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The map label for this gene is serA [H]

Identifier: 116623056

GI number: 116623056

Start: 5014000

End: 5015202

Strand: Reverse

Name: serA [H]

Synonym: Acid_3960

Alternate gene names: 116623056

Gene position: 5015202-5014000 (Counterclockwise)

Preceding gene: 116623057

Following gene: 116623055

Centisome position: 50.32

GC content: 65.75

Gene sequence:

>1203_bases
ATGCGGATACTGATCGCGGATGAATTCGAGCAGTCCGGCCGCGAGCAGCTGAATGCGCTGGGCTGCGAAGTGCGGTTCGC
GCCGAAGCTGAAGGATGAGGCGCTGGTGGCGGAGGTAGATTCCTTCCGCCCGGATGTGCTGGTGGTGCGATCCACCAAGG
TGCCGGAGGCCGTGCTGGCCGCCGGCGCTCTCAAACTGGTGGTGCGAGCCGGAGCAGGCCACAACACGATCGATGTGGGC
GCGGCGTCGCGGCGCGGGATCTACGTTTCCAATTGCCCGGGGAAGAATTCGGTGGCGGTGGCGGAGTTGGCGTTTGGCCT
GATCCTGGCGCTGGACCGCCAGATCGCCGACAACGTGATCGCGCTGCGCGAGGGCCGTTGGAATAAGAGCGGCTTCTCCA
AGGCGCGTGGACTCTTCGGGCGCACGCTCGGGCTGATTGGCGTGGGACAAATCGGCCGCGAGATGATTCCGCGCGCCCGC
GCATTCGGGCTACCCGTAGTGGCATGGAGCCGGAGCCTCACGCCGGAATCCGCCAAGGCACTCGGAGTGGAGTACAAACC
CTCGCCCGCGGAAGTGGCGGCGGCGGCCGACATCGTCAGCGTGCATGTGGCGCTGAACCCGCAGACGAAAGGGATGCTGA
ACGCCGAGTGGATTGCCGCGCTGCGCCCAGGCGCGTACTTCATCAACACCTCACGGGCAGAAGTGGTGGATCAGGAGGCG
CTGTCGCGCGCGGTGACGGAGAAGGGAATTCGCGCCGGGCTGGATGTCTTCGCCAAGGAGCCGGCGGGCGGCGCGGGCGA
CTTCGCCGACGAGATCGTCAAACTCAACGGCGTTTACGGCACGCACCACATTGGAGCATCGACCGAGCAGGCGCAGGAGG
CCATCGCGGCGGAGACCGTGCGCATTATCCGCACGTTCCTCCAGACCGGGAAGGTTCCGAACGTGGTCAACCTGGCGCGG
ACGACGCCGGCGACCTGCGCGCTAGTGGTGCGCCACCTGGATCGCCCGGGCGTGCTCGCGGCCGTGCTGGATTCGGTGCG
TGCGGCCGGCATCAACGTGCAGGAGATGGAGAACATCATCTTCGAAGGCGCGGAAGCGGCGGTGGCGCGCATTCATTTGG
AAACCGTGCCAGACGAGGATGTGCTCGGCCGGATCCGCGGCTCGAACCCGCATATTCTAGAAGCCAACGTTATCATTTTG
TGA

Upstream 100 bases:

>100_bases
TTCGCCGGCCTCGCCGGACGCGCAGCCAATGAGAGCCTGTCGCCGGGCGACATTAAAAAGTCCATCAAGACGTGGCGAGC
CGACGAATACCGGGTGTGAG

Downstream 100 bases:

>100_bases
GTCGCCACACCGTGGCAATACTCGTGCGTGTTAACCCCAGGAGATGACACGTAGGAAGAAATGGCTGGCGGGGATTGGCC
TCGCGGCCGGCGTAGCGCTG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MRILIADEFEQSGREQLNALGCEVRFAPKLKDEALVAEVDSFRPDVLVVRSTKVPEAVLAAGALKLVVRAGAGHNTIDVG
AASRRGIYVSNCPGKNSVAVAELAFGLILALDRQIADNVIALREGRWNKSGFSKARGLFGRTLGLIGVGQIGREMIPRAR
AFGLPVVAWSRSLTPESAKALGVEYKPSPAEVAAAADIVSVHVALNPQTKGMLNAEWIAALRPGAYFINTSRAEVVDQEA
LSRAVTEKGIRAGLDVFAKEPAGGAGDFADEIVKLNGVYGTHHIGASTEQAQEAIAAETVRIIRTFLQTGKVPNVVNLAR
TTPATCALVVRHLDRPGVLAAVLDSVRAAGINVQEMENIIFEGAEAAVARIHLETVPDEDVLGRIRGSNPHILEANVIIL

Sequences:

>Translated_400_residues
MRILIADEFEQSGREQLNALGCEVRFAPKLKDEALVAEVDSFRPDVLVVRSTKVPEAVLAAGALKLVVRAGAGHNTIDVG
AASRRGIYVSNCPGKNSVAVAELAFGLILALDRQIADNVIALREGRWNKSGFSKARGLFGRTLGLIGVGQIGREMIPRAR
AFGLPVVAWSRSLTPESAKALGVEYKPSPAEVAAAADIVSVHVALNPQTKGMLNAEWIAALRPGAYFINTSRAEVVDQEA
LSRAVTEKGIRAGLDVFAKEPAGGAGDFADEIVKLNGVYGTHHIGASTEQAQEAIAAETVRIIRTFLQTGKVPNVVNLAR
TTPATCALVVRHLDRPGVLAAVLDSVRAAGINVQEMENIIFEGAEAAVARIHLETVPDEDVLGRIRGSNPHILEANVIIL
>Mature_400_residues
MRILIADEFEQSGREQLNALGCEVRFAPKLKDEALVAEVDSFRPDVLVVRSTKVPEAVLAAGALKLVVRAGAGHNTIDVG
AASRRGIYVSNCPGKNSVAVAELAFGLILALDRQIADNVIALREGRWNKSGFSKARGLFGRTLGLIGVGQIGREMIPRAR
AFGLPVVAWSRSLTPESAKALGVEYKPSPAEVAAAADIVSVHVALNPQTKGMLNAEWIAALRPGAYFINTSRAEVVDQEA
LSRAVTEKGIRAGLDVFAKEPAGGAGDFADEIVKLNGVYGTHHIGASTEQAQEAIAAETVRIIRTFLQTGKVPNVVNLAR
TTPATCALVVRHLDRPGVLAAVLDSVRAAGINVQEMENIIFEGAEAAVARIHLETVPDEDVLGRIRGSNPHILEANVIIL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=36.6771159874608, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI61743967, Length=278, Percent_Identity=33.0935251798561, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4557497, Length=278, Percent_Identity=33.0935251798561, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI145580578, Length=274, Percent_Identity=34.3065693430657, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4557499, Length=274, Percent_Identity=34.3065693430657, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=34.3065693430657, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=30.3501945525292, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789279, Length=389, Percent_Identity=30.5912596401028, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1787645, Length=321, Percent_Identity=25.5451713395639, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082289, Length=250, Percent_Identity=29.2, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788660, Length=254, Percent_Identity=31.1023622047244, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=37.0860927152318, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=263, Percent_Identity=31.5589353612167, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=375, Percent_Identity=33.8666666666667, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=375, Percent_Identity=33.0666666666667, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324055, Length=268, Percent_Identity=31.3432835820896, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=307, Percent_Identity=27.6872964169381, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=36.0927152317881, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=33.5820895522388, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=33.5820895522388, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=33.5820895522388, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=33.5820895522388, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=33.5820895522388, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=32.8185328185328, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=28.3464566929134, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585514, Length=254, Percent_Identity=28.3464566929134, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574282, Length=254, Percent_Identity=28.3464566929134, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551003, Length=254, Percent_Identity=28.3464566929134, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574284, Length=254, Percent_Identity=28.3464566929134, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 42452; Mature: 42452

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIADEFEQSGREQLNALGCEVRFAPKLKDEALVAEVDSFRPDVLVVRSTKVPEAVLA
CEEEEECHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHH
AGALKLVVRAGAGHNTIDVGAASRRGIYVSNCPGKNSVAVAELAFGLILALDRQIADNVI
HHHHHHHEECCCCCCEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCEE
ALREGRWNKSGFSKARGLFGRTLGLIGVGQIGREMIPRARAFGLPVVAWSRSLTPESAKA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCEECCCCCCCCHHHH
LGVEYKPSPAEVAAAADIVSVHVALNPQTKGMLNAEWIAALRPGAYFINTSRAEVVDQEA
CCCCCCCCHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHH
LSRAVTEKGIRAGLDVFAKEPAGGAGDFADEIVKLNGVYGTHHIGASTEQAQEAIAAETV
HHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
RIIRTFLQTGKVPNVVNLARTTPATCALVVRHLDRPGVLAAVLDSVRAAGINVQEMENII
HHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHH
FEGAEAAVARIHLETVPDEDVLGRIRGSNPHILEANVIIL
HCCCCCEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEC
>Mature Secondary Structure
MRILIADEFEQSGREQLNALGCEVRFAPKLKDEALVAEVDSFRPDVLVVRSTKVPEAVLA
CEEEEECHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHH
AGALKLVVRAGAGHNTIDVGAASRRGIYVSNCPGKNSVAVAELAFGLILALDRQIADNVI
HHHHHHHEECCCCCCEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCEE
ALREGRWNKSGFSKARGLFGRTLGLIGVGQIGREMIPRARAFGLPVVAWSRSLTPESAKA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCEECCCCCCCCHHHH
LGVEYKPSPAEVAAAADIVSVHVALNPQTKGMLNAEWIAALRPGAYFINTSRAEVVDQEA
CCCCCCCCHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHH
LSRAVTEKGIRAGLDVFAKEPAGGAGDFADEIVKLNGVYGTHHIGASTEQAQEAIAAETV
HHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
RIIRTFLQTGKVPNVVNLARTTPATCALVVRHLDRPGVLAAVLDSVRAAGINVQEMENII
HHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHH
FEGAEAAVARIHLETVPDEDVLGRIRGSNPHILEANVIIL
HCCCCCEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]