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The map label for this gene is kbl [C]

Identifier: 116624524

GI number: 116624524

Start: 6826344

End: 6827597

Strand: Reverse

Name: kbl [C]

Synonym: Acid_5448

Alternate gene names: 116624524

Gene position: 6827597-6826344 (Counterclockwise)

Preceding gene: 116624525

Following gene: 116624521

Centisome position: 68.51

GC content: 61.8

Gene sequence:

>1254_bases
ATGGAACTGAGGACCATGCGCGTATCGACTAGCGATATCACCGGCAAAAGAAAGGGCAGCGGCTCGAACGATATTTTCGA
GAAGTGCCGAAATTTCACTCGTCCGAGTGATTTGCAAGCCGCCGGGCTTTACATGTACTTCGAGGTTTTTGGCGACCGCG
AAGGATGTGGAGCTGGCGAAGTCCGCATGGGGCGCCGCAAAGTGCTGATGTTCGGGTCCAACGACTATCTGGACCTGATC
ACGCACCCGAAGGTGAAGGAGGCCTCGGTACAGGCGCTCAAGAAGTACGGCAGCGGTTGCAGCGGCTCGCGGCTGTTGAA
CGGCACGCTGGATCTGCACGTCAAACTGGAAACCGAACTTGCCTCATTCGTTCATAAAGAAGCGGCTATCATATTCGGCA
CCGGCTTCCAGGCCAATTACGCCACGCTGAGCGCGTTGACGGAAAAAGGCGACGTGATGGTCTGCGATCACAACCTGCAT
GCCAGCCTGGTGGAAGGAGCGCTGCGCTCGCCGGCGCGAACCGTGCGGTTTCGCCACAACGACATGGACCACTTCGAGCG
GTGTCTGGAGAACTGCCCGCCCGAAGAGAAGATTTTCATCGTGAGTGAAGGCGTGTTCAGCATGGAAGGCGATATCGCCG
ACCTGCAGGGAATTTTGAAGCTGGCCAAGCCGTATGGCGCGCGCACGTATGTGGACGAAGCGCACGGCATCGGAGTGCTT
GGGGAGACCGGGGCGGGCGCGGCGGAGCACTTGGGCGTGCTGGACGACGTGGACATCGTGATGGGCACGTTCAGCAAGTC
GCTGGCATCGGTGGGCGGCTTCATTGCGGGCGAACGCGCGGTGATCGATTACCTGAAGCACACGGCGCGGCCGTTTGTGT
TCTCGGCCAGCCTGCCGGCGGCGAGCGTGGCGGCCGTCGGAGCGGCGCTGCAGATCATGAGGAAAGAGCCGGAGCGACGG
CTGCACCTGCTGCGGATCGCGCAGTTGCTGCGCGACGAGTTGCGGGCACGCGGTTTCAACGTGCTGCCGGGCGAGACGGC
GATTGTGCCGGTGGTGATTCAGCAGGAGCTGGATCTGTGCCGGCTTTGCAAGGCGCTGCTGGAAGAGGGCATCTACATCA
ACCCGGTGCTGCGTCCGGCGGCGGCGCAGAATTTATTGCGGATCTCGTGCACAGCGGCGCACACGGAGAAGCACGTGGAG
CGGCTGGTGAATACGCTGGTGCGGGTCGCGGCTGAGCTCGGGATCGAGCGGTAG

Upstream 100 bases:

>100_bases
GCGATTGCGAGATGTCGTGGATTCTTGAAGACAACGTGCTCATGAATCGCTCGTTAGAAGTGATGGGGGCAAAGCGTTAC
AAGGCATATCGAATTTATGA

Downstream 100 bases:

>100_bases
GAGCTTCTTCAGGAATCAGATTAGCCCACGGCTTGCGCCGTGGGCTTTTTTACGTGAAATACGGGAAGCCTGTCTTACTT
TGGGTTTTGCATGGAGGTTT

Product: serine palmitoyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MELRTMRVSTSDITGKRKGSGSNDIFEKCRNFTRPSDLQAAGLYMYFEVFGDREGCGAGEVRMGRRKVLMFGSNDYLDLI
THPKVKEASVQALKKYGSGCSGSRLLNGTLDLHVKLETELASFVHKEAAIIFGTGFQANYATLSALTEKGDVMVCDHNLH
ASLVEGALRSPARTVRFRHNDMDHFERCLENCPPEEKIFIVSEGVFSMEGDIADLQGILKLAKPYGARTYVDEAHGIGVL
GETGAGAAEHLGVLDDVDIVMGTFSKSLASVGGFIAGERAVIDYLKHTARPFVFSASLPAASVAAVGAALQIMRKEPERR
LHLLRIAQLLRDELRARGFNVLPGETAIVPVVIQQELDLCRLCKALLEEGIYINPVLRPAAAQNLLRISCTAAHTEKHVE
RLVNTLVRVAAELGIER

Sequences:

>Translated_417_residues
MELRTMRVSTSDITGKRKGSGSNDIFEKCRNFTRPSDLQAAGLYMYFEVFGDREGCGAGEVRMGRRKVLMFGSNDYLDLI
THPKVKEASVQALKKYGSGCSGSRLLNGTLDLHVKLETELASFVHKEAAIIFGTGFQANYATLSALTEKGDVMVCDHNLH
ASLVEGALRSPARTVRFRHNDMDHFERCLENCPPEEKIFIVSEGVFSMEGDIADLQGILKLAKPYGARTYVDEAHGIGVL
GETGAGAAEHLGVLDDVDIVMGTFSKSLASVGGFIAGERAVIDYLKHTARPFVFSASLPAASVAAVGAALQIMRKEPERR
LHLLRIAQLLRDELRARGFNVLPGETAIVPVVIQQELDLCRLCKALLEEGIYINPVLRPAAAQNLLRISCTAAHTEKHVE
RLVNTLVRVAAELGIER
>Mature_417_residues
MELRTMRVSTSDITGKRKGSGSNDIFEKCRNFTRPSDLQAAGLYMYFEVFGDREGCGAGEVRMGRRKVLMFGSNDYLDLI
THPKVKEASVQALKKYGSGCSGSRLLNGTLDLHVKLETELASFVHKEAAIIFGTGFQANYATLSALTEKGDVMVCDHNLH
ASLVEGALRSPARTVRFRHNDMDHFERCLENCPPEEKIFIVSEGVFSMEGDIADLQGILKLAKPYGARTYVDEAHGIGVL
GETGAGAAEHLGVLDDVDIVMGTFSKSLASVGGFIAGERAVIDYLKHTARPFVFSASLPAASVAAVGAALQIMRKEPERR
LHLLRIAQLLRDELRARGFNVLPGETAIVPVVIQQELDLCRLCKALLEEGIYINPVLRPAAAQNLLRISCTAAHTEKHVE
RLVNTLVRVAAELGIER

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=364, Percent_Identity=33.2417582417582, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI83977440, Length=364, Percent_Identity=33.2417582417582, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI83977444, Length=364, Percent_Identity=33.2417582417582, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI7657118, Length=347, Percent_Identity=34.2939481268012, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=34.2939481268012, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI4502025, Length=359, Percent_Identity=32.3119777158774, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI40316939, Length=359, Percent_Identity=32.3119777158774, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=32.7913279132791, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=33.5135135135135, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI5454084, Length=263, Percent_Identity=36.5019011406844, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1790046, Length=353, Percent_Identity=33.4277620396601, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=34.1040462427746, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71994529, Length=385, Percent_Identity=30.9090909090909, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=32.6086956521739, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=31.767955801105, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=31.767955801105, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=303, Percent_Identity=32.3432343234323, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71982625, Length=303, Percent_Identity=32.3432343234323, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320438, Length=379, Percent_Identity=33.509234828496, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=352, Percent_Identity=30.1136363636364, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323954, Length=280, Percent_Identity=33.9285714285714, Blast_Score=155, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=32.122905027933, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17137420, Length=387, Percent_Identity=33.0749354005168, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24653280, Length=274, Percent_Identity=31.021897810219, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24653276, Length=274, Percent_Identity=31.021897810219, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24653278, Length=274, Percent_Identity=31.021897810219, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 45565; Mature: 45565

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRTMRVSTSDITGKRKGSGSNDIFEKCRNFTRPSDLQAAGLYMYFEVFGDREGCGAGE
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHEEEEEEECCCCCCCCCC
VRMGRRKVLMFGSNDYLDLITHPKVKEASVQALKKYGSGCSGSRLLNGTLDLHVKLETEL
EECCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEHHHH
ASFVHKEAAIIFGTGFQANYATLSALTEKGDVMVCDHNLHASLVEGALRSPARTVRFRHN
HHHHHHCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCHHHEEECCC
DMDHFERCLENCPPEEKIFIVSEGVFSMEGDIADLQGILKLAKPYGARTYVDEAHGIGVL
CHHHHHHHHHHCCCCCEEEEEECCCEECCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEE
GETGAGAAEHLGVLDDVDIVMGTFSKSLASVGGFIAGERAVIDYLKHTARPFVFSASLPA
CCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCEEEECCCCH
ASVAAVGAALQIMRKEPERRLHLLRIAQLLRDELRARGFNVLPGETAIVPVVIQQELDLC
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHCCHH
RLCKALLEEGIYINPVLRPAAAQNLLRISCTAAHTEKHVERLVNTLVRVAAELGIER
HHHHHHHHCCCEECCCCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MELRTMRVSTSDITGKRKGSGSNDIFEKCRNFTRPSDLQAAGLYMYFEVFGDREGCGAGE
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHEEEEEEECCCCCCCCCC
VRMGRRKVLMFGSNDYLDLITHPKVKEASVQALKKYGSGCSGSRLLNGTLDLHVKLETEL
EECCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEHHHH
ASFVHKEAAIIFGTGFQANYATLSALTEKGDVMVCDHNLHASLVEGALRSPARTVRFRHN
HHHHHHCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCHHHEEECCC
DMDHFERCLENCPPEEKIFIVSEGVFSMEGDIADLQGILKLAKPYGARTYVDEAHGIGVL
CHHHHHHHHHHCCCCCEEEEEECCCEECCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEE
GETGAGAAEHLGVLDDVDIVMGTFSKSLASVGGFIAGERAVIDYLKHTARPFVFSASLPA
CCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCEEEECCCCH
ASVAAVGAALQIMRKEPERRLHLLRIAQLLRDELRARGFNVLPGETAIVPVVIQQELDLC
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHCCHH
RLCKALLEEGIYINPVLRPAAAQNLLRISCTAAHTEKHVERLVNTLVRVAAELGIER
HHHHHHHHCCCEECCCCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA