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The map label for this gene is fabF [H]

Identifier: 116622648

GI number: 116622648

Start: 4494328

End: 4495575

Strand: Direct

Name: fabF [H]

Synonym: Acid_3547

Alternate gene names: 116622648

Gene position: 4494328-4495575 (Clockwise)

Preceding gene: 116622640

Following gene: 116622649

Centisome position: 45.1

GC content: 64.74

Gene sequence:

>1248_bases
ATGGGTTTGGAGCGGCGCGTCGTGGTGACCGGGGTCGGATTGATCAGCCCGGTCGGCATCGGCACGGAAAATACCTGGAA
AGCGATCACGGCGGGAAAGTCCGGCATCGCGTCCATTACGCAATTCGATGCCACCGACTACGATTGCCAAATCGCCGGCG
AGGTCAAGGGCTTCGACCCCACGAATTGGATTGAGCGCAAGGACGTCAAGAAGTTGGGCCGCTTCGCGCAATTCGCCGTG
GCCGCCAGCCAAATGGCGCTGACGGACGCGGGGTTGAAGATCGATGAGACCAATGCCGAGCGCGTCGGCGTACTGATCGG
CGCCGGGATCGGCGGCTTCGAAGTGATCGAGCGCGAATATCGCACGCTGATGGAGAAGGGTCCGAGCCGGATATCGCCGT
TTTTCATTCCAGCCACGATCATCAACCTGGCGGCCGGGCAGGTCTCGATCCGCACCGGCGCCAAGGGACCGAACAGCGCG
GTCGCGACGGCCTGCACCACGGGAGCGCACGCCATCGGCGATGCCTTTAAGTTGATTCAGCGGCGCGCCGCCGATGCCAT
GATCTGCGGCGGCACCGAGGCTGCGATCACGCCGCTCGGCGTCGCGGGATTCTGCGCGATGCGGGCCATGTCCACGCGCA
ACCAGGATCCGGAGAGAGCCTCGCGTCCTTGGGACCGCGACCGCGACGGCTTCGTGATCGGCGAGGGCGGTGGCATCCTG
ATTCTGGAAGAGCGTGAGAGCGCGCTGCGCCGCGGCGCCCCGATTGTCGCCGAGATCGTGGGCTACGGAATGAGCAGCGA
CGCTTATCACCTCTCCGCGCCGCTCGAGGATGGCGACGGCATTCTGCGCGTGATGCGCAATGCATTGGACGATGCGGGCC
TCGTGCCGGAGCAGATCGAATACCTGAACGCGCACGCAACTTCGACGCCGCTCGGCGATCGCGGCGAGGCGTGTGCAATC
ATGCGGCTGTTCGGCGAAACGCCGCGGCGCCTGGCGGTGAGTTCCACCAAGTCGATGACGGGCCACCTGCTGGGCGGCTC
GGGTTCGCTCGAAGCCGGACTCGCGGTGCTCGCCATCCGCGACCAGGTTGCTCCGCCTACGATCAACCTGGAGAATCGCG
ATCCGGAAATCTGGCTGGACCTGGTGCCGAAGTGCGCGCGGCCGCTGCCGATTACATACGCGATGAGTAACTCGTTTGGC
TTCGGCGGCACCAATGGCTGCCTGATCTTCCACAGCCACTCGATATAA

Upstream 100 bases:

>100_bases
TTCCCGATGCAAACCGTTGCGATCCGTTGAAGCGACTCCGGGTCAAGTGGCATCGTTTATACTGTATATGCAGTTTAGCG
CGCGAGAGGGGAATTCGTAC

Downstream 100 bases:

>100_bases
GCAGCGTGTAAGCCGGCGGGAGCCAAGGTATGATCTAAGAGGGGGATATTCACTGAATGGCAGTACCGATTTCGCAGATG
TGGAGAGTAGGCAGCTACAT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MGLERRVVVTGVGLISPVGIGTENTWKAITAGKSGIASITQFDATDYDCQIAGEVKGFDPTNWIERKDVKKLGRFAQFAV
AASQMALTDAGLKIDETNAERVGVLIGAGIGGFEVIEREYRTLMEKGPSRISPFFIPATIINLAAGQVSIRTGAKGPNSA
VATACTTGAHAIGDAFKLIQRRAADAMICGGTEAAITPLGVAGFCAMRAMSTRNQDPERASRPWDRDRDGFVIGEGGGIL
ILEERESALRRGAPIVAEIVGYGMSSDAYHLSAPLEDGDGILRVMRNALDDAGLVPEQIEYLNAHATSTPLGDRGEACAI
MRLFGETPRRLAVSSTKSMTGHLLGGSGSLEAGLAVLAIRDQVAPPTINLENRDPEIWLDLVPKCARPLPITYAMSNSFG
FGGTNGCLIFHSHSI

Sequences:

>Translated_415_residues
MGLERRVVVTGVGLISPVGIGTENTWKAITAGKSGIASITQFDATDYDCQIAGEVKGFDPTNWIERKDVKKLGRFAQFAV
AASQMALTDAGLKIDETNAERVGVLIGAGIGGFEVIEREYRTLMEKGPSRISPFFIPATIINLAAGQVSIRTGAKGPNSA
VATACTTGAHAIGDAFKLIQRRAADAMICGGTEAAITPLGVAGFCAMRAMSTRNQDPERASRPWDRDRDGFVIGEGGGIL
ILEERESALRRGAPIVAEIVGYGMSSDAYHLSAPLEDGDGILRVMRNALDDAGLVPEQIEYLNAHATSTPLGDRGEACAI
MRLFGETPRRLAVSSTKSMTGHLLGGSGSLEAGLAVLAIRDQVAPPTINLENRDPEIWLDLVPKCARPLPITYAMSNSFG
FGGTNGCLIFHSHSI
>Mature_414_residues
GLERRVVVTGVGLISPVGIGTENTWKAITAGKSGIASITQFDATDYDCQIAGEVKGFDPTNWIERKDVKKLGRFAQFAVA
ASQMALTDAGLKIDETNAERVGVLIGAGIGGFEVIEREYRTLMEKGPSRISPFFIPATIINLAAGQVSIRTGAKGPNSAV
ATACTTGAHAIGDAFKLIQRRAADAMICGGTEAAITPLGVAGFCAMRAMSTRNQDPERASRPWDRDRDGFVIGEGGGILI
LEERESALRRGAPIVAEIVGYGMSSDAYHLSAPLEDGDGILRVMRNALDDAGLVPEQIEYLNAHATSTPLGDRGEACAIM
RLFGETPRRLAVSSTKSMTGHLLGGSGSLEAGLAVLAIRDQVAPPTINLENRDPEIWLDLVPKCARPLPITYAMSNSFGF
GGTNGCLIFHSHSI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=46.7625899280576, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI223972627, Length=185, Percent_Identity=40.5405405405405, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI41872631, Length=400, Percent_Identity=25.25, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1787337, Length=408, Percent_Identity=54.4117647058823, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=36.7149758454106, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=37.3493975903614, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=42.1455938697318, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI212642053, Length=344, Percent_Identity=24.4186046511628, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=256, Percent_Identity=26.953125, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=35.0446428571429, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=44.2583732057416, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI221330659, Length=392, Percent_Identity=24.4897959183673, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI19920632, Length=392, Percent_Identity=24.4897959183673, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581345, Length=370, Percent_Identity=22.7027027027027, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43900; Mature: 43768

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLERRVVVTGVGLISPVGIGTENTWKAITAGKSGIASITQFDATDYDCQIAGEVKGFDP
CCCCCEEEEEECCHHCCCCCCCCCCCEEEECCCCCCCHHEECCCCCCCEEEECCCCCCCC
TNWIERKDVKKLGRFAQFAVAASQMALTDAGLKIDETNAERVGVLIGAGIGGFEVIEREY
CCHHHHHHