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The map label for this gene is cynR [H]

Identifier: 116622916

GI number: 116622916

Start: 4847355

End: 4848188

Strand: Direct

Name: cynR [H]

Synonym: Acid_3817

Alternate gene names: 116622916

Gene position: 4847355-4848188 (Clockwise)

Preceding gene: 116622913

Following gene: 116622917

Centisome position: 48.64

GC content: 62.59

Gene sequence:

>834_bases
ATGTCGCGTGGTGCGGAGCACTGTGGGGTTAGCCAGTCGGCGGCGAGCCAGCACGTACAGGAGGTGGAAAGGCGTCTTGG
GGTTACCTTGCTGGACCGCAGCAAGCGTCCCTTGGAGTTGACACCGGCGGGGCGACTTTACCAGGAATTCTGCCGCGAGG
TGTTGCGGCGGGAAGAAGAATTCACTCTTTCGCTGGAATCGATCAAGGGAGATGTGGAAGGGACGGTACGCATCGTCTCG
ATCTACTCGACGGGCTTGAGCGAGATGAGCCGGCTGCGCGAGGAGTTCGCGGCGCGCTACCCCACGGCGCAACTGCACGT
AGAGTACATGCGTCCCGATAAGATCTACGAGGCGGTACGGCGGGATACGGCGGATTTGGGGCTGGTGAGCTATCCGGAGG
CGAGCAGGGAAATCGCGGCGATTCCCTGGCGGGAGGAGGAAATGCACGTCGCGGTGCCGCCCAGCCATCCGTTCGCGAGC
CGTGACGAGGTCTTTCCTGCCGACCTGACGGGGCAGGACTTTATCGGGTTCGACGAAGACCTGCGGATCCGGCGTGAACT
CGACCGGTTCTTGCGTGCGCAGGCAGTGGAAGTCAACCTGGTGATGCATTTCGATAACATCCAGATGATTAAAGAAGCGG
TGGCCCTGGGGTCGGGGATCAGCATTCTGCCGGCGCGCACGATGCAGGCCGAGATCGAGCAGGGCCGATTGGTGGCGGTG
AAGCTGCATGCGCCGGAACTGGTGCGGCCGGTCGGGATTCTGCATCGCAAGCGGAAGAAGTTCAACAGCGCCACACGCGC
GCTGCTCGGCATGCTGGTGGGCACCACGGCTTGA

Upstream 100 bases:

>100_bases
AAAAATATTCCACAGCTACAATTAGAACGTCTTATGGTATGATCGGCACGTGGTCTTCTGGGAACAACGTCTTTTCAAAG
AGATAGCCGCGACGCGGAGT

Downstream 100 bases:

>100_bases
ACGGGCCACGCTTGTCCCGCCTTGTTTTTCGCCTTTGTTCATAATAAACCGGTTAGGTAGCCATGGAATGCAAAAAGCGG
GCCACATAGCCCGCTTTTGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSRGAEHCGVSQSAASQHVQEVERRLGVTLLDRSKRPLELTPAGRLYQEFCREVLRREEEFTLSLESIKGDVEGTVRIVS
IYSTGLSEMSRLREEFAARYPTAQLHVEYMRPDKIYEAVRRDTADLGLVSYPEASREIAAIPWREEEMHVAVPPSHPFAS
RDEVFPADLTGQDFIGFDEDLRIRRELDRFLRAQAVEVNLVMHFDNIQMIKEAVALGSGISILPARTMQAEIEQGRLVAV
KLHAPELVRPVGILHRKRKKFNSATRALLGMLVGTTA

Sequences:

>Translated_277_residues
MSRGAEHCGVSQSAASQHVQEVERRLGVTLLDRSKRPLELTPAGRLYQEFCREVLRREEEFTLSLESIKGDVEGTVRIVS
IYSTGLSEMSRLREEFAARYPTAQLHVEYMRPDKIYEAVRRDTADLGLVSYPEASREIAAIPWREEEMHVAVPPSHPFAS
RDEVFPADLTGQDFIGFDEDLRIRRELDRFLRAQAVEVNLVMHFDNIQMIKEAVALGSGISILPARTMQAEIEQGRLVAV
KLHAPELVRPVGILHRKRKKFNSATRALLGMLVGTTA
>Mature_276_residues
SRGAEHCGVSQSAASQHVQEVERRLGVTLLDRSKRPLELTPAGRLYQEFCREVLRREEEFTLSLESIKGDVEGTVRIVSI
YSTGLSEMSRLREEFAARYPTAQLHVEYMRPDKIYEAVRRDTADLGLVSYPEASREIAAIPWREEEMHVAVPPSHPFASR
DEVFPADLTGQDFIGFDEDLRIRRELDRFLRAQAVEVNLVMHFDNIQMIKEAVALGSGISILPARTMQAEIEQGRLVAVK
LHAPELVRPVGILHRKRKKFNSATRALLGMLVGTTA

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=277, Percent_Identity=27.0758122743682, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788481, Length=261, Percent_Identity=27.2030651340996, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790399, Length=262, Percent_Identity=24.8091603053435, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788748, Length=269, Percent_Identity=27.1375464684015, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788887, Length=228, Percent_Identity=25.8771929824561, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787530, Length=229, Percent_Identity=24.0174672489083, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI145693105, Length=274, Percent_Identity=20.8029197080292, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=25.609756097561, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788296, Length=221, Percent_Identity=21.7194570135747, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790262, Length=233, Percent_Identity=23.6051502145923, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787806, Length=234, Percent_Identity=22.2222222222222, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31305; Mature: 31174

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGAEHCGVSQSAASQHVQEVERRLGVTLLDRSKRPLELTPAGRLYQEFCREVLRREEE
CCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCEEECCCHHHHHHHHHHHHCCCHH
FTLSLESIKGDVEGTVRIVSIYSTGLSEMSRLREEFAARYPTAQLHVEYMRPDKIYEAVR
HEEEHHHHCCCCCCEEEEEEEHHHCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
RDTADLGLVSYPEASREIAAIPWREEEMHVAVPPSHPFASRDEVFPADLTGQDFIGFDED
HCHHHCCEEECCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRIRRELDRFLRAQAVEVNLVMHFDNIQMIKEAVALGSGISILPARTMQAEIEQGRLVAV
HHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCEEEE
KLHAPELVRPVGILHRKRKKFNSATRALLGMLVGTTA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRGAEHCGVSQSAASQHVQEVERRLGVTLLDRSKRPLELTPAGRLYQEFCREVLRREEE
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCEEECCCHHHHHHHHHHHHCCCHH
FTLSLESIKGDVEGTVRIVSIYSTGLSEMSRLREEFAARYPTAQLHVEYMRPDKIYEAVR
HEEEHHHHCCCCCCEEEEEEEHHHCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
RDTADLGLVSYPEASREIAAIPWREEEMHVAVPPSHPFASRDEVFPADLTGQDFIGFDED
HCHHHCCEEECCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRIRRELDRFLRAQAVEVNLVMHFDNIQMIKEAVALGSGISILPARTMQAEIEQGRLVAV
HHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCEEEE
KLHAPELVRPVGILHRKRKKFNSATRALLGMLVGTTA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]