Click here to switch to the map view.

The map label for this gene is lutP [H]

Identifier: 116624069

GI number: 116624069

Start: 6291042

End: 6292625

Strand: Direct

Name: lutP [H]

Synonym: Acid_4983

Alternate gene names: 116624069

Gene position: 6291042-6292625 (Clockwise)

Preceding gene: 116624068

Following gene: 116624075

Centisome position: 63.13

GC content: 62.75

Gene sequence:

>1584_bases
ATGTGGGAACAGACCTATACACCGGTTGGAGGCAGCCTGCCGCTCTCGGCACTGGTCGCCGCGATTCCGATCTTTACACT
GCTCGTACTCCTCGGAGTGATGCGCAAACCCGCGTGGATGGCCTCCCTGGTGGGTCTAACCGCGGCCGCCGTGGTCGCCA
TCGGAGTCTACGGAATGCCCTTAGGCCTGGCCGCCGGAGCCGTCACGTTCGGCGCCGCCTTCGGACTGTTCCCGATTGGA
TGGGTCGTTTTCAGCGCGATTCTGCTCTATCGCATCACGCTCGAGACCGGCAAATTCGAAGTGCTCAAGGATTCCATCGG
CCACCTCACCAATGATTCACGACTGCAGGCGCTGCTGATCGCGTTCGCATTCGGCGCATTCATCGAGGGAGCCGCGGGCT
TCGGCACACCGGTCGCGGTTGCGGCGGCGATGTTGACCGGCCTGGGCTTCGAACCCTTTTATGCCGCAGCCATCTGCCTG
TTGGCCAATACCGCGCCGGTCGCTTTCGGCTCTATTGGCATTCCGATCACCACGCTCGCGGTCACCACAGGGCTGCCGCT
CGACCGCCTGAGCGCCGGAGTCGGCCGGATCTGCGCACCCGTATCGCTCTTTATTCCCGCCTACCTAATCGCTGTGATGA
GCGGTTGGAAAGGTCTGAAGGGCGTGCTGCCCGCCGCCGCCGCATGCGGCATCGCGTTCGGCGGCACGCAATTCCTGGTC
TCCAATTTCATGGGTCCGCAGCTTACCGATATCCTGGCGTCGATGGCCGCGATGGGCGCGCTGCTCATCGTTATCCGGCG
CCGCGGCGGCGGAAGTCAAAAGCATAGCGGCCACGCCATCGCGATGGCATGGGTACCCTATATTCTGCTGGTGATCTTCG
TGCTTCTGTGGGGTTATAAGCCGCTGCAGACGTGGCTCGACAGTTTCAGCGTGCCGGTGAACTGGCCGGGGCTGCACAAC
ATGATTACCCGAATGCCGGCGGCGGTGGCGAAGCCCACCCTGTACCCCGCGCTATACAAGTTCCCTTGGCTTTCCGCGTC
CGGCACAGCATGCCTTTTCGCGGCCATACTTTCGGCGATGATCACCGGGCTATCGCTGGCGCAATTCGGCCGCGTGCTGC
GGCACACAGCAAAGCAACTGGCGCTCGCGGAATTGACGTTGGCCACGGTGCTCGGGCTTGCCATGCTGATGAACTACTCC
GGATCCACCGCAACGCTCGGGCTGGCCTTCGCCGCCACAGGTGTGATGTTCCCTTTCTTCAGCGCCCTGCTCGGCTGGCT
CGGCGTTTTCCTGACCGGCAGCGACACTTCGGCCAACGCACTATTCGGCACGCTGCAGGTGGTCACGGCGCAAAAGCTCG
GTCAGAACCCTGTGTTGATGGCCGCAGCCAATTCCGCCGGCGGCGTGATGGGCAAGATGATCAGCCTCACCAGCATCGCG
GTTGCGGCCGCAGCCACCAGTATGAAGCGCGAGGACGAGGCCCTTCTTTTCCGCTTCACGCTCCGCCACAGCATCTTTCT
CGCCAGCGTGATCGGCATCCTTGTGATGTTCTACGCCTATGTAATGCCGGGCTGGGCTCCGTAG

Upstream 100 bases:

>100_bases
ACCGCGCTGCCCAAGACCGGTACTGGGAAAATTTTGAAACGCGAGCTCCGGGAAAAACTCTGGAGCAACAAAGACCTCCG
CATCCAAGGCTAAGGGTATT

Downstream 100 bases:

>100_bases
ATTACTGCACCTGAACGACCCCCACAATGAACCGCCACGGCGCGCTGCCGATGTAGTAGAACGGATAACAAGTGAGCAGC
GTTAATACTCTTTCCGCTTG

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MWEQTYTPVGGSLPLSALVAAIPIFTLLVLLGVMRKPAWMASLVGLTAAAVVAIGVYGMPLGLAAGAVTFGAAFGLFPIG
WVVFSAILLYRITLETGKFEVLKDSIGHLTNDSRLQALLIAFAFGAFIEGAAGFGTPVAVAAAMLTGLGFEPFYAAAICL
LANTAPVAFGSIGIPITTLAVTTGLPLDRLSAGVGRICAPVSLFIPAYLIAVMSGWKGLKGVLPAAAACGIAFGGTQFLV
SNFMGPQLTDILASMAAMGALLIVIRRRGGGSQKHSGHAIAMAWVPYILLVIFVLLWGYKPLQTWLDSFSVPVNWPGLHN
MITRMPAAVAKPTLYPALYKFPWLSASGTACLFAAILSAMITGLSLAQFGRVLRHTAKQLALAELTLATVLGLAMLMNYS
GSTATLGLAFAATGVMFPFFSALLGWLGVFLTGSDTSANALFGTLQVVTAQKLGQNPVLMAAANSAGGVMGKMISLTSIA
VAAAATSMKREDEALLFRFTLRHSIFLASVIGILVMFYAYVMPGWAP

Sequences:

>Translated_527_residues
MWEQTYTPVGGSLPLSALVAAIPIFTLLVLLGVMRKPAWMASLVGLTAAAVVAIGVYGMPLGLAAGAVTFGAAFGLFPIG
WVVFSAILLYRITLETGKFEVLKDSIGHLTNDSRLQALLIAFAFGAFIEGAAGFGTPVAVAAAMLTGLGFEPFYAAAICL
LANTAPVAFGSIGIPITTLAVTTGLPLDRLSAGVGRICAPVSLFIPAYLIAVMSGWKGLKGVLPAAAACGIAFGGTQFLV
SNFMGPQLTDILASMAAMGALLIVIRRRGGGSQKHSGHAIAMAWVPYILLVIFVLLWGYKPLQTWLDSFSVPVNWPGLHN
MITRMPAAVAKPTLYPALYKFPWLSASGTACLFAAILSAMITGLSLAQFGRVLRHTAKQLALAELTLATVLGLAMLMNYS
GSTATLGLAFAATGVMFPFFSALLGWLGVFLTGSDTSANALFGTLQVVTAQKLGQNPVLMAAANSAGGVMGKMISLTSIA
VAAAATSMKREDEALLFRFTLRHSIFLASVIGILVMFYAYVMPGWAP
>Mature_527_residues
MWEQTYTPVGGSLPLSALVAAIPIFTLLVLLGVMRKPAWMASLVGLTAAAVVAIGVYGMPLGLAAGAVTFGAAFGLFPIG
WVVFSAILLYRITLETGKFEVLKDSIGHLTNDSRLQALLIAFAFGAFIEGAAGFGTPVAVAAAMLTGLGFEPFYAAAICL
LANTAPVAFGSIGIPITTLAVTTGLPLDRLSAGVGRICAPVSLFIPAYLIAVMSGWKGLKGVLPAAAACGIAFGGTQFLV
SNFMGPQLTDILASMAAMGALLIVIRRRGGGSQKHSGHAIAMAWVPYILLVIFVLLWGYKPLQTWLDSFSVPVNWPGLHN
MITRMPAAVAKPTLYPALYKFPWLSASGTACLFAAILSAMITGLSLAQFGRVLRHTAKQLALAELTLATVLGLAMLMNYS
GSTATLGLAFAATGVMFPFFSALLGWLGVFLTGSDTSANALFGTLQVVTAQKLGQNPVLMAAANSAGGVMGKMISLTSIA
VAAAATSMKREDEALLFRFTLRHSIFLASVIGILVMFYAYVMPGWAP

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=556, Percent_Identity=43.705035971223, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1790031, Length=546, Percent_Identity=40.8424908424908, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 54913; Mature: 54913

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]