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The map label for this gene is gpmA

Identifier: 116623464

GI number: 116623464

Start: 5536569

End: 5537315

Strand: Direct

Name: gpmA

Synonym: Acid_4374

Alternate gene names: 116623464

Gene position: 5536569-5537315 (Clockwise)

Preceding gene: 116623463

Following gene: 116623466

Centisome position: 55.56

GC content: 63.72

Gene sequence:

>747_bases
GTGAAGAAACTCGTTCTCATCCGCCACGGCGAAAGCACGTGGAACAAAGAAAATCGCTTCACCGGCTGGACCGACGTCGA
TCTCTCCGACGAAGGCCGCCAGCAGGCCACCGAAGCCGCCGAGGTGCTCAAACGGGAAGGCTACGTCTTTGACGTGGCCT
ACACCAGCGTCCTCAAGCGCGCGATCCGCACTCTGTGGACGGTGCTCGACGGCATGGACCTGATGTGGATCCCGGTGCAC
CGCTCCTGGCGCCTGAATGAACGCCACTATGGCGCGCTGCAGGGCCTTAACAAGGCGGAGACGGCCGCGAAGTTCGGCGA
GGACCAGGTCAAAATCTGGCGCCGCAGCTACGACATCCCACCGCCCGTCCTGACCGCGGACGACCCGCGCTTCCCCGGCC
ACGACCCGCGCTACCAGAGCCTCACCAAGGAAGAGCTCCCGCTCACGGAGTGCCTGAAGGACACCGTGGCGCGCTTCCTT
CCCTTGTGGCACGACACCATCGCGCCCGCGATCAGGAGCGGTCAGCGCGTCATCATCGCCGCCCACGGCAACAGCCTGCG
CGCTCTCGTGAAGTACCTCGATGGCGTCAGCGAAGCCGATATCGTCGAGCTCAATATCCCCACCGGCATGCCGCTAGTTT
ATGAGCTCGATGACGACCTCAAACCCCTAAACCGCTACTACCTCGGCGACCCAGAGAAGGTGAAGGCCGCCATGGAAGCC
GTCGCCGCCCAGGGCAAGAAGAAGTAG

Upstream 100 bases:

>100_bases
CTAGCCGCACCGACCGCATCTGCAAGTACAACCAGCTGCTCCGGATCGAAGAGCGCCTCGGTTCGTCGGCCGTGTTCCCC
GGCAGAAAGGCCTACAGCCG

Downstream 100 bases:

>100_bases
GGCAGGCCTCCCCGGTCTGTCCACACGGACGGGAGCCGCGAACGTCAACGGATCGCGGCTCCATCTCGCGGAAGTAGTCT
AATTGGGAGTGGGCTTTTGG

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKKLVLIRHGESTWNKENRFTGWTDVDLSDEGRQQATEAAEVLKREGYVFDVAYTSVLKRAIRTLWTVLDGMDLMWIPVH
RSWRLNERHYGALQGLNKAETAAKFGEDQVKIWRRSYDIPPPVLTADDPRFPGHDPRYQSLTKEELPLTECLKDTVARFL
PLWHDTIAPAIRSGQRVIIAAHGNSLRALVKYLDGVSEADIVELNIPTGMPLVYELDDDLKPLNRYYLGDPEKVKAAMEA
VAAQGKKK

Sequences:

>Translated_248_residues
MKKLVLIRHGESTWNKENRFTGWTDVDLSDEGRQQATEAAEVLKREGYVFDVAYTSVLKRAIRTLWTVLDGMDLMWIPVH
RSWRLNERHYGALQGLNKAETAAKFGEDQVKIWRRSYDIPPPVLTADDPRFPGHDPRYQSLTKEELPLTECLKDTVARFL
PLWHDTIAPAIRSGQRVIIAAHGNSLRALVKYLDGVSEADIVELNIPTGMPLVYELDDDLKPLNRYYLGDPEKVKAAMEA
VAAQGKKK
>Mature_248_residues
MKKLVLIRHGESTWNKENRFTGWTDVDLSDEGRQQATEAAEVLKREGYVFDVAYTSVLKRAIRTLWTVLDGMDLMWIPVH
RSWRLNERHYGALQGLNKAETAAKFGEDQVKIWRRSYDIPPPVLTADDPRFPGHDPRYQSLTKEELPLTECLKDTVARFL
PLWHDTIAPAIRSGQRVIIAAHGNSLRALVKYLDGVSEADIVELNIPTGMPLVYELDDDLKPLNRYYLGDPEKVKAAMEA
VAAQGKKK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=249, Percent_Identity=60.2409638554217, Blast_Score=316, Evalue=1e-86,
Organism=Homo sapiens, GI4505753, Length=249, Percent_Identity=63.0522088353414, Blast_Score=311, Evalue=4e-85,
Organism=Homo sapiens, GI71274132, Length=249, Percent_Identity=60.6425702811245, Blast_Score=295, Evalue=2e-80,
Organism=Homo sapiens, GI4502445, Length=251, Percent_Identity=45.4183266932271, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI40353764, Length=251, Percent_Identity=45.4183266932271, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=63.9751552795031, Blast_Score=201, Evalue=6e-52,
Organism=Escherichia coli, GI1786970, Length=246, Percent_Identity=66.6666666666667, Blast_Score=347, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6322697, Length=247, Percent_Identity=55.4655870445344, Blast_Score=267, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6324516, Length=294, Percent_Identity=30.952380952381, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6320183, Length=296, Percent_Identity=32.0945945945946, Blast_Score=142, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646216, Length=250, Percent_Identity=55.6, Blast_Score=280, Evalue=6e-76,
Organism=Drosophila melanogaster, GI85725270, Length=250, Percent_Identity=54.4, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI85725272, Length=250, Percent_Identity=54.4, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24650981, Length=250, Percent_Identity=54.4, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI28571815, Length=249, Percent_Identity=38.5542168674699, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI28571817, Length=249, Percent_Identity=38.5542168674699, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24648979, Length=249, Percent_Identity=38.5542168674699, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_SOLUE (Q01YD0)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825620.1
- ProteinModelPortal:   Q01YD0
- SMR:   Q01YD0
- STRING:   Q01YD0
- GeneID:   4427368
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_4374
- NMPDR:   fig|234267.9.peg.4160
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   Q01YD0
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28239; Mature: 28239

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVLIRHGESTWNKENRFTGWTDVDLSDEGRQQATEAAEVLKREGYVFDVAYTSVLKR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
AIRTLWTVLDGMDLMWIPVHRSWRLNERHYGALQGLNKAETAAKFGEDQVKIWRRSYDIP
HHHHHHHHHCCCCEEEEECCCCEECCCHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCC
PPVLTADDPRFPGHDPRYQSLTKEELPLTECLKDTVARFLPLWHDTIAPAIRSGQRVIIA
CCCCCCCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSLRALVKYLDGVSEADIVELNIPTGMPLVYELDDDLKPLNRYYLGDPEKVKAAMEA
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHH
VAAQGKKK
HHHCCCCC
>Mature Secondary Structure
MKKLVLIRHGESTWNKENRFTGWTDVDLSDEGRQQATEAAEVLKREGYVFDVAYTSVLKR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
AIRTLWTVLDGMDLMWIPVHRSWRLNERHYGALQGLNKAETAAKFGEDQVKIWRRSYDIP
HHHHHHHHHCCCCEEEEECCCCEECCCHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCC
PPVLTADDPRFPGHDPRYQSLTKEELPLTECLKDTVARFLPLWHDTIAPAIRSGQRVIIA
CCCCCCCCCCCCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSLRALVKYLDGVSEADIVELNIPTGMPLVYELDDDLKPLNRYYLGDPEKVKAAMEA
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHH
VAAQGKKK
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA