Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 116623384

GI number: 116623384

Start: 5438608

End: 5439993

Strand: Reverse

Name: fumC [H]

Synonym: Acid_4293

Alternate gene names: 116623384

Gene position: 5439993-5438608 (Counterclockwise)

Preceding gene: 116623393

Following gene: 116623383

Centisome position: 54.59

GC content: 63.64

Gene sequence:

>1386_bases
ATGATCGCGCCGGTTCGTAAGGAAACTGACAGCCACGGTGAAGTCGAAGTCCCCGCCGATAAGCTCTGGGGCGCCCAGAC
CCAGCGTTCCCTCGAGCATTTCAGCATCGGCCGCGATCTCATGCCGCGCGAGATGATCACTGCCTACGCCACCTTGAAAA
AGGCCGCGGCCGCGGCGAACCACGAGATCGGGGGCCTCGACGACGAGCGCCACAAATTGATCGCCCAGGCCTGCGACGAA
ATCCTCGCTGGTCTGCACCACGACATGTTTCCCCTTCACGTCTGGATCTCCGGCAGCGGCACCCAGTTCAATATGAACGT
GAACGAGGTCATCTCTAATCGCTGCTGCCAGCTCGCCGGCACCCCGTTGGGCAGCAAGACCCCCGTCCACCCCAACGACC
ACGTGAACATGTCGCAGTCGTCGAATGACACCTTTCCCGCTGCGATGTACATCGCGGCCGCCGTCAACGTGAAGCAGCGC
CTGACTCCGGCCGTCACCGCCCTGCGCGATGCCATCCACGAAAAAGCCCGCGCGTGGAACGACATCATCAAAATCGGCCG
CACCCACCTGCAGGACGCCACCCCGCTGACGCTCGGCCAGGAATGGTCCGGCTACGCTGCGATGTTGACCGACGATCTCG
ATCGCCTCGAGTCCGCGCTTCCCGGCCTCTACCGCCTCGCGCTCGGCGGCACTGCCGTGGGAACCGGCATCAACGCGCCT
CCGGAGTTCGGAGCGGCGGCAGCCGCCGGAATCGCCGCGCTCACCGGCCTGCCCTTCGTATCCGCTCCGAACAAGTTCGC
CGTGCAAGGCGCGCACGATGCCCTGGTGCAACTCTCCGGCACGCTCCGCACCCTCGCCGTGTCCCTGTACAAAATCGCCA
ACGACATTCGCCTGCTCTCCTGCGGACCCCGCGCTGGAATTGCGGAGTTGTCCCTCCCCGAAAATGAGCCCGGCTCCTCC
ATCATGCCGGGCAAGGTCAACCCCACCCAGTGCGAGTCGCTCACCATGATCGCCGCCCAGGTAATGGCCAACGACGTCGC
CGTCGGTCTCGCCGGCGCTGGCGGCCATCTCGAAATGAACGTCTACAAGCCGCTGCTCATCTTCAACATCACCCACTCCC
TCGAGATCCTCACCGGCGGCGTCACCAACTTCCGCAAATACCTGGTCGAAGGTACCCGCCCCAATCGGAAAAAGATCCAG
GAGTACCTCGACCGTTCTCTGATGCTGGTAACGGCTCTCACTCCCGTCATCGGCTATGACAAGGCAGCCCAGATCGCTCA
CTACGCCCAGCACAATGACCTGACCCTGAAAGCCGCCGCCCTGCACCTGGGCTTCGTGACCGAGCACGACTTCGATCGCC
TGGTCGATCCCCGCAAGATGGTGTAG

Upstream 100 bases:

>100_bases
GCCGAAGGCTGCGTGTTCGCCGGCGCCATCTCCAGCATCACCGGGGAATCCGACCTCTAACTTCATTTCTGGCTACCATC
ATGGAGGTAGGAACAAATCC

Downstream 100 bases:

>100_bases
CCTACTCATTCTTCTTAGCGTTACTCTGCGGCTCTGCGGCTCTGCGAGAAATGTCTTCTCCCCGCGTCTGCTATAATCCG
CCAACAGAGACTTTTGGAGG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 2 [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MIAPVRKETDSHGEVEVPADKLWGAQTQRSLEHFSIGRDLMPREMITAYATLKKAAAAANHEIGGLDDERHKLIAQACDE
ILAGLHHDMFPLHVWISGSGTQFNMNVNEVISNRCCQLAGTPLGSKTPVHPNDHVNMSQSSNDTFPAAMYIAAAVNVKQR
LTPAVTALRDAIHEKARAWNDIIKIGRTHLQDATPLTLGQEWSGYAAMLTDDLDRLESALPGLYRLALGGTAVGTGINAP
PEFGAAAAAGIAALTGLPFVSAPNKFAVQGAHDALVQLSGTLRTLAVSLYKIANDIRLLSCGPRAGIAELSLPENEPGSS
IMPGKVNPTQCESLTMIAAQVMANDVAVGLAGAGGHLEMNVYKPLLIFNITHSLEILTGGVTNFRKYLVEGTRPNRKKIQ
EYLDRSLMLVTALTPVIGYDKAAQIAHYAQHNDLTLKAAALHLGFVTEHDFDRLVDPRKMV

Sequences:

>Translated_461_residues
MIAPVRKETDSHGEVEVPADKLWGAQTQRSLEHFSIGRDLMPREMITAYATLKKAAAAANHEIGGLDDERHKLIAQACDE
ILAGLHHDMFPLHVWISGSGTQFNMNVNEVISNRCCQLAGTPLGSKTPVHPNDHVNMSQSSNDTFPAAMYIAAAVNVKQR
LTPAVTALRDAIHEKARAWNDIIKIGRTHLQDATPLTLGQEWSGYAAMLTDDLDRLESALPGLYRLALGGTAVGTGINAP
PEFGAAAAAGIAALTGLPFVSAPNKFAVQGAHDALVQLSGTLRTLAVSLYKIANDIRLLSCGPRAGIAELSLPENEPGSS
IMPGKVNPTQCESLTMIAAQVMANDVAVGLAGAGGHLEMNVYKPLLIFNITHSLEILTGGVTNFRKYLVEGTRPNRKKIQ
EYLDRSLMLVTALTPVIGYDKAAQIAHYAQHNDLTLKAAALHLGFVTEHDFDRLVDPRKMV
>Mature_461_residues
MIAPVRKETDSHGEVEVPADKLWGAQTQRSLEHFSIGRDLMPREMITAYATLKKAAAAANHEIGGLDDERHKLIAQACDE
ILAGLHHDMFPLHVWISGSGTQFNMNVNEVISNRCCQLAGTPLGSKTPVHPNDHVNMSQSSNDTFPAAMYIAAAVNVKQR
LTPAVTALRDAIHEKARAWNDIIKIGRTHLQDATPLTLGQEWSGYAAMLTDDLDRLESALPGLYRLALGGTAVGTGINAP
PEFGAAAAAGIAALTGLPFVSAPNKFAVQGAHDALVQLSGTLRTLAVSLYKIANDIRLLSCGPRAGIAELSLPENEPGSS
IMPGKVNPTQCESLTMIAAQVMANDVAVGLAGAGGHLEMNVYKPLLIFNITHSLEILTGGVTNFRKYLVEGTRPNRKKIQ
EYLDRSLMLVTALTPVIGYDKAAQIAHYAQHNDLTLKAAALHLGFVTEHDFDRLVDPRKMV

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=458, Percent_Identity=55.8951965065502, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI266458395, Length=73, Percent_Identity=47.945205479452, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=56.4551422319475, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI87082375, Length=460, Percent_Identity=36.304347826087, Blast_Score=298, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=56.7099567099567, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=56.9230769230769, Blast_Score=377, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=53.1317494600432, Blast_Score=496, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=56.4270152505447, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=56.4270152505447, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=55.8695652173913, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=55.4347826086957, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24583245, Length=466, Percent_Identity=48.7124463519313, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49585; Mature: 49585

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAPVRKETDSHGEVEVPADKLWGAQTQRSLEHFSIGRDLMPREMITAYATLKKAAAAAN
CCCCCCCCCCCCCCEECCHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
HEIGGLDDERHKLIAQACDEILAGLHHDMFPLHVWISGSGTQFNMNVNEVISNRCCQLAG
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHCC
TPLGSKTPVHPNDHVNMSQSSNDTFPAAMYIAAAVNVKQRLTPAVTALRDAIHEKARAWN
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIIKIGRTHLQDATPLTLGQEWSGYAAMLTDDLDRLESALPGLYRLALGGTAVGTGINAP
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCC
PEFGAAAAAGIAALTGLPFVSAPNKFAVQGAHDALVQLSGTLRTLAVSLYKIANDIRLLS
CCCCHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
CGPRAGIAELSLPENEPGSSIMPGKVNPTQCESLTMIAAQVMANDVAVGLAGAGGHLEMN
CCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEE
VYKPLLIFNITHSLEILTGGVTNFRKYLVEGTRPNRKKIQEYLDRSLMLVTALTPVIGYD
EECCEEEEEEHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KAAQIAHYAQHNDLTLKAAALHLGFVTEHDFDRLVDPRKMV
HHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure
MIAPVRKETDSHGEVEVPADKLWGAQTQRSLEHFSIGRDLMPREMITAYATLKKAAAAAN
CCCCCCCCCCCCCCEECCHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
HEIGGLDDERHKLIAQACDEILAGLHHDMFPLHVWISGSGTQFNMNVNEVISNRCCQLAG
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHCC
TPLGSKTPVHPNDHVNMSQSSNDTFPAAMYIAAAVNVKQRLTPAVTALRDAIHEKARAWN
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIIKIGRTHLQDATPLTLGQEWSGYAAMLTDDLDRLESALPGLYRLALGGTAVGTGINAP
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCC
PEFGAAAAAGIAALTGLPFVSAPNKFAVQGAHDALVQLSGTLRTLAVSLYKIANDIRLLS
CCCCHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
CGPRAGIAELSLPENEPGSSIMPGKVNPTQCESLTMIAAQVMANDVAVGLAGAGGHLEMN
CCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEE
VYKPLLIFNITHSLEILTGGVTNFRKYLVEGTRPNRKKIQEYLDRSLMLVTALTPVIGYD
EECCEEEEEEHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KAAQIAHYAQHNDLTLKAAALHLGFVTEHDFDRLVDPRKMV
HHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]