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The map label for this gene is norM [H]

Identifier: 116622840

GI number: 116622840

Start: 4752641

End: 4754050

Strand: Direct

Name: norM [H]

Synonym: Acid_3740

Alternate gene names: 116622840

Gene position: 4752641-4754050 (Clockwise)

Preceding gene: 116622838

Following gene: 116622844

Centisome position: 47.69

GC content: 63.62

Gene sequence:

>1410_bases
ATGCAGACGACCACGCAGTCTCAGCGCCGCCGGCACCGCAACTGGCGACTCCTGCGCGAAGCAATAGCCGGCACCTCTCA
GGATTTTACCCAGGGCAGCCTGACCCGCGGGATCGCGCTGCTCGCCATCCCGACGATTCTCGAAATGGTAATGGAATCCA
CATTCGGAGTCGTGGATGCTTTTTGGGTGGCGCGACTGGGCGCCGATTCGATGGCGGCGGTGGGACTGACCGAAGCCGTC
ATCGTGCTGGTGTTCGCGATTGCGATGGGACTGGCGATGGCGGCGACGGCTACGATTGCGCGGCGGATCGGCGAACATGA
TCCGGAAGGCGCGTCGGTGGCCGCGGTTCAGGCGATCGGCAGCGGTGTTGCGCTCGCGATTCCGCTGGGCATTGGGGGCT
ATGTGTTCGCGCCGCAACTGCTTGCGTTCATGCACGCGACTCCGGGCGTGATCGCGACCGGGACGGCGTATTCGCGGATC
ATTCTCGGCGGCAACCTCGCGATCGTGATGTTGTTCCTGATCAACGGCATTTTCCGCGGCTCAGGCGATGCCGCGATCGC
GATGCGGACACTTTGGATGGCCAACCTGATCAACATGGCGCTCGACCCCTGCTTTATTTACGGGCTTGGACCATTTCCAA
GACTCGGCGTGACGGGCGCGGCGGTCGCGACCACCGCCGGGCGGAGTCTCGGTGTGCTGTATCAGCTTTACGTGCTGGGC
AGCGGGCGCGCCCGTGTCGCGATCGCGCGGCGGCACCTGCGCATCGATTGGCCGGTGCTGCGACGGCTGTTTGGAGTCGC
GCGCACCGCGATGGTTCAGTACTTCATTGCGACCGCCAGCTGGCTGAGCCTGGCGCGCATCAACGCGGGATTCGGCAGCG
ACGCGGTGGCGGGCTATTCACTTGCGATCCGCATCATCCTTTTCGCCCTGATGCCTTCGTGGGGTATCTGCTCGGCGGCG
GCAACTCTCGTCGGGCAGAATCTTGGCGCCAACCGGCCGGACCGCAGCGAGCGCGCGGTTTGGCTCGCAGGGCTTTACAA
CATGACGTTCCTCTCGATTGTCGGCATCGTGTTCGTCGCCGCAGCGCACCGGCTGGTGGGCCTGTTCAATCCCAGCCCCG
GAGTGGCGCCGTTTGCGGTGGGTTGCCTGCAAGTGGTCAGCCTCGGATATCCGTTTTACGCATGGGGCATGATCATGGAG
CAATCCTTCAACGGCGCGGGCGATACGGTGACGCCCACATGCATTAATTTCGGCTGCTACTGGATGTTTCAGATTCCGCT
GGCGTGGTATCTCAGCCGGCAACTTGGACCGAAGGGCGTCTACGTGGCGATCTGTGCCGCCGAAAGCGTGCTGGCGATCG
TCAGCATCGCGTTGTTCCGGCGCGGAGGATGGAAAAAGGTGGTGGTGTGA

Upstream 100 bases:

>100_bases
GTCCGTTCGTCAGCGATTGCCGCTGACACCCTCCTCACGGACACCGCGTCTCAATTCCTGAGCCGCAAATTTTAAACCTT
ACTAGCCCCCGGAGAAGTTT

Downstream 100 bases:

>100_bases
CGGGCAGGCCGCGGGTGGCGGCCTGCCATTCCGGTTAGGTTTAGCAGTTAGCCTTTGGATTTCGGCGGGAAGTGTTCGAA
CATCTTTTGCACTGCCTCAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MQTTTQSQRRRHRNWRLLREAIAGTSQDFTQGSLTRGIALLAIPTILEMVMESTFGVVDAFWVARLGADSMAAVGLTEAV
IVLVFAIAMGLAMAATATIARRIGEHDPEGASVAAVQAIGSGVALAIPLGIGGYVFAPQLLAFMHATPGVIATGTAYSRI
ILGGNLAIVMLFLINGIFRGSGDAAIAMRTLWMANLINMALDPCFIYGLGPFPRLGVTGAAVATTAGRSLGVLYQLYVLG
SGRARVAIARRHLRIDWPVLRRLFGVARTAMVQYFIATASWLSLARINAGFGSDAVAGYSLAIRIILFALMPSWGICSAA
ATLVGQNLGANRPDRSERAVWLAGLYNMTFLSIVGIVFVAAAHRLVGLFNPSPGVAPFAVGCLQVVSLGYPFYAWGMIME
QSFNGAGDTVTPTCINFGCYWMFQIPLAWYLSRQLGPKGVYVAICAAESVLAIVSIALFRRGGWKKVVV

Sequences:

>Translated_469_residues
MQTTTQSQRRRHRNWRLLREAIAGTSQDFTQGSLTRGIALLAIPTILEMVMESTFGVVDAFWVARLGADSMAAVGLTEAV
IVLVFAIAMGLAMAATATIARRIGEHDPEGASVAAVQAIGSGVALAIPLGIGGYVFAPQLLAFMHATPGVIATGTAYSRI
ILGGNLAIVMLFLINGIFRGSGDAAIAMRTLWMANLINMALDPCFIYGLGPFPRLGVTGAAVATTAGRSLGVLYQLYVLG
SGRARVAIARRHLRIDWPVLRRLFGVARTAMVQYFIATASWLSLARINAGFGSDAVAGYSLAIRIILFALMPSWGICSAA
ATLVGQNLGANRPDRSERAVWLAGLYNMTFLSIVGIVFVAAAHRLVGLFNPSPGVAPFAVGCLQVVSLGYPFYAWGMIME
QSFNGAGDTVTPTCINFGCYWMFQIPLAWYLSRQLGPKGVYVAICAAESVLAIVSIALFRRGGWKKVVV
>Mature_469_residues
MQTTTQSQRRRHRNWRLLREAIAGTSQDFTQGSLTRGIALLAIPTILEMVMESTFGVVDAFWVARLGADSMAAVGLTEAV
IVLVFAIAMGLAMAATATIARRIGEHDPEGASVAAVQAIGSGVALAIPLGIGGYVFAPQLLAFMHATPGVIATGTAYSRI
ILGGNLAIVMLFLINGIFRGSGDAAIAMRTLWMANLINMALDPCFIYGLGPFPRLGVTGAAVATTAGRSLGVLYQLYVLG
SGRARVAIARRHLRIDWPVLRRLFGVARTAMVQYFIATASWLSLARINAGFGSDAVAGYSLAIRIILFALMPSWGICSAA
ATLVGQNLGANRPDRSERAVWLAGLYNMTFLSIVGIVFVAAAHRLVGLFNPSPGVAPFAVGCLQVVSLGYPFYAWGMIME
QSFNGAGDTVTPTCINFGCYWMFQIPLAWYLSRQLGPKGVYVAICAAESVLAIVSIALFRRGGWKKVVV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=450, Percent_Identity=24.2222222222222, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49931; Mature: 49931

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00888 CNMP_BINDING_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTTQSQRRRHRNWRLLREAIAGTSQDFTQGSLTRGIALLAIPTILEMVMESTFGVVDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWVARLGADSMAAVGLTEAVIVLVFAIAMGLAMAATATIARRIGEHDPEGASVAAVQAIG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
SGVALAIPLGIGGYVFAPQLLAFMHATPGVIATGTAYSRIILGGNLAIVMLFLINGIFRG
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCHHEEEEECCCHHHHHHHHHHHHHCC
SGDAAIAMRTLWMANLINMALDPCFIYGLGPFPRLGVTGAAVATTAGRSLGVLYQLYVLG
CCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCCHHHHHHEEEEEC
SGRARVAIARRHLRIDWPVLRRLFGVARTAMVQYFIATASWLSLARINAGFGSDAVAGYS
CCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LAIRIILFALMPSWGICSAAATLVGQNLGANRPDRSERAVWLAGLYNMTFLSIVGIVFVA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
AAHRLVGLFNPSPGVAPFAVGCLQVVSLGYPFYAWGMIMEQSFNGAGDTVTPTCINFGCY
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
WMFQIPLAWYLSRQLGPKGVYVAICAAESVLAIVSIALFRRGGWKKVVV
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MQTTTQSQRRRHRNWRLLREAIAGTSQDFTQGSLTRGIALLAIPTILEMVMESTFGVVDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWVARLGADSMAAVGLTEAVIVLVFAIAMGLAMAATATIARRIGEHDPEGASVAAVQAIG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
SGVALAIPLGIGGYVFAPQLLAFMHATPGVIATGTAYSRIILGGNLAIVMLFLINGIFRG
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCHHEEEEECCCHHHHHHHHHHHHHCC
SGDAAIAMRTLWMANLINMALDPCFIYGLGPFPRLGVTGAAVATTAGRSLGVLYQLYVLG
CCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCCHHHHHHEEEEEC
SGRARVAIARRHLRIDWPVLRRLFGVARTAMVQYFIATASWLSLARINAGFGSDAVAGYS
CCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LAIRIILFALMPSWGICSAAATLVGQNLGANRPDRSERAVWLAGLYNMTFLSIVGIVFVA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
AAHRLVGLFNPSPGVAPFAVGCLQVVSLGYPFYAWGMIMEQSFNGAGDTVTPTCINFGCY
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
WMFQIPLAWYLSRQLGPKGVYVAICAAESVLAIVSIALFRRGGWKKVVV
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]