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The map label for this gene is phhA [H]

Identifier: 116623191

GI number: 116623191

Start: 5207017

End: 5207937

Strand: Direct

Name: phhA [H]

Synonym: Acid_4098

Alternate gene names: 116623191

Gene position: 5207017-5207937 (Clockwise)

Preceding gene: 116623190

Following gene: 116623193

Centisome position: 52.25

GC content: 58.52

Gene sequence:

>921_bases
ATGGCCAGCACTCTTGCGGCACCCGGACTAACGACCGGACGGGCGCCATTTGTGGAGGAAGCTCGCACGCGCGGCGAGCT
TTATATTACACAACCGTACGAACTCTATTCTAAAGAGAATCATGAGGCTTGGCAGAAGCTATTCAAGCGCATCCATACGC
GTTGGGAACGTTATGCAAATGATCATTTCCTGCGTGGGGTAGAAGCGCTCGAGCTGCCGCACGACCGGGTTCCCCGGCTC
ACGGATGTCAACCGGCGGCTGCAACCGCTGACGGGATTCCAGGCGAAGCCAGTGAGCGGGTACGTGCCTGGCTTTCTGTT
CTTCGACTGTCTGAGGCGGCGAGAATTTCCCACTACAATCACGATTCGTCCGGCGGACCGGATGGACTACCTGCCGGAGC
CTGACATTTTCCATGATGTCGCCGGGCACGTGCCGATGCACACCGAGAGGCAATTCGCGGACACGCTGGTGCGGTTCGGC
GATTGCGCGGTAACGGCGGCGCGGATTACGGCGGAGGTAAAGGATCCGGCGAAGCGAGTGCGGCGGCTGACGAGCATCAT
GCGGGCGATGTCGCGTTTCTTCTGGTTCACGGTGGAATTTGGGCTGATGCGCGGGACCAAGGGGACGGTCGCGTATGGGA
GCGGGCTGCTGAGCTCGTATGGGGAACTGGAGCACGCGATTGAGTCGGATGAAGTCCAAAGGTATCCGATCCAGCTCGAA
TGGGTGATTAATCAGGTGGCGGAGATCGACCACTATCAGCCGATTTTGTTTGTGGTGGATTCGTTCGAGCACCTGTTCGA
CCTGGTGGATGAATTTGAAAAATGGATGATCGAGGGGAAGCTGTACAACGTGGCGCCGGGGCTGCCGGAGATCGCGGAAG
GGGATTTGCAGAGTTTTCTTGACGCGGCGGGCACGAGATAA

Upstream 100 bases:

>100_bases
GGACGCGGGCTGCGGAGCCTGCCACAGCCTATAGCACCACTCCGGGGAGGTTGTCATAATCCCAAGCTTCTGGTATGGTG
AAACCAGCAGGGAGGGAATC

Downstream 100 bases:

>100_bases
GAAAGAGATTAGTGGGTACGCCAGGCGCGCGCGGCGTGAACGTGGAAGCCGCCTGAAAGGCGACTGCAGGCACGATTGCC
TGCCCCACAGTGCGGCGAGC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MASTLAAPGLTTGRAPFVEEARTRGELYITQPYELYSKENHEAWQKLFKRIHTRWERYANDHFLRGVEALELPHDRVPRL
TDVNRRLQPLTGFQAKPVSGYVPGFLFFDCLRRREFPTTITIRPADRMDYLPEPDIFHDVAGHVPMHTERQFADTLVRFG
DCAVTAARITAEVKDPAKRVRRLTSIMRAMSRFFWFTVEFGLMRGTKGTVAYGSGLLSSYGELEHAIESDEVQRYPIQLE
WVINQVAEIDHYQPILFVVDSFEHLFDLVDEFEKWMIEGKLYNVAPGLPEIAEGDLQSFLDAAGTR

Sequences:

>Translated_306_residues
MASTLAAPGLTTGRAPFVEEARTRGELYITQPYELYSKENHEAWQKLFKRIHTRWERYANDHFLRGVEALELPHDRVPRL
TDVNRRLQPLTGFQAKPVSGYVPGFLFFDCLRRREFPTTITIRPADRMDYLPEPDIFHDVAGHVPMHTERQFADTLVRFG
DCAVTAARITAEVKDPAKRVRRLTSIMRAMSRFFWFTVEFGLMRGTKGTVAYGSGLLSSYGELEHAIESDEVQRYPIQLE
WVINQVAEIDHYQPILFVVDSFEHLFDLVDEFEKWMIEGKLYNVAPGLPEIAEGDLQSFLDAAGTR
>Mature_305_residues
ASTLAAPGLTTGRAPFVEEARTRGELYITQPYELYSKENHEAWQKLFKRIHTRWERYANDHFLRGVEALELPHDRVPRLT
DVNRRLQPLTGFQAKPVSGYVPGFLFFDCLRRREFPTTITIRPADRMDYLPEPDIFHDVAGHVPMHTERQFADTLVRFGD
CAVTAARITAEVKDPAKRVRRLTSIMRAMSRFFWFTVEFGLMRGTKGTVAYGSGLLSSYGELEHAIESDEVQRYPIQLEW
VINQVAEIDHYQPILFVVDSFEHLFDLVDEFEKWMIEGKLYNVAPGLPEIAEGDLQSFLDAAGTR

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=241, Percent_Identity=32.3651452282158, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI88900501, Length=236, Percent_Identity=33.0508474576271, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI88900503, Length=236, Percent_Identity=33.0508474576271, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI88900505, Length=236, Percent_Identity=33.0508474576271, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4759248, Length=245, Percent_Identity=29.3877551020408, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI31795563, Length=243, Percent_Identity=31.2757201646091, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71980736, Length=234, Percent_Identity=31.1965811965812, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17531391, Length=235, Percent_Identity=29.7872340425532, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI115532103, Length=250, Percent_Identity=26.8, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115533973, Length=250, Percent_Identity=26.8, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980731, Length=129, Percent_Identity=31.7829457364341, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62472054, Length=236, Percent_Identity=33.4745762711864, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24660393, Length=236, Percent_Identity=33.4745762711864, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17136774, Length=249, Percent_Identity=29.718875502008, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17136776, Length=249, Percent_Identity=29.718875502008, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24654994, Length=238, Percent_Identity=31.0924369747899, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 35259; Mature: 35127

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTLAAPGLTTGRAPFVEEARTRGELYITQPYELYSKENHEAWQKLFKRIHTRWERYAN
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHCC
DHFLRGVEALELPHDRVPRLTDVNRRLQPLTGFQAKPVSGYVPGFLFFDCLRRREFPTTI
HHHHHCHHHHCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEE
TIRPADRMDYLPEPDIFHDVAGHVPMHTERQFADTLVRFGDCAVTAARITAEVKDPAKRV
EECCCHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLTSIMRAMSRFFWFTVEFGLMRGTKGTVAYGSGLLSSYGELEHAIESDEVQRYPIQLE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHH
WVINQVAEIDHYQPILFVVDSFEHLFDLVDEFEKWMIEGKLYNVAPGLPEIAEGDLQSFL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHH
DAAGTR
HHCCCC
>Mature Secondary Structure 
ASTLAAPGLTTGRAPFVEEARTRGELYITQPYELYSKENHEAWQKLFKRIHTRWERYAN
CCCCCCCCCCCCCCCHHHHHHCCCCEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHCC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HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655752; 14500782; 12096915 [H]