Click here to switch to the map view.

The map label for this gene is wzc [H]

Identifier: 116623969

GI number: 116623969

Start: 6157806

End: 6159479

Strand: Direct

Name: wzc [H]

Synonym: Acid_4881

Alternate gene names: 116623969

Gene position: 6157806-6159479 (Clockwise)

Preceding gene: 116623968

Following gene: 116623970

Centisome position: 61.79

GC content: 62.19

Gene sequence:

>1674_bases
GTGGCTATGCATCGATCACCGCGGTCGCAAGCGTCCAGCCGGCACAACGGCGCCCAGGAAAGAAGCGCCCAGGAGTGGAG
CGTCGCCGACTGCATACGCATCCTCCGCCGTCGCAAGCTCACTCTGCTGTGGATTACGTGCCTGGGCCTCCTGGTCACCA
CCCTCATCACCCTTGCGCAATCCCACGTCTATCGCTCGCGCGCGGCGCTCGAGCTCCAGAGATACAACGAGGACTTCCTC
GATCTCCGCGAGATCTATCCGGCGCCGGCATACGTGGTCGATCCGGGCTGGTACATGCAAACTCAGGCGGAATTGCTGCG
GCAGGACGGATTGATCGAACAGGTCGCACGCCAGTTTCACCTGGAGTCGCGGCCGGAATATCAGCCGCGCTCGAGTTTTC
TAAGCAAACTTCACCAGGACATACGAGTGAGCCAGGTGCACACTAGCCGTCTCGTACAAATCGTGTGCGAAGCGCGCGAG
CCGCGGCTTGCGGCCGACCTCTGCAACACCTTGGCCCACACCTTTATCGAAGACAGCATTCGAGCACGACAGCAGGCCGC
GCGGCAGACCTACGAATCGCTAAGCTCACAGCTTCGGAAGCTCAGGCCTTCCGGCCCGGGCAGCGATTCACGGGCATACG
CGATCATGCGGCAGCAGGCGAGTACGGCCAGGTTGGCGTCCGGGATGCGCCAGTCGGCGATGCGCGTCGTGGATCCGGCG
ACCCCGGCGCCTCGTCCTTTTACGCCAAACCTGCCGTTGAACCTGATCATCGGTGCGCTGGCCGCATTCCTGATCGCGAT
TGGGTACGTGATGCTACGGGAGCAGAGCACTTCGGCCCTCCACTCGCCGGGCGAGGCCGGCATCTTTCTGGCGCTGCCGG
AACTTGGAGCCATCCCCAAGGATGGTAAGTGGAAGCGTCCTGCGTTCCGATATTTCAACCCGGTGAACGGCAAGCTCCGC
ATCGAAAGGGCCGTATTGGAACAGGCCTCATCGCACCTGTCGGAGTCCTTTCGCGCGACTCTGGCCTCCATCCTCACCAC
CCCGCATCACGCCGGGCTCGCTCACAACCTCGTGTTCACCAGTTCCCGGCCGATGGAAGGCAAGACCACGGTGGTCAGCA
ATCTCGGCCTCGCACTTGCCGAGACTGGCAGGCAGGTCTTGTTGATCGATGGCGACATGCGCCGTCCGCAACTTCACAGG
GTCTTCGACCAGCCGAATGGCTGGGGCCTGAGCGACGTCCTTCGCGAATGGAACTCCATTGAGGAACTGCCTCTCAAGGT
GCTCGTCAAGAAGACGGCCGTCTCAAAGCTCTACCTGCTGCCCGGCGGAACATCCACTGGCAACATTTCCAATCTTCTCC
ATTCGGGCCGGATGTCCAAGCTGCTGGCGCGCTTCCGTGAGGAGTTCGACTATGTGTTGGTCGATGCGCCGCCTTGCCTT
GAGTTCGCGGATGCCCGAAACATGGCCCGCTCCGCCGATGGGCTTGTGCTCGTGGTGCGAGCCAGGCACACCGATCGAAA
GATCGCCGAGACCGCGGTGCAACGCCTTGCGTGCGACGGGATTCGCATGGCAGGCGTGATTTTGAACGGCTGGGACGCCT
CCTGCGCGGGACACCTCGTCAGACCGTTCGAAGGCGTTGGGAACAGAGCCTATGACCTCACTTGTCGCCATTGA

Upstream 100 bases:

>100_bases
CCGCCTCGTCTGCATCGAAGAGCTTTCCGGCTGGCGGGATGGGCGCCCGTGGTCGGCGTCATGCGCAACTTCGCTCGATG
TACTCCAGGGAGACTGAACA

Downstream 100 bases:

>100_bases
AAATGTCGCGCCGCCGCCCAAACTGCTCAGCGCTCTGCTGGCGGGCTACGTGGTGTTGCTTCCCTACCAGTTCGAGGTCG
GGAACGAAGTCAATTTCGCC

Product: lipopolysaccharide biosynthesis

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MAMHRSPRSQASSRHNGAQERSAQEWSVADCIRILRRRKLTLLWITCLGLLVTTLITLAQSHVYRSRAALELQRYNEDFL
DLREIYPAPAYVVDPGWYMQTQAELLRQDGLIEQVARQFHLESRPEYQPRSSFLSKLHQDIRVSQVHTSRLVQIVCEARE
PRLAADLCNTLAHTFIEDSIRARQQAARQTYESLSSQLRKLRPSGPGSDSRAYAIMRQQASTARLASGMRQSAMRVVDPA
TPAPRPFTPNLPLNLIIGALAAFLIAIGYVMLREQSTSALHSPGEAGIFLALPELGAIPKDGKWKRPAFRYFNPVNGKLR
IERAVLEQASSHLSESFRATLASILTTPHHAGLAHNLVFTSSRPMEGKTTVVSNLGLALAETGRQVLLIDGDMRRPQLHR
VFDQPNGWGLSDVLREWNSIEELPLKVLVKKTAVSKLYLLPGGTSTGNISNLLHSGRMSKLLARFREEFDYVLVDAPPCL
EFADARNMARSADGLVLVVRARHTDRKIAETAVQRLACDGIRMAGVILNGWDASCAGHLVRPFEGVGNRAYDLTCRH

Sequences:

>Translated_557_residues
MAMHRSPRSQASSRHNGAQERSAQEWSVADCIRILRRRKLTLLWITCLGLLVTTLITLAQSHVYRSRAALELQRYNEDFL
DLREIYPAPAYVVDPGWYMQTQAELLRQDGLIEQVARQFHLESRPEYQPRSSFLSKLHQDIRVSQVHTSRLVQIVCEARE
PRLAADLCNTLAHTFIEDSIRARQQAARQTYESLSSQLRKLRPSGPGSDSRAYAIMRQQASTARLASGMRQSAMRVVDPA
TPAPRPFTPNLPLNLIIGALAAFLIAIGYVMLREQSTSALHSPGEAGIFLALPELGAIPKDGKWKRPAFRYFNPVNGKLR
IERAVLEQASSHLSESFRATLASILTTPHHAGLAHNLVFTSSRPMEGKTTVVSNLGLALAETGRQVLLIDGDMRRPQLHR
VFDQPNGWGLSDVLREWNSIEELPLKVLVKKTAVSKLYLLPGGTSTGNISNLLHSGRMSKLLARFREEFDYVLVDAPPCL
EFADARNMARSADGLVLVVRARHTDRKIAETAVQRLACDGIRMAGVILNGWDASCAGHLVRPFEGVGNRAYDLTCRH
>Mature_556_residues
AMHRSPRSQASSRHNGAQERSAQEWSVADCIRILRRRKLTLLWITCLGLLVTTLITLAQSHVYRSRAALELQRYNEDFLD
LREIYPAPAYVVDPGWYMQTQAELLRQDGLIEQVARQFHLESRPEYQPRSSFLSKLHQDIRVSQVHTSRLVQIVCEAREP
RLAADLCNTLAHTFIEDSIRARQQAARQTYESLSSQLRKLRPSGPGSDSRAYAIMRQQASTARLASGMRQSAMRVVDPAT
PAPRPFTPNLPLNLIIGALAAFLIAIGYVMLREQSTSALHSPGEAGIFLALPELGAIPKDGKWKRPAFRYFNPVNGKLRI
ERAVLEQASSHLSESFRATLASILTTPHHAGLAHNLVFTSSRPMEGKTTVVSNLGLALAETGRQVLLIDGDMRRPQLHRV
FDQPNGWGLSDVLREWNSIEELPLKVLVKKTAVSKLYLLPGGTSTGNISNLLHSGRMSKLLARFREEFDYVLVDAPPCLE
FADARNMARSADGLVLVVRARHTDRKIAETAVQRLACDGIRMAGVILNGWDASCAGHLVRPFEGVGNRAYDLTCRH

