Click here to switch to the map view.

The map label for this gene is sdaA [H]

Identifier: 116624060

GI number: 116624060

Start: 6282868

End: 6284499

Strand: Direct

Name: sdaA [H]

Synonym: Acid_4974

Alternate gene names: 116624060

Gene position: 6282868-6284499 (Clockwise)

Preceding gene: 116624059

Following gene: 116624061

Centisome position: 63.05

GC content: 59.99

Gene sequence:

>1632_bases
ATGTCTGATAGCCCTCTGAAACCGTTAACTCAGTCAGGTGAAACCGAAGTGGACGATCCGCTTGGGTCGGTCAACGACAT
AGCCTCACAAGATGTTCCCGACGGCGTCGATAGGCGAGCCTTCCTGATGCGAAGCGCGCTGATCGGCGCGACGGCAATCA
TTCTGGACCGTCCCGTGTCGGCCCAACAGAAAGCGGATAGGTTGGCGACCACGCCGCCGACACCGCAGCTTTCCCCGACC
CTGAATGTCGTTAAAGAGCAGAAGGGCCCTGTGATGACGACCCTGGACGAATTTTATAAGGTGGGACCGGGTCCATCGAG
TTCGCATACCATCGGCCCGATGCGCATCACCTATGATTTTTACCAGCGCTGCACGAAGTTACCCGCGGCCGATCTCGCCC
AGGCAACGGCGCTCAAGGTTAACCTGTTCGGGAGTCTCAGTGCAACGGGCAAAGGGCATGGAACGGAGCGCGCATCGCTC
GCGGGACTAGTGGGCAAAGAGCCCGCTACTGTAGATCCGGCATTTCTCGATAGTTTGCGTGATCAGCCGGATCAGTCGTT
CCCGGTGAAACTTGGACCCAAGACCGTGGACGTCACGCTCAAGGACGTGGTGTTCGATGCTACCGATGGCAATTTCCCCC
ATCCCAACACGATGACGGTCAAGCTGATGGCGGGAAACAAGGTGCTTCTCGAGCAGGAATATTACTCCGTGGGCGGCGGA
TTCATCGAGTGGAAGGGGTATAAGCCGCCGAAGAAGAACGCACCCAAGTACCCGTTCGCGACGATGAAGGAGCTGCGGCA
GCACGCCGAACAAAACAACCTCACGATTTCCGATGTAATTCTCGCGAACGAAATGTCGATTCCCGGCAGGAGCCAGGATG
AGGTCTATGCGTTCATCGACAAGATCACCGGCGCAATGGTGGCGATCGTGAAATCTGGCCTGAGCGCGCCGGATGGCGTA
TTGCCCGGGCCGATTAAACTGCAATCGAAGGCCGCTGAGGTTTACAAGCGGGCGATGGACGACCAGTTCGAGGCTGACCG
CGGAATCGGTTGTCTTTCGGCATACGCGTTGGCGGGGTCGGAGGAAAACGGGCGAGGCCACCTGGTGGTCACCGCGCCGA
CAGGCGGTTCGGCCGGAGTGCTTCCGGCGCTTGTCTACGGGCTGGGCGAAGGAGGGCGCAAACTTACGCAGGACCAGATC
CGTAAGGGCATGCTCGCCGCAGCCGCGATCGGATACCTGTGCAAGCACAATGCGACGCTTTCCGCTGCCGAGGGCGGCTG
CCAGGCGGAGATCGGCGTAGCATCCGCGATGGCGGCGGCATTAGTCGCCGCAGCGTATGACGCGAGCCCCAGAGTGATCG
AGAACGCAGCGGAATCCGCCCTGGAGCACCATCTTGGAATGACCTGCGACCCGGTAGCGGGTTACGTGCAGGTCCCTTGC
ATCGAACGATGCGCATTCGGGGCCGTGAAAGCCTGGACAGCCTGGGCCATCGCGAGCAACGAGATTGCATCCAGGCACCG
GGTGGACCTGGATGCGACCATCACGGCGATGGCTCAGACGGCTAAGGACATGAACAGCAAGTACAAGGAAACCAGCCAGG
CCGGACTCGCGCAATCCGTAACGCTTTGCTGA

Upstream 100 bases:

>100_bases
ACAGTGGTGGTCGCGGGACTGGTGGGGCCTGGAAGCGCTGAGATTACAGCTACCGCGAAACAATAGGCCGCGACGTGACA
GAAGACAAAGGAGAATTGAA

Downstream 100 bases:

>100_bases
TTGGGGCTGGTCGCCGTGGAATTCGAGGTTACGCCGGTATTTCCGACTTTGATCGGCCGCTTCCGGGTACCGGATGCCGA
CTCGATGAATCGGGATCTGC

Product: L-serine ammonia-lyase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MSDSPLKPLTQSGETEVDDPLGSVNDIASQDVPDGVDRRAFLMRSALIGATAIILDRPVSAQQKADRLATTPPTPQLSPT
LNVVKEQKGPVMTTLDEFYKVGPGPSSSHTIGPMRITYDFYQRCTKLPAADLAQATALKVNLFGSLSATGKGHGTERASL
AGLVGKEPATVDPAFLDSLRDQPDQSFPVKLGPKTVDVTLKDVVFDATDGNFPHPNTMTVKLMAGNKVLLEQEYYSVGGG
FIEWKGYKPPKKNAPKYPFATMKELRQHAEQNNLTISDVILANEMSIPGRSQDEVYAFIDKITGAMVAIVKSGLSAPDGV
LPGPIKLQSKAAEVYKRAMDDQFEADRGIGCLSAYALAGSEENGRGHLVVTAPTGGSAGVLPALVYGLGEGGRKLTQDQI
RKGMLAAAAIGYLCKHNATLSAAEGGCQAEIGVASAMAAALVAAAYDASPRVIENAAESALEHHLGMTCDPVAGYVQVPC
IERCAFGAVKAWTAWAIASNEIASRHRVDLDATITAMAQTAKDMNSKYKETSQAGLAQSVTLC

Sequences:

>Translated_543_residues
MSDSPLKPLTQSGETEVDDPLGSVNDIASQDVPDGVDRRAFLMRSALIGATAIILDRPVSAQQKADRLATTPPTPQLSPT
LNVVKEQKGPVMTTLDEFYKVGPGPSSSHTIGPMRITYDFYQRCTKLPAADLAQATALKVNLFGSLSATGKGHGTERASL
AGLVGKEPATVDPAFLDSLRDQPDQSFPVKLGPKTVDVTLKDVVFDATDGNFPHPNTMTVKLMAGNKVLLEQEYYSVGGG
FIEWKGYKPPKKNAPKYPFATMKELRQHAEQNNLTISDVILANEMSIPGRSQDEVYAFIDKITGAMVAIVKSGLSAPDGV
LPGPIKLQSKAAEVYKRAMDDQFEADRGIGCLSAYALAGSEENGRGHLVVTAPTGGSAGVLPALVYGLGEGGRKLTQDQI
RKGMLAAAAIGYLCKHNATLSAAEGGCQAEIGVASAMAAALVAAAYDASPRVIENAAESALEHHLGMTCDPVAGYVQVPC
IERCAFGAVKAWTAWAIASNEIASRHRVDLDATITAMAQTAKDMNSKYKETSQAGLAQSVTLC
>Mature_542_residues
SDSPLKPLTQSGETEVDDPLGSVNDIASQDVPDGVDRRAFLMRSALIGATAIILDRPVSAQQKADRLATTPPTPQLSPTL
NVVKEQKGPVMTTLDEFYKVGPGPSSSHTIGPMRITYDFYQRCTKLPAADLAQATALKVNLFGSLSATGKGHGTERASLA
GLVGKEPATVDPAFLDSLRDQPDQSFPVKLGPKTVDVTLKDVVFDATDGNFPHPNTMTVKLMAGNKVLLEQEYYSVGGGF
IEWKGYKPPKKNAPKYPFATMKELRQHAEQNNLTISDVILANEMSIPGRSQDEVYAFIDKITGAMVAIVKSGLSAPDGVL
PGPIKLQSKAAEVYKRAMDDQFEADRGIGCLSAYALAGSEENGRGHLVVTAPTGGSAGVLPALVYGLGEGGRKLTQDQIR
KGMLAAAAIGYLCKHNATLSAAEGGCQAEIGVASAMAAALVAAAYDASPRVIENAAESALEHHLGMTCDPVAGYVQVPCI
ERCAFGAVKAWTAWAIASNEIASRHRVDLDATITAMAQTAKDMNSKYKETSQAGLAQSVTLC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=463, Percent_Identity=41.2526997840173, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1789161, Length=463, Percent_Identity=38.4449244060475, Blast_Score=289, Evalue=4e-79,
Organism=Escherichia coli, GI1788116, Length=460, Percent_Identity=38.9130434782609, Blast_Score=284, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 57366; Mature: 57235

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSPLKPLTQSGETEVDDPLGSVNDIASQDVPDGVDRRAFLMRSALIGATAIILDRPVS
CCCCCCCCHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCCC
AQQKADRLATTPPTPQLSPTLNVVKEQKGPVMTTLDEFYKVGPGPSSSHTIGPMRITYDF
HHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEHHH
YQRCTKLPAADLAQATALKVNLFGSLSATGKGHGTERASLAGLVGKEPATVDPAFLDSLR
HHHHHCCCHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHH
DQPDQSFPVKLGPKTVDVTLKDVVFDATDGNFPHPNTMTVKLMAGNKVLLEQEYYSVGGG
CCCCCCCCEEECCCEEEEEEEHEEEECCCCCCCCCCCEEEEEEECCEEEEEHHHHHCCCC
FIEWKGYKPPKKNAPKYPFATMKELRQHAEQNNLTISDVILANEMSIPGRSQDEVYAFID
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHEEEECCCCCCCCCHHHHHHHHH
KITGAMVAIVKSGLSAPDGVLPGPIKLQSKAAEVYKRAMDDQFEADRGIGCLSAYALAGS
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHCCC
EENGRGHLVVTAPTGGSAGVLPALVYGLGEGGRKLTQDQIRKGMLAAAAIGYLCKHNATL
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
SAAEGGCQAEIGVASAMAAALVAAAYDASPRVIENAAESALEHHLGMTCDPVAGYVQVPC
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCH
IERCAFGAVKAWTAWAIASNEIASRHRVDLDATITAMAQTAKDMNSKYKETSQAGLAQSV
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHC
TLC
CCC
>Mature Secondary Structure 
SDSPLKPLTQSGETEVDDPLGSVNDIASQDVPDGVDRRAFLMRSALIGATAIILDRPVS
CCCCCCCHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCCC
AQQKADRLATTPPTPQLSPTLNVVKEQKGPVMTTLDEFYKVGPGPSSSHTIGPMRITYDF
HHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEHHH
YQRCTKLPAADLAQATALKVNLFGSLSATGKGHGTERASLAGLVGKEPATVDPAFLDSLR
HHHHHCCCHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHH
DQPDQSFPVKLGPKTVDVTLKDVVFDATDGNFPHPNTMTVKLMAGNKVLLEQEYYSVGGG
CCCCCCCCEEECCCEEEEEEEHEEEECCCCCCCCCCCEEEEEEECCEEEEEHHHHHCCCC
FIEWKGYKPPKKNAPKYPFATMKELRQHAEQNNLTISDVILANEMSIPGRSQDEVYAFID
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHEEEECCCCCCCCCHHHHHHHHH
KITGAMVAIVKSGLSAPDGVLPGPIKLQSKAAEVYKRAMDDQFEADRGIGCLSAYALAGS
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHCCC
EENGRGHLVVTAPTGGSAGVLPALVYGLGEGGRKLTQDQIRKGMLAAAAIGYLCKHNATL
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
SAAEGGCQAEIGVASAMAAALVAAAYDASPRVIENAAESALEHHLGMTCDPVAGYVQVPC
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCH
IERCAFGAVKAWTAWAIASNEIASRHRVDLDATITAMAQTAKDMNSKYKETSQAGLAQSV
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHC
TLC
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]