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The map label for this gene is ywrD [H]

Identifier: 116623025

GI number: 116623025

Start: 4965710

End: 4967452

Strand: Direct

Name: ywrD [H]

Synonym: Acid_3929

Alternate gene names: 116623025

Gene position: 4965710-4967452 (Clockwise)

Preceding gene: 116623014

Following gene: 116623029

Centisome position: 49.83

GC content: 63.91

Gene sequence:

>1743_bases
ATGAAATTGCTGCTACTTGCGATGGCAATTGCCTGCGTCATCTCGGCGCAGGATGACGGTCCCGCGACCCCAACCCGAAC
GTCCGGCGGCACTCCAGCCGCAGCGCCGCCGCCGGCCCGCGAGCAGGCTCGTTCGATGATCGTCACGCAGTACGGCATTG
TGGCGGCGTCGCAGTTCCTGGCATCGCAGGCCGGGGCGAAGATGCTGGAGCAGGGCGGCAATGCGATTGATGCGGCGATC
GCGGCGAATGCAGTGCTCGGGCTGACGCAGCCGTATGTGAATGGCATGGGCGGCGACCTGTTCGCGATCGTGTACGAGGC
GAAGACGGGAAAGGTCTACGGGCTCAACTCGAGCGGATGGACTCCGAAGGCGCTGACCATCGACTACCTGAAGAGCAAGG
GAATCGACAAGATTGACCGCACCGGCGTGCACACGATCACGGTGCCGGGCTGCGTGGCGGGTTGGGACGCGCTGCGCAAG
CGCTTCGGGACCAAGCCGTTTTCGGAACTGCTGGCATCGGCGATCTTTTATGCGGAGAACGGTTTCCCGCTGCCCGAGTT
CGGGGCGCGGTCGTGGATCTCGCAGCCGCTGTTGAAGCAGCCGGGGTATGCGCAGACCTATCTGCCGGGCGGCAAGCGTC
CGCAGCTGGGCGACGTGTTCAAGAATCCGGCGCTGGGCGAATCGCTGCGGCAAGTGGCGGCGAAGGGTCGCGACGGATAT
TACAAGGGCAAGATGGCTGAGAACCTGGTGTCGTTTTTGCGCGAGCAGGGCGGCGCGCACACGCTGCAAGATTTCTCGGA
GTTCGAGCCGGAGTGGGTGGAGCCAATTTCGACCACGTACCGCGGCTGGGATGTGTTCGAGCTGCCGCCCAACGGACAGG
GCGTGGCGGCGCTTTCGATGCTGAACATCATGGAGAATTTCCCGTTGAAGGATTACGGGCACAATTCGGCGGCGGCGCTG
CACGTGATGATCGAGGCGAAGAAGCTGGCGTACGCCGATATGGCGCGGTATGTAGGCGATCCGCGGTTCGGCCCGGTGCC
GGTGAAGGAGATGCTCTCGAAGGACCTGGCGAAGCAGCGCGCCGGGTTGATCAGCATGGAGAAGGCGAGCTGCAAGGTGC
TGCCCTCGGAGATCCGTCAAGAGTTGGACGCACACGGGCACGAGACGATTTATATGTCGGCGATCGACAAAGAGGGCAAC
ATCGTATCGCTGATTCAGAGCAATTACGCGGGGTACGGCACGGGGATGGTGGCGCCGGGAGCGGGGTTCAGCTTCCACAA
TCGCGGGGCGGGATTCGATATGGAGCCGGGCAAGCCGAATTCGCTCGCCGGGAGGAAGAGGCCGCTGCATACGATCATCC
CGGCGTTCATGCGCAAGGGCGATGTGACGGTGGGCTTCGGGATCATGGGCGGGTGGAATCAATCGCAGGCGCACGCGCAG
TTCGTGGCGAACGTGGTGGATTTCGGGATGAATGTGCAGATGGCGCTGGAATCGGCGCGGTTCACCAAGGGGACATTCGA
TGGCTGCGATTTGCAAATGGAATCGCGGGTGCCGGAGGCGGTGCGGCAGGAGCTCGCGCGGCGCGGGCACGTGATCACGC
CGGTGGGCGCGTTCGCGACCGCGATGGGGAATGGCGAGGCGGTGATGCGCGATGCCAAGCGCGGCGTGAATTTCGGGGCA
AGCGATCCGCGGACGGATGGCGCGGCGATCCCGCAGCAGCCGAATGTGGGGACGATTAAGTAG

Upstream 100 bases:

>100_bases
GCCGTGTCCGAAAGCCAGCAACTCCATCTCGCGATGAAGCGAGGGACTGTGCCACTTCACGTAGTCTCTTTGCATCCCAC
GTCATGGTACACTTTTCGCC

Downstream 100 bases:

>100_bases
GGCGAGGAGTGCCGCGCATTGCGGCGAGCCGCGAATTGGGCGTCGCAAGGGGTCGAGCCGGCTGCACGGTCGAAAGCCAA
GGCGAGCAAGGGAATACTCT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKLLLLAMAIACVISAQDDGPATPTRTSGGTPAAAPPPAREQARSMIVTQYGIVAASQFLASQAGAKMLEQGGNAIDAAI
AANAVLGLTQPYVNGMGGDLFAIVYEAKTGKVYGLNSSGWTPKALTIDYLKSKGIDKIDRTGVHTITVPGCVAGWDALRK
RFGTKPFSELLASAIFYAENGFPLPEFGARSWISQPLLKQPGYAQTYLPGGKRPQLGDVFKNPALGESLRQVAAKGRDGY
YKGKMAENLVSFLREQGGAHTLQDFSEFEPEWVEPISTTYRGWDVFELPPNGQGVAALSMLNIMENFPLKDYGHNSAAAL
HVMIEAKKLAYADMARYVGDPRFGPVPVKEMLSKDLAKQRAGLISMEKASCKVLPSEIRQELDAHGHETIYMSAIDKEGN
IVSLIQSNYAGYGTGMVAPGAGFSFHNRGAGFDMEPGKPNSLAGRKRPLHTIIPAFMRKGDVTVGFGIMGGWNQSQAHAQ
FVANVVDFGMNVQMALESARFTKGTFDGCDLQMESRVPEAVRQELARRGHVITPVGAFATAMGNGEAVMRDAKRGVNFGA
SDPRTDGAAIPQQPNVGTIK

Sequences:

>Translated_580_residues
MKLLLLAMAIACVISAQDDGPATPTRTSGGTPAAAPPPAREQARSMIVTQYGIVAASQFLASQAGAKMLEQGGNAIDAAI
AANAVLGLTQPYVNGMGGDLFAIVYEAKTGKVYGLNSSGWTPKALTIDYLKSKGIDKIDRTGVHTITVPGCVAGWDALRK
RFGTKPFSELLASAIFYAENGFPLPEFGARSWISQPLLKQPGYAQTYLPGGKRPQLGDVFKNPALGESLRQVAAKGRDGY
YKGKMAENLVSFLREQGGAHTLQDFSEFEPEWVEPISTTYRGWDVFELPPNGQGVAALSMLNIMENFPLKDYGHNSAAAL
HVMIEAKKLAYADMARYVGDPRFGPVPVKEMLSKDLAKQRAGLISMEKASCKVLPSEIRQELDAHGHETIYMSAIDKEGN
IVSLIQSNYAGYGTGMVAPGAGFSFHNRGAGFDMEPGKPNSLAGRKRPLHTIIPAFMRKGDVTVGFGIMGGWNQSQAHAQ
FVANVVDFGMNVQMALESARFTKGTFDGCDLQMESRVPEAVRQELARRGHVITPVGAFATAMGNGEAVMRDAKRGVNFGA
SDPRTDGAAIPQQPNVGTIK
>Mature_580_residues
MKLLLLAMAIACVISAQDDGPATPTRTSGGTPAAAPPPAREQARSMIVTQYGIVAASQFLASQAGAKMLEQGGNAIDAAI
AANAVLGLTQPYVNGMGGDLFAIVYEAKTGKVYGLNSSGWTPKALTIDYLKSKGIDKIDRTGVHTITVPGCVAGWDALRK
RFGTKPFSELLASAIFYAENGFPLPEFGARSWISQPLLKQPGYAQTYLPGGKRPQLGDVFKNPALGESLRQVAAKGRDGY
YKGKMAENLVSFLREQGGAHTLQDFSEFEPEWVEPISTTYRGWDVFELPPNGQGVAALSMLNIMENFPLKDYGHNSAAAL
HVMIEAKKLAYADMARYVGDPRFGPVPVKEMLSKDLAKQRAGLISMEKASCKVLPSEIRQELDAHGHETIYMSAIDKEGN
IVSLIQSNYAGYGTGMVAPGAGFSFHNRGAGFDMEPGKPNSLAGRKRPLHTIIPAFMRKGDVTVGFGIMGGWNQSQAHAQ
FVANVVDFGMNVQMALESARFTKGTFDGCDLQMESRVPEAVRQELARRGHVITPVGAFATAMGNGEAVMRDAKRGVNFGA
SDPRTDGAAIPQQPNVGTIK

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI109148539, Length=596, Percent_Identity=26.1744966442953, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI73915092, Length=557, Percent_Identity=25.8527827648115, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI73915090, Length=557, Percent_Identity=25.8527827648115, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI73915096, Length=557, Percent_Identity=25.8527827648115, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI73915094, Length=557, Percent_Identity=25.8527827648115, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI113429324, Length=557, Percent_Identity=24.9551166965889, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI113429326, Length=558, Percent_Identity=24.5519713261649, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI153266885, Length=396, Percent_Identity=25.5050505050505, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI153266901, Length=396, Percent_Identity=25.5050505050505, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI153266907, Length=396, Percent_Identity=23.7373737373737, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1789856, Length=534, Percent_Identity=31.2734082397004, Blast_Score=228, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI193208245, Length=565, Percent_Identity=24.4247787610619, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=567, Percent_Identity=24.1622574955908, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=518, Percent_Identity=25.4826254826255, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=522, Percent_Identity=24.5210727969349, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI212646519, Length=431, Percent_Identity=27.8422273781903, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI72000294, Length=429, Percent_Identity=27.972027972028, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551474, Length=552, Percent_Identity=25.5434782608696, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24642670, Length=552, Percent_Identity=25.5434782608696, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24642666, Length=552, Percent_Identity=25.5434782608696, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI161077880, Length=552, Percent_Identity=25.5434782608696, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI161077878, Length=552, Percent_Identity=25.5434782608696, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI18859893, Length=524, Percent_Identity=25.1908396946565, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18859741, Length=507, Percent_Identity=24.4575936883629, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI161077496, Length=513, Percent_Identity=23.3918128654971, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62112; Mature: 62112

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLLAMAIACVISAQDDGPATPTRTSGGTPAAAPPPAREQARSMIVTQYGIVAASQFL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASQAGAKMLEQGGNAIDAAIAANAVLGLTQPYVNGMGGDLFAIVYEAKTGKVYGLNSSGW
HHHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHCCCCCCEEEEEEEECCCEEEECCCCCC
TPKALTIDYLKSKGIDKIDRTGVHTITVPGCVAGWDALRKRFGTKPFSELLASAIFYAEN
CCCCEEHHHHHCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
GFPLPEFGARSWISQPLLKQPGYAQTYLPGGKRPQLGDVFKNPALGESLRQVAAKGRDGY
CCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCC
YKGKMAENLVSFLREQGGAHTLQDFSEFEPEWVEPISTTYRGWDVFELPPNGQGVAALSM
CCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHH
LNIMENFPLKDYGHNSAAALHVMIEAKKLAYADMARYVGDPRFGPVPVKEMLSKDLAKQR
HHHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AGLISMEKASCKVLPSEIRQELDAHGHETIYMSAIDKEGNIVSLIQSNYAGYGTGMVAPG
HCCEEECCCHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCC
AGFSFHNRGAGFDMEPGKPNSLAGRKRPLHTIIPAFMRKGDVTVGFGIMGGWNQSQAHAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
FVANVVDFGMNVQMALESARFTKGTFDGCDLQMESRVPEAVRQELARRGHVITPVGAFAT
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEHHHCCHHHHHHHHHHCCCEECCHHHHHH
AMGNGEAVMRDAKRGVNFGASDPRTDGAAIPQQPNVGTIK
HCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLLLLAMAIACVISAQDDGPATPTRTSGGTPAAAPPPAREQARSMIVTQYGIVAASQFL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASQAGAKMLEQGGNAIDAAIAANAVLGLTQPYVNGMGGDLFAIVYEAKTGKVYGLNSSGW
HHHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHCCCCCCEEEEEEEECCCEEEECCCCCC
TPKALTIDYLKSKGIDKIDRTGVHTITVPGCVAGWDALRKRFGTKPFSELLASAIFYAEN
CCCCEEHHHHHCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
GFPLPEFGARSWISQPLLKQPGYAQTYLPGGKRPQLGDVFKNPALGESLRQVAAKGRDGY
CCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCC
YKGKMAENLVSFLREQGGAHTLQDFSEFEPEWVEPISTTYRGWDVFELPPNGQGVAALSM
CCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHH
LNIMENFPLKDYGHNSAAALHVMIEAKKLAYADMARYVGDPRFGPVPVKEMLSKDLAKQR
HHHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AGLISMEKASCKVLPSEIRQELDAHGHETIYMSAIDKEGNIVSLIQSNYAGYGTGMVAPG
HCCEEECCCHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCC
AGFSFHNRGAGFDMEPGKPNSLAGRKRPLHTIIPAFMRKGDVTVGFGIMGGWNQSQAHAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
FVANVVDFGMNVQMALESARFTKGTFDGCDLQMESRVPEAVRQELARRGHVITPVGAFAT
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEHHHCCHHHHHHHHHHCCCEECCHHHHHH
AMGNGEAVMRDAKRGVNFGASDPRTDGAAIPQQPNVGTIK
HCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]