BacMap

Definition	Candidatus Solibacter usitatus Ellin6076 chromosome, complete genome.
Accession	NC_008536
Length	9,965,640

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The map label for this gene is ycdF [H]

Identifier: 116623346

GI number: 116623346

Start: 5382768

End: 5383559

Strand: Direct

Name: ycdF [H]

Synonym: Acid_4255

Alternate gene names: 116623346

Gene position: 5382768-5383559 (Clockwise)

Preceding gene: 116623345

Following gene: 116623347

Centisome position: 54.01

GC content: 67.42

Gene sequence:

>792_bases
ATGGACTTAGGATTGAAAGGTAAGGTCGCGATGGTGGCGGCCGCCAGCCAGGGGCTGGGATACGCAATCGCGCGCGTGCT
GGCAGCCGAAGGGGCGAAAGTTTCGATTGCCGCGCGCAAGCGGGAGACCGTCTCCGCCGCCGCCGCGCGGATTGCCGAAG
AGACCGGCGCCGAGGTGATCTCCTCGGTGGCGGACGTCACGTCCGTGGAGGCGATCGAGGCCTGGTATGAGGCCACGCTC
GAAGCCTTCGCCGGCGTCGATGTTCTGGTGACCAACTCCGGCGGACCGCCGGCCGGGCCGGCGTCGGGCTTCGATGACGC
TGCGTGGAAGAACGCCTTCGAAATCCTGGTGCTCGGCGCGGTGCGGACCATCCGCGTGGTGGCGCCTTCCATGGAGGCGC
GCGGCGGCGGCAGCATCCTGATGCTGACCTCGTCCTCGGTGAAGAATCCGATTCCCAATCTCGGGCTCTCCAACGTGATC
CGCCCATGCGTGTCGGCGATGGCGAAGACGTTCGCCGACGAGTTCGCATCGAAAAAGATCCGCGTCAATCAACTCGTGCC
CGGCCGCATCGCGACCGAGCGCCTCACTTATCTCGATGACGCCAACGCCAAGAAGGCCGGGGTGACGCTGGAAGAACAGC
GCAAGCGCTCCGCCGCGGCAATCCCGATGGGCCGCTACGGCGCCCCCGAGGAATTCGCCCGCGCCGCCGCCTTCCTCCTC
TCCGACGCCGCCTCCTACATCACCGGCGCGACCCTCCAGGTCGATGGCGGCGCCATCCGATCGATCGCGTAG

Upstream 100 bases:

>100_bases
TCTCCGCGACGCTGGCGGAGATCCTCGGAATTCCCAAGCCCAGCGCCTCCGTGGGACGCGTGCTCGAAGAAATGTTCGCG
AAGTAGTTAAACTGGACGCC

Downstream 100 bases:

>100_bases
CACGGGCCAACGAGCCGCGACCGTGAGGGAGCGATCGCCCGATCATTGTTTGCGGCTCTCGCCGCAATGTATTACACCGC
TCTTGTTTGCTCGCAGGCCG

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: GLCDH-II; GDH-II; General stress protein 74; GSP74 [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MDLGLKGKVAMVAAASQGLGYAIARVLAAEGAKVSIAARKRETVSAAAARIAEETGAEVISSVADVTSVEAIEAWYEATL
EAFAGVDVLVTNSGGPPAGPASGFDDAAWKNAFEILVLGAVRTIRVVAPSMEARGGGSILMLTSSSVKNPIPNLGLSNVI
RPCVSAMAKTFADEFASKKIRVNQLVPGRIATERLTYLDDANAKKAGVTLEEQRKRSAAAIPMGRYGAPEEFARAAAFLL
SDAASYITGATLQVDGGAIRSIA

Sequences:

>Translated_263_residues
MDLGLKGKVAMVAAASQGLGYAIARVLAAEGAKVSIAARKRETVSAAAARIAEETGAEVISSVADVTSVEAIEAWYEATL
EAFAGVDVLVTNSGGPPAGPASGFDDAAWKNAFEILVLGAVRTIRVVAPSMEARGGGSILMLTSSSVKNPIPNLGLSNVI
RPCVSAMAKTFADEFASKKIRVNQLVPGRIATERLTYLDDANAKKAGVTLEEQRKRSAAAIPMGRYGAPEEFARAAAFLL
SDAASYITGATLQVDGGAIRSIA
>Mature_263_residues
MDLGLKGKVAMVAAASQGLGYAIARVLAAEGAKVSIAARKRETVSAAAARIAEETGAEVISSVADVTSVEAIEAWYEATL
EAFAGVDVLVTNSGGPPAGPASGFDDAAWKNAFEILVLGAVRTIRVVAPSMEARGGGSILMLTSSSVKNPIPNLGLSNVI
RPCVSAMAKTFADEFASKKIRVNQLVPGRIATERLTYLDDANAKKAGVTLEEQRKRSAAAIPMGRYGAPEEFARAAAFLL
SDAASYITGATLQVDGGAIRSIA

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=34.375, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI126723750, Length=259, Percent_Identity=31.6602316602317, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=32.6848249027237, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=32.295719844358, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=35.2631578947368, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI126723191, Length=215, Percent_Identity=31.6279069767442, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI10190704, Length=260, Percent_Identity=30, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI4503301, Length=255, Percent_Identity=29.8039215686275, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI7705925, Length=260, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7705855, Length=193, Percent_Identity=26.4248704663212, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI226371731, Length=191, Percent_Identity=29.8429319371728, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI109715829, Length=254, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4557649, Length=222, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=29.296875, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787905, Length=263, Percent_Identity=31.5589353612167, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=34.6303501945525, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=29.0196078431373, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=30.6513409961686, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082160, Length=265, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1790717, Length=266, Percent_Identity=26.6917293233083, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=27.9693486590038, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786812, Length=264, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367365, Length=258, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=25.4901960784314, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=31.1023622047244, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=31.25, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=27.8810408921933, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=262, Percent_Identity=28.6259541984733, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561272, Length=256, Percent_Identity=30.46875, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=28.996282527881, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=28.4584980237154, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=27.734375, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=25.0922509225092, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=262, Percent_Identity=28.2442748091603, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=27.4509803921569, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=26.615969581749, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=28.125, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=256, Percent_Identity=28.90625, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=26.7924528301887, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=28.8888888888889, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=25.5555555555556, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=25.3787878787879, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=25.9541984732824, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=257, Percent_Identity=29.1828793774319, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=24.6212121212121, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=27.7566539923954, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=28.0155642023346, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=31.496062992126, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=31.0077519379845, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=31.3725490196078, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639444, Length=267, Percent_Identity=29.9625468164794, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=31.3953488372093, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=28.6821705426357, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644337, Length=261, Percent_Identity=29.1187739463602, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663911, Length=195, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24584748, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076933, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 27097; Mature: 27097

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGLKGKVAMVAAASQGLGYAIARVLAAEGAKVSIAARKRETVSAAAARIAEETGAEVI
CCCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
SSVADVTSVEAIEAWYEATLEAFAGVDVLVTNSGGPPAGPASGFDDAAWKNAFEILVLGA
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VRTIRVVAPSMEARGGGSILMLTSSSVKNPIPNLGLSNVIRPCVSAMAKTFADEFASKKI
HHHHHEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
RVNQLVPGRIATERLTYLDDANAKKAGVTLEEQRKRSAAAIPMGRYGAPEEFARAAAFLL
EEECCCCCHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
SDAASYITGATLQVDGGAIRSIA
HHHHHHHCCCEEEECCCHHCCCC
>Mature Secondary Structure
MDLGLKGKVAMVAAASQGLGYAIARVLAAEGAKVSIAARKRETVSAAAARIAEETGAEVI
CCCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
SSVADVTSVEAIEAWYEATLEAFAGVDVLVTNSGGPPAGPASGFDDAAWKNAFEILVLGA
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VRTIRVVAPSMEARGGGSILMLTSSSVKNPIPNLGLSNVIRPCVSAMAKTFADEFASKKI
HHHHHEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
RVNQLVPGRIATERLTYLDDANAKKAGVTLEEQRKRSAAAIPMGRYGAPEEFARAAAFLL
EEECCCCCHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
SDAASYITGATLQVDGGAIRSIA
HHHHHHHCCCEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9298659 [H]