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG0489

COG function: function code D; ATPases involved in chromosome partitioning

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=303, Percent_Identity=31.3531353135314, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787216, Length=310, Percent_Identity=29.3548387096774, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 62165; Mature: 62034

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMHRSPRSQASSRHNGAQERSAQEWSVADCIRILRRRKLTLLWITCLGLLVTTLITLAQ
CCCCCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SHVYRSRAALELQRYNEDFLDLREIYPAPAYVVDPGWYMQTQAELLRQDGLIEQVARQFH
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHC
LESRPEYQPRSSFLSKLHQDIRVSQVHTSRLVQIVCEAREPRLAADLCNTLAHTFIEDSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RARQQAARQTYESLSSQLRKLRPSGPGSDSRAYAIMRQQASTARLASGMRQSAMRVVDPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPAPRPFTPNLPLNLIIGALAAFLIAIGYVMLREQSTSALHSPGEAGIFLALPELGAIPK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCC
DGKWKRPAFRYFNPVNGKLRIERAVLEQASSHLSESFRATLASILTTPHHAGLAHNLVFT
CCCCCCCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCEEEE
SSRPMEGKTTVVSNLGLALAETGRQVLLIDGDMRRPQLHRVFDQPNGWGLSDVLREWNSI
CCCCCCCCHHHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHCCH
EELPLKVLVKKTAVSKLYLLPGGTSTGNISNLLHSGRMSKLLARFREEFDYVLVDAPPCL
HHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCH
EFADARNMARSADGLVLVVRARHTDRKIAETAVQRLACDGIRMAGVILNGWDASCAGHLV
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHH
RPFEGVGNRAYDLTCRH
CHHHHCCCCEEEEEECC
>Mature Secondary Structure 
AMHRSPRSQASSRHNGAQERSAQEWSVADCIRILRRRKLTLLWITCLGLLVTTLITLAQ
CCCCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SHVYRSRAALELQRYNEDFLDLREIYPAPAYVVDPGWYMQTQAELLRQDGLIEQVARQFH
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHC
LESRPEYQPRSSFLSKLHQDIRVSQVHTSRLVQIVCEAREPRLAADLCNTLAHTFIEDSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RARQQAARQTYESLSSQLRKLRPSGPGSDSRAYAIMRQQASTARLASGMRQSAMRVVDPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPAPRPFTPNLPLNLIIGALAAFLIAIGYVMLREQSTSALHSPGEAGIFLALPELGAIPK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCC
DGKWKRPAFRYFNPVNGKLRIERAVLEQASSHLSESFRATLASILTTPHHAGLAHNLVFT
CCCCCCCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCEEEE
SSRPMEGKTTVVSNLGLALAETGRQVLLIDGDMRRPQLHRVFDQPNGWGLSDVLREWNSI
CCCCCCCCHHHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHCCH
EELPLKVLVKKTAVSKLYLLPGGTSTGNISNLLHSGRMSKLLARFREEFDYVLVDAPPCL
HHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCH
EFADARNMARSADGLVLVVRARHTDRKIAETAVQRLACDGIRMAGVILNGWDASCAGHLV
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHH
RPFEGVGNRAYDLTCRH
CHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]