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The map label for this gene is cheA [H]

Identifier: 116624447

GI number: 116624447

Start: 6729199

End: 6731229

Strand: Direct

Name: cheA [H]

Synonym: Acid_5369

Alternate gene names: 116624447

Gene position: 6729199-6731229 (Clockwise)

Preceding gene: 116624446

Following gene: 116624448

Centisome position: 67.52

GC content: 61.6

Gene sequence:

>2031_bases
ATGCCATCACGAGAATTGCGAAGAGAAATTGAAGATCTCGCCCTCCGGCTGGTTGTCGGCGAGCCGGAGGACACCGGCGG
CGCGGCCAGGTGGTTACCGGCGTTCGAACAAATCCGCGAGCGCGCCCAGCGTGAACAGGCGATCGACGTTTCTATCGCGG
CAGGGTCGTTTCTCGATAATATGCGCCGCAGTGCGCTCTCCGAATCCGCTCTGCAGGATGGCATTGCTGCCTTGCAGAAA
GCCCTGGACGCCCCTGCGGTTGCAGCCGCCGCCGATATCCTTCCGGCCCAGGATCCCGAACTGATGTCAGATTTTATCGT
GGAGAGCCGCGAACACCTGGCCAACGTGGAAACCCAGGTTCTCACGCTGGAGCGCGAACCCACTAATTCCGAGTCGCTGA
ACGCGGTCTTCCGGGGCTTCCACACCATCAAGGGACTGGCCGGCTTTCTCGAGCTCTGGGAGATCCAGAAGCTGGCCCAT
GAAGTGGAGACCGTTCTCGACCGGGCGCGCAACTCCCAATGGACCATCACTGGCAACGCCATCGATGTCATCCTGGAAAG
CGCCGATTACCTCAGGCGCTGGCTGGCCCACCTGGAATCCGTGCTCCAGCACCGGGCATCCGACCCGCCCCAGCGCGATG
AGGCTCTGCTTTCGCGCATCGTCCTGCTTTCCTCGGAACCCGATGCCGGCGCACCGGGGCTCGACGCGCTGGCAATGGCT
GTGACCTCAATCCCGGCTCCCGGAGAGGTTCCCTCCTTGATTGCGGAGCCGCCGGCCGCGGCACTTCAACCCGCGCCGCC
AGTCCCTGCCGAATCGTCCGCTCCCACCCCACCCCCGAACCAGACGGGCCGCCGCGAAACTATGGCGGTCAAAGTCGATA
CCGCCAAGCTCGATTACCTGGTGGATATGGCGGGAGAAATGGTTATCGCGGAATCCCTGGTCCGCCATGACCAGGAATTG
TCCGCGATCAAGAACCCTCTGTTACACCGCAAAATCGCCCACATGACACGAATCACGGCGGAATTGCAGAAGACTGCGAT
GGCGATGCGCCTGGTCCCCATGGGTCCGCTCTTCCGCCGCATGGCCCGCCTGGTGCGCGATCTCTCCCGCCAATTCGGTA
AGCAGGTGGAGATGGAGACGCAAGGTGACGATATCGAACTCGACCGCACCATCGTCGAGGAGTTGTCCGATCCCCTGATG
CATATGGTGCGGAATGCGCTTGACCATGGCGTCGAGTTCCCTTCTGAGCGCGAAAAAACCGGCAAGCCCGCCACCGCCCG
CCTGCTTCTCAAAGCCCAGCATCAGGCCGGACAGGTCGTCATCGAAATCACCGACGATGGACGTGGCCTGGATCGGAGCA
AGATCCTCGATCGTGCCGTTCAGAAAGGCCTGGTTCGCGCCTCCGACACCCTGACCGACAATGAGGTTTTCAACCTGATC
TTCGAGCCGGGCTTCACCACCGCCGCTCAGGTGACCAACGTGTCCGGCCGTGGGGTCGGTATGGACGTGGTACGCCGTCA
CATCGAGAAACTGCGTGGACGCATCGAGATCCGCAGCAGTCTCGGCCGCGGCGCCACTTTCCTGCTCAAACTTCCCCTGA
CGCTGGCGATTATCGATGGCCTCGTCGTCACCGTCGGTGGAGAGCGCTACATCGTCCCTCTGTTCGCTGTGCGCGAGATG
TTTCGTCCCACCGCCGAAACCATTTGGACAGTTCAGCAGCGGGCCGAGATGGCTCTTGTTCGCGGAACCCTGTTGCCTGT
GGTCCGCCTCTACCGCGCCTTTGGTGTCACGCCGCGCAGCGAAGATCCCTGCCAGGGGGTGCTGGTCGTAGCCGATGTGG
AAGGGCAGCAATTCTGCATTCTGGTGGATGATCTGATCGGAAAACAGGAGGTCGTGATCAAAACCCTTGGAGACACGTTC
AAAAACGTTAGCGGGATCGCCGGCGGCGCAATTCTGGGAGACGGCCGCGTCGGCCTGATTCTGGACCTGGACCGGATCTT
CAAGGATAAGAACAGTGAATCACCGCGTTGA

Upstream 100 bases:

>100_bases
AAGCTCACCCGAGGACACCGGGCCGGCCCAGCATATCGATCAGGAAGTCCACAGCCTCGTCGAGCGCGTACGGCGGCCGG
ATTCGAAAGGTCTCTGAGTC

Downstream 100 bases:

>100_bases
AGCCGTCGAGTCCGATGGAGTACAACCGCTCGCCGATCGCGAGTTCGAACAAATCCGCCGGTTGGCCCACCGCACCTTCG
GACTCGATCTGAAACCGGGC

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MPSRELRREIEDLALRLVVGEPEDTGGAARWLPAFEQIRERAQREQAIDVSIAAGSFLDNMRRSALSESALQDGIAALQK
ALDAPAVAAAADILPAQDPELMSDFIVESREHLANVETQVLTLEREPTNSESLNAVFRGFHTIKGLAGFLELWEIQKLAH
EVETVLDRARNSQWTITGNAIDVILESADYLRRWLAHLESVLQHRASDPPQRDEALLSRIVLLSSEPDAGAPGLDALAMA
VTSIPAPGEVPSLIAEPPAAALQPAPPVPAESSAPTPPPNQTGRRETMAVKVDTAKLDYLVDMAGEMVIAESLVRHDQEL
SAIKNPLLHRKIAHMTRITAELQKTAMAMRLVPMGPLFRRMARLVRDLSRQFGKQVEMETQGDDIELDRTIVEELSDPLM
HMVRNALDHGVEFPSEREKTGKPATARLLLKAQHQAGQVVIEITDDGRGLDRSKILDRAVQKGLVRASDTLTDNEVFNLI
FEPGFTTAAQVTNVSGRGVGMDVVRRHIEKLRGRIEIRSSLGRGATFLLKLPLTLAIIDGLVVTVGGERYIVPLFAVREM
FRPTAETIWTVQQRAEMALVRGTLLPVVRLYRAFGVTPRSEDPCQGVLVVADVEGQQFCILVDDLIGKQEVVIKTLGDTF
KNVSGIAGGAILGDGRVGLILDLDRIFKDKNSESPR

Sequences:

>Translated_676_residues
MPSRELRREIEDLALRLVVGEPEDTGGAARWLPAFEQIRERAQREQAIDVSIAAGSFLDNMRRSALSESALQDGIAALQK
ALDAPAVAAAADILPAQDPELMSDFIVESREHLANVETQVLTLEREPTNSESLNAVFRGFHTIKGLAGFLELWEIQKLAH
EVETVLDRARNSQWTITGNAIDVILESADYLRRWLAHLESVLQHRASDPPQRDEALLSRIVLLSSEPDAGAPGLDALAMA
VTSIPAPGEVPSLIAEPPAAALQPAPPVPAESSAPTPPPNQTGRRETMAVKVDTAKLDYLVDMAGEMVIAESLVRHDQEL
SAIKNPLLHRKIAHMTRITAELQKTAMAMRLVPMGPLFRRMARLVRDLSRQFGKQVEMETQGDDIELDRTIVEELSDPLM
HMVRNALDHGVEFPSEREKTGKPATARLLLKAQHQAGQVVIEITDDGRGLDRSKILDRAVQKGLVRASDTLTDNEVFNLI
FEPGFTTAAQVTNVSGRGVGMDVVRRHIEKLRGRIEIRSSLGRGATFLLKLPLTLAIIDGLVVTVGGERYIVPLFAVREM
FRPTAETIWTVQQRAEMALVRGTLLPVVRLYRAFGVTPRSEDPCQGVLVVADVEGQQFCILVDDLIGKQEVVIKTLGDTF
KNVSGIAGGAILGDGRVGLILDLDRIFKDKNSESPR
>Mature_675_residues
PSRELRREIEDLALRLVVGEPEDTGGAARWLPAFEQIRERAQREQAIDVSIAAGSFLDNMRRSALSESALQDGIAALQKA
LDAPAVAAAADILPAQDPELMSDFIVESREHLANVETQVLTLEREPTNSESLNAVFRGFHTIKGLAGFLELWEIQKLAHE
VETVLDRARNSQWTITGNAIDVILESADYLRRWLAHLESVLQHRASDPPQRDEALLSRIVLLSSEPDAGAPGLDALAMAV
TSIPAPGEVPSLIAEPPAAALQPAPPVPAESSAPTPPPNQTGRRETMAVKVDTAKLDYLVDMAGEMVIAESLVRHDQELS
AIKNPLLHRKIAHMTRITAELQKTAMAMRLVPMGPLFRRMARLVRDLSRQFGKQVEMETQGDDIELDRTIVEELSDPLMH
MVRNALDHGVEFPSEREKTGKPATARLLLKAQHQAGQVVIEITDDGRGLDRSKILDRAVQKGLVRASDTLTDNEVFNLIF
EPGFTTAAQVTNVSGRGVGMDVVRRHIEKLRGRIEIRSSLGRGATFLLKLPLTLAIIDGLVVTVGGERYIVPLFAVREMF
RPTAETIWTVQQRAEMALVRGTLLPVVRLYRAFGVTPRSEDPCQGVLVVADVEGQQFCILVDDLIGKQEVVIKTLGDTFK
NVSGIAGGAILGDGRVGLILDLDRIFKDKNSESPR

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=419, Percent_Identity=42.0047732696897, Blast_Score=332, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR015162
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01584 CheW; PF09078 CheY-binding; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74166; Mature: 74035

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRELRREIEDLALRLVVGEPEDTGGAARWLPAFEQIRERAQREQAIDVSIAAGSFLDN
CCCHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHH
MRRSALSESALQDGIAALQKALDAPAVAAAADILPAQDPELMSDFIVESREHLANVETQV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEE
LTLEREPTNSESLNAVFRGFHTIKGLAGFLELWEIQKLAHEVETVLDRARNSQWTITGNA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
IDVILESADYLRRWLAHLESVLQHRASDPPQRDEALLSRIVLLSSEPDAGAPGLDALAMA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VTSIPAPGEVPSLIAEPPAAALQPAPPVPAESSAPTPPPNQTGRRETMAVKVDTAKLDYL
HHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHH
VDMAGEMVIAESLVRHDQELSAIKNPLLHRKIAHMTRITAELQKTAMAMRLVPMGPLFRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
MARLVRDLSRQFGKQVEMETQGDDIELDRTIVEELSDPLMHMVRNALDHGVEFPSEREKT
HHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
GKPATARLLLKAQHQAGQVVIEITDDGRGLDRSKILDRAVQKGLVRASDTLTDNEVFNLI
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHEE
FEPGFTTAAQVTNVSGRGVGMDVVRRHIEKLRGRIEIRSSLGRGATFLLKLPLTLAIIDG
ECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCC
LVVTVGGERYIVPLFAVREMFRPTAETIWTVQQRAEMALVRGTLLPVVRLYRAFGVTPRS
EEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDPCQGVLVVADVEGQQFCILVDDLIGKQEVVIKTLGDTFKNVSGIAGGAILGDGRVGLI
CCCCCCEEEEEECCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEE
LDLDRIFKDKNSESPR
EEHHHHHCCCCCCCCC
>Mature Secondary Structure 
PSRELRREIEDLALRLVVGEPEDTGGAARWLPAFEQIRERAQREQAIDVSIAAGSFLDN
CCHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHH
MRRSALSESALQDGIAALQKALDAPAVAAAADILPAQDPELMSDFIVESREHLANVETQV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEE
LTLEREPTNSESLNAVFRGFHTIKGLAGFLELWEIQKLAHEVETVLDRARNSQWTITGNA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
IDVILESADYLRRWLAHLESVLQHRASDPPQRDEALLSRIVLLSSEPDAGAPGLDALAMA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VTSIPAPGEVPSLIAEPPAAALQPAPPVPAESSAPTPPPNQTGRRETMAVKVDTAKLDYL
HHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHH
VDMAGEMVIAESLVRHDQELSAIKNPLLHRKIAHMTRITAELQKTAMAMRLVPMGPLFRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
MARLVRDLSRQFGKQVEMETQGDDIELDRTIVEELSDPLMHMVRNALDHGVEFPSEREKT
HHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
GKPATARLLLKAQHQAGQVVIEITDDGRGLDRSKILDRAVQKGLVRASDTLTDNEVFNLI
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHEE
FEPGFTTAAQVTNVSGRGVGMDVVRRHIEKLRGRIEIRSSLGRGATFLLKLPLTLAIIDG
ECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCC
LVVTVGGERYIVPLFAVREMFRPTAETIWTVQQRAEMALVRGTLLPVVRLYRAFGVTPRS
EEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDPCQGVLVVADVEGQQFCILVDDLIGKQEVVIKTLGDTFKNVSGIAGGAILGDGRVGLI
CCCCCCEEEEEECCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEE
LDLDRIFKDKNSESPR
EEHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3278311; 11677609 [H]