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The map label for this gene is msrA [H]

Identifier: 116623604

GI number: 116623604

Start: 5712879

End: 5713415

Strand: Reverse

Name: msrA [H]

Synonym: Acid_4514

Alternate gene names: 116623604

Gene position: 5713415-5712879 (Counterclockwise)

Preceding gene: 116623612

Following gene: 116623601

Centisome position: 57.33

GC content: 60.89

Gene sequence:

>537_bases
ATGGAAACCATAACTCTGGGAGGGGGCTGCTTCTGGTGTCTGGAAGCGGTCTACGTGGAAATGGAAGGCGTGCAATCCGT
GGTCTCCGGCTACATGGGCGGCCATCTCGCCGACCCCGACTACCGCGCCGTCTGTACCGGCAGCACCGGCCATATCGAGG
TAGTGCAGGTCACCTACGACCCGGCCGTAACTTCCACGCGCGAAATCCTGGAAGTCTTTTTCGCCATCCACGACCCCACC
TCGCTCGATCGCCAGGGCAACGACGCCGGCACCCAGTACCGCTCCGCCATCTTCTATCACACCCAGGAGCAGTACGAAAT
CTCGCAGGCGCTCATCGACGAGCTGGAGCGCGAAAAAATCTGGAGCCGCCCCATCGTCACCGAAGTCCGTCCCGCCGTGA
AATTCTATCCCGCGGAGGACTACCACCAGAACTACTTCGCCAACAACCCGCAGCAGCCCTACTGCTCCTTCGTGGTCTCC
CCCAAAGTCCGCAAGTTCCGCGAAAAGTTTGCCGCCAAAATGCGCAAGCGCGCCTGA

Upstream 100 bases:

>100_bases
TATGCCGGCCTGTGCGCGGCCGGCGCCGCCACTATCTATTTTTACGCGGCGCGCCACGTTCCGGTTACCGCCATCACGCC
AATCGACGACAATATAGGAC

Downstream 100 bases:

>100_bases
CGCCGCTCGCCGCCCCGCTTGTTTGCTCGCAGCCCGCAAACATCCGCACCGGAATATTCGCCGCCCCATCAGAGCCTGGT
GGGGCAGGCAATCTTGCTTG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
METITLGGGCFWCLEAVYVEMEGVQSVVSGYMGGHLADPDYRAVCTGSTGHIEVVQVTYDPAVTSTREILEVFFAIHDPT
SLDRQGNDAGTQYRSAIFYHTQEQYEISQALIDELEREKIWSRPIVTEVRPAVKFYPAEDYHQNYFANNPQQPYCSFVVS
PKVRKFREKFAAKMRKRA

Sequences:

>Translated_178_residues
METITLGGGCFWCLEAVYVEMEGVQSVVSGYMGGHLADPDYRAVCTGSTGHIEVVQVTYDPAVTSTREILEVFFAIHDPT
SLDRQGNDAGTQYRSAIFYHTQEQYEISQALIDELEREKIWSRPIVTEVRPAVKFYPAEDYHQNYFANNPQQPYCSFVVS
PKVRKFREKFAAKMRKRA
>Mature_178_residues
METITLGGGCFWCLEAVYVEMEGVQSVVSGYMGGHLADPDYRAVCTGSTGHIEVVQVTYDPAVTSTREILEVFFAIHDPT
SLDRQGNDAGTQYRSAIFYHTQEQYEISQALIDELEREKIWSRPIVTEVRPAVKFYPAEDYHQNYFANNPQQPYCSFVVS
PKVRKFREKFAAKMRKRA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=44.8717948717949, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=44.8717948717949, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=47.787610619469, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=44.4444444444444, Blast_Score=136, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=30.8219178082192, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=38.75, Blast_Score=114, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=36.5853658536585, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45553131, Length=158, Percent_Identity=36.0759493670886, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664631, Length=164, Percent_Identity=36.5853658536585, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20319; Mature: 20319

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METITLGGGCFWCLEAVYVEMEGVQSVVSGYMGGHLADPDYRAVCTGSTGHIEVVQVTYD
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEEEC
PAVTSTREILEVFFAIHDPTSLDRQGNDAGTQYRSAIFYHTQEQYEISQALIDELEREKI
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEECHHHHHHHHHHHHHHHHHHH
WSRPIVTEVRPAVKFYPAEDYHQNYFANNPQQPYCSFVVSPKVRKFREKFAAKMRKRA
HCCCCHHHHCHHHEECCCHHHHHHHCCCCCCCCHHEEEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
METITLGGGCFWCLEAVYVEMEGVQSVVSGYMGGHLADPDYRAVCTGSTGHIEVVQVTYD
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEEEC
PAVTSTREILEVFFAIHDPTSLDRQGNDAGTQYRSAIFYHTQEQYEISQALIDELEREKI
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEECHHHHHHHHHHHHHHHHHHH
WSRPIVTEVRPAVKFYPAEDYHQNYFANNPQQPYCSFVVSPKVRKFREKFAAKMRKRA
HCCCCHHHHCHHHEECCCHHHHHHHCCCCCCCCHHEEEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA