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The map label for this gene is pdp [H]

Identifier: 116624313

GI number: 116624313

Start: 6565421

End: 6566725

Strand: Direct

Name: pdp [H]

Synonym: Acid_5231

Alternate gene names: 116624313

Gene position: 6565421-6566725 (Clockwise)

Preceding gene: 116624311

Following gene: 116624314

Centisome position: 65.88

GC content: 61.15

Gene sequence:

>1305_bases
ATGCGTACAGTTGACTTGATTCAGCGCAAGCGCGGCGGCGAAGAACTCTCTCCTGAAGAGATCGCGTTCTTGGTAAACGG
GTACACCGCCGGCGAAATTCCCGATTATCAGATGTCGGCCTTTCTGATGGCCGTCTTCTTCACCGGGATGACTGATCGCG
AGGTCAGCCCCCTTACGGAGGCCATGCTGCACTCCGGCGAAACGCTGGACCTTTCCGGGATTCCCGGCGTGAAGGTCGAT
AAGCATTCCACCGGCGGCGTGGGCGATAAGACGAGCTTCATCGTGGCACCGCTCGCGGCGGCCGCGGGAGTGGTAGTGCC
GATGATGTCTGGGCGCGCGCTCGGACATACCGGGGGGACGCTGGACAAGCTGGAATCCATTCCGGGCTTCCGCACCGATC
TCAGCACCGAACAATTTCAGAAGCAGCTGGCTGAACTGGGCCTGGCCTTCATCGGACAATCCGATCAACTGGCGCCGGCG
GACCGCAAACTGTACGCGTTGCGCGATGTGACGGCGACGGTGGAATCGATCCCGCTGATCTCTTCCTCAATCATGTCGAA
GAAGCTGGCGGAGGGTATCGATGCGCTGGTACTGGATGTGAAGGTGGGTAGCGGCGCATTCATGAAGAAGCAGGTGGACG
CGCGGCGGCTGGCACAAACGATGGTCGGCATCGGTCGCCGGATGGATAAGAAGGTACAGGCGCTGATCACGGACATGAAT
CAGCCGCTGGGTTATGCGATCGGCAACGCGCTGGAGATCATGGAAGCCTCGCAGACGCTGCAGAACGCGGGCCCCGCTGA
TTTGACCAAGCTTTCCCTGGAGCTGGCCGCGCGGATGATTTACCTGGGCAAGAAGGCGCCGACGCTGGAAGAAGCGCGGC
TGATTGCGCAGAATCATCTGGTGGACGGCTCGGCTTACAAGAAATTCAAGCAGGTGGTAGCGGCGCAGGGCGGCAATCCG
CAGGCGCTGGACAAGTTCGAGTTGCTGCCCAATGCGACCGGAATGCGCGAGATCACATCGCCGCGGGCCGGCTACGTGGC
GGCGATCAACGCGCAGGATATCGGCGTCTCCAGCAACATGATCGGGGCGGGACGGGAGACCAAGGACGATACGATCGATC
CGGCCGTCGGCATCATCCTGGAAGTCAAGATCGGCGAGAAGGTGGATGCGGGCAGCGTGCTGTGCCGCCTCTACTACACC
AAGGAAGACAACGTGGACGAGGCCGCCGAAATGGTGGAGGATGCCTTCCGCGTGTCCGGCACCAAGCCTGATGAGCGCGA
GCTCATCCTGGAAGTTGTCGGCTAA

Upstream 100 bases:

>100_bases
TCGGGTGCCGAAGCACCCGGGAGGGGAGGGTTTGTTTCCAGGCGGGCACCTGATCGCCTTTACTTTGAACCCCTTGGGAT
GGTAGGCTAAGTTACTCATA

Downstream 100 bases:

>100_bases
TGGAGCGTTTCACGGGGTTGCTGGGCCTCGTCGTGATCCTGGCAGTCGCGTGGTTGTTTTCCACTCACAAACGCGAGATC
AAGCTACGGTTGATCGCGTG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRTVDLIQRKRGGEELSPEEIAFLVNGYTAGEIPDYQMSAFLMAVFFTGMTDREVSPLTEAMLHSGETLDLSGIPGVKVD
KHSTGGVGDKTSFIVAPLAAAAGVVVPMMSGRALGHTGGTLDKLESIPGFRTDLSTEQFQKQLAELGLAFIGQSDQLAPA
DRKLYALRDVTATVESIPLISSSIMSKKLAEGIDALVLDVKVGSGAFMKKQVDARRLAQTMVGIGRRMDKKVQALITDMN
QPLGYAIGNALEIMEASQTLQNAGPADLTKLSLELAARMIYLGKKAPTLEEARLIAQNHLVDGSAYKKFKQVVAAQGGNP
QALDKFELLPNATGMREITSPRAGYVAAINAQDIGVSSNMIGAGRETKDDTIDPAVGIILEVKIGEKVDAGSVLCRLYYT
KEDNVDEAAEMVEDAFRVSGTKPDERELILEVVG

Sequences:

>Translated_434_residues
MRTVDLIQRKRGGEELSPEEIAFLVNGYTAGEIPDYQMSAFLMAVFFTGMTDREVSPLTEAMLHSGETLDLSGIPGVKVD
KHSTGGVGDKTSFIVAPLAAAAGVVVPMMSGRALGHTGGTLDKLESIPGFRTDLSTEQFQKQLAELGLAFIGQSDQLAPA
DRKLYALRDVTATVESIPLISSSIMSKKLAEGIDALVLDVKVGSGAFMKKQVDARRLAQTMVGIGRRMDKKVQALITDMN
QPLGYAIGNALEIMEASQTLQNAGPADLTKLSLELAARMIYLGKKAPTLEEARLIAQNHLVDGSAYKKFKQVVAAQGGNP
QALDKFELLPNATGMREITSPRAGYVAAINAQDIGVSSNMIGAGRETKDDTIDPAVGIILEVKIGEKVDAGSVLCRLYYT
KEDNVDEAAEMVEDAFRVSGTKPDERELILEVVG
>Mature_434_residues
MRTVDLIQRKRGGEELSPEEIAFLVNGYTAGEIPDYQMSAFLMAVFFTGMTDREVSPLTEAMLHSGETLDLSGIPGVKVD
KHSTGGVGDKTSFIVAPLAAAAGVVVPMMSGRALGHTGGTLDKLESIPGFRTDLSTEQFQKQLAELGLAFIGQSDQLAPA
DRKLYALRDVTATVESIPLISSSIMSKKLAEGIDALVLDVKVGSGAFMKKQVDARRLAQTMVGIGRRMDKKVQALITDMN
QPLGYAIGNALEIMEASQTLQNAGPADLTKLSLELAARMIYLGKKAPTLEEARLIAQNHLVDGSAYKKFKQVVAAQGGNP
QALDKFELLPNATGMREITSPRAGYVAAINAQDIGVSSNMIGAGRETKDDTIDPAVGIILEVKIGEKVDAGSVLCRLYYT
KEDNVDEAAEMVEDAFRVSGTKPDERELILEVVG

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=404, Percent_Identity=43.3168316831683, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI4503445, Length=404, Percent_Identity=43.3168316831683, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI166158922, Length=404, Percent_Identity=43.3168316831683, Blast_Score=292, Evalue=3e-79,
Organism=Escherichia coli, GI1790842, Length=408, Percent_Identity=43.3823529411765, Blast_Score=305, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46434; Mature: 46434

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVDLIQRKRGGEELSPEEIAFLVNGYTAGEIPDYQMSAFLMAVFFTGMTDREVSPLTE
CCCHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
AMLHSGETLDLSGIPGVKVDKHSTGGVGDKTSFIVAPLAAAAGVVVPMMSGRALGHTGGT
HHHCCCCEEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKLESIPGFRTDLSTEQFQKQLAELGLAFIGQSDQLAPADRKLYALRDVTATVESIPLI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SSSIMSKKLAEGIDALVLDVKVGSGAFMKKQVDARRLAQTMVGIGRRMDKKVQALITDMN
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPLGYAIGNALEIMEASQTLQNAGPADLTKLSLELAARMIYLGKKAPTLEEARLIAQNHL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
VDGSAYKKFKQVVAAQGGNPQALDKFELLPNATGMREITSPRAGYVAAINAQDIGVSSNM
CCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCC
IGAGRETKDDTIDPAVGIILEVKIGEKVDAGSVLCRLYYTKEDNVDEAAEMVEDAFRVSG
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
TKPDERELILEVVG
CCCCHHHHHHEECC
>Mature Secondary Structure
MRTVDLIQRKRGGEELSPEEIAFLVNGYTAGEIPDYQMSAFLMAVFFTGMTDREVSPLTE
CCCHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
AMLHSGETLDLSGIPGVKVDKHSTGGVGDKTSFIVAPLAAAAGVVVPMMSGRALGHTGGT
HHHCCCCEEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKLESIPGFRTDLSTEQFQKQLAELGLAFIGQSDQLAPADRKLYALRDVTATVESIPLI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SSSIMSKKLAEGIDALVLDVKVGSGAFMKKQVDARRLAQTMVGIGRRMDKKVQALITDMN
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPLGYAIGNALEIMEASQTLQNAGPADLTKLSLELAARMIYLGKKAPTLEEARLIAQNHL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
VDGSAYKKFKQVVAAQGGNPQALDKFELLPNATGMREITSPRAGYVAAINAQDIGVSSNM
CCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCC
IGAGRETKDDTIDPAVGIILEVKIGEKVDAGSVLCRLYYTKEDNVDEAAEMVEDAFRVSG
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
TKPDERELILEVVG
CCCCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]