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The map label for this gene is aqpZ [H]

Identifier: 116623958

GI number: 116623958

Start: 6149822

End: 6150553

Strand: Reverse

Name: aqpZ [H]

Synonym: Acid_4870

Alternate gene names: 116623958

Gene position: 6150553-6149822 (Counterclockwise)

Preceding gene: 116623959

Following gene: 116623957

Centisome position: 61.72

GC content: 63.39

Gene sequence:

>732_bases
ATGTCTCTTACAAGAAGGGCGATGGCCGAGCTCGTCGGCACGTTCTGGCTGGTCTTCGGGGGCTGCGGAAGCGCGGTGTT
GGCCGCCGCCTTTCCAATCTTAGGCATCGGTTTTCTGGGTGTCTCGCTGGCATTCGGACTTACTCTCCTGACCATGGCAT
ACGCCATCGGACACATATCCGGTTGCCACCTGAACCCCGCTGTCTCCATCGGCCTCGCCGTTGCGCGCCGTTTCCCGGCG
CACGAACTACTTCATTACATCGCGGCGCAGGTAGGCGGCGGCATCCTGGCCTCCGCGATTCTCTACCTGATCGCCAGCGG
GAAACCTGGCTTTGATCTGTCGGGTGGTTTCGCGGCGAATGGGTACGGGCTGCACTCACCCGGTGGATATGCTCTTCTTG
CGTGCCTGGTGGCCGAGATGGTTCTCACCTTCATGTTCCTGATGATCATCCTCGGGGCAACCGACGAACGTGCGCCGGTG
GGCTTCGCTCCCATCGCCATCGGGTTCGGCCTGACGCTCGCTTGCTTGATCGGCATCCCGGTGACCAATCTCTCCGTGAA
TCCCGCGCGCAGCACCGGACCCGCCCTGATCGTCGGCGGTTGGGCTTTGGAACAGCTCTGGCTCTTCTGGGTGGCGCCAA
TCCTGGGCGCGGTACTGGCCGGCGTGGTTTATCCCGCCCTGGCGCACAGAGGAGCAACGGAAACCGTACGCACCCCGCGG
CTCGCGGCCTGA

Upstream 100 bases:

>100_bases
TAGGAAGGTGTCCGGACCATGCGGCTGGTGGTGACAGAGGCCGGCCTGCCAGCTTGGCGACACAAAATCCTGCCTGATTT
GTGGTGTAAGTGGAGGTTAT

Downstream 100 bases:

>100_bases
CGCACGAGGCAAACAAAAACCATGTTGTGGCCATCGAGGCATGCCTTCGCCACGTGCGGAGGCGTCATATTACTGGTCAT
CTTCGCGGCTTGCAGCGGGG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSLTRRAMAELVGTFWLVFGGCGSAVLAAAFPILGIGFLGVSLAFGLTLLTMAYAIGHISGCHLNPAVSIGLAVARRFPA
HELLHYIAAQVGGGILASAILYLIASGKPGFDLSGGFAANGYGLHSPGGYALLACLVAEMVLTFMFLMIILGATDERAPV
GFAPIAIGFGLTLACLIGIPVTNLSVNPARSTGPALIVGGWALEQLWLFWVAPILGAVLAGVVYPALAHRGATETVRTPR
LAA

Sequences:

>Translated_243_residues
MSLTRRAMAELVGTFWLVFGGCGSAVLAAAFPILGIGFLGVSLAFGLTLLTMAYAIGHISGCHLNPAVSIGLAVARRFPA
HELLHYIAAQVGGGILASAILYLIASGKPGFDLSGGFAANGYGLHSPGGYALLACLVAEMVLTFMFLMIILGATDERAPV
GFAPIAIGFGLTLACLIGIPVTNLSVNPARSTGPALIVGGWALEQLWLFWVAPILGAVLAGVVYPALAHRGATETVRTPR
LAA
>Mature_242_residues
SLTRRAMAELVGTFWLVFGGCGSAVLAAAFPILGIGFLGVSLAFGLTLLTMAYAIGHISGCHLNPAVSIGLAVARRFPAH
ELLHYIAAQVGGGILASAILYLIASGKPGFDLSGGFAANGYGLHSPGGYALLACLVAEMVLTFMFLMIILGATDERAPVG
FAPIAIGFGLTLACLIGIPVTNLSVNPARSTGPALIVGGWALEQLWLFWVAPILGAVLAGVVYPALAHRGATETVRTPRL
AA

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4755125, Length=191, Percent_Identity=38.2198952879581, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4502181, Length=191, Percent_Identity=38.2198952879581, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=38.1165919282511, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4502179, Length=226, Percent_Identity=34.070796460177, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI37694062, Length=243, Percent_Identity=37.037037037037, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI6912506, Length=228, Percent_Identity=34.2105263157895, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI86792455, Length=223, Percent_Identity=31.390134529148, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI45446752, Length=204, Percent_Identity=32.843137254902, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI157266307, Length=249, Percent_Identity=31.7269076305221, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4826645, Length=249, Percent_Identity=28.1124497991968, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI22538420, Length=263, Percent_Identity=28.5171102661597, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4502187, Length=245, Percent_Identity=28.1632653061224, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787101, Length=207, Percent_Identity=69.5652173913043, Blast_Score=275, Evalue=1e-75,
Organism=Escherichia coli, GI1790362, Length=265, Percent_Identity=27.5471698113208, Blast_Score=68, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71993722, Length=236, Percent_Identity=32.6271186440678, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17558372, Length=235, Percent_Identity=28.5106382978723, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71992966, Length=239, Percent_Identity=25.5230125523013, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652747, Length=235, Percent_Identity=33.6170212765957, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551084, Length=235, Percent_Identity=33.6170212765957, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136672, Length=221, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550503, Length=231, Percent_Identity=28.1385281385281, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652751, Length=242, Percent_Identity=30.9917355371901, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19922038, Length=242, Percent_Identity=30.9917355371901, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24762342, Length=238, Percent_Identity=28.1512605042017, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24762344, Length=231, Percent_Identity=30.3030303030303, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762346, Length=231, Percent_Identity=30.3030303030303, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762348, Length=231, Percent_Identity=30.3030303030303, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130305, Length=231, Percent_Identity=30.3030303030303, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24913; Mature: 24782

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTRRAMAELVGTFWLVFGGCGSAVLAAAFPILGIGFLGVSLAFGLTLLTMAYAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSIGLAVARRFPAHELLHYIAAQVGGGILASAILYLIASGKPGFDLSGGFAAN
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GYGLHSPGGYALLACLVAEMVLTFMFLMIILGATDERAPVGFAPIAIGFGLTLACLIGIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
VTNLSVNPARSTGPALIVGGWALEQLWLFWVAPILGAVLAGVVYPALAHRGATETVRTPR
CCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
LAA
CCC
>Mature Secondary Structure 
SLTRRAMAELVGTFWLVFGGCGSAVLAAAFPILGIGFLGVSLAFGLTLLTMAYAIGHIS
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSIGLAVARRFPAHELLHYIAAQVGGGILASAILYLIASGKPGFDLSGGFAAN
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GYGLHSPGGYALLACLVAEMVLTFMFLMIILGATDERAPVGFAPIAIGFGLTLACLIGIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
VTNLSVNPARSTGPALIVGGWALEQLWLFWVAPILGAVLAGVVYPALAHRGATETVRTPR
CCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
LAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]