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The map label for this gene is bfmBAB [H]

Identifier: 116622787

GI number: 116622787

Start: 4678503

End: 4680596

Strand: Reverse

Name: bfmBAB [H]

Synonym: Acid_3687

Alternate gene names: 116622787

Gene position: 4680596-4678503 (Counterclockwise)

Preceding gene: 116622789

Following gene: 116622780

Centisome position: 46.97

GC content: 66.38

Gene sequence:

>2094_bases
GTGGCCACCAAAACCAGCATTCCGCAAAATCAGAATACTGTCGATGTCTTGACTCCCGACCAGCTCATCCGCGCCTTCCG
CATCATGCATACGGCGCGCCGCCTCGACGACCGCGAGATCGCCCTGAAGCGCCAGAACCGCATCTTCTTCCAGATCTCCG
GCGCCGGACACGAGGCCGTCCAGGTCGCCGCCGCCATGTCTCTCCGCCCCGGCCGCGATTGGGTTTATCCCTACTACCGC
GACCGCGCCCTCTGCCTCGCCCTGGGCGTCACACCCCTCGAAATGCTCCAGCAGGCCGTGGGCGCCGCCGCCGACCCTGC
CTCGGGCGGCCGCCAGATGCCCTCGCACTGGGGCAATGCCGCCTACAACATCGTCAGCTCTTCCTCGCCCACCGGCACCC
AATACAACCAGGCCGCGGGCTGCGCGGAAGCCGGCCGCTATCGCGACCCCAAGTCCGACGAGATCACCCTGGTCTGCTCC
GGCGAAGGCGCCACCAGCGAAGGCGAATTCTGGGAATCGCTGAACATCGCCGCCCTCAAGCGGCTGCCCCTTCTCTACCT
GATCGAGGACAACGGCTACGCAATCAGCGTCCCCATCGAGCAGCAGACCGCCGGCGGCAGCATATCCGCCCTCACAGCCG
CTATCCCCGGCCTCTTCCGCCAGGAAATCGACGGCACGGATTTCTTCGCCTCCTGGCAGGCCATGCAGGCCGCCGTTCGC
TACTGCCGCGAAGGCAGCGGCCCCGCGCTGGTCCACGCCCACTGCATCCGTCCATACTCCCACTCCCTCTCGGACGATGA
GCGCCTCTACAAGACCCCCGCCGAACGCGCTGCCGAAGCCGAGCGCGATCCGGTCCTGCGCTTTCCCAAGCTCCTTATCG
ATGAAGGCGTCCTCGACCGCCGCATGCTCCAGGACATCACCCACGAAATCGACGAAGAGATCCAGCAGGCCACCCAGACC
GCCCTCCACGACGAGCCGCCTTCACCGGCCTCCGCCCTGGTCCATCTCTATTCCGATCTCGACCCCTGTGCACCGGCCTT
CCATGCCGAGCCCCGTTTTCAGGGCGCGCCCATGACCATGGTGGACCTGATCAACGCCACCCTCCGCGAGGAAATGCGCC
GCAATCCGGACATCCTTGTGTTCGGCGAAGATGTGGCCGACGCCTCGCGCGAACAGAATCTCACCGAGGTCAAAGGCAAA
GGCGGCGTCTTTAAAGTCACGCACGGGCTGCAATCCGAATTCGGCGCGCGCCGCGCCTTCAACGCGCCCATCGCCGAAGC
CGCCATCGTCGGCCGCGCTATCGGCATGGCCGCTCGCGGACTTAAGCCCGTCGCCGAAATCCAGTTCTTCGACTACATCT
GGCCCGCCATGATGCAGCTCCGCGATGAGCTCGCCACCATGCGCTGGCGCTCCAACGGCGCCTTCTCCGCGCCCGCGATC
ATCCGCGTCCCCATCGGCGGCTATCTCAACGGCGGCGCGATTTATCACAGCCAGTGCGGCGAGTCGATCTTCACCCACAT
CCCGGGCCTCCGCGTGGTCTTCCCCAGCAACGCCGCCGACGCCTGCGGCCTGCTCCGCACCGCCTTGCGCTCCGACGACC
CGGTCCTCTTCCTGGAACACAAGCGTCTCTACCGCGAGCCCTATAACCGCTCGCCCCACCCCGGCGCCGACTACACGGTT
CCCTTCGGCAGCGCCAAGGTCGTGAAGCCCGGCCAGAATCTCACCGTCATCACCTATGGCGCGCTGGTGCAGAAATCCCT
CCTCGCCGCCACCCAGATCGAACGCCGCGACGCCGCCATCAGCATCGAGATCCTCGACCTGCGCACTCTCGCCCCCTACG
ATTGGGACGCCATCCGCGCTTCCGTGGAAAAGACCAGCCGCGTCCTGGTGGTCCACGAGGACACGCTCTCCTGGGGCTAC
GGCGCCGAAATCGCCGCCCGCATCGCCGACGAGCTGTTCGACAAACTTGACGCGCCCGTCCGCCGCGTCGGCGCCCTCGA
TACCTGGATCGGCTATCACCCGCAGCTCGAAGCCGCCATCCTCCCCCAAACCGACACGCTGGTCACCGCCATCGACCACC
TGCTTGCCTACTGA

Upstream 100 bases:

>100_bases
CTTCTCAAATTGTGCATCCGATCATGATAGCCGCCTGGGAGCGCCACCACTCGCTCGTGGATCACAGGCTCGATCGTATA
AACTGTAGACGGAGGGACGG

Downstream 100 bases:

>100_bases
GGTGGCTTGCTGACACCACCGGTCAGCTAAGGATTGATGATGCGGTGCAGGTCGAGAGCGGGAGGGGCCACCTCAGCCTG
GCTCAACATAATATGAACCT

Product: dehydrogenase, E1 component

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MATKTSIPQNQNTVDVLTPDQLIRAFRIMHTARRLDDREIALKRQNRIFFQISGAGHEAVQVAAAMSLRPGRDWVYPYYR
DRALCLALGVTPLEMLQQAVGAAADPASGGRQMPSHWGNAAYNIVSSSSPTGTQYNQAAGCAEAGRYRDPKSDEITLVCS
GEGATSEGEFWESLNIAALKRLPLLYLIEDNGYAISVPIEQQTAGGSISALTAAIPGLFRQEIDGTDFFASWQAMQAAVR
YCREGSGPALVHAHCIRPYSHSLSDDERLYKTPAERAAEAERDPVLRFPKLLIDEGVLDRRMLQDITHEIDEEIQQATQT
ALHDEPPSPASALVHLYSDLDPCAPAFHAEPRFQGAPMTMVDLINATLREEMRRNPDILVFGEDVADASREQNLTEVKGK
GGVFKVTHGLQSEFGARRAFNAPIAEAAIVGRAIGMAARGLKPVAEIQFFDYIWPAMMQLRDELATMRWRSNGAFSAPAI
IRVPIGGYLNGGAIYHSQCGESIFTHIPGLRVVFPSNAADACGLLRTALRSDDPVLFLEHKRLYREPYNRSPHPGADYTV
PFGSAKVVKPGQNLTVITYGALVQKSLLAATQIERRDAAISIEILDLRTLAPYDWDAIRASVEKTSRVLVVHEDTLSWGY
GAEIAARIADELFDKLDAPVRRVGALDTWIGYHPQLEAAILPQTDTLVTAIDHLLAY

Sequences:

>Translated_697_residues
MATKTSIPQNQNTVDVLTPDQLIRAFRIMHTARRLDDREIALKRQNRIFFQISGAGHEAVQVAAAMSLRPGRDWVYPYYR
DRALCLALGVTPLEMLQQAVGAAADPASGGRQMPSHWGNAAYNIVSSSSPTGTQYNQAAGCAEAGRYRDPKSDEITLVCS
GEGATSEGEFWESLNIAALKRLPLLYLIEDNGYAISVPIEQQTAGGSISALTAAIPGLFRQEIDGTDFFASWQAMQAAVR
YCREGSGPALVHAHCIRPYSHSLSDDERLYKTPAERAAEAERDPVLRFPKLLIDEGVLDRRMLQDITHEIDEEIQQATQT
ALHDEPPSPASALVHLYSDLDPCAPAFHAEPRFQGAPMTMVDLINATLREEMRRNPDILVFGEDVADASREQNLTEVKGK
GGVFKVTHGLQSEFGARRAFNAPIAEAAIVGRAIGMAARGLKPVAEIQFFDYIWPAMMQLRDELATMRWRSNGAFSAPAI
IRVPIGGYLNGGAIYHSQCGESIFTHIPGLRVVFPSNAADACGLLRTALRSDDPVLFLEHKRLYREPYNRSPHPGADYTV
PFGSAKVVKPGQNLTVITYGALVQKSLLAATQIERRDAAISIEILDLRTLAPYDWDAIRASVEKTSRVLVVHEDTLSWGY
GAEIAARIADELFDKLDAPVRRVGALDTWIGYHPQLEAAILPQTDTLVTAIDHLLAY
>Mature_696_residues
ATKTSIPQNQNTVDVLTPDQLIRAFRIMHTARRLDDREIALKRQNRIFFQISGAGHEAVQVAAAMSLRPGRDWVYPYYRD
RALCLALGVTPLEMLQQAVGAAADPASGGRQMPSHWGNAAYNIVSSSSPTGTQYNQAAGCAEAGRYRDPKSDEITLVCSG
EGATSEGEFWESLNIAALKRLPLLYLIEDNGYAISVPIEQQTAGGSISALTAAIPGLFRQEIDGTDFFASWQAMQAAVRY
CREGSGPALVHAHCIRPYSHSLSDDERLYKTPAERAAEAERDPVLRFPKLLIDEGVLDRRMLQDITHEIDEEIQQATQTA
LHDEPPSPASALVHLYSDLDPCAPAFHAEPRFQGAPMTMVDLINATLREEMRRNPDILVFGEDVADASREQNLTEVKGKG
GVFKVTHGLQSEFGARRAFNAPIAEAAIVGRAIGMAARGLKPVAEIQFFDYIWPAMMQLRDELATMRWRSNGAFSAPAII
RVPIGGYLNGGAIYHSQCGESIFTHIPGLRVVFPSNAADACGLLRTALRSDDPVLFLEHKRLYREPYNRSPHPGADYTVP
FGSAKVVKPGQNLTVITYGALVQKSLLAATQIERRDAAISIEILDLRTLAPYDWDAIRASVEKTSRVLVVHEDTLSWGYG
AEIAARIADELFDKLDAPVRRVGALDTWIGYHPQLEAAILPQTDTLVTAIDHLLAY

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=322, Percent_Identity=36.9565217391304, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI34101272, Length=322, Percent_Identity=36.9565217391304, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI156564403, Length=340, Percent_Identity=33.5294117647059, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI291084858, Length=340, Percent_Identity=32.0588235294118, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=30.0911854103343, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI4505685, Length=330, Percent_Identity=28.7878787878788, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI291084742, Length=330, Percent_Identity=28.7878787878788, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI11386135, Length=326, Percent_Identity=29.4478527607362, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI258645172, Length=326, Percent_Identity=29.1411042944785, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=27.9761904761905, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI291084757, Length=330, Percent_Identity=25.4545454545455, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17506935, Length=311, Percent_Identity=39.2282958199357, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17538422, Length=340, Percent_Identity=35.5882352941176, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI86563357, Length=293, Percent_Identity=31.740614334471, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI86563355, Length=293, Percent_Identity=31.740614334471, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32564172, Length=374, Percent_Identity=27.807486631016, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17536047, Length=374, Percent_Identity=27.807486631016, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319698, Length=341, Percent_Identity=35.1906158357771, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321026, Length=327, Percent_Identity=26.605504587156, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI160714832, Length=344, Percent_Identity=36.046511627907, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI160714828, Length=344, Percent_Identity=36.046511627907, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI21358145, Length=340, Percent_Identity=35.8823529411765, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24650940, Length=340, Percent_Identity=35.8823529411765, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI21355903, Length=308, Percent_Identity=30.8441558441558, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24639744, Length=352, Percent_Identity=26.4204545454545, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28571106, Length=352, Percent_Identity=26.4204545454545, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24639740, Length=352, Percent_Identity=26.4204545454545, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24639746, Length=340, Percent_Identity=26.1764705882353, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24639748, Length=323, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 76580; Mature: 76448

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKTSIPQNQNTVDVLTPDQLIRAFRIMHTARRLDDREIALKRQNRIFFQISGAGHEAV
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHEECCEEEEEECCCCHHHH
QVAAAMSLRPGRDWVYPYYRDRALCLALGVTPLEMLQQAVGAAADPASGGRQMPSHWGNA
HHHHHHHCCCCCCCCCCHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCC
AYNIVSSSSPTGTQYNQAAGCAEAGRYRDPKSDEITLVCSGEGATSEGEFWESLNIAALK
EEEEECCCCCCCCCCHHHCCHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCHHHHH
RLPLLYLIEDNGYAISVPIEQQTAGGSISALTAAIPGLFRQEIDGTDFFASWQAMQAAVR
HCCEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YCREGSGPALVHAHCIRPYSHSLSDDERLYKTPAERAAEAERDPVLRFPKLLIDEGVLDR
HHHCCCCCEEEEEEECCCHHCCCCCCHHHHHCHHHHHHHCCCCCHHHHHHHHHHCCHHHH
RMLQDITHEIDEEIQQATQTALHDEPPSPASALVHLYSDLDPCAPAFHAEPRFQGAPMTM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
VDLINATLREEMRRNPDILVFGEDVADASREQNLTEVKGKGGVFKVTHGLQSEFGARRAF
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCHHHHCCCCCEEEECCCHHHHHCCHHCC
NAPIAEAAIVGRAIGMAARGLKPVAEIQFFDYIWPAMMQLRDELATMRWRSNGAFSAPAI
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
IRVPIGGYLNGGAIYHSQCGESIFTHIPGLRVVFPSNAADACGLLRTALRSDDPVLFLEH
EEECCCCEECCCEEEHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEC
KRLYREPYNRSPHPGADYTVPFGSAKVVKPGQNLTVITYGALVQKSLLAATQIERRDAAI
HHHHHCCCCCCCCCCCCEEECCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEE
SIEILDLRTLAPYDWDAIRASVEKTSRVLVVHEDTLSWGYGAEIAARIADELFDKLDAPV
EEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCHHH
RRVGALDTWIGYHPQLEAAILPQTDTLVTAIDHLLAY
HHHCCHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ATKTSIPQNQNTVDVLTPDQLIRAFRIMHTARRLDDREIALKRQNRIFFQISGAGHEAV
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHEECCEEEEEECCCCHHHH
QVAAAMSLRPGRDWVYPYYRDRALCLALGVTPLEMLQQAVGAAADPASGGRQMPSHWGNA
HHHHHHHCCCCCCCCCCHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCC
AYNIVSSSSPTGTQYNQAAGCAEAGRYRDPKSDEITLVCSGEGATSEGEFWESLNIAALK
EEEEECCCCCCCCCCHHHCCHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCHHHHH
RLPLLYLIEDNGYAISVPIEQQTAGGSISALTAAIPGLFRQEIDGTDFFASWQAMQAAVR
HCCEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YCREGSGPALVHAHCIRPYSHSLSDDERLYKTPAERAAEAERDPVLRFPKLLIDEGVLDR
HHHCCCCCEEEEEEECCCHHCCCCCCHHHHHCHHHHHHHCCCCCHHHHHHHHHHCCHHHH
RMLQDITHEIDEEIQQATQTALHDEPPSPASALVHLYSDLDPCAPAFHAEPRFQGAPMTM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
VDLINATLREEMRRNPDILVFGEDVADASREQNLTEVKGKGGVFKVTHGLQSEFGARRAF
HHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCHHHHCCCCCEEEECCCHHHHHCCHHCC
NAPIAEAAIVGRAIGMAARGLKPVAEIQFFDYIWPAMMQLRDELATMRWRSNGAFSAPAI
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
IRVPIGGYLNGGAIYHSQCGESIFTHIPGLRVVFPSNAADACGLLRTALRSDDPVLFLEH
EEECCCCEECCCEEEHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEC
KRLYREPYNRSPHPGADYTVPFGSAKVVKPGQNLTVITYGALVQKSLLAATQIERRDAAI
HHHHHCCCCCCCCCCCCEEECCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEE
SIEILDLRTLAPYDWDAIRASVEKTSRVLVVHEDTLSWGYGAEIAARIADELFDKLDAPV
EEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCHHH
RRVGALDTWIGYHPQLEAAILPQTDTLVTAIDHLLAY
HHHCCHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]