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The map label for this gene is chuR [H]

Identifier: 116623937

GI number: 116623937

Start: 6124592

End: 6125854

Strand: Reverse

Name: chuR [H]

Synonym: Acid_4849

Alternate gene names: 116623937

Gene position: 6125854-6124592 (Counterclockwise)

Preceding gene: 116623938

Following gene: 116623936

Centisome position: 61.47

GC content: 59.54

Gene sequence:

>1263_bases
ATGTCCGTTACCCCCGAGCTCCCCAAAGTATGGCCGCGCAACGCGCCCTCTTCCATTCATGTGTTAGCCAAGCCTACAGG
CGCGATCTGTAACCTGGATTGTAAGTACTGCTTCTTCCTCTCCAAGGAAACCCTCTACCCAGGCAGCAAATTTCGCATGG
CGGAAGACACCCTCGAAGCCTACGTCAAACAAGTGATCGAGTCTCAGCAATCCAGCCATGTGACCATAGCCTGGCAGGGC
GGAGAACCGACATTAATGGGGCTTGATTTCTTTCGTCAGGCCAGTGTCCTTGCGCGCAAACACCTCCGCCGCGGCGCCAC
CCTCGAACACACCATTCAAACCAATGGCATTCTGCTCGACCGCGAGTGGTGCGAGTTCCTGCGCGAGAATTCCTTCCTGG
TCGGCCTCTCCATCGATGGCCCGGAAGCCATGCATGACGCCTATCGCGTCGATAAGTCCGGCGCGCCCACTTTTTCGCAC
GTGATGCGCGCCGCCCGCCTGATGCAGCAGCACCAGGTGGAGTTTAACGTCCTGTGTACCGTCCACGACGCCAACGTGGG
CCATGCGGCCGAGGTCTACCGCTTCTTCCGCGATGAAGTCAAAACCCAGTTCATGCAGTTCATTCCGATCGTGGAGCGAT
CCACCATGGAACTGCTGGAGATCGCCAATGCCGGCTGGGGAGATCAGAACCGGCGCCGCCCCCTCTACACCCAGGATGGC
GCGCTTGTGACCGAACGGACCGTCAGGCCCGAGGCCTGGGGCCGCTTCCTCATCGAACTCTTCGACGAGTGGATCGCGCA
TGACGTCGGCGATGTCTTCATCCAGCTATTCGAATCGGCGCTTGCCTCGTGGCTCGGTCTGCCTCCGTCGTTGTGTATCT
TTGCCGAAACCTGCGGCAATGCCCTGGCACTGGAGCATAACGGCGATCTCTACTCCTGCGATCACTTTGTCGAGCCTCGC
TTCCACCTGGGCAACATTAAGCAGCAGCACCTCGTCCAAATGGCCGCTTCAGACCGCCAGAGAGCCTTCGGAGCGCTCAA
GCGCGACACACTCCCGCGCTATTGCCGCGAATGCGAAGTCCGCTTCGCCTGCAACGGAGAGTGTCCCCGCAACCGCTTCG
TCGATACCCCCGATGGTGAGCCCGGCTTGAACTATCTTTGCGCCGGATACAAAGCATTCTTCAAGCACGTCGATCGTCCC
ATGAAACTCATGGCCGCCTTGCTCCGCGAGGGCAAGGATGCCTCCGGCATAATGGCCGCATAG

Upstream 100 bases:

>100_bases
CTGCGGCGCCGGGGTTTACGCCTCGGTGCTCATGCTCACCTGAAGGCAAGTTTCTTACATCCGCCTTCCAACTGCCGCAT
CAACGCAGCATCGAGTTGCT

Downstream 100 bases:

>100_bases
CTTACAGTCAGCCCTGCCGGGTAGGTTTGATACAGTGTTCTCATTCGAATGAGAATCACTTCGGCTGTCCTCGGCCTGCT
CGCCGCCCACACCATCCTTT

Product: radical SAM domain-containing protein

Products: NA

Alternate protein names: AnSME; Chondroitin sulfate/heparin utilization regulation protein; Ser-type sulfatase-activating enzyme [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSVTPELPKVWPRNAPSSIHVLAKPTGAICNLDCKYCFFLSKETLYPGSKFRMAEDTLEAYVKQVIESQQSSHVTIAWQG
GEPTLMGLDFFRQASVLARKHLRRGATLEHTIQTNGILLDREWCEFLRENSFLVGLSIDGPEAMHDAYRVDKSGAPTFSH
VMRAARLMQQHQVEFNVLCTVHDANVGHAAEVYRFFRDEVKTQFMQFIPIVERSTMELLEIANAGWGDQNRRRPLYTQDG
ALVTERTVRPEAWGRFLIELFDEWIAHDVGDVFIQLFESALASWLGLPPSLCIFAETCGNALALEHNGDLYSCDHFVEPR
FHLGNIKQQHLVQMAASDRQRAFGALKRDTLPRYCRECEVRFACNGECPRNRFVDTPDGEPGLNYLCAGYKAFFKHVDRP
MKLMAALLREGKDASGIMAA

Sequences:

>Translated_420_residues
MSVTPELPKVWPRNAPSSIHVLAKPTGAICNLDCKYCFFLSKETLYPGSKFRMAEDTLEAYVKQVIESQQSSHVTIAWQG
GEPTLMGLDFFRQASVLARKHLRRGATLEHTIQTNGILLDREWCEFLRENSFLVGLSIDGPEAMHDAYRVDKSGAPTFSH
VMRAARLMQQHQVEFNVLCTVHDANVGHAAEVYRFFRDEVKTQFMQFIPIVERSTMELLEIANAGWGDQNRRRPLYTQDG
ALVTERTVRPEAWGRFLIELFDEWIAHDVGDVFIQLFESALASWLGLPPSLCIFAETCGNALALEHNGDLYSCDHFVEPR
FHLGNIKQQHLVQMAASDRQRAFGALKRDTLPRYCRECEVRFACNGECPRNRFVDTPDGEPGLNYLCAGYKAFFKHVDRP
MKLMAALLREGKDASGIMAA
>Mature_419_residues
SVTPELPKVWPRNAPSSIHVLAKPTGAICNLDCKYCFFLSKETLYPGSKFRMAEDTLEAYVKQVIESQQSSHVTIAWQGG
EPTLMGLDFFRQASVLARKHLRRGATLEHTIQTNGILLDREWCEFLRENSFLVGLSIDGPEAMHDAYRVDKSGAPTFSHV
MRAARLMQQHQVEFNVLCTVHDANVGHAAEVYRFFRDEVKTQFMQFIPIVERSTMELLEIANAGWGDQNRRRPLYTQDGA
LVTERTVRPEAWGRFLIELFDEWIAHDVGDVFIQLFESALASWLGLPPSLCIFAETCGNALALEHNGDLYSCDHFVEPRF
HLGNIKQQHLVQMAASDRQRAFGALKRDTLPRYCRECEVRFACNGECPRNRFVDTPDGEPGLNYLCAGYKAFFKHVDRPM
KLMAALLREGKDASGIMAA

Specific function: Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Links the heparin and the chondroitin sulfate utilization pathways which contribute to the colonization of the intestinal tract. May catalyze the activation of chondro-6- sulfatase, i

COG id: COG0641

COG function: function code R; Arylsulfatase regulator (Fe-S oxidoreductase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family [H]

Homologues:

Organism=Escherichia coli, GI48994973, Length=405, Percent_Identity=45.679012345679, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI87081923, Length=391, Percent_Identity=38.1074168797954, Blast_Score=288, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 47624; Mature: 47493

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTPELPKVWPRNAPSSIHVLAKPTGAICNLDCKYCFFLSKETLYPGSKFRMAEDTLEA
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHH
YVKQVIESQQSSHVTIAWQGGEPTLMGLDFFRQASVLARKHLRRGATLEHTIQTNGILLD
HHHHHHHCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEE
REWCEFLRENSFLVGLSIDGPEAMHDAYRVDKSGAPTFSHVMRAARLMQQHQVEFNVLCT
HHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
VHDANVGHAAEVYRFFRDEVKTQFMQFIPIVERSTMELLEIANAGWGDQNRRRPLYTQDG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCC
ALVTERTVRPEAWGRFLIELFDEWIAHDVGDVFIQLFESALASWLGLPPSLCIFAETCGN
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
ALALEHNGDLYSCDHFVEPRFHLGNIKQQHLVQMAASDRQRAFGALKRDTLPRYCRECEV
EEEEECCCCEEECHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
RFACNGECPRNRFVDTPDGEPGLNYLCAGYKAFFKHVDRPMKLMAALLREGKDASGIMAA
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SVTPELPKVWPRNAPSSIHVLAKPTGAICNLDCKYCFFLSKETLYPGSKFRMAEDTLEA
CCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHH
YVKQVIESQQSSHVTIAWQGGEPTLMGLDFFRQASVLARKHLRRGATLEHTIQTNGILLD
HHHHHHHCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEE
REWCEFLRENSFLVGLSIDGPEAMHDAYRVDKSGAPTFSHVMRAARLMQQHQVEFNVLCT
HHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
VHDANVGHAAEVYRFFRDEVKTQFMQFIPIVERSTMELLEIANAGWGDQNRRRPLYTQDG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCC
ALVTERTVRPEAWGRFLIELFDEWIAHDVGDVFIQLFESALASWLGLPPSLCIFAETCGN
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
ALALEHNGDLYSCDHFVEPRFHLGNIKQQHLVQMAASDRQRAFGALKRDTLPRYCRECEV
EEEEECCCCEEECHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
RFACNGECPRNRFVDTPDGEPGLNYLCAGYKAFFKHVDRPMKLMAALLREGKDASGIMAA
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1429442; 12663928 [H]