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The map label for this gene is ykgC [H]

Identifier: 116623321

GI number: 116623321

Start: 5357527

End: 5358897

Strand: Reverse

Name: ykgC [H]

Synonym: Acid_4230

Alternate gene names: 116623321

Gene position: 5358897-5357527 (Counterclockwise)

Preceding gene: 116623331

Following gene: 116623320

Centisome position: 53.77

GC content: 63.31

Gene sequence:

>1371_bases
ATGGCCACTCAGTTCGATGCGATCGTCATTGGTACAGGGCAGGCGGGCCCGTCACTGGCACGCCGCCTCGCCGCCACCGG
GAGGAAGGTCGCCGTCATCGAACGCAAGCTCTTTGGGGGTACCTGCGTCAACACGGGCTGCATCCCGACCAAAACCATGG
TCGCCAGCGCCTATGCCGCCCAGATGGTGCGCCGCGCCGCCGAGTTCGGTGTCGATGTTCCCGCCCCGACCATCGACATG
AAGCGCGTCAAGGCGCGCAAGGACGCCGTCTCCGCCGCCTCCCGCGTTGGCCTCGAAAATTCCCTCAAGCACCTGGAAAA
CTGTACGGTTTACGAAGGCCACGCCCGCTTTGAATCCCCCGTCGAAATCAGCGTCGGAGCCGACCGTCTGTCGGCCCCAT
GGATGTTCATCAATGTCGGTGGCCGCGCCATCGTGCCCGCCATGCCCGGCGTCGATGCCATCGACCACCTGACCAACAGC
TCGATGATGGCGGTCGATTTTCTGCCCAAGCACCTGATCGTCGTCGGCGGCAGCTACATCGGACTCGAATTCGGCCAGAT
GTTCCGGCGCTTCGGCAGCCGGGTCACCATCCTCGAAATGAGCCCGCGCCTGGTCCACCGCGAGGATGAAGACGTCTCCA
TAGCCATGCGCGAGATTCTGGAGCGCGAAGGCATCGAGGTGCGCCTCAACGCCAAATGCATCGCCTTCTCTCGCAGCGGC
AACGATCTGATCGCGCATGCCGAGTGCGCGGAAGGCTCGCCCGACATCGCCGGCTCACACGTCCTTCTGGCCGTCGGCCG
CCGTCCCAATACCGACGATCTCGGCCTCGAAAAGGCCGGCGTCGCGGTGGACGGACACGGCTACATCACGGTGGACGACG
AGCTCCGCACCAACGTCCCCGGCATCTGGGCCATGGGCGATTGCAACGGCAAAGGCGCCTTCACCCATACCTCTTATAAC
GATTACGAAATCGTCGCCGCCAACCTGCTCGATAACGACCCACGCCGCGTTAGCGACCGCATCGCCTGCTACGCCCTTTA
CACCGACCCGCCGCTCGGCCGCGCCGGAATGACGGAAGCCGAAGCCCGCAAAACAGGTCGCCCGCTGCTGATCGGGAAAC
GCCCCATGACACGCGTCGCCCGCGCCGTCGAAAAGGGCGAGCAGCAGGGCTTCATGAAGGTGGTGATCGATAAGGAGTCG
AAGAAGATACTGGGTGCCGCCATTCTGGGCACCGGCGGGGACGAAGTGGTTCACTCCATCCTCGATATTATGTACGCCAA
GGCGCCTTACACCGTGATTCAGCGCGCCGTCCACATTCATCCCACCGTCAGCGAATTGATCCCGACCTTGCTTGGAGAAT
TGGAGGGTTAG

Upstream 100 bases:

>100_bases
CCTCAAACCCAATAGACGCGGCGCAAGGGCATTTTCTTCCACTTTTCTTGCGGTATATCCTCTTTAGAATGAGCGCCTAT
AAAAGGGGTATCCTGTTGCA

Downstream 100 bases:

>100_bases
ATGTCGATCTGCGTCCTGTTCGCGTTCTTGATCGGAGTGGTCGCCGGGCTCCGCGCCCTGACCGCGCCCACTGCCGTCAG
CTGGGCGGCAGCCCTGCGAT

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MATQFDAIVIGTGQAGPSLARRLAATGRKVAVIERKLFGGTCVNTGCIPTKTMVASAYAAQMVRRAAEFGVDVPAPTIDM
KRVKARKDAVSAASRVGLENSLKHLENCTVYEGHARFESPVEISVGADRLSAPWMFINVGGRAIVPAMPGVDAIDHLTNS
SMMAVDFLPKHLIVVGGSYIGLEFGQMFRRFGSRVTILEMSPRLVHREDEDVSIAMREILEREGIEVRLNAKCIAFSRSG
NDLIAHAECAEGSPDIAGSHVLLAVGRRPNTDDLGLEKAGVAVDGHGYITVDDELRTNVPGIWAMGDCNGKGAFTHTSYN
DYEIVAANLLDNDPRRVSDRIACYALYTDPPLGRAGMTEAEARKTGRPLLIGKRPMTRVARAVEKGEQQGFMKVVIDKES
KKILGAAILGTGGDEVVHSILDIMYAKAPYTVIQRAVHIHPTVSELIPTLLGELEG

Sequences:

>Translated_456_residues
MATQFDAIVIGTGQAGPSLARRLAATGRKVAVIERKLFGGTCVNTGCIPTKTMVASAYAAQMVRRAAEFGVDVPAPTIDM
KRVKARKDAVSAASRVGLENSLKHLENCTVYEGHARFESPVEISVGADRLSAPWMFINVGGRAIVPAMPGVDAIDHLTNS
SMMAVDFLPKHLIVVGGSYIGLEFGQMFRRFGSRVTILEMSPRLVHREDEDVSIAMREILEREGIEVRLNAKCIAFSRSG
NDLIAHAECAEGSPDIAGSHVLLAVGRRPNTDDLGLEKAGVAVDGHGYITVDDELRTNVPGIWAMGDCNGKGAFTHTSYN
DYEIVAANLLDNDPRRVSDRIACYALYTDPPLGRAGMTEAEARKTGRPLLIGKRPMTRVARAVEKGEQQGFMKVVIDKES
KKILGAAILGTGGDEVVHSILDIMYAKAPYTVIQRAVHIHPTVSELIPTLLGELEG
>Mature_455_residues
ATQFDAIVIGTGQAGPSLARRLAATGRKVAVIERKLFGGTCVNTGCIPTKTMVASAYAAQMVRRAAEFGVDVPAPTIDMK
RVKARKDAVSAASRVGLENSLKHLENCTVYEGHARFESPVEISVGADRLSAPWMFINVGGRAIVPAMPGVDAIDHLTNSS
MMAVDFLPKHLIVVGGSYIGLEFGQMFRRFGSRVTILEMSPRLVHREDEDVSIAMREILEREGIEVRLNAKCIAFSRSGN
DLIAHAECAEGSPDIAGSHVLLAVGRRPNTDDLGLEKAGVAVDGHGYITVDDELRTNVPGIWAMGDCNGKGAFTHTSYND
YEIVAANLLDNDPRRVSDRIACYALYTDPPLGRAGMTEAEARKTGRPLLIGKRPMTRVARAVEKGEQQGFMKVVIDKESK
KILGAAILGTGGDEVVHSILDIMYAKAPYTVIQRAVHIHPTVSELIPTLLGELEG

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=29.6137339055794, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=26.8558951965066, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI291045266, Length=477, Percent_Identity=24.9475890985325, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI33519430, Length=462, Percent_Identity=24.8917748917749, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI33519428, Length=462, Percent_Identity=24.8917748917749, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI33519426, Length=462, Percent_Identity=24.8917748917749, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI148277065, Length=463, Percent_Identity=25.2699784017279, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI148277071, Length=462, Percent_Identity=24.8917748917749, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=27.7542372881356, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=24.5243128964059, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=34.5733041575492, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=29.1666666666667, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789915, Length=455, Percent_Identity=28.7912087912088, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=25.219298245614, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=27.6688453159041, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71983429, Length=455, Percent_Identity=28.1318681318681, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=455, Percent_Identity=28.1318681318681, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17557007, Length=483, Percent_Identity=26.9151138716356, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=488, Percent_Identity=24.5901639344262, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17559934, Length=139, Percent_Identity=29.4964028776978, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=29.0672451193059, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=26.1146496815287, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=454, Percent_Identity=25.1101321585903, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21358499, Length=454, Percent_Identity=28.8546255506608, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=25.5863539445629, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=25.7995735607676, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=25.9574468085106, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17737741, Length=468, Percent_Identity=23.5042735042735, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 49142; Mature: 49011

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQFDAIVIGTGQAGPSLARRLAATGRKVAVIERKLFGGTCVNTGCIPTKTMVASAYAA
CCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHH
QMVRRAAEFGVDVPAPTIDMKRVKARKDAVSAASRVGLENSLKHLENCTVYEGHARFESP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCCCCCC
VEISVGADRLSAPWMFINVGGRAIVPAMPGVDAIDHLTNSSMMAVDFLPKHLIVVGGSYI
EEEEECCCCCCCCEEEEEECCEEEECCCCCCHHHHHHCCCCEEEEECCCCEEEEECCCHH
GLEFGQMFRRFGSRVTILEMSPRLVHREDEDVSIAMREILEREGIEVRLNAKCIAFSRSG
HHHHHHHHHHHCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHCCCEEEECCEEEEEECCC
NDLIAHAECAEGSPDIAGSHVLLAVGRRPNTDDLGLEKAGVAVDGHGYITVDDELRTNVP
CCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCHHHCCCC
GIWAMGDCNGKGAFTHTSYNDYEIVAANLLDNDPRRVSDRIACYALYTDPPLGRAGMTEA
CEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCHHHCCCEEEEEEECCCCCCCCCCCHH
EARKTGRPLLIGKRPMTRVARAVEKGEQQGFMKVVIDKESKKILGAAILGTGGDEVVHSI
HHHHCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEEECCCHHHHHHHH
LDIMYAKAPYTVIQRAVHIHPTVSELIPTLLGELEG
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATQFDAIVIGTGQAGPSLARRLAATGRKVAVIERKLFGGTCVNTGCIPTKTMVASAYAA
CCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHH
QMVRRAAEFGVDVPAPTIDMKRVKARKDAVSAASRVGLENSLKHLENCTVYEGHARFESP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCCCCCC
VEISVGADRLSAPWMFINVGGRAIVPAMPGVDAIDHLTNSSMMAVDFLPKHLIVVGGSYI
EEEEECCCCCCCCEEEEEECCEEEECCCCCCHHHHHHCCCCEEEEECCCCEEEEECCCHH
GLEFGQMFRRFGSRVTILEMSPRLVHREDEDVSIAMREILEREGIEVRLNAKCIAFSRSG
HHHHHHHHHHHCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHCCCEEEECCEEEEEECCC
NDLIAHAECAEGSPDIAGSHVLLAVGRRPNTDDLGLEKAGVAVDGHGYITVDDELRTNVP
CCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCHHHCCCC
GIWAMGDCNGKGAFTHTSYNDYEIVAANLLDNDPRRVSDRIACYALYTDPPLGRAGMTEA
CEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCHHHCCCEEEEEEECCCCCCCCCCCHH
EARKTGRPLLIGKRPMTRVARAVEKGEQQGFMKVVIDKESKKILGAAILGTGGDEVVHSI
HHHHCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEEECCCHHHHHHHH
LDIMYAKAPYTVIQRAVHIHPTVSELIPTLLGELEG
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]