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The map label for this gene is gudP [H]

Identifier: 116623139

GI number: 116623139

Start: 5131781

End: 5133040

Strand: Reverse

Name: gudP [H]

Synonym: Acid_4045

Alternate gene names: 116623139

Gene position: 5133040-5131781 (Counterclockwise)

Preceding gene: 116623142

Following gene: 116623137

Centisome position: 51.51

GC content: 62.46

Gene sequence:

>1260_bases
ATGGTCACCACGGTAGGTGTTGTCCGGACCTCGCTGTCCGGGAAGGAATGGCGGGTGCTGATCCTGTTAGTGATCTCCGC
CTTCATCAACTACATCGACCGCACCACGCTATCCGTAGCCGCCACCGACATCCAACGCGAACTCGGCCTTACGAATACGC
AGCTCGGCAGCCTCCAGTCGGCCTTCTTCGCCACCTACGCCCTTTCGCAGCTCAGCTTCGCGGCAGGTTGGGTGGTGGGT
CGCTTCCATGTGGGCTGGGTACTCGCCGGAGGATTTTTCCTATGGTCCGGCGCGACGGGACTGACCGGCCTCGCCGGGAC
CTTCACGGTGATCTTCACGCTGCGTCTGCTGCTGGGGATCGGCGAATCCGTAAGCTACCCTTCCTACTCCCGCATTCTGG
CCAGCGAATACCCGGAGCATCACCGCGGTTTTGCCAACGCGTTGATTGATGCGGGAACCAAATTGGGTCCGGCGCTCGGG
ATCCTCATAGGCGGACTGCTGGTATCGCAAGTGGGCTGGCGCATCTTCTTTTTCGTGCTCGGCGGCGGCAGCCTGCTGTG
GCTCGTCCCGTGGTCGATGTGGATGCCGCAGGGCAAAGCCGTGGCTTCGCGCGAGGATGGCAGTGACGTCCCGACCATTG
CCGCCATCCTGTTGCAGCGCTCCGCCTGGTTCACGGCCTTCGGCCTTTTCTGCAGCAACTACTATTGGTACTTCCTGATC
ACCTGGCTGCCCGCCTACCTGGAGAAAGAACGCCACTTCCCGAAGGCCAAGATGGCGATCTTCGGATGGTTCCCGTTCGT
GGCGATTTCGGTTTCCTGCGTGATCTCAGGGTGGCTGAGCGATCGCCTGATCGCGCGCGGCGGCTCTCCCACCCGCGTGC
GCAAGACCTTCGCCGGACTCGGGTTGACGGGCGCGACCTTTCTGATCCCCGTGGTGCTGGTGAAGGATGCGAACATTTCC
ATGGCATTGCTCACGCTCGCCTGTCTCTTCTTCGGTATCTATACCTCGAACCTGTTTGCCATCTCGCAGACCCTCGCCGG
GCCCGCCGCCGCCGGCAAGTGGACCAGTTTCCAGAATGGCTTCGGGAATCTCGCGGGCGTACTCGCGCCCACATTGACCG
GCTTGGTCGTGGACCGCACTGGTGAATTTTACTGGGCGTTCGTGGTCGCGGCCGGCTTCGCCTTGGCCGGAGCCTGCATG
TTTGTGTTCGGAGTCGGGCCGATCCGCCGCGTTCAATTCCGCGGATGCCGGGCGGTCTAG

Upstream 100 bases:

>100_bases
ACCTGCCCGTAGGCGGCCGCCGCGAAGATCAGGAACCGAAAATATCGAAGCACCGCACTTCGATCTTACCGCCCTGCTGC
AAGCGGTATAGAATGGCTCG

Downstream 100 bases:

>100_bases
CGAGAACAGCGCAGCGTGCCGGCGGCCTCCGGGCCGCTATACTTGCCCTCGAGCCGTGCGCCTTGAATCGTGCCTTCAAA
CAGGTACGGCTTTGCGTTGA

Product: major facilitator transporter

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MVTTVGVVRTSLSGKEWRVLILLVISAFINYIDRTTLSVAATDIQRELGLTNTQLGSLQSAFFATYALSQLSFAAGWVVG
RFHVGWVLAGGFFLWSGATGLTGLAGTFTVIFTLRLLLGIGESVSYPSYSRILASEYPEHHRGFANALIDAGTKLGPALG
ILIGGLLVSQVGWRIFFFVLGGGSLLWLVPWSMWMPQGKAVASREDGSDVPTIAAILLQRSAWFTAFGLFCSNYYWYFLI
TWLPAYLEKERHFPKAKMAIFGWFPFVAISVSCVISGWLSDRLIARGGSPTRVRKTFAGLGLTGATFLIPVVLVKDANIS
MALLTLACLFFGIYTSNLFAISQTLAGPAAAGKWTSFQNGFGNLAGVLAPTLTGLVVDRTGEFYWAFVVAAGFALAGACM
FVFGVGPIRRVQFRGCRAV

Sequences:

>Translated_419_residues
MVTTVGVVRTSLSGKEWRVLILLVISAFINYIDRTTLSVAATDIQRELGLTNTQLGSLQSAFFATYALSQLSFAAGWVVG
RFHVGWVLAGGFFLWSGATGLTGLAGTFTVIFTLRLLLGIGESVSYPSYSRILASEYPEHHRGFANALIDAGTKLGPALG
ILIGGLLVSQVGWRIFFFVLGGGSLLWLVPWSMWMPQGKAVASREDGSDVPTIAAILLQRSAWFTAFGLFCSNYYWYFLI
TWLPAYLEKERHFPKAKMAIFGWFPFVAISVSCVISGWLSDRLIARGGSPTRVRKTFAGLGLTGATFLIPVVLVKDANIS
MALLTLACLFFGIYTSNLFAISQTLAGPAAAGKWTSFQNGFGNLAGVLAPTLTGLVVDRTGEFYWAFVVAAGFALAGACM
FVFGVGPIRRVQFRGCRAV
>Mature_419_residues
MVTTVGVVRTSLSGKEWRVLILLVISAFINYIDRTTLSVAATDIQRELGLTNTQLGSLQSAFFATYALSQLSFAAGWVVG
RFHVGWVLAGGFFLWSGATGLTGLAGTFTVIFTLRLLLGIGESVSYPSYSRILASEYPEHHRGFANALIDAGTKLGPALG
ILIGGLLVSQVGWRIFFFVLGGGSLLWLVPWSMWMPQGKAVASREDGSDVPTIAAILLQRSAWFTAFGLFCSNYYWYFLI
TWLPAYLEKERHFPKAKMAIFGWFPFVAISVSCVISGWLSDRLIARGGSPTRVRKTFAGLGLTGATFLIPVVLVKDANIS
MALLTLACLFFGIYTSNLFAISQTLAGPAAAGKWTSFQNGFGNLAGVLAPTLTGLVVDRTGEFYWAFVVAAGFALAGACM
FVFGVGPIRRVQFRGCRAV

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=400, Percent_Identity=27.75, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI6912666, Length=378, Percent_Identity=25.1322751322751, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI9966811, Length=390, Percent_Identity=22.8205128205128, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21322234, Length=414, Percent_Identity=22.9468599033816, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI9945322, Length=360, Percent_Identity=23.8888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI148743791, Length=340, Percent_Identity=24.7058823529412, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI148728191, Length=297, Percent_Identity=24.9158249158249, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1789152, Length=443, Percent_Identity=28.8939051918736, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789515, Length=444, Percent_Identity=28.1531531531532, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87082320, Length=424, Percent_Identity=28.5377358490566, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI2367379, Length=419, Percent_Identity=25.7756563245823, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI2367193, Length=413, Percent_Identity=22.2760290556901, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082231, Length=434, Percent_Identity=22.8110599078341, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17535049, Length=405, Percent_Identity=23.9506172839506, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17554148, Length=372, Percent_Identity=23.6559139784946, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24584153, Length=390, Percent_Identity=24.1025641025641, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648416, Length=427, Percent_Identity=25.0585480093677, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356189, Length=427, Percent_Identity=25.0585480093677, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583789, Length=357, Percent_Identity=26.0504201680672, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24639764, Length=415, Percent_Identity=25.3012048192771, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19920686, Length=417, Percent_Identity=24.4604316546763, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24580790, Length=360, Percent_Identity=25.5555555555556, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573708, Length=390, Percent_Identity=24.3589743589744, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573707, Length=390, Percent_Identity=24.3589743589744, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573299, Length=439, Percent_Identity=26.4236902050114, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20130167, Length=327, Percent_Identity=24.4648318042813, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221474708, Length=152, Percent_Identity=30.9210526315789, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24654215, Length=446, Percent_Identity=24.6636771300448, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19922400, Length=446, Percent_Identity=24.6636771300448, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45267; Mature: 45267

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTVGVVRTSLSGKEWRVLILLVISAFINYIDRTTLSVAATDIQRELGLTNTQLGSLQS
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AFFATYALSQLSFAAGWVVGRFHVGWVLAGGFFLWSGATGLTGLAGTFTVIFTLRLLLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHHHC
GESVSYPSYSRILASEYPEHHRGFANALIDAGTKLGPALGILIGGLLVSQVGWRIFFFVL
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEE
GGGSLLWLVPWSMWMPQGKAVASREDGSDVPTIAAILLQRSAWFTAFGLFCSNYYWYFLI
CCCCEEEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
TWLPAYLEKERHFPKAKMAIFGWFPFVAISVSCVISGWLSDRLIARGGSPTRVRKTFAGL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GLTGATFLIPVVLVKDANISMALLTLACLFFGIYTSNLFAISQTLAGPAAAGKWTSFQNG
CCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCC
FGNLAGVLAPTLTGLVVDRTGEFYWAFVVAAGFALAGACMFVFGVGPIRRVQFRGCRAV
CHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MVTTVGVVRTSLSGKEWRVLILLVISAFINYIDRTTLSVAATDIQRELGLTNTQLGSLQS
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AFFATYALSQLSFAAGWVVGRFHVGWVLAGGFFLWSGATGLTGLAGTFTVIFTLRLLLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHHHC
GESVSYPSYSRILASEYPEHHRGFANALIDAGTKLGPALGILIGGLLVSQVGWRIFFFVL
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEE
GGGSLLWLVPWSMWMPQGKAVASREDGSDVPTIAAILLQRSAWFTAFGLFCSNYYWYFLI
CCCCEEEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
TWLPAYLEKERHFPKAKMAIFGWFPFVAISVSCVISGWLSDRLIARGGSPTRVRKTFAGL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GLTGATFLIPVVLVKDANISMALLTLACLFFGIYTSNLFAISQTLAGPAAAGKWTSFQNG
CCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCC
FGNLAGVLAPTLTGLVVDRTGEFYWAFVVAAGFALAGACMFVFGVGPIRRVQFRGCRAV
CHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]