLMLAPAPHLDGQYSAFGRIVE
GMEVLDLFEKEELTGETPKRRLEIIEATIDK
>Mature_351_residues
MRFLPLLLCSVAFAQSPADLEAVVTTDLGVFRFEFAADKAPKHVQHFIQLAREGFYDGSAFHRVVAYGIIQGGDPLLKEP
KTPRKLWGTGGLNQLAGEFSDMKHERGVVSTVSIPNKLDSDGSQFFICISPQPPLDGKFSAFGRVSEGMDVVEKISQSPN
NADGMVEKPVRILKVVIERKKVEPFVNEPVEQLKRTVTMKTTLGTLKIKMEPDWAPNHVRNFLKLAETGWLNGTSFHRIV
KGFVVQGGMENSRVNGAAHPADRWVRPLNGEFRKDVQHVRGIVSMARSDDPNSATTSFFLMLAPAPHLDGQYSAFGRIVE
GMEVLDLFEKEELTGETPKRRLEIIEATIDK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=157, Percent_Identity=35.031847133758, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI24308049, Length=161, Percent_Identity=34.1614906832298, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22547215, Length=154, Percent_Identity=35.7142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22547212, Length=154, Percent_Identity=35.7142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI7657473, Length=154, Percent_Identity=35.7142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI7706339, Length=157, Percent_Identity=31.8471337579618, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI10863927, Length=160, Percent_Identity=36.875, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI310110104, Length=145, Percent_Identity=35.1724137931034, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI310129267, Length=141, Percent_Identity=35.4609929078014, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI310120620, Length=141, Percent_Identity=35.4609929078014, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI5031987, Length=154, Percent_Identity=38.961038961039, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI64276486, Length=145, Percent_Identity=30.3448275862069, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4826932, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI27735045, Length=165, Percent_Identity=29.0909090909091, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI6631100, Length=182, Percent_Identity=31.3186813186813, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4758950, Length=153, Percent_Identity=35.9477124183007, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4505991, Length=173, Percent_Identity=33.5260115606936, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI256017253, Length=135, Percent_Identity=37.7777777777778, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI221139811, Length=135, Percent_Identity=37.7777777777778, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI256017251, Length=135, Percent_Identity=37.7777777777778, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1789763, Length=140, Percent_Identity=33.5714285714286, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786736, Length=138, Percent_Identity=34.7826086956522, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=167, Percent_Identity=34.1317365269461, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=35.2112676056338, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=135, Percent_Identity=37.037037037037, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=135, Percent_Identity=37.037037037037, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=138, Percent_Identity=32.6086956521739, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17506307, Length=123, Percent_Identity=41.4634146341463, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=137, Percent_Identity=32.1167883211679, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=165, Percent_Identity=33.9393939393939, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=129, Percent_Identity=39.5348837209302, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=148, Percent_Identity=36.4864864864865, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=166, Percent_Identity=31.9277108433735, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=146, Percent_Identity=37.6712328767123, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652460, Length=137, Percent_Identity=37.956204379562, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17986117, Length=157, Percent_Identity=35.031847133758, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922376, Length=141, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21357249, Length=136, Percent_Identity=34.5588235294118, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19922912, Length=137, Percent_Identity=34.3065693430657, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664125, Length=155, Percent_Identity=36.1290322580645, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357783, Length=155, Percent_Identity=36.1290322580645, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586038, Length=159, Percent_Identity=30.8176100628931, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45549139, Length=147, Percent_Identity=34.6938775510204, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 39014; Mature: 39014

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLPLLLCSVAFAQSPADLEAVVTTDLGVFRFEFAADKAPKHVQHFIQLAREGFYDGSA
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEHHHCCCHHHHHHHHHHHHHCCCCCHH
FHRVVAYGIIQGGDPLLKEPKTPRKLWGTGGLNQLAGEFSDMKHERGVVSTVSIPNKLDS
HHHHHHHHHHCCCCHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCC
DGSQFFICISPQPPLDGKFSAFGRVSEGMDVVEKISQSPNNADGMVEKPVRILKVVIERK
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
KVEPFVNEPVEQLKRTVTMKTTLGTLKIKMEPDWAPNHVRNFLKLAETGWLNGTSFHRIV
HCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
KGFVVQGGMENSRVNGAAHPADRWVRPLNGEFRKDVQHVRGIVSMARSDDPNSATTSFFL
HHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEE
MLAPAPHLDGQYSAFGRIVEGMEVLDLFEKEELTGETPKRRLEIIEATIDK
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFLPLLLCSVAFAQSPADLEAVVTTDLGVFRFEFAADKAPKHVQHFIQLAREGFYDGSA
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEHHHCCCHHHHHHHHHHHHHCCCCCHH
FHRVVAYGIIQGGDPLLKEPKTPRKLWGTGGLNQLAGEFSDMKHERGVVSTVSIPNKLDS
HHHHHHHHHHCCCCHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCC
DGSQFFICISPQPPLDGKFSAFGRVSEGMDVVEKISQSPNNADGMVEKPVRILKVVIERK
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
KVEPFVNEPVEQLKRTVTMKTTLGTLKIKMEPDWAPNHVRNFLKLAETGWLNGTSFHRIV
HCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
KGFVVQGGMENSRVNGAAHPADRWVRPLNGEFRKDVQHVRGIVSMARSDDPNSATTSFFL
HHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEE
MLAPAPHLDGQYSAFGRIVEGMEVLDLFEKEELTGETPKRRLEIIEATIDK
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA