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The map label for this gene is lpxD1 [H]

Identifier: 116622690

GI number: 116622690

Start: 4544080

End: 4545201

Strand: Reverse

Name: lpxD1 [H]

Synonym: Acid_3589

Alternate gene names: 116622690

Gene position: 4545201-4544080 (Counterclockwise)

Preceding gene: 116622696

Following gene: 116622689

Centisome position: 45.61

GC content: 64.62

Gene sequence:

>1122_bases
ATGTTGGCGATAGTCCCACCGCGAACCGCGACCGTCAGGCAGCGATCTACAATCCGTGCCTTGAGGTACGCTGTAGGTGC
GATGAGACTTCGTGAAATTGCCGACGCGCTCGGCTGCCGCCTGGCAGGCGACGGCGAAATCGAAATCCTCGGCGTCGCCG
GGATGGAGCACGCTGGCCCCGGTCACCTCACCTTCCTGGCCAATCCCAAGTACGCACCCAAGGTCCGCCATACCAGAGCC
AGCGCCATCCTGGTGGCCGAAGCGCTCCCGGGCTTGGAAATCGCCTGCCTGGTCTCCGACAACCCGTACCTGGATTTCGC
CCGCGCCCTGGCCCTCTTCTACCAGCCGCCGCGCCCCGCCCCTGGCATCCACCCGCAGGCCTACGTCGCCCCTACCGCGA
CGCTCGGCACGGGCTGCTCCGTCGGCCCCTTCGCGGTGGTCGGCGAGCGCGTACGGGTGGGCAAAAACGCAGTTATCCAC
CCCCACGTTGTGCTCTACGAAGGTGTCGAGGTCGGCGACGATTTCCTGGCGCATTCGCACGCCACGGTGCGTGAGTTTTG
TCGCATCGGCAATCGCGTCACCCTGCAGAACGGCGTAGTGGTGGGCGGCGACGGCTTTGGGTTTGCGCGGCGCGCCGACG
GCGCCCAAATAAAGATCGTCCAATCCGGCGTCACCATCATCGAGGATGATGTGGAGATTCAGTCGCTTACCTCGATCGAT
CGCGCCACCGTGGGCGAAACCCGCGTCAAGCGCGGCGCCAAGATCGATAGCCTGGTGCAGGTAGGCCACGCGTGCACGGT
CGGCGAGGACAATATCATCTGCGCCCAAACCGGTCTGGCCGGCAGCACGGTGCTGGAGCGCAACGTGGTGCTCGCCGGCC
AGGTCGGGTCGAGCGGCCATCTCACGGTACACGAAGGCGCCGTGGTCTATGCCCAAAGCGGCATCGGCGGCGATGTCGCC
AAGGGCGATCGCATCTCCGGTTCCCCGGCCTTCGCCGCCGGTGAATGGCTGCGCGCCGTCACCGCCTTCCAAAAACTCCC
CGAGTTGCTCAAGACCGTGCGCGAATTGAAAAAGAAAGTCGATGAGTTAAGACAGAATGTCGAATCCAACTCCGCCTCAT
AG

Upstream 100 bases:

>100_bases
AACTATTGAACCCCAGATTTAGACGTGTGACGCTCGAAAATGCGCCTCCCGGCCGGTGAAATTGGTGAAGCATTCTTAAC
CCTTTCTTGTAGGGGACCAT

Downstream 100 bases:

>100_bases
CGAGCGGCGCCCCGTCGCCTACCTGAACGATAAGTTCCTTAACAGCCCCGACGCCCGGGCGCTGCGCATCCTGGCGGAGT
TCCTGGAACCGCTGGCCCAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MLAIVPPRTATVRQRSTIRALRYAVGAMRLREIADALGCRLAGDGEIEILGVAGMEHAGPGHLTFLANPKYAPKVRHTRA
SAILVAEALPGLEIACLVSDNPYLDFARALALFYQPPRPAPGIHPQAYVAPTATLGTGCSVGPFAVVGERVRVGKNAVIH
PHVVLYEGVEVGDDFLAHSHATVREFCRIGNRVTLQNGVVVGGDGFGFARRADGAQIKIVQSGVTIIEDDVEIQSLTSID
RATVGETRVKRGAKIDSLVQVGHACTVGEDNIICAQTGLAGSTVLERNVVLAGQVGSSGHLTVHEGAVVYAQSGIGGDVA
KGDRISGSPAFAAGEWLRAVTAFQKLPELLKTVRELKKKVDELRQNVESNSAS

Sequences:

>Translated_373_residues
MLAIVPPRTATVRQRSTIRALRYAVGAMRLREIADALGCRLAGDGEIEILGVAGMEHAGPGHLTFLANPKYAPKVRHTRA
SAILVAEALPGLEIACLVSDNPYLDFARALALFYQPPRPAPGIHPQAYVAPTATLGTGCSVGPFAVVGERVRVGKNAVIH
PHVVLYEGVEVGDDFLAHSHATVREFCRIGNRVTLQNGVVVGGDGFGFARRADGAQIKIVQSGVTIIEDDVEIQSLTSID
RATVGETRVKRGAKIDSLVQVGHACTVGEDNIICAQTGLAGSTVLERNVVLAGQVGSSGHLTVHEGAVVYAQSGIGGDVA
KGDRISGSPAFAAGEWLRAVTAFQKLPELLKTVRELKKKVDELRQNVESNSAS
>Mature_373_residues
MLAIVPPRTATVRQRSTIRALRYAVGAMRLREIADALGCRLAGDGEIEILGVAGMEHAGPGHLTFLANPKYAPKVRHTRA
SAILVAEALPGLEIACLVSDNPYLDFARALALFYQPPRPAPGIHPQAYVAPTATLGTGCSVGPFAVVGERVRVGKNAVIH
PHVVLYEGVEVGDDFLAHSHATVREFCRIGNRVTLQNGVVVGGDGFGFARRADGAQIKIVQSGVTIIEDDVEIQSLTSID
RATVGETRVKRGAKIDSLVQVGHACTVGEDNIICAQTGLAGSTVLERNVVLAGQVGSSGHLTVHEGAVVYAQSGIGGDVA
KGDRISGSPAFAAGEWLRAVTAFQKLPELLKTVRELKKKVDELRQNVESNSAS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=338, Percent_Identity=31.9526627218935, Blast_Score=174, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 39337; Mature: 39337

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAIVPPRTATVRQRSTIRALRYAVGAMRLREIADALGCRLAGDGEIEILGVAGMEHAGP
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEEECCCCCCCC
GHLTFLANPKYAPKVRHTRASAILVAEALPGLEIACLVSDNPYLDFARALALFYQPPRPA
CEEEEEECCCCCCCHHHCHHHEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCC
PGIHPQAYVAPTATLGTGCSVGPFAVVGERVRVGKNAVIHPHVVLYEGVEVGDDFLAHSH
CCCCCCEEECCCCCCCCCCCCCCHHHHCCHHHCCCCCEECCEEEEEECCCCCCHHHHCCH
ATVREFCRIGNRVTLQNGVVVGGDGFGFARRADGAQIKIVQSGVTIIEDDVEIQSLTSID
HHHHHHHHCCCEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHH
RATVGETRVKRGAKIDSLVQVGHACTVGEDNIICAQTGLAGSTVLERNVVLAGQVGSSGH
HHHCCHHHHHCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCEEECCEEEEECCCCCCC
LTVHEGAVVYAQSGIGGDVAKGDRISGSPAFAAGEWLRAVTAFQKLPELLKTVRELKKKV
EEEECCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DELRQNVESNSAS
HHHHHHHHCCCCC
>Mature Secondary Structure
MLAIVPPRTATVRQRSTIRALRYAVGAMRLREIADALGCRLAGDGEIEILGVAGMEHAGP
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEEECCCCCCCC
GHLTFLANPKYAPKVRHTRASAILVAEALPGLEIACLVSDNPYLDFARALALFYQPPRPA
CEEEEEECCCCCCCHHHCHHHEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCC
PGIHPQAYVAPTATLGTGCSVGPFAVVGERVRVGKNAVIHPHVVLYEGVEVGDDFLAHSH
CCCCCCEEECCCCCCCCCCCCCCHHHHCCHHHCCCCCEECCEEEEEECCCCCCHHHHCCH
ATVREFCRIGNRVTLQNGVVVGGDGFGFARRADGAQIKIVQSGVTIIEDDVEIQSLTSID
HHHHHHHHCCCEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHH
RATVGETRVKRGAKIDSLVQVGHACTVGEDNIICAQTGLAGSTVLERNVVLAGQVGSSGH
HHHCCHHHHHCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCEEECCEEEEECCCCCCC
LTVHEGAVVYAQSGIGGDVAKGDRISGSPAFAAGEWLRAVTAFQKLPELLKTVRELKKKV
EEEECCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DELRQNVESNSAS
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA