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The map label for this gene is mutS [H]

Identifier: 116622678

GI number: 116622678

Start: 4527320

End: 4529155

Strand: Reverse

Name: mutS [H]

Synonym: Acid_3577

Alternate gene names: 116622678

Gene position: 4529155-4527320 (Counterclockwise)

Preceding gene: 116622679

Following gene: 116622677

Centisome position: 45.45

GC content: 66.72

Gene sequence:

>1836_bases
ATGACTCCCGATCCCCGCTCCGCCTACACGAAACTGCTTGCCGAACGCCGCGCGGAGATCGCGGCGCGAGAAGCGCGGCA
CCGGCGGTTGGGCCACGCCAAGATCGCGGTGGCGGCGGCGGGTGTCGCGGTGGTCTGGCTGGCGCTCTCCAGGGGCGGCG
GCGGGTCAATCCTGTGGGTGCTCCTGCCGATCGCGGCATTCGTAGCACTGGTGGTGATCCACGAAAAACTGCTGGCCGAC
CTCGAACGGCGGAGGCGCGCGGCCCGGTTCTTCGAAAAGGGACTCTCGCGGCTGGACGGGGAGTGGGCCGGAGCCGGCGA
ATCGGGTGAGCGGTACAACGATCCGGCGCATCCCTACGCGCTCGATCTCGACCTCTTCGGCAAGGGCAGCGTCTTCGAAC
TGCTGTGCACCGCGCGCACCCAAATTGGCGAGGACCGCCTGGCGCAATGGCTTAAAATTCCGGCAGCGCCCGAGGTCGTG
ACGGAGAGGCAGGCCGCGGTCGAGGAGTTGCGCAACCGGCTGGACCTTCGCGAGCAACTGGCCATCCTGGCGGAGGAGGC
GCGCAGCGGGGTGGATCCGGCGGCGCTGGCACAGTGGGGCGAGGCTCCTGCGCGGCTGCGCGCTACGGGCTTCCGGTTCA
AAGTGCGGCTCTTCACTATCCTGGGCCTGGCAGGATTCGTGGCGCTCTGGATTCACCTGGCGGTGTCGGCGAGCGTGCTT
CACCTGGCGCCCCAGATGGATGCGCTGCTGCTGGATTTCTTCCTGGTCGCGCTGCTGATCAACGGCTGGTTCCTTTACCG
CCACAGTGGCGAGATGGGCGCGGCGGCTTCGCAGGTGGAGGAGGCGGCGCATGAGCTGGGGCTGCTTTCCGAAGTTCTGG
TCCGGATGGAACGCGAGCAGTTCCGGTGTCCGCTGTTGGCCGGATTGCGCAGCTCGCTCGACGTGGAAGGCGCACCGCCT
TCACACCGCCTGGCGCGATTGAAGCGCCTGGTGGAATACCTGGATTCGCGTGACAACGTGTTCGTGCGCGTGCTCGAGCC
CTTCCTGCTCTGGACACCGCACCTCGCGCTCAAGGTGGAGGATTGGCGCGCGCATTCCGGCACTGCCGTACGGCGCTGGC
TGCACGCCGCCGGGGAAATGGAGGCGCTGTGCTCGCTGGCCAGCCACGCGTACGAGCACCCGGCAGACCCGTTCCCGGAA
TTCACTCCGGAAGGGCCGTGGCTCGAAGGCGAGGGGCTCGGGCATCCGCTACTGCCGGAGAGCAAGGTGGTGCGTAACGA
TATCCGCATCGGCGGCGAGCTGCGTGTGTACGTGGTGAGCGGCAGCAACATGTCGGGCAAGAGCACCATGCTACGGACTC
TGGGCGTGAATGCGGTGCTCGCGCAGGCTGGTGCCCCGGTCCGGGCGCACCGTCTGCGCCTATCGCCGCTGGCGATCGGC
GCATCGATCCGGCTGACCGATTCCCTGCAGGGAGGCGTCTCGCGATTCTATGCCGAGATTCTGCGTCTGCGGCAGATTCT
GGATGAGACGGCGGGGTCGCTGCCAGTCCTATTCCTGATCGACGAATTTCTACACGGCACCAACTCCCACGACCGGCGCA
TCGGGGCGGAGGCGCTGGTGCGCGGCCTGGTGGAGCGCGGCGCGATCGGGCTGATTACCACCCACGACCTGGCGCTCGCC
GATATCGCCGAACAATTGGGCGAGCGCGCGGCCAATGTCCACTTCGAAGACCAGATCGTGGAGGGGCAGATCCGCTTCGA
CTACCATATGCGCCCCGGAGTTGTGCGCAAGAGTAACGCAATCGAGCTGATGCGCCAGGTAGGTTTGGAGATTTGA

Upstream 100 bases:

>100_bases
TGACGATCGCGGGATTGGGGATGGTCGCCGCAACCCCCAAATATCTTCACTCGCGACGATGAAGCGCTCGCGCGCTTCCG
CGCGACAATGGGGATAGCGA

Downstream 100 bases:

>100_bases
ACGCGGAGGGCATTCGGGAACTGGCGCGCGCCTGCGGTTTTGAACTGGCGGGCGTCGCGTCTGCCCTACCGGCGGAAGAT
CGCGCGCGGTATCACGATTG

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MTPDPRSAYTKLLAERRAEIAAREARHRRLGHAKIAVAAAGVAVVWLALSRGGGGSILWVLLPIAAFVALVVIHEKLLAD
LERRRRAARFFEKGLSRLDGEWAGAGESGERYNDPAHPYALDLDLFGKGSVFELLCTARTQIGEDRLAQWLKIPAAPEVV
TERQAAVEELRNRLDLREQLAILAEEARSGVDPAALAQWGEAPARLRATGFRFKVRLFTILGLAGFVALWIHLAVSASVL
HLAPQMDALLLDFFLVALLINGWFLYRHSGEMGAAASQVEEAAHELGLLSEVLVRMEREQFRCPLLAGLRSSLDVEGAPP
SHRLARLKRLVEYLDSRDNVFVRVLEPFLLWTPHLALKVEDWRAHSGTAVRRWLHAAGEMEALCSLASHAYEHPADPFPE
FTPEGPWLEGEGLGHPLLPESKVVRNDIRIGGELRVYVVSGSNMSGKSTMLRTLGVNAVLAQAGAPVRAHRLRLSPLAIG
ASIRLTDSLQGGVSRFYAEILRLRQILDETAGSLPVLFLIDEFLHGTNSHDRRIGAEALVRGLVERGAIGLITTHDLALA
DIAEQLGERAANVHFEDQIVEGQIRFDYHMRPGVVRKSNAIELMRQVGLEI

Sequences:

>Translated_611_residues
MTPDPRSAYTKLLAERRAEIAAREARHRRLGHAKIAVAAAGVAVVWLALSRGGGGSILWVLLPIAAFVALVVIHEKLLAD
LERRRRAARFFEKGLSRLDGEWAGAGESGERYNDPAHPYALDLDLFGKGSVFELLCTARTQIGEDRLAQWLKIPAAPEVV
TERQAAVEELRNRLDLREQLAILAEEARSGVDPAALAQWGEAPARLRATGFRFKVRLFTILGLAGFVALWIHLAVSASVL
HLAPQMDALLLDFFLVALLINGWFLYRHSGEMGAAASQVEEAAHELGLLSEVLVRMEREQFRCPLLAGLRSSLDVEGAPP
SHRLARLKRLVEYLDSRDNVFVRVLEPFLLWTPHLALKVEDWRAHSGTAVRRWLHAAGEMEALCSLASHAYEHPADPFPE
FTPEGPWLEGEGLGHPLLPESKVVRNDIRIGGELRVYVVSGSNMSGKSTMLRTLGVNAVLAQAGAPVRAHRLRLSPLAIG
ASIRLTDSLQGGVSRFYAEILRLRQILDETAGSLPVLFLIDEFLHGTNSHDRRIGAEALVRGLVERGAIGLITTHDLALA
DIAEQLGERAANVHFEDQIVEGQIRFDYHMRPGVVRKSNAIELMRQVGLEI
>Mature_610_residues
TPDPRSAYTKLLAERRAEIAAREARHRRLGHAKIAVAAAGVAVVWLALSRGGGGSILWVLLPIAAFVALVVIHEKLLADL
ERRRRAARFFEKGLSRLDGEWAGAGESGERYNDPAHPYALDLDLFGKGSVFELLCTARTQIGEDRLAQWLKIPAAPEVVT
ERQAAVEELRNRLDLREQLAILAEEARSGVDPAALAQWGEAPARLRATGFRFKVRLFTILGLAGFVALWIHLAVSASVLH
LAPQMDALLLDFFLVALLINGWFLYRHSGEMGAAASQVEEAAHELGLLSEVLVRMEREQFRCPLLAGLRSSLDVEGAPPS
HRLARLKRLVEYLDSRDNVFVRVLEPFLLWTPHLALKVEDWRAHSGTAVRRWLHAAGEMEALCSLASHAYEHPADPFPEF
TPEGPWLEGEGLGHPLLPESKVVRNDIRIGGELRVYVVSGSNMSGKSTMLRTLGVNAVLAQAGAPVRAHRLRLSPLAIGA
SIRLTDSLQGGVSRFYAEILRLRQILDETAGSLPVLFLIDEFLHGTNSHDRRIGAEALVRGLVERGAIGLITTHDLALAD
IAEQLGERAANVHFEDQIVEGQIRFDYHMRPGVVRKSNAIELMRQVGLEI

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI4504191, Length=233, Percent_Identity=32.618025751073, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789089, Length=258, Percent_Identity=27.1317829457364, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508445, Length=219, Percent_Identity=29.2237442922374, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=237, Percent_Identity=27.0042194092827, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664545, Length=554, Percent_Identity=23.826714801444, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 67363; Mature: 67231

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDPRSAYTKLLAERRAEIAAREARHRRLGHAKIAVAAAGVAVVWLALSRGGGGSILWV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLPIAAFVALVVIHEKLLADLERRRRAARFFEKGLSRLDGEWAGAGESGERYNDPAHPYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LDLDLFGKGSVFELLCTARTQIGEDRLAQWLKIPAAPEVVTERQAAVEELRNRLDLREQL
EEEEECCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AILAEEARSGVDPAALAQWGEAPARLRATGFRFKVRLFTILGLAGFVALWIHLAVSASVL
HHHHHHHHCCCCHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAPQMDALLLDFFLVALLINGWFLYRHSGEMGAAASQVEEAAHELGLLSEVLVRMEREQ
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRCPLLAGLRSSLDVEGAPPSHRLARLKRLVEYLDSRDNVFVRVLEPFLLWTPHLALKVE
HCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCEEEEEE
DWRAHSGTAVRRWLHAAGEMEALCSLASHAYEHPADPFPEFTPEGPWLEGEGLGHPLLPE
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SKVVRNDIRIGGELRVYVVSGSNMSGKSTMLRTLGVNAVLAQAGAPVRAHRLRLSPLAIG
HHHHHHHHEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHEEECCEEEC
ASIRLTDSLQGGVSRFYAEILRLRQILDETAGSLPVLFLIDEFLHGTNSHDRRIGAEALV
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
RGLVERGAIGLITTHDLALADIAEQLGERAANVHFEDQIVEGQIRFDYHMRPGVVRKSNA
HHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCHHHEEECEEEEEEECCCCCCCCCHH
IELMRQVGLEI
HHHHHHHCCCC
>Mature Secondary Structure 
TPDPRSAYTKLLAERRAEIAAREARHRRLGHAKIAVAAAGVAVVWLALSRGGGGSILWV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLPIAAFVALVVIHEKLLADLERRRRAARFFEKGLSRLDGEWAGAGESGERYNDPAHPYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LDLDLFGKGSVFELLCTARTQIGEDRLAQWLKIPAAPEVVTERQAAVEELRNRLDLREQL
EEEEECCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AILAEEARSGVDPAALAQWGEAPARLRATGFRFKVRLFTILGLAGFVALWIHLAVSASVL
HHHHHHHHCCCCHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLAPQMDALLLDFFLVALLINGWFLYRHSGEMGAAASQVEEAAHELGLLSEVLVRMEREQ
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRCPLLAGLRSSLDVEGAPPSHRLARLKRLVEYLDSRDNVFVRVLEPFLLWTPHLALKVE
HCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCEEEEEE
DWRAHSGTAVRRWLHAAGEMEALCSLASHAYEHPADPFPEFTPEGPWLEGEGLGHPLLPE
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SKVVRNDIRIGGELRVYVVSGSNMSGKSTMLRTLGVNAVLAQAGAPVRAHRLRLSPLAIG
HHHHHHHHEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHEEECCEEEC
ASIRLTDSLQGGVSRFYAEILRLRQILDETAGSLPVLFLIDEFLHGTNSHDRRIGAEALV
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
RGLVERGAIGLITTHDLALADIAEQLGERAANVHFEDQIVEGQIRFDYHMRPGVVRKSNA
HHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCHHHEEECEEEEEEECCCCCCCCCHH
IELMRQVGLEI
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA