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The map label for this gene is pepQ [H]

Identifier: 116623505

GI number: 116623505

Start: 5583483

End: 5584649

Strand: Direct

Name: pepQ [H]

Synonym: Acid_4415

Alternate gene names: 116623505

Gene position: 5583483-5584649 (Clockwise)

Preceding gene: 116623504

Following gene: 116623506

Centisome position: 56.03

GC content: 62.98

Gene sequence:

>1167_bases
ATGAACCTTGCTGACATTCAACAGGAAATTCGCAACCAAAAGCTCGATGGGTGGCTGTTCTTCGATCACCACATGCGTGA
CCCGCTGGCATACCGGGTGCTCGGATTGCCGCCCGGGAAAGTCTCGCGCCGCTGGTATTACATGATCCCCGCCGAGGGCG
AGCCCAAGGGGATGGAGCACCGCATCGAGCGCAACCAGCTCGCCAGTCTGCCTGGCGAGAAGATCGCCTACTCCAGTTGG
ACCGAACAGCTCGCCGCGCTCGGCAAGCTGACGGCCGGAATGAAGCGCGTCGCCATGCAGTATTCGCCGATGTGCGCGGT
GCCTTATGTCGCGACCGTGGACGCCGGGACCGTGGAGCTGGTGCGCAGCCTTGGCGTGGACGTGGTCACTTCCGCCGAGC
TGATCCAGATCTTCGAAGCGCGCTGGACACCCGAGCAGCTCGAATCCCACCTCGAAGTTGGACGCCGCGTTGATAAGGTC
CGCGCCGCAGCCTTCGAGTTGATCCGCGAACGCACGCGCAACGGCGCCGCACTGCAGGAAGTCGAGGTCAAGGATTTCGT
CCGCAAGGGCTTCGCCGATGCCGGACTGCTCACCGATAGCGGCCCAATCGTGGGTTGCAACGCCAACGCCTCCAATCCTC
ACTACGAGCCCAGCGCCCAAGTCACTGCGCCGATCAAGTCCGGCGATTGGGTGCTGCTTGATATGTGGGCCAAGCTCGAT
CAGCCCCGCGCAGTCTACTACGACATCACCTGGACGGCCTTCTGCGGCGATAGCCCCACCGACGAAATGCGCCGCGTCTT
TACCACCGTGCGCGACGCCCGCGACGCCGCCATTAAGCGAGTCACGGAGGCCATGGCGCATGGGCAAACGCTGCACGGTT
ACGAAGTGGACGACGCCTGCCGCGCCGTCATCATCAAATCCGGCTATGCCGAATACTTCACGCACCGCACCGGTCACTCC
ATCGGCGTAGAGGTCCACGGCAACGGCGCCAACATGGATAATTTCGAGACGCACGACGAGCGGCGCGTGATGCCGTGGAG
CTGCTTCTCGGTGGAACCCGGCATCTACCTGCCGAACTTCGGCGTGCGTTCGGAAATCAACATGTTCATCGGCGACCATG
ACGCGCGCGTCACCGGCGCCATCCAGCGCGACATGGTCCTGCTCTAA

Upstream 100 bases:

>100_bases
CGCGCGTGCGCATTGTGACGGGCTTGACAAGCCGCATCAAGGTTGTAGAGATTGAGGGAGTCCCACAAGAAGATTTGGAA
AGGCGTTTGAAGGCTTCACC

Downstream 100 bases:

>100_bases
TGCCGCAGGCGCTGGCTGCCCTCGCAACGCTGCTCTCTTTCGCCCCGCATGGGAATAAAGTGGAGCTGCGCCTGGATCGC
GGCAGCGCCGAGTTAGTCTG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNLADIQQEIRNQKLDGWLFFDHHMRDPLAYRVLGLPPGKVSRRWYYMIPAEGEPKGMEHRIERNQLASLPGEKIAYSSW
TEQLAALGKLTAGMKRVAMQYSPMCAVPYVATVDAGTVELVRSLGVDVVTSAELIQIFEARWTPEQLESHLEVGRRVDKV
RAAAFELIRERTRNGAALQEVEVKDFVRKGFADAGLLTDSGPIVGCNANASNPHYEPSAQVTAPIKSGDWVLLDMWAKLD
QPRAVYYDITWTAFCGDSPTDEMRRVFTTVRDARDAAIKRVTEAMAHGQTLHGYEVDDACRAVIIKSGYAEYFTHRTGHS
IGVEVHGNGANMDNFETHDERRVMPWSCFSVEPGIYLPNFGVRSEINMFIGDHDARVTGAIQRDMVLL

Sequences:

>Translated_388_residues
MNLADIQQEIRNQKLDGWLFFDHHMRDPLAYRVLGLPPGKVSRRWYYMIPAEGEPKGMEHRIERNQLASLPGEKIAYSSW
TEQLAALGKLTAGMKRVAMQYSPMCAVPYVATVDAGTVELVRSLGVDVVTSAELIQIFEARWTPEQLESHLEVGRRVDKV
RAAAFELIRERTRNGAALQEVEVKDFVRKGFADAGLLTDSGPIVGCNANASNPHYEPSAQVTAPIKSGDWVLLDMWAKLD
QPRAVYYDITWTAFCGDSPTDEMRRVFTTVRDARDAAIKRVTEAMAHGQTLHGYEVDDACRAVIIKSGYAEYFTHRTGHS
IGVEVHGNGANMDNFETHDERRVMPWSCFSVEPGIYLPNFGVRSEINMFIGDHDARVTGAIQRDMVLL
>Mature_388_residues
MNLADIQQEIRNQKLDGWLFFDHHMRDPLAYRVLGLPPGKVSRRWYYMIPAEGEPKGMEHRIERNQLASLPGEKIAYSSW
TEQLAALGKLTAGMKRVAMQYSPMCAVPYVATVDAGTVELVRSLGVDVVTSAELIQIFEARWTPEQLESHLEVGRRVDKV
RAAAFELIRERTRNGAALQEVEVKDFVRKGFADAGLLTDSGPIVGCNANASNPHYEPSAQVTAPIKSGDWVLLDMWAKLD
QPRAVYYDITWTAFCGDSPTDEMRRVFTTVRDARDAAIKRVTEAMAHGQTLHGYEVDDACRAVIIKSGYAEYFTHRTGHS
IGVEVHGNGANMDNFETHDERRVMPWSCFSVEPGIYLPNFGVRSEINMFIGDHDARVTGAIQRDMVLL

Specific function: Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Escherichia coli, GI1788728, Length=258, Percent_Identity=30.2325581395349, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 43532; Mature: 43532

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLADIQQEIRNQKLDGWLFFDHHMRDPLAYRVLGLPPGKVSRRWYYMIPAEGEPKGMEH
CCHHHHHHHHHHCCCCEEEEECCCCCCCHHEEEECCCCCCCCCEEEEEEECCCCCCCHHH
RIERNQLASLPGEKIAYSSWTEQLAALGKLTAGMKRVAMQYSPMCAVPYVATVDAGTVEL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHH
VRSLGVDVVTSAELIQIFEARWTPEQLESHLEVGRRVDKVRAAAFELIRERTRNGAALQE
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VEVKDFVRKGFADAGLLTDSGPIVGCNANASNPHYEPSAQVTAPIKSGDWVLLDMWAKLD
HHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEEHHHCC
QPRAVYYDITWTAFCGDSPTDEMRRVFTTVRDARDAAIKRVTEAMAHGQTLHGYEVDDAC
CCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHH
RAVIIKSGYAEYFTHRTGHSIGVEVHGNGANMDNFETHDERRVMPWSCFSVEPGIYLPNF
HEEEECCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEECCCC
GVRSEINMFIGDHDARVTGAIQRDMVLL
CCCCEEEEEECCCCCEEEHHHHCCEECC
>Mature Secondary Structure
MNLADIQQEIRNQKLDGWLFFDHHMRDPLAYRVLGLPPGKVSRRWYYMIPAEGEPKGMEH
CCHHHHHHHHHHCCCCEEEEECCCCCCCHHEEEECCCCCCCCCEEEEEEECCCCCCCHHH
RIERNQLASLPGEKIAYSSWTEQLAALGKLTAGMKRVAMQYSPMCAVPYVATVDAGTVEL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHH
VRSLGVDVVTSAELIQIFEARWTPEQLESHLEVGRRVDKVRAAAFELIRERTRNGAALQE
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VEVKDFVRKGFADAGLLTDSGPIVGCNANASNPHYEPSAQVTAPIKSGDWVLLDMWAKLD
HHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEEHHHCC
QPRAVYYDITWTAFCGDSPTDEMRRVFTTVRDARDAAIKRVTEAMAHGQTLHGYEVDDAC
CCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHH
RAVIIKSGYAEYFTHRTGHSIGVEVHGNGANMDNFETHDERRVMPWSCFSVEPGIYLPNF
HEEEECCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEECCCC
GVRSEINMFIGDHDARVTGAIQRDMVLL
CCCCEEEEEECCCCCEEEHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10075426 [H]