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The map label for this gene is fumA [H]

Identifier: 116624499

GI number: 116624499

Start: 6791563

End: 6793080

Strand: Reverse

Name: fumA [H]

Synonym: Acid_5423

Alternate gene names: 116624499

Gene position: 6793080-6791563 (Counterclockwise)

Preceding gene: 116624500

Following gene: 116624497

Centisome position: 68.17

GC content: 63.64

Gene sequence:

>1518_bases
ATGGAATTCCTAGTCAACAGCCTGCTTGAACTGATCACCCAGACCTCCACCAACCTGCCACCCGACGTGCGCGCCGCGAT
GTCGATCGCCGCCAATCAGGAGGTGCCCGGGACGCAATCCTCCCAGGCCCTGGATATCATCCTCTCGAACGTCGATATGG
CGGTCGAAGACGAAGGGCCGATCTGCCAGGACACCGGCATGCCGACGTTCTTCGTGCATACGCCGGTGGGCGTGAACCAG
ATCAAGATCAAGAAGGCCATCCAGGAGGCAGTTGCGGAAGCCACGAAACGCGGCAAGCTGCGTCCCAATTCGGTGGACTC
GCTAACCGGCAAGAACAGCGGCAACAACCTCGGTGAAGAAACTCCGGTGGTGCACTTCGAGCAGTGGGAAGAGGATTTCA
TCGAGGTCAAGCTGGTGCTGAAGGGCGGCGGCTGCGAAAACAAAAACATCCAGTACTCGGTGCCGTGCAACCTGGATCAC
CTGGGCCGCGCCGACCGTAACCTGGAAGGCGTTCGCAAGTGCCTGCTGCATGCGGTATGGCAGGCGCAGGGACAGGGCTG
CGCGCCGGGCGCCATCGGCGTCTGCATCGGCAGCGACCGCGCGCACGGGTACGCGCTGGCGAAAGGCCAGCTGTTCCGCA
CGCTCGACGACGTGAACCCGAATCCGGTTCTGGCGCAACTGGAAGCCGAGGTCATGGAAGAGGCCAACCGTCTCGGCGTA
GGCGCCATGGGTTTTGGCGGGAAGGCCAGCCTGATCGGCTGCAAGATTACCGCGGCCAATCGCCTGCCCGCGAGTTTCTT
CGTCAGCGTGGCGTACGATTGCTGGGCGTTCCGCCGCCTCGGCGTACACCTGGACGCGGCCAGCGGCGCGATCACGAAGT
GGATGTACCGCGACCCCGAGCGCGCGGTTGAAAAGATGGCGCGCGGCGAAGGCTTCCCGCTGACCGGGCGCGAAGTGGTG
CTGACGCCCCCCTTGACGGAAGCGCAGATGCGCGCGCTGAAGGTCGGCGACGTGGTGCTGATCGATGGCGAGATGTACAC
CGGCCGCGACAATGTGCACGCGTACCTGATGAAGAATCCTCCCCCGGTCGATTTGAACGGCGCGGCGCTCTACCATTGCG
GTCCGGTGATGCTCCAGGAAGGCGGCGAATGGAAGGTGAAAGCCGCCGGTCCCACCACCAGCATCCGCGAGGAACCCTAT
CAGGCCCACGTGATCAGGCAGTATGGCGTGCGCGCCGTGATCGGCAAGGGCGGCATGGGCAAGAAGACGCTCGACGCACT
GCAGGAATGCGGCGCGGTCTACCTGAACGGCATCGGCGGCGCGGCGCAGTATTACGCGCGCACGGTGGAGAAGGTGCTCG
ACGTCAATCTGCAGGAGTTCGGCATACCCGAAGCTATGTGGCACCTGCGCGTCAAGGGTTTCGCGGCAATCGTCACTATG
GACGCGCACGGCAATAGTCTTCACGCCGACGTGGAGAAGGCGACCGGTGAAGCGCTCGCAACGTTGCAGAAGGTGTGA

Upstream 100 bases:

>100_bases
CAACCTGCCCGCCATCAAGCCCGGCATGAACGCAGACGTCCGCCTCAAGCTGGAATAGCGCGGCCCGCGCAGTGTCCTAC
AATAGACGTTCGGAACTGAT

Downstream 100 bases:

>100_bases
GCGGATTGCTACACTAAAGTCTCCCTGGCCGGGTAGCTCAGCTGGTAGAGCAACGGACTGAAAATCCGTGTGTCGGCGGT
TCGATCCCGTCCCCGGCCAC

Product: fumarase

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MEFLVNSLLELITQTSTNLPPDVRAAMSIAANQEVPGTQSSQALDIILSNVDMAVEDEGPICQDTGMPTFFVHTPVGVNQ
IKIKKAIQEAVAEATKRGKLRPNSVDSLTGKNSGNNLGEETPVVHFEQWEEDFIEVKLVLKGGGCENKNIQYSVPCNLDH
LGRADRNLEGVRKCLLHAVWQAQGQGCAPGAIGVCIGSDRAHGYALAKGQLFRTLDDVNPNPVLAQLEAEVMEEANRLGV
GAMGFGGKASLIGCKITAANRLPASFFVSVAYDCWAFRRLGVHLDAASGAITKWMYRDPERAVEKMARGEGFPLTGREVV
LTPPLTEAQMRALKVGDVVLIDGEMYTGRDNVHAYLMKNPPPVDLNGAALYHCGPVMLQEGGEWKVKAAGPTTSIREEPY
QAHVIRQYGVRAVIGKGGMGKKTLDALQECGAVYLNGIGGAAQYYARTVEKVLDVNLQEFGIPEAMWHLRVKGFAAIVTM
DAHGNSLHADVEKATGEALATLQKV

Sequences:

>Translated_505_residues
MEFLVNSLLELITQTSTNLPPDVRAAMSIAANQEVPGTQSSQALDIILSNVDMAVEDEGPICQDTGMPTFFVHTPVGVNQ
IKIKKAIQEAVAEATKRGKLRPNSVDSLTGKNSGNNLGEETPVVHFEQWEEDFIEVKLVLKGGGCENKNIQYSVPCNLDH
LGRADRNLEGVRKCLLHAVWQAQGQGCAPGAIGVCIGSDRAHGYALAKGQLFRTLDDVNPNPVLAQLEAEVMEEANRLGV
GAMGFGGKASLIGCKITAANRLPASFFVSVAYDCWAFRRLGVHLDAASGAITKWMYRDPERAVEKMARGEGFPLTGREVV
LTPPLTEAQMRALKVGDVVLIDGEMYTGRDNVHAYLMKNPPPVDLNGAALYHCGPVMLQEGGEWKVKAAGPTTSIREEPY
QAHVIRQYGVRAVIGKGGMGKKTLDALQECGAVYLNGIGGAAQYYARTVEKVLDVNLQEFGIPEAMWHLRVKGFAAIVTM
DAHGNSLHADVEKATGEALATLQKV
>Mature_505_residues
MEFLVNSLLELITQTSTNLPPDVRAAMSIAANQEVPGTQSSQALDIILSNVDMAVEDEGPICQDTGMPTFFVHTPVGVNQ
IKIKKAIQEAVAEATKRGKLRPNSVDSLTGKNSGNNLGEETPVVHFEQWEEDFIEVKLVLKGGGCENKNIQYSVPCNLDH
LGRADRNLEGVRKCLLHAVWQAQGQGCAPGAIGVCIGSDRAHGYALAKGQLFRTLDDVNPNPVLAQLEAEVMEEANRLGV
GAMGFGGKASLIGCKITAANRLPASFFVSVAYDCWAFRRLGVHLDAASGAITKWMYRDPERAVEKMARGEGFPLTGREVV
LTPPLTEAQMRALKVGDVVLIDGEMYTGRDNVHAYLMKNPPPVDLNGAALYHCGPVMLQEGGEWKVKAAGPTTSIREEPY
QAHVIRQYGVRAVIGKGGMGKKTLDALQECGAVYLNGIGGAAQYYARTVEKVLDVNLQEFGIPEAMWHLRVKGFAAIVTM
DAHGNSLHADVEKATGEALATLQKV

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789443, Length=181, Percent_Identity=39.7790055248619, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1789442, Length=289, Percent_Identity=29.757785467128, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787897, Length=482, Percent_Identity=26.5560165975104, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790564, Length=482, Percent_Identity=25.9336099585062, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 54442; Mature: 54442

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLVNSLLELITQTSTNLPPDVRAAMSIAANQEVPGTQSSQALDIILSNVDMAVEDEGP
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHEEEEECCCEEECCCCC
ICQDTGMPTFFVHTPVGVNQIKIKKAIQEAVAEATKRGKLRPNSVDSLTGKNSGNNLGEE
EECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TPVVHFEQWEEDFIEVKLVLKGGGCENKNIQYSVPCNLDHLGRADRNLEGVRKCLLHAVW
CCEEEHHHHCCCEEEEEEEEECCCCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHHHHH
QAQGQGCAPGAIGVCIGSDRAHGYALAKGQLFRTLDDVNPNPVLAQLEAEVMEEANRLGV
HHCCCCCCCCCEEEEECCCCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
GAMGFGGKASLIGCKITAANRLPASFFVSVAYDCWAFRRLGVHLDAASGAITKWMYRDPE
CEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHCCHH
RAVEKMARGEGFPLTGREVVLTPPLTEAQMRALKVGDVVLIDGEMYTGRDNVHAYLMKNP
HHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHEEECCEEEECCEEEECCCCEEEEEECCC
PPVDLNGAALYHCGPVMLQEGGEWKVKAAGPTTSIREEPYQAHVIRQYGVRAVIGKGGMG
CCCCCCCEEEEECCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEECCCCCC
KKTLDALQECGAVYLNGIGGAAQYYARTVEKVLDVNLQEFGIPEAMWHLRVKGFAAIVTM
HHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHEEEEEEEEEEE
DAHGNSLHADVEKATGEALATLQKV
ECCCCCEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFLVNSLLELITQTSTNLPPDVRAAMSIAANQEVPGTQSSQALDIILSNVDMAVEDEGP
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHEEEEECCCEEECCCCC
ICQDTGMPTFFVHTPVGVNQIKIKKAIQEAVAEATKRGKLRPNSVDSLTGKNSGNNLGEE
EECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TPVVHFEQWEEDFIEVKLVLKGGGCENKNIQYSVPCNLDHLGRADRNLEGVRKCLLHAVW
CCEEEHHHHCCCEEEEEEEEECCCCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHHHHH
QAQGQGCAPGAIGVCIGSDRAHGYALAKGQLFRTLDDVNPNPVLAQLEAEVMEEANRLGV
HHCCCCCCCCCEEEEECCCCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
GAMGFGGKASLIGCKITAANRLPASFFVSVAYDCWAFRRLGVHLDAASGAITKWMYRDPE
CEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHCCHH
RAVEKMARGEGFPLTGREVVLTPPLTEAQMRALKVGDVVLIDGEMYTGRDNVHAYLMKNP
HHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHEEECCEEEECCEEEECCCCEEEEEECCC
PPVDLNGAALYHCGPVMLQEGGEWKVKAAGPTTSIREEPYQAHVIRQYGVRAVIGKGGMG
CCCCCCCEEEEECCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEECCCCCC
KKTLDALQECGAVYLNGIGGAAQYYARTVEKVLDVNLQEFGIPEAMWHLRVKGFAAIVTM
HHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHEEEEEEEEEEE
DAHGNSLHADVEKATGEALATLQKV
ECCCCCEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8473853 [H]