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The map label for this gene is yuxL [H]

Identifier: 116624042

GI number: 116624042

Start: 6253731

End: 6255986

Strand: Direct

Name: yuxL [H]

Synonym: Acid_4956

Alternate gene names: 116624042

Gene position: 6253731-6255986 (Clockwise)

Preceding gene: 116624037

Following gene: 116624045

Centisome position: 62.75

GC content: 63.16

Gene sequence:

>2256_bases
ATGACCCGCGCCCGACTTCGACTTGGCTTTTGCTTCGCCGGCCTGGCTTTTTCGGCGATCGCCGCGAGCGATTCCACTTT
TGGAGTGGAGGATATGCTGGACGTCCGCACCGTGAATATCGGCGCGCTCAGTGACAATGGACGGTGGCTGGCCGCCACCT
CCGGATCGCTGCGCGACCGCATCGGGATCGACAATCACCGGTTTGCGGACCCGACGTACATTGCGCCCAATCACCAGGAC
CTGCTGGTGATCGACACGCAATCGGGCGCGTCGAGGAAGGTCTTCGCGGACCGCCGGCAGGTGACCGCGCTGGCCTGGTC
GCCGGACGGCGCGCGCCTGGCGATGCTCGCCCTATCCGGGGAAACGTATGTGCCGGTGATTTGGGATCGCGCTTCGGGCC
AGCAAATTGCAGTCCCGCTGCCCGCCGGCAAGATCGCCGCGGAGAACGCGGAGCTTCGCTGGAGCGGGGACGGCGCACGG
CTGCTGATCAACCTGCGGCCGGCGGAGTGGCGCGCCAAAGCCGCGGAGCGCTTCCGGCAGGAGACGCAGGGCATGGTCGT
GTTTCATTCGAGCAAGGAGCCCTTCCTGGCGTGGGACGACGTCCGGCGAATGTCACTGGAGAAATCGCTGGCGGCCTTCG
AAGTGAAGACGGGTAAGTGGACGGAGTTGATTGCCAACGCGAAGCTGGGCGCTTACGAGTTGACCGAAGATGGCGCGGCG
CTTACGTATCAATCCGACAACACAAAGAAGACCGACTACGACGTGATTGGCGGCACCGATAACGAGCTGCGCACCATGCC
GGCCGCTGGCGGAAATTCAACCGTGCTGCTGAAGAGCACGAAGGGGCTCACGCTCATCTGGTCGCGGGACGGACGGCGCT
ACGCCTACTCGAAAGACGGCGTGGTGATGCTGGGCGGGATTGAAGGCGGCGAGGCCAAGCCAGTGGCCGGCGCGAAACCA
CCCGCGCCGGACAAGGACAAGCCCGAAGAACCGACCGACGCCGAAAAGGAGAAGCGCGCGAAGGAGCGATTCACGGCCGT
GCGGCTCAGTCCCAAGGGCGACTTCCTGCTGGCCTCCAATAAGGAAGGATTGTGGATGGTAGACACGGCATCGCACACGC
GCGACCTGTTCATCAAGATGCCGGAGGAGGACAAGCTCGCGCCCCGCTACGATGCGGTAGGTTGGAACGCCGAGGGCAGC
GTGCTCTATCTGAGTTACTCCTCGCGGATCCGGTGGGAGCGCGGGCTGGCGCGCTACGACGTGCGTTCGAAGAAGGTCTC
CGAGTTGTGGAAGGACAATCACATTTACTCCAACTTCCGCGTATCGAAGGATGGGAGCACGATCGTGTTCACGGCGGCCG
CAGGCAACCGGCCGAGCGATCTGTACGCCGTCACAGACGAGATGAAGGCCGCGAGGCGACTGACCACGCTCAACCCGCAG
ATCGAGCAGAAGCAGCTGGGCAACACCGAGCTCGTTACTTACCTGGATGCCGACGGGAAGAAGCTCAACGGCGTCCTGTA
CTATCCGGCGGACTATCAGCCGGGCCGCAAGTATCCGACGATCGTGCTGGTATACGAACAATTCTTCGACGATGTGTTCA
ACAGCTTCAACAGCCTGCTCACGGCCAATGGGTACGCCGTGCTGCAGCCCTCAGTGGAGTTCGAGACGGGCTTCCCCGGC
GAGAGCTGGCTGAAGGGCGCGACCGCGGCGGTCAACAAAGTGATCGATATGGGGGTGGCCGATCCCGACAGGCTTGGTAT
CCAGGGGACCAGCTACGGCGGGTACGCGACCAATCTCCTGATCACGCAGACCAACCGGTTCAAGGCGGCGGTCAACGTCA
GCGGCAAGGTGGATATGATCAGCTTCTACACGGACAGCCCGCGTCTCGGCGTGCGCAACATCCACGCGCCGGAGAAGAGC
CAGGACCGGCTCGGCGCCACGCTGTGGCAGCAGCCGCAGAAATACCTGCAGCATTCCGCCATTCTGTACGCGGATCGGAT
CAAGACACCGCTGCTGTTGATCAATGGCGAGCAGGACCATAACGTTCCGGCGCGGCAGGGGATGGAGATGTACTACGCGC
TGCGCCGGTTGAACAAGGAGGTCGCGTGGGTGCTGTATCCCAACGGCGGACATGGCATGCCGACCTCCACTATCGAAGAA
GTTCGCGACTATTCGCAGCGGATTCTGGACTGGTACGCCGCGTACCTGAAGAAGCCGTCGGACGCCGCTTCGGCCCCGAC
GACGGCGGGTCAGTAG

Upstream 100 bases:

>100_bases
TAGAATCGCGATGAAAAGGAGTGACGCTGCGGCTCGCATTATCAGAGTGTAGCGTGCTCGGCGACCCGACTGTGCTAGTT
TTCTAAGACAAGGAGTTCCC

Downstream 100 bases:

>100_bases
GCCCAAGGTATCGTATGATTAGGTAGTCACGCACCAATGCGGATGTGGCGAAACTGGCAGACGCGCTGGATTTAGGTTCC
AGTTCCCGCGAGGGAGTGTA

Product: peptidase S9 prolyl oligopeptidase

Products: oxohex-2-enedioate [C]

Alternate protein names: NA

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MTRARLRLGFCFAGLAFSAIAASDSTFGVEDMLDVRTVNIGALSDNGRWLAATSGSLRDRIGIDNHRFADPTYIAPNHQD
LLVIDTQSGASRKVFADRRQVTALAWSPDGARLAMLALSGETYVPVIWDRASGQQIAVPLPAGKIAAENAELRWSGDGAR
LLINLRPAEWRAKAAERFRQETQGMVVFHSSKEPFLAWDDVRRMSLEKSLAAFEVKTGKWTELIANAKLGAYELTEDGAA
LTYQSDNTKKTDYDVIGGTDNELRTMPAAGGNSTVLLKSTKGLTLIWSRDGRRYAYSKDGVVMLGGIEGGEAKPVAGAKP
PAPDKDKPEEPTDAEKEKRAKERFTAVRLSPKGDFLLASNKEGLWMVDTASHTRDLFIKMPEEDKLAPRYDAVGWNAEGS
VLYLSYSSRIRWERGLARYDVRSKKVSELWKDNHIYSNFRVSKDGSTIVFTAAAGNRPSDLYAVTDEMKAARRLTTLNPQ
IEQKQLGNTELVTYLDADGKKLNGVLYYPADYQPGRKYPTIVLVYEQFFDDVFNSFNSLLTANGYAVLQPSVEFETGFPG
ESWLKGATAAVNKVIDMGVADPDRLGIQGTSYGGYATNLLITQTNRFKAAVNVSGKVDMISFYTDSPRLGVRNIHAPEKS
QDRLGATLWQQPQKYLQHSAILYADRIKTPLLLINGEQDHNVPARQGMEMYYALRRLNKEVAWVLYPNGGHGMPTSTIEE
VRDYSQRILDWYAAYLKKPSDAASAPTTAGQ

Sequences:

>Translated_751_residues
MTRARLRLGFCFAGLAFSAIAASDSTFGVEDMLDVRTVNIGALSDNGRWLAATSGSLRDRIGIDNHRFADPTYIAPNHQD
LLVIDTQSGASRKVFADRRQVTALAWSPDGARLAMLALSGETYVPVIWDRASGQQIAVPLPAGKIAAENAELRWSGDGAR
LLINLRPAEWRAKAAERFRQETQGMVVFHSSKEPFLAWDDVRRMSLEKSLAAFEVKTGKWTELIANAKLGAYELTEDGAA
LTYQSDNTKKTDYDVIGGTDNELRTMPAAGGNSTVLLKSTKGLTLIWSRDGRRYAYSKDGVVMLGGIEGGEAKPVAGAKP
PAPDKDKPEEPTDAEKEKRAKERFTAVRLSPKGDFLLASNKEGLWMVDTASHTRDLFIKMPEEDKLAPRYDAVGWNAEGS
VLYLSYSSRIRWERGLARYDVRSKKVSELWKDNHIYSNFRVSKDGSTIVFTAAAGNRPSDLYAVTDEMKAARRLTTLNPQ
IEQKQLGNTELVTYLDADGKKLNGVLYYPADYQPGRKYPTIVLVYEQFFDDVFNSFNSLLTANGYAVLQPSVEFETGFPG
ESWLKGATAAVNKVIDMGVADPDRLGIQGTSYGGYATNLLITQTNRFKAAVNVSGKVDMISFYTDSPRLGVRNIHAPEKS
QDRLGATLWQQPQKYLQHSAILYADRIKTPLLLINGEQDHNVPARQGMEMYYALRRLNKEVAWVLYPNGGHGMPTSTIEE
VRDYSQRILDWYAAYLKKPSDAASAPTTAGQ
>Mature_750_residues
TRARLRLGFCFAGLAFSAIAASDSTFGVEDMLDVRTVNIGALSDNGRWLAATSGSLRDRIGIDNHRFADPTYIAPNHQDL
LVIDTQSGASRKVFADRRQVTALAWSPDGARLAMLALSGETYVPVIWDRASGQQIAVPLPAGKIAAENAELRWSGDGARL
LINLRPAEWRAKAAERFRQETQGMVVFHSSKEPFLAWDDVRRMSLEKSLAAFEVKTGKWTELIANAKLGAYELTEDGAAL
TYQSDNTKKTDYDVIGGTDNELRTMPAAGGNSTVLLKSTKGLTLIWSRDGRRYAYSKDGVVMLGGIEGGEAKPVAGAKPP
APDKDKPEEPTDAEKEKRAKERFTAVRLSPKGDFLLASNKEGLWMVDTASHTRDLFIKMPEEDKLAPRYDAVGWNAEGSV
LYLSYSSRIRWERGLARYDVRSKKVSELWKDNHIYSNFRVSKDGSTIVFTAAAGNRPSDLYAVTDEMKAARRLTTLNPQI
EQKQLGNTELVTYLDADGKKLNGVLYYPADYQPGRKYPTIVLVYEQFFDDVFNSFNSLLTANGYAVLQPSVEFETGFPGE
SWLKGATAAVNKVIDMGVADPDRLGIQGTSYGGYATNLLITQTNRFKAAVNVSGKVDMISFYTDSPRLGVRNIHAPEKSQ
DRLGATLWQQPQKYLQHSAILYADRIKTPLLLINGEQDHNVPARQGMEMYYALRRLNKEVAWVLYPNGGHGMPTSTIEEV
RDYSQRILDWYAAYLKKPSDAASAPTTAGQ

Specific function: Unknown

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=308, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25144537, Length=218, Percent_Identity=27.5229357798165, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25144540, Length=218, Percent_Identity=27.5229357798165, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17552908, Length=192, Percent_Identity=28.125, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.1.1.45 [C]

Molecular weight: Translated: 83157; Mature: 83025

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRARLRLGFCFAGLAFSAIAASDSTFGVEDMLDVRTVNIGALSDNGRWLAATSGSLRDR
CCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHEEEEEEEEEECCCCCEEEECCCCCHHH
IGIDNHRFADPTYIAPNHQDLLVIDTQSGASRKVFADRRQVTALAWSPDGARLAMLALSG
CCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECC
ETYVPVIWDRASGQQIAVPLPAGKIAAENAELRWSGDGARLLINLRPAEWRAKAAERFRQ
CEEEEEEEECCCCCEEEEECCCCCEEECCCEEEECCCCEEEEEEECCCHHHHHHHHHHHH
ETQGMVVFHSSKEPFLAWDDVRRMSLEKSLAAFEVKTGKWTELIANAKLGAYELTEDGAA
HCCCEEEEECCCCCEEEHHHHHHHHHHHHHEEEEECCCCHHHHHHCCCCCEEEECCCCCE
LTYQSDNTKKTDYDVIGGTDNELRTMPAAGGNSTVLLKSTKGLTLIWSRDGRRYAYSKDG
EEEECCCCCCCCEEEECCCCCCCEEECCCCCCCEEEEEECCCEEEEECCCCCEEEECCCC
VVMLGGIEGGEAKPVAGAKPPAPDKDKPEEPTDAEKEKRAKERFTAVRLSPKGDFLLASN
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEEECC
KEGLWMVDTASHTRDLFIKMPEEDKLAPRYDAVGWNAEGSVLYLSYSSRIRWERGLARYD
CCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEHHHCCHHHH
VRSKKVSELWKDNHIYSNFRVSKDGSTIVFTAAAGNRPSDLYAVTDEMKAARRLTTLNPQ
HHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCC
IEQKQLGNTELVTYLDADGKKLNGVLYYPADYQPGRKYPTIVLVYEQFFDDVFNSFNSLL
HHHHHCCCCEEEEEEECCCCEECEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHE
TANGYAVLQPSVEFETGFPGESWLKGATAAVNKVIDMGVADPDRLGIQGTSYGGYATNLL
ECCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCEEEEEE
ITQTNRFKAAVNVSGKVDMISFYTDSPRLGVRNIHAPEKSQDRLGATLWQQPQKYLQHSA
EEECCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ILYADRIKTPLLLINGEQDHNVPARQGMEMYYALRRLNKEVAWVLYPNGGHGMPTSTIEE
EEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
VRDYSQRILDWYAAYLKKPSDAASAPTTAGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRARLRLGFCFAGLAFSAIAASDSTFGVEDMLDVRTVNIGALSDNGRWLAATSGSLRDR
CCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHEEEEEEEEEECCCCCEEEECCCCCHHH
IGIDNHRFADPTYIAPNHQDLLVIDTQSGASRKVFADRRQVTALAWSPDGARLAMLALSG
CCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECC
ETYVPVIWDRASGQQIAVPLPAGKIAAENAELRWSGDGARLLINLRPAEWRAKAAERFRQ
CEEEEEEEECCCCCEEEEECCCCCEEECCCEEEECCCCEEEEEEECCCHHHHHHHHHHHH
ETQGMVVFHSSKEPFLAWDDVRRMSLEKSLAAFEVKTGKWTELIANAKLGAYELTEDGAA
HCCCEEEEECCCCCEEEHHHHHHHHHHHHHEEEEECCCCHHHHHHCCCCCEEEECCCCCE
LTYQSDNTKKTDYDVIGGTDNELRTMPAAGGNSTVLLKSTKGLTLIWSRDGRRYAYSKDG
EEEECCCCCCCCEEEECCCCCCCEEECCCCCCCEEEEEECCCEEEEECCCCCEEEECCCC
VVMLGGIEGGEAKPVAGAKPPAPDKDKPEEPTDAEKEKRAKERFTAVRLSPKGDFLLASN
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEEECC
KEGLWMVDTASHTRDLFIKMPEEDKLAPRYDAVGWNAEGSVLYLSYSSRIRWERGLARYD
CCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEHHHCCHHHH
VRSKKVSELWKDNHIYSNFRVSKDGSTIVFTAAAGNRPSDLYAVTDEMKAARRLTTLNPQ
HHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCC
IEQKQLGNTELVTYLDADGKKLNGVLYYPADYQPGRKYPTIVLVYEQFFDDVFNSFNSLL
HHHHHCCCCEEEEEEECCCCEECEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHE
TANGYAVLQPSVEFETGFPGESWLKGATAAVNKVIDMGVADPDRLGIQGTSYGGYATNLL
ECCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCEEEEEE
ITQTNRFKAAVNVSGKVDMISFYTDSPRLGVRNIHAPEKSQDRLGATLWQQPQKYLQHSA
EEECCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ILYADRIKTPLLLINGEQDHNVPARQGMEMYYALRRLNKEVAWVLYPNGGHGMPTSTIEE
EEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
VRDYSQRILDWYAAYLKKPSDAASAPTTAGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-carboxymethylenebut-2-en-4-olide; H2O [C]

Specific reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]