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The map label for this gene is tmk [H]

Identifier: 116623132

GI number: 116623132

Start: 5123816

End: 5124595

Strand: Direct

Name: tmk [H]

Synonym: Acid_4038

Alternate gene names: 116623132

Gene position: 5123816-5124595 (Clockwise)

Preceding gene: 116623130

Following gene: 116623133

Centisome position: 51.41

GC content: 61.92

Gene sequence:

>780_bases
ATGACTCTCTTCCCTGCCCTCGCCCGCCGCCGTCAATCCGACAAGCGTCTGCGTGAAATGGTGGCGGCCCGCGAGGCGCG
GCGCGGATTGCTGATTGCGTTCGAAGGCCCCGACGGCTCGGGCAAAACCACGCAGCGCAAGCTCTTCAAGAACTGGCTGA
AGAGCGAAGGGCACGAAGTGGTAACCACGAAGTGGAACTCCTCTGCTTTGATCAAGCCACTGGTGAAGGCCCGGAAGGCG
GCCCGTTCGCTGAGCCCTGAAGAGTTCAGCCTGTTACACGCCGCCGATTTCCGGTATCGCCTGGAGACGGAGATTCTGCC
GGCACTCTGGCAGGGCCAGGTGGTGGTGGCGGACCGTTACCTGTTCACGGCGCTGGCGCGCGACGCTGCCCGAGGGATGG
ATCTGCACTGGCTGCTCGAGGTTTACCGGCCGCTGTTTTGGCCGGACCTGGTCTTCTATTTTTCGGTGTCGCCGGAGACC
TCGGGCAAGCGGATCGCGGCCGAGCGCGCGCCTAACTTTTACGAGGCCGGCCAGGATGTCACGGAGATAGCCGATCCCTT
TCAAAGTTATGCGCACTTTATCGGTCGCGTGATTCAGGAGTACGAGGCGCTGGCCAAGGTCTTCCGGTTCGTGACCGTGG
ATGCCGAACAATCCATCTTCGACCAACACCGGCAGATCCGCGAACTGTTCGCGGAGGGCGTACGGCGGCCGTGGCAGGAG
TGGAACCAGGAAGTGCTGCTGGAATGGTTGAGCCACTATCCGGAGGGAATGCAGAAATGA

Upstream 100 bases:

>100_bases
TCTCGATCATGCTTCGGAACAGCTTAGCAGTTATATATTTGTAGCGTCACCGGCGGATGCGCGATATGATCTTGGAACGA
TGCCGGAAGCGTTTTGACCG

Downstream 100 bases:

>100_bases
GCGCGCCAGTTCCCGCCAAGGGCCGGTTGATCGCGCTCGAAGGCTCGGGCGGACGCCCGATGGCGGTGGCCGGGAAATTT
CTGGCCCGCGAATTCCGCCA

Product: thymidylate kinase/thymidylate synthase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTLFPALARRRQSDKRLREMVAAREARRGLLIAFEGPDGSGKTTQRKLFKNWLKSEGHEVVTTKWNSSALIKPLVKARKA
ARSLSPEEFSLLHAADFRYRLETEILPALWQGQVVVADRYLFTALARDAARGMDLHWLLEVYRPLFWPDLVFYFSVSPET
SGKRIAAERAPNFYEAGQDVTEIADPFQSYAHFIGRVIQEYEALAKVFRFVTVDAEQSIFDQHRQIRELFAEGVRRPWQE
WNQEVLLEWLSHYPEGMQK

Sequences:

>Translated_259_residues
MTLFPALARRRQSDKRLREMVAAREARRGLLIAFEGPDGSGKTTQRKLFKNWLKSEGHEVVTTKWNSSALIKPLVKARKA
ARSLSPEEFSLLHAADFRYRLETEILPALWQGQVVVADRYLFTALARDAARGMDLHWLLEVYRPLFWPDLVFYFSVSPET
SGKRIAAERAPNFYEAGQDVTEIADPFQSYAHFIGRVIQEYEALAKVFRFVTVDAEQSIFDQHRQIRELFAEGVRRPWQE
WNQEVLLEWLSHYPEGMQK
>Mature_258_residues
TLFPALARRRQSDKRLREMVAAREARRGLLIAFEGPDGSGKTTQRKLFKNWLKSEGHEVVTTKWNSSALIKPLVKARKAA
RSLSPEEFSLLHAADFRYRLETEILPALWQGQVVVADRYLFTALARDAARGMDLHWLLEVYRPLFWPDLVFYFSVSPETS
GKRIAAERAPNFYEAGQDVTEIADPFQSYAHFIGRVIQEYEALAKVFRFVTVDAEQSIFDQHRQIRELFAEGVRRPWQEW
NQEVLLEWLSHYPEGMQK

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Drosophila melanogaster, GI28573735, Length=218, Percent_Identity=29.8165137614679, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 30146; Mature: 30015

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFPALARRRQSDKRLREMVAAREARRGLLIAFEGPDGSGKTTQRKLFKNWLKSEGHEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEE
VTTKWNSSALIKPLVKARKAARSLSPEEFSLLHAADFRYRLETEILPALWQGQVVVADRY
EEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
LFTALARDAARGMDLHWLLEVYRPLFWPDLVFYFSVSPETSGKRIAAERAPNFYEAGQDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCHHHCCCHH
TEIADPFQSYAHFIGRVIQEYEALAKVFRFVTVDAEQSIFDQHRQIRELFAEGVRRPWQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHH
WNQEVLLEWLSHYPEGMQK
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLFPALARRRQSDKRLREMVAAREARRGLLIAFEGPDGSGKTTQRKLFKNWLKSEGHEV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEE
VTTKWNSSALIKPLVKARKAARSLSPEEFSLLHAADFRYRLETEILPALWQGQVVVADRY
EEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
LFTALARDAARGMDLHWLLEVYRPLFWPDLVFYFSVSPETSGKRIAAERAPNFYEAGQDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCHHHCCCHH
TEIADPFQSYAHFIGRVIQEYEALAKVFRFVTVDAEQSIFDQHRQIRELFAEGVRRPWQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHH
WNQEVLLEWLSHYPEGMQK
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]