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The map label for this gene is folD

Identifier: 116623868

GI number: 116623868

Start: 6047562

End: 6048482

Strand: Direct

Name: folD

Synonym: Acid_4780

Alternate gene names: 116623868

Gene position: 6047562-6048482 (Clockwise)

Preceding gene: 116623867

Following gene: 116623869

Centisome position: 60.68

GC content: 63.84

Gene sequence:

>921_bases
ATGCCGCGAATTCTCGACGGAAATCGCGTACGCGATGAGATCAAAGGCGAGCTGAAACCGCGGATCGCGGCGCTCGCCGC
CCATGGACGGCCGCCTGGCCTGGCCGTGGTGCTGGTGGGCAACAACCCGGCATCTGAGATCTACGTACGCAACAAGATCA
AGACCTGCCATGATCTGGGGATCTACTCCGAATCGATCACGCCTCCCGATACCATTTCCACGGAAGAACTGCTCGCGATT
GTCCAAGGGCTGAACGCGCGCGCGGAGATCGATGGAATCCTGGTGCAACTTCCCCTTCCGCCGCAGGTGGATACGAAACG
GATTCTGATGGCAGTCTCTCCGGCCAAGGACGTGGACGGGTTTCACCCCTGCAACGTCGGTGCGCTGGTGGCCAATCTTC
CGGCGCCCCGGGCCTGCACGCCGGCGGGAATTATGGAGTTGCTGAAGCGCGGCGGAATCCCGATCGCGGGACAGCGGGCG
GTGGTCGTGGGGCGCAGCGACATCGTGGGCAAGCCGGTAGCGATGCTCCTGCTCCACGAGCACGCCACGGTTACGATCTG
CCATTCGAAGACGCCGGACCTGAAGTCCCTGTGCCGGGAGGCCGATATCCTGGTTGCGGCGATCGGCCGGGCGGCGATGA
TCACGGGCGAGTTCATCAAACCGGGAGCGACCGTCATCGATGTCGGCACGAACCATGTCGCGGACCGCGAAAAGGCGGCG
CGGATCTACCGGAATTCGCCGGAGAAGATGGCGAATTTCGACAAGCGCGGCAACCTGCTGATTGGGGACGTGGATCCGGT
AGGTGTAGTGGAAAAGGCCGGGGCGTACACGCCCGTGCCGGGCGGCGTCGGACCGCTCACGATCGCGATGCTGATGGTCA
ATACGGTGGCCTCGGCGGAGCGTCGAGCGGGCGTATGCTGA

Upstream 100 bases:

>100_bases
GAGGAAGCGCGGGCAGCGGCGGAGAGCTTGCGCGAGCAGTTCACGGCGGCGCCGGTCACGCGGCACGGTCCGGCATCTTC
ACACGTTATGATTGAGAAGA

Downstream 100 bases:

>100_bases
AGGTTGGGCTGACTGGTGGAATTGGCTGTGGCAAGAGCTTCGTGGGTGAGGCGCTGGCAGACTACGGGTGCCTGGTGGTT
CACGCGGACGACTTGGGACA

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MPRILDGNRVRDEIKGELKPRIAALAAHGRPPGLAVVLVGNNPASEIYVRNKIKTCHDLGIYSESITPPDTISTEELLAI
VQGLNARAEIDGILVQLPLPPQVDTKRILMAVSPAKDVDGFHPCNVGALVANLPAPRACTPAGIMELLKRGGIPIAGQRA
VVVGRSDIVGKPVAMLLLHEHATVTICHSKTPDLKSLCREADILVAAIGRAAMITGEFIKPGATVIDVGTNHVADREKAA
RIYRNSPEKMANFDKRGNLLIGDVDPVGVVEKAGAYTPVPGGVGPLTIAMLMVNTVASAERRAGVC

Sequences:

>Translated_306_residues
MPRILDGNRVRDEIKGELKPRIAALAAHGRPPGLAVVLVGNNPASEIYVRNKIKTCHDLGIYSESITPPDTISTEELLAI
VQGLNARAEIDGILVQLPLPPQVDTKRILMAVSPAKDVDGFHPCNVGALVANLPAPRACTPAGIMELLKRGGIPIAGQRA
VVVGRSDIVGKPVAMLLLHEHATVTICHSKTPDLKSLCREADILVAAIGRAAMITGEFIKPGATVIDVGTNHVADREKAA
RIYRNSPEKMANFDKRGNLLIGDVDPVGVVEKAGAYTPVPGGVGPLTIAMLMVNTVASAERRAGVC
>Mature_305_residues
PRILDGNRVRDEIKGELKPRIAALAAHGRPPGLAVVLVGNNPASEIYVRNKIKTCHDLGIYSESITPPDTISTEELLAIV
QGLNARAEIDGILVQLPLPPQVDTKRILMAVSPAKDVDGFHPCNVGALVANLPAPRACTPAGIMELLKRGGIPIAGQRAV
VVGRSDIVGKPVAMLLLHEHATVTICHSKTPDLKSLCREADILVAAIGRAAMITGEFIKPGATVIDVGTNHVADREKAAR
IYRNSPEKMANFDKRGNLLIGDVDPVGVVEKAGAYTPVPGGVGPLTIAMLMVNTVASAERRAGVC

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI94721354, Length=309, Percent_Identity=45.9546925566343, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI222136639, Length=307, Percent_Identity=41.6938110749186, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI222418558, Length=309, Percent_Identity=42.3948220064725, Blast_Score=212, Evalue=4e-55,
Organism=Escherichia coli, GI1786741, Length=297, Percent_Identity=43.4343434343434, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17568735, Length=277, Percent_Identity=42.9602888086643, Blast_Score=198, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321643, Length=312, Percent_Identity=41.6666666666667, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319558, Length=304, Percent_Identity=40.1315789473684, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI62472483, Length=304, Percent_Identity=45.3947368421053, Blast_Score=233, Evalue=9e-62,
Organism=Drosophila melanogaster, GI45551871, Length=304, Percent_Identity=45.3947368421053, Blast_Score=233, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24645718, Length=304, Percent_Identity=45.3947368421053, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17137370, Length=304, Percent_Identity=45.3947368421053, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17136816, Length=313, Percent_Identity=41.85303514377, Blast_Score=220, Evalue=8e-58,
Organism=Drosophila melanogaster, GI17136818, Length=313, Percent_Identity=41.85303514377, Blast_Score=220, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_SOLUE (Q01X76)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826024.1
- ProteinModelPortal:   Q01X76
- SMR:   Q01X76
- STRING:   Q01X76
- GeneID:   4426976
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_4780
- NMPDR:   fig|234267.9.peg.4533
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   TYVRNKQ
- ProtClustDB:   CLSK775178
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 32279; Mature: 32148

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRILDGNRVRDEIKGELKPRIAALAAHGRPPGLAVVLVGNNPASEIYVRNKIKTCHDLG
CCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEECCCCCHHEEEHHHHHHHHHHC
IYSESITPPDTISTEELLAIVQGLNARAEIDGILVQLPLPPQVDTKRILMAVSPAKDVDG
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEECEEEEEECCCCCCCCCEEEEEECCCCCCCC
FHPCNVGALVANLPAPRACTPAGIMELLKRGGIPIAGQRAVVVGRSDIVGKPVAMLLLHE
CCCCCCCHHEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEC
HATVTICHSKTPDLKSLCREADILVAAIGRAAMITGEFIKPGATVIDVGTNHVADREKAA
CCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHEEECCCCCCCCEEEECCCCCCHHHHHHH
RIYRNSPEKMANFDKRGNLLIGDVDPVGVVEKAGAYTPVPGGVGPLTIAMLMVNTVASAE
HHHCCCHHHHHCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RRAGVC
HHCCCC
>Mature Secondary Structure 
PRILDGNRVRDEIKGELKPRIAALAAHGRPPGLAVVLVGNNPASEIYVRNKIKTCHDLG
CCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEECCCCCHHEEEHHHHHHHHHHC
IYSESITPPDTISTEELLAIVQGLNARAEIDGILVQLPLPPQVDTKRILMAVSPAKDVDG
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEECEEEEEECCCCCCCCCEEEEEECCCCCCCC
FHPCNVGALVANLPAPRACTPAGIMELLKRGGIPIAGQRAVVVGRSDIVGKPVAMLLLHE
CCCCCCCHHEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEC
HATVTICHSKTPDLKSLCREADILVAAIGRAAMITGEFIKPGATVIDVGTNHVADREKAA
CCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHEEECCCCCCCCEEEECCCCCCHHHHHHH
RIYRNSPEKMANFDKRGNLLIGDVDPVGVVEKAGAYTPVPGGVGPLTIAMLMVNTVASAE
HHHCCCHHHHHCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RRAGVC
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA