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The map label for this gene is cefD [H]

Identifier: 116624137

GI number: 116624137

Start: 6382835

End: 6384094

Strand: Direct

Name: cefD [H]

Synonym: Acid_5053

Alternate gene names: 116624137

Gene position: 6382835-6384094 (Clockwise)

Preceding gene: 116624136

Following gene: 116624138

Centisome position: 64.05

GC content: 65.08

Gene sequence:

>1260_bases
ATGCAGCCTCGCCGAAATTTTCTGACCGCCCTCGCCGCGCCCCTTCTCGCGCGCTCCGCTGCAGCCCAATCCAAGGCCGC
GCCCGGCCTCCCCAAACCCGGCGACCCCGCCTATTGGGCCAAGGTGCGCGACCAGTTCCTGCTCGCTCGCGACAAGGTCT
TTTTCAATAACGGCACCATCGGCGCCATGCCCAAGGTCGTCCTCGACCGCACCGTGGAGCACCTCCGCAAAATGGCCACC
GACGTCGCCGACTGGGATTACAAATCCGGCCAGGAGTGGATCGCCGGCTACGGTCCCATGCCCGAGATCCGCGCCAAAAC
CGCCCGTCTGCTCAACGCCCAGCCCGCCGAAATCGCGCTCACCGAAAACGTCACCGCTGCCATGAGCTACGTCGCCGCCG
GACTCACGCTCGAACCCGGCAGCGAAATCCTGATCAGCGACCAGGAACATCCCGGCGGACAATGTCCCTGGCTCAACGCC
GCCAAACGCCACGGCGCCAGCGTGCAGATGGTCCACATCCCCAAGCCCGCCGAGAACCCCGCGCAGGTCATGGACGTCTT
CCGCAACGCTCTCAACTCCCGCACCCGCGTGCTCGCCATCTCGCACGTCATCACCGGCAGCGGCGCCATCATGCCCGTGA
AGGAGATGTGCGCCGAAGCCCGCGCCCGCGGCATCTTCACCGTCATCGATGGAGCCCAGGCCGTCGGCCACATCCCCGTT
GACCTCGAATCCATGGGCTGCGACGCCTACGTGGGATGCTTCCACAAATGGCTGCTCGCTCCCGCCGGCACCGGTCTCCT
CTACCTCCGCAAGGGCAGTGCCTCCAAAGTCTGGTCCACCCTCGCCAGTTCGCATTGGAACGATCACGAAGACGAGGGCT
TCCGCTTCAGCCAGCGCGGCACCGGCAGCCTCTCCCTCCTCATGGGCGTGGACGCCGCCCTCGACTTCCACCAGGAAATC
GGCCCCGGGCGCGTGCAAGAGCGCGTTAAATTCCTCGGCGATTACCTCCGCGACGGCCTCCGCAAAATTCCCGGCGCGCG
CATCTATTCCCCCGTCGATAACGCAATGTGCGCCGGCATCACCGTCTATGGCGTCAACGGCGTCACTGGCCAGCAATTGC
AGGATGAAATGTGGGCCCACGGCAAACTCAGGCCCCGCGCCTCCGGAGGCATCGGAGTTCGCCACTCTACCCACATCTTC
AACAGCCCCCAGGAAATCGACAAAGCACTTGCGGTAGTTCGCTCACTCTCCAAGGCCTGA

Upstream 100 bases:

>100_bases
AAGCTCGTCTCCGAAATCACCGAGCGCGTCACCGCCCGCGCCCAGGTCTACTACCGCCCCGATGGCTCGATAACGAACTG
GTAACAATAGGAGGACACCC

Downstream 100 bases:

>100_bases
ACGCGAAAATTTCTGTTGCTACCGCCGAACCGTCAGGCTACAATCATGAGGCGAATAAAAAGCGAATCTCCCTGTGGAGG
AACATCATGAGAATCAGCGA

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MQPRRNFLTALAAPLLARSAAAQSKAAPGLPKPGDPAYWAKVRDQFLLARDKVFFNNGTIGAMPKVVLDRTVEHLRKMAT
DVADWDYKSGQEWIAGYGPMPEIRAKTARLLNAQPAEIALTENVTAAMSYVAAGLTLEPGSEILISDQEHPGGQCPWLNA
AKRHGASVQMVHIPKPAENPAQVMDVFRNALNSRTRVLAISHVITGSGAIMPVKEMCAEARARGIFTVIDGAQAVGHIPV
DLESMGCDAYVGCFHKWLLAPAGTGLLYLRKGSASKVWSTLASSHWNDHEDEGFRFSQRGTGSLSLLMGVDAALDFHQEI
GPGRVQERVKFLGDYLRDGLRKIPGARIYSPVDNAMCAGITVYGVNGVTGQQLQDEMWAHGKLRPRASGGIGVRHSTHIF
NSPQEIDKALAVVRSLSKA

Sequences:

>Translated_419_residues
MQPRRNFLTALAAPLLARSAAAQSKAAPGLPKPGDPAYWAKVRDQFLLARDKVFFNNGTIGAMPKVVLDRTVEHLRKMAT
DVADWDYKSGQEWIAGYGPMPEIRAKTARLLNAQPAEIALTENVTAAMSYVAAGLTLEPGSEILISDQEHPGGQCPWLNA
AKRHGASVQMVHIPKPAENPAQVMDVFRNALNSRTRVLAISHVITGSGAIMPVKEMCAEARARGIFTVIDGAQAVGHIPV
DLESMGCDAYVGCFHKWLLAPAGTGLLYLRKGSASKVWSTLASSHWNDHEDEGFRFSQRGTGSLSLLMGVDAALDFHQEI
GPGRVQERVKFLGDYLRDGLRKIPGARIYSPVDNAMCAGITVYGVNGVTGQQLQDEMWAHGKLRPRASGGIGVRHSTHIF
NSPQEIDKALAVVRSLSKA
>Mature_419_residues
MQPRRNFLTALAAPLLARSAAAQSKAAPGLPKPGDPAYWAKVRDQFLLARDKVFFNNGTIGAMPKVVLDRTVEHLRKMAT
DVADWDYKSGQEWIAGYGPMPEIRAKTARLLNAQPAEIALTENVTAAMSYVAAGLTLEPGSEILISDQEHPGGQCPWLNA
AKRHGASVQMVHIPKPAENPAQVMDVFRNALNSRTRVLAISHVITGSGAIMPVKEMCAEARARGIFTVIDGAQAVGHIPV
DLESMGCDAYVGCFHKWLLAPAGTGLLYLRKGSASKVWSTLASSHWNDHEDEGFRFSQRGTGSLSLLMGVDAALDFHQEI
GPGRVQERVKFLGDYLRDGLRKIPGARIYSPVDNAMCAGITVYGVNGVTGQQLQDEMWAHGKLRPRASGGIGVRHSTHIF
NSPQEIDKALAVVRSLSKA

Specific function: Catalyzes the reversible isomerization between isopenicillin N and penicillin N [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1787970, Length=265, Percent_Identity=29.0566037735849, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789175, Length=332, Percent_Identity=27.710843373494, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI48994898, Length=336, Percent_Identity=25.297619047619, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =5.1.1.17 [H]

Molecular weight: Translated: 45331; Mature: 45331

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPRRNFLTALAAPLLARSAAAQSKAAPGLPKPGDPAYWAKVRDQFLLARDKVFFNNGTI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEECCCCC
GAMPKVVLDRTVEHLRKMATDVADWDYKSGQEWIAGYGPMPEIRAKTARLLNAQPAEIAL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCEEEE
TENVTAAMSYVAAGLTLEPGSEILISDQEHPGGQCPWLNAAKRHGASVQMVHIPKPAENP
ECCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCHHHHCCCEEEEEECCCCCCCH
AQVMDVFRNALNSRTRVLAISHVITGSGAIMPVKEMCAEARARGIFTVIDGAQAVGHIPV
HHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCHHHCCCCC
DLESMGCDAYVGCFHKWLLAPAGTGLLYLRKGSASKVWSTLASSHWNDHEDEGFRFSQRG
CHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCEECCCC
TGSLSLLMGVDAALDFHQEIGPGRVQERVKFLGDYLRDGLRKIPGARIYSPVDNAMCAGI
CCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCE
TVYGVNGVTGQQLQDEMWAHGKLRPRASGGIGVRHSTHIFNSPQEIDKALAVVRSLSKA
EEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQPRRNFLTALAAPLLARSAAAQSKAAPGLPKPGDPAYWAKVRDQFLLARDKVFFNNGTI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEECCCCC
GAMPKVVLDRTVEHLRKMATDVADWDYKSGQEWIAGYGPMPEIRAKTARLLNAQPAEIAL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCEEEE
TENVTAAMSYVAAGLTLEPGSEILISDQEHPGGQCPWLNAAKRHGASVQMVHIPKPAENP
ECCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCHHHHCCCEEEEEECCCCCCCH
AQVMDVFRNALNSRTRVLAISHVITGSGAIMPVKEMCAEARARGIFTVIDGAQAVGHIPV
HHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCHHHCCCCC
DLESMGCDAYVGCFHKWLLAPAGTGLLYLRKGSASKVWSTLASSHWNDHEDEGFRFSQRG
CHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCEECCCC
TGSLSLLMGVDAALDFHQEIGPGRVQERVKFLGDYLRDGLRKIPGARIYSPVDNAMCAGI
CCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCE
TVYGVNGVTGQQLQDEMWAHGKLRPRASGGIGVRHSTHIFNSPQEIDKALAVVRSLSKA
EEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1694525; 2804141 [H]