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The map label for this gene is copR [H]

Identifier: 116624553

GI number: 116624553

Start: 6870280

End: 6870969

Strand: Direct

Name: copR [H]

Synonym: Acid_5477

Alternate gene names: 116624553

Gene position: 6870280-6870969 (Clockwise)

Preceding gene: 116624551

Following gene: 116624554

Centisome position: 68.94

GC content: 64.35

Gene sequence:

>690_bases
GTGCGTATTCTGCTGGTTGAAGACGAAAGCCGCGTCGCCGGATTTCTGGCTAAGGGGCTGCGCGAACAGGCGTACGCGGT
GGATCTCGCGGCCGACGGCGAAAGCGCTCTCTACCAGGCGGCGGTCAACCACTACGACCTGGTGATTCTGGACGTGATGC
TGCCCCTGAAGAACGGGTACGCTGTCTGCCGCGAATTGCGGGCCGCGGGATTTAGCGCGCCGATTCTCATGTTGACGGCG
CGCGATTCCATCGACGATCGCGTGGCGGGGCTGGATTCCGGCGCCGACGATTACCTGGTAAAGCCGTTCGATTTTAAAGA
GCTGCTGGCCCGGCTGCGCGCGCTTTCGCGGCGTTCCGGGGATCCGCGGCCGGAAGCGCTGAGAGTCGCGGACCTGACGG
TGAATACGGCCAGCCATGCGGTGGAGCGGGGCGGACGAATTATCAGCCTCACCGCCAAGGAATACGCGCTGCTGGAGTTT
CTAATGCTCAACCAGGACCGCGTGGTGGGCCGGGAAGCGATCGCGCAGCACGTGTGGGAGGAGACGTTCGACGCCTTCAC
CAACGTGATCGACGTCTACATCAAGAGGCTGCGCGCCAAGCTCGATGGGCCGGGATCGCCGCGGCTGATCCACACGCGCC
GGGGCGAGGGCTACATCCTCACGGCGAAGCCGGAGGCCGGCGATGTTTAA

Upstream 100 bases:

>100_bases
CCTCACCTCGTCAACAGGATTCCACAAATGGGGCACGGGTGTCACGATAAGAAAACGCGTTCATTGTGCGTTCATCCGCG
GGAAGTCAAAATGAAAGGAC

Downstream 100 bases:

>100_bases
GAGCCTCCGCGCGCGCCTGACAGCGCTTTACCTGGTGCTGTTCTCGCTGTTGTTCGTCCTATTCAGCCTGTCCCTGTACG
GTGAACTCTCGCGGTCTTTG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRILLVEDESRVAGFLAKGLREQAYAVDLAADGESALYQAAVNHYDLVILDVMLPLKNGYAVCRELRAAGFSAPILMLTA
RDSIDDRVAGLDSGADDYLVKPFDFKELLARLRALSRRSGDPRPEALRVADLTVNTASHAVERGGRIISLTAKEYALLEF
LMLNQDRVVGREAIAQHVWEETFDAFTNVIDVYIKRLRAKLDGPGSPRLIHTRRGEGYILTAKPEAGDV

Sequences:

>Translated_229_residues
MRILLVEDESRVAGFLAKGLREQAYAVDLAADGESALYQAAVNHYDLVILDVMLPLKNGYAVCRELRAAGFSAPILMLTA
RDSIDDRVAGLDSGADDYLVKPFDFKELLARLRALSRRSGDPRPEALRVADLTVNTASHAVERGGRIISLTAKEYALLEF
LMLNQDRVVGREAIAQHVWEETFDAFTNVIDVYIKRLRAKLDGPGSPRLIHTRRGEGYILTAKPEAGDV
>Mature_229_residues
MRILLVEDESRVAGFLAKGLREQAYAVDLAADGESALYQAAVNHYDLVILDVMLPLKNGYAVCRELRAAGFSAPILMLTA
RDSIDDRVAGLDSGADDYLVKPFDFKELLARLRALSRRSGDPRPEALRVADLTVNTASHAVERGGRIISLTAKEYALLEF
LMLNQDRVVGREAIAQHVWEETFDAFTNVIDVYIKRLRAKLDGPGSPRLIHTRRGEGYILTAKPEAGDV

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=50.2262443438914, Blast_Score=210, Evalue=6e-56,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=45.945945945946, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=40.8888888888889, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36.4444444444444, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=39.3805309734513, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.6681614349776, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=33.1818181818182, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=36.986301369863, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=38.5281385281385, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1788394, Length=205, Percent_Identity=35.1219512195122, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=33.4782608695652, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=30.6034482758621, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=32.3144104803493, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790437, Length=178, Percent_Identity=32.5842696629214, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=139, Percent_Identity=33.8129496402878, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25310; Mature: 25310

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDESRVAGFLAKGLREQAYAVDLAADGESALYQAAVNHYDLVILDVMLPLKNGY
CEEEEECCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCCEEEEEEHHHCCCCH
AVCRELRAAGFSAPILMLTARDSIDDRVAGLDSGADDYLVKPFDFKELLARLRALSRRSG
HHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCC
DPRPEALRVADLTVNTASHAVERGGRIISLTAKEYALLEFLMLNQDRVVGREAIAQHVWE
CCCCHHEEEEEEEECHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ETFDAFTNVIDVYIKRLRAKLDGPGSPRLIHTRRGEGYILTAKPEAGDV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCCC
>Mature Secondary Structure
MRILLVEDESRVAGFLAKGLREQAYAVDLAADGESALYQAAVNHYDLVILDVMLPLKNGY
CEEEEECCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCCEEEEEEHHHCCCCH
AVCRELRAAGFSAPILMLTARDSIDDRVAGLDSGADDYLVKPFDFKELLARLRALSRRSG
HHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCC
DPRPEALRVADLTVNTASHAVERGGRIISLTAKEYALLEFLMLNQDRVVGREAIAQHVWE
CCCCHHEEEEEEEECHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ETFDAFTNVIDVYIKRLRAKLDGPGSPRLIHTRRGEGYILTAKPEAGDV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]