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The map label for this gene is pncB2 [H]

Identifier: 116623609

GI number: 116623609

Start: 5718171

End: 5719484

Strand: Direct

Name: pncB2 [H]

Synonym: Acid_4519

Alternate gene names: 116623609

Gene position: 5718171-5719484 (Clockwise)

Preceding gene: 116623608

Following gene: 116623610

Centisome position: 57.38

GC content: 67.35

Gene sequence:

>1314_bases
ATGAACGGGCTGCTCACCGACCTATACGAACTCACGATGGCCGCCGGCTATTTCGAAGCCGGCAAGGCGGCCGAGAAGGC
CACGTTCGAATTCACCATCCGCCGGCTGCCCGCGCATCGCAATTTCGCGCTGATGGCGGGGCTGCCGCAGGTGGTGGATT
ACCTGCTCAACCTGAGTTTCAGCGACGAGGAAGTGGACTACCTGCGCGGGTTGCCGCAGTTCGCGCGTGTCTCCTCTGCT
TTCTTCGATTCCCTGCGCACGTTCCGTTTCACGGGCGACCTCTTCGCAGTCCCGGAGGGCACCCCGCTGTTCGCGGGTGA
GCCGGTGCTCACGATTCGCGCACCGATCATGGAGGCGCAGATTCCGGAGACGTACCTGCTCTCGGAGATTACCTTTCAGA
CCCTGATCGCGAGCAAAGCAGCGCGGTGCGTGGAGGCCGCCGGGGGGCGGCCGATCGCGGAGTTCGGCACCCGCCGGGCG
CACACCGCCGAGGCCGGCACGCTGGGTGCGCGGGCGGCGTACATCGGCGGCTGCGCGGGCACCAGCAACACGCTTGCGGG
TCTGCGCTACGGCATCCCGGTGATGGGTACGGCAGCACACTCCTGGGTGATGAGCTTCCCCTGCGAGGTGGACGCGTTCC
GCAAGCTGCAGCGCGTGATGGGCGAAGCCACGGTGCAACTGCTGGATACCTACGACACGGTGGAGGGCGCTCGCCGCGCG
GTGAAGGCCGGCGGGCCGATCTGGGGCGTGCGGCTGGATAGCGGCGATTTCGACGTACTCTCGCGGCAGGTGCGTGCGAT
TCTCGACGAGGGCGGAATGCAGCAGGCGAAGATCATGGCGAGCGGCGACCTGGACGAGTACCGCATCCGCGAGCTGGTGC
GGGGCGGGGCGCCGATCGACGCTTTCGGGGTCGGCACGCAGCTGGCGACGTCGGCGGACGCGCCGAATATGGGCGCGATC
TACAAACTGGTGGAAGTGGAGATCTGCGGCATCAAACGCTTCACCGCGAAGTACAGCGAGGAGAAGGGTTCCCTGCCCGG
CGCCAAGCAGGTCTTCCGCGACGTGGCGCGCGATGTGATCGCGCGTTCCGGCGAATGCGGCAAGGGCGAGGCGCTGCTGC
GGCCGATCCTGCTGGGCGGACGTCTGATCGAGCCGCTGCCGACGATCGAACAGGCGCGGGAGCGCGCCGCCAGGATGATC
GCAGCGCTCCCGGAGCATTTGCGACAATTGGAAACGGGCGAGCCCTGGCCGGTGATCGAGAGCCGCGAATTGCGCGAGCT
GATCGGCCGGACCCGCTCCAATCTGCGCGGATGA

Upstream 100 bases:

>100_bases
GGTCGAGGAATTGATGAAGGCCGCGGCCGATGTAAAGGAAGCAGCGCCCGAGCCCGCGAAGAAGAAGTAGCGGAGCGGGC
GTTTTCGCCTGCCACCTTCT

Downstream 100 bases:

>100_bases
AAACTCTTTTCTTCGATATCGATTCGCAACTGGATTTCCTGTATCCCGCGGGTGCGTTGTATGTGCCCGGGGGCGAACGC
GTAGTGCCGGCGATCGCGCG

Product: putative nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNGLLTDLYELTMAAGYFEAGKAAEKATFEFTIRRLPAHRNFALMAGLPQVVDYLLNLSFSDEEVDYLRGLPQFARVSSA
FFDSLRTFRFTGDLFAVPEGTPLFAGEPVLTIRAPIMEAQIPETYLLSEITFQTLIASKAARCVEAAGGRPIAEFGTRRA
HTAEAGTLGARAAYIGGCAGTSNTLAGLRYGIPVMGTAAHSWVMSFPCEVDAFRKLQRVMGEATVQLLDTYDTVEGARRA
VKAGGPIWGVRLDSGDFDVLSRQVRAILDEGGMQQAKIMASGDLDEYRIRELVRGGAPIDAFGVGTQLATSADAPNMGAI
YKLVEVEICGIKRFTAKYSEEKGSLPGAKQVFRDVARDVIARSGECGKGEALLRPILLGGRLIEPLPTIEQARERAARMI
AALPEHLRQLETGEPWPVIESRELRELIGRTRSNLRG

Sequences:

>Translated_437_residues
MNGLLTDLYELTMAAGYFEAGKAAEKATFEFTIRRLPAHRNFALMAGLPQVVDYLLNLSFSDEEVDYLRGLPQFARVSSA
FFDSLRTFRFTGDLFAVPEGTPLFAGEPVLTIRAPIMEAQIPETYLLSEITFQTLIASKAARCVEAAGGRPIAEFGTRRA
HTAEAGTLGARAAYIGGCAGTSNTLAGLRYGIPVMGTAAHSWVMSFPCEVDAFRKLQRVMGEATVQLLDTYDTVEGARRA
VKAGGPIWGVRLDSGDFDVLSRQVRAILDEGGMQQAKIMASGDLDEYRIRELVRGGAPIDAFGVGTQLATSADAPNMGAI
YKLVEVEICGIKRFTAKYSEEKGSLPGAKQVFRDVARDVIARSGECGKGEALLRPILLGGRLIEPLPTIEQARERAARMI
AALPEHLRQLETGEPWPVIESRELRELIGRTRSNLRG
>Mature_437_residues
MNGLLTDLYELTMAAGYFEAGKAAEKATFEFTIRRLPAHRNFALMAGLPQVVDYLLNLSFSDEEVDYLRGLPQFARVSSA
FFDSLRTFRFTGDLFAVPEGTPLFAGEPVLTIRAPIMEAQIPETYLLSEITFQTLIASKAARCVEAAGGRPIAEFGTRRA
HTAEAGTLGARAAYIGGCAGTSNTLAGLRYGIPVMGTAAHSWVMSFPCEVDAFRKLQRVMGEATVQLLDTYDTVEGARRA
VKAGGPIWGVRLDSGDFDVLSRQVRAILDEGGMQQAKIMASGDLDEYRIRELVRGGAPIDAFGVGTQLATSADAPNMGAI
YKLVEVEICGIKRFTAKYSEEKGSLPGAKQVFRDVARDVIARSGECGKGEALLRPILLGGRLIEPLPTIEQARERAARMI
AALPEHLRQLETGEPWPVIESRELRELIGRTRSNLRG

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=520, Percent_Identity=30.5769230769231, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71997952, Length=533, Percent_Identity=27.3921200750469, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71997947, Length=533, Percent_Identity=27.3921200750469, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71997955, Length=234, Percent_Identity=37.1794871794872, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24581587, Length=518, Percent_Identity=27.992277992278, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=36.8932038834951, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=36.8932038834951, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=36.8932038834951, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=36.8932038834951, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=36.8932038834951, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 47537; Mature: 47537

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLLTDLYELTMAAGYFEAGKAAEKATFEFTIRRLPAHRNFALMAGLPQVVDYLLNLSF
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCC
SDEEVDYLRGLPQFARVSSAFFDSLRTFRFTGDLFAVPEGTPLFAGEPVLTIRAPIMEAQ
CCHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCCEEEEECCHHHHC
IPETYLLSEITFQTLIASKAARCVEAAGGRPIAEFGTRRAHTAEAGTLGARAAYIGGCAG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCC
TSNTLAGLRYGIPVMGTAAHSWVMSFPCEVDAFRKLQRVMGEATVQLLDTYDTVEGARRA
CCHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAGGPIWGVRLDSGDFDVLSRQVRAILDEGGMQQAKIMASGDLDEYRIRELVRGGAPID
HHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHHHHHCCCCCC
AFGVGTQLATSADAPNMGAIYKLVEVEICGIKRFTAKYSEEKGSLPGAKQVFRDVARDVI
HHCCCCHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ARSGECGKGEALLRPILLGGRLIEPLPTIEQARERAARMIAALPEHLRQLETGEPWPVIE
HCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SRELRELIGRTRSNLRG
CHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNGLLTDLYELTMAAGYFEAGKAAEKATFEFTIRRLPAHRNFALMAGLPQVVDYLLNLSF
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCC
SDEEVDYLRGLPQFARVSSAFFDSLRTFRFTGDLFAVPEGTPLFAGEPVLTIRAPIMEAQ
CCHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCCEEEEECCHHHHC
IPETYLLSEITFQTLIASKAARCVEAAGGRPIAEFGTRRAHTAEAGTLGARAAYIGGCAG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCC
TSNTLAGLRYGIPVMGTAAHSWVMSFPCEVDAFRKLQRVMGEATVQLLDTYDTVEGARRA
CCHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAGGPIWGVRLDSGDFDVLSRQVRAILDEGGMQQAKIMASGDLDEYRIRELVRGGAPID
HHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHHHHHCCCCCC
AFGVGTQLATSADAPNMGAIYKLVEVEICGIKRFTAKYSEEKGSLPGAKQVFRDVARDVI
HHCCCCHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ARSGECGKGEALLRPILLGGRLIEPLPTIEQARERAARMIAALPEHLRQLETGEPWPVIE
HCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SRELRELIGRTRSNLRG
CHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]