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The map label for this gene is chaA [C]

Identifier: 116622909

GI number: 116622909

Start: 4834070

End: 4835167

Strand: Direct

Name: chaA [C]

Synonym: Acid_3810

Alternate gene names: 116622909

Gene position: 4834070-4835167 (Clockwise)

Preceding gene: 116622906

Following gene: 116622910

Centisome position: 48.51

GC content: 61.75

Gene sequence:

>1098_bases
ATGAGGACGTCGAACGCCGCCCTTATCCGCGAATGGACAATGCTGGTGGCCCTCGCCTCATCCGCCCTCTTCTTCGTCTT
TGGGCGCAGTTGGCTGGCGGACCTCTCCAATCCCATGTGGCTCGCGTTCCTGTTCGTCTGGCCATTCGCCGTAATTCTCC
TCTCGGCGACGTCCGTGGTACGTCATGCCGAAAGCCTCGCCGCGATACTCGGCGAACCGCTCGGGACGCTCGTACTGACC
CTCTCGATCACCGGTATCGAGGTGATGATGATCGCCTCGGTCATGTTCGCCGGAGAGGGCCACCCGGCTCTCGCGCGCGA
CGCGGTCTTCAGCGTCGCCATGATCGGGCTGAACGGAATCGTCGGCCTGTCGCTGATCGTGGGCGGGATTCGTTACCGAG
AGCAGCAGTACAACCTGCAAGGCGCGCAGGCCTTTCTGGCCGTTCTGGTGCCCCTTCTGGTGCTCGGCCTCGTCCTGCCC
AACTATACGGTGTCGGCAGCCGGCCCCACCATGTCTCCGCTGCAAGCCGGCTCCCAGATCGTAATTTCGCTCGCCCTGTA
CGGCGTGTTTCTCGCGATTCAAAATGTGCGCCATCGCGAGTACTTCATGGCGGACCCCGATGCGGCCACCGATATCCCCG
CGACGATTTCGCCCTGGTATCACTTCCCGTTCCTGTTGGGCTACCTGTTGCTGATTGTCTACCTCGCCGAACAAATCGCG
ATACCGATCGACTACAGCATCGACGTTCTCAAACTGCCGCCGGCCTTGGGCGGCCTGCTCGTATCGGTCCTCGTCATGAC
CTCGGAATCCCTGAGCGCCGTGCGCGCGGCCATGGCGAATGAGCTCCAACGCTCGGTGAACCTCCTCTTGGGAAGCGTGC
TCGCCTCCACCAGCTTGACCATCCCCGCCGTGCTTGCGATCGGCTTTATCTCGGGCCAAACCATCATCCTCGGTCTCGGT
CCCGTGGAGATGACGCTGCTTCTGTTGACTGTTGGGGTGAGCGCGTTGACCTTCGCCAGCGGTCGAACCAATGTCCTGCT
CGGCGCCGTGCACCTGGTATTATTCCTGGCGTACCTGATGCTGATCTTTGAGCACTAG

Upstream 100 bases:

>100_bases
GCAAACACTACCACGGCGGCGAGTGGGTTCCGCCTGAGAAGGCCGAGCATGCTAGGGAACTGGCACCTCACGATCTTTCG
GTCAAGACTCGTGGACAACC

Downstream 100 bases:

>100_bases
CAGGTCCTTCCACTTCGCGGCGCGCTCTTCGGCCGTGAACGACAGCGCCTCCACAAACTCGCGTCGATATAGGGTGAATG
CCCTCGCCCAACCTCCGCCG

Product: sodium/calcium exchanger membrane region

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MRTSNAALIREWTMLVALASSALFFVFGRSWLADLSNPMWLAFLFVWPFAVILLSATSVVRHAESLAAILGEPLGTLVLT
LSITGIEVMMIASVMFAGEGHPALARDAVFSVAMIGLNGIVGLSLIVGGIRYREQQYNLQGAQAFLAVLVPLLVLGLVLP
NYTVSAAGPTMSPLQAGSQIVISLALYGVFLAIQNVRHREYFMADPDAATDIPATISPWYHFPFLLGYLLLIVYLAEQIA
IPIDYSIDVLKLPPALGGLLVSVLVMTSESLSAVRAAMANELQRSVNLLLGSVLASTSLTIPAVLAIGFISGQTIILGLG
PVEMTLLLLTVGVSALTFASGRTNVLLGAVHLVLFLAYLMLIFEH

Sequences:

>Translated_365_residues
MRTSNAALIREWTMLVALASSALFFVFGRSWLADLSNPMWLAFLFVWPFAVILLSATSVVRHAESLAAILGEPLGTLVLT
LSITGIEVMMIASVMFAGEGHPALARDAVFSVAMIGLNGIVGLSLIVGGIRYREQQYNLQGAQAFLAVLVPLLVLGLVLP
NYTVSAAGPTMSPLQAGSQIVISLALYGVFLAIQNVRHREYFMADPDAATDIPATISPWYHFPFLLGYLLLIVYLAEQIA
IPIDYSIDVLKLPPALGGLLVSVLVMTSESLSAVRAAMANELQRSVNLLLGSVLASTSLTIPAVLAIGFISGQTIILGLG
PVEMTLLLLTVGVSALTFASGRTNVLLGAVHLVLFLAYLMLIFEH
>Mature_365_residues
MRTSNAALIREWTMLVALASSALFFVFGRSWLADLSNPMWLAFLFVWPFAVILLSATSVVRHAESLAAILGEPLGTLVLT
LSITGIEVMMIASVMFAGEGHPALARDAVFSVAMIGLNGIVGLSLIVGGIRYREQQYNLQGAQAFLAVLVPLLVLGLVLP
NYTVSAAGPTMSPLQAGSQIVISLALYGVFLAIQNVRHREYFMADPDAATDIPATISPWYHFPFLLGYLLLIVYLAEQIA
IPIDYSIDVLKLPPALGGLLVSVLVMTSESLSAVRAAMANELQRSVNLLLGSVLASTSLTIPAVLAIGFISGQTIILGLG
PVEMTLLLLTVGVSALTFASGRTNVLLGAVHLVLFLAYLMLIFEH

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=319, Percent_Identity=39.1849529780564, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 38921; Mature: 38921

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSNAALIREWTMLVALASSALFFVFGRSWLADLSNPMWLAFLFVWPFAVILLSATSVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RHAESLAAILGEPLGTLVLTLSITGIEVMMIASVMFAGEGHPALARDAVFSVAMIGLNGI
HHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VGLSLIVGGIRYREQQYNLQGAQAFLAVLVPLLVLGLVLPNYTVSAAGPTMSPLQAGSQI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHCCHHH
VISLALYGVFLAIQNVRHREYFMADPDAATDIPATISPWYHFPFLLGYLLLIVYLAEQIA
HHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
IPIDYSIDVLKLPPALGGLLVSVLVMTSESLSAVRAAMANELQRSVNLLLGSVLASTSLT
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
IPAVLAIGFISGQTIILGLGPVEMTLLLLTVGVSALTFASGRTNVLLGAVHLVLFLAYLM
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LIFEH
HHHCC
>Mature Secondary Structure
MRTSNAALIREWTMLVALASSALFFVFGRSWLADLSNPMWLAFLFVWPFAVILLSATSVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RHAESLAAILGEPLGTLVLTLSITGIEVMMIASVMFAGEGHPALARDAVFSVAMIGLNGI
HHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VGLSLIVGGIRYREQQYNLQGAQAFLAVLVPLLVLGLVLPNYTVSAAGPTMSPLQAGSQI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHCCHHH
VISLALYGVFLAIQNVRHREYFMADPDAATDIPATISPWYHFPFLLGYLLLIVYLAEQIA
HHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
IPIDYSIDVLKLPPALGGLLVSVLVMTSESLSAVRAAMANELQRSVNLLLGSVLASTSLT
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
IPAVLAIGFISGQTIILGLGPVEMTLLLLTVGVSALTFASGRTNVLLGAVHLVLFLAYLM
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LIFEH
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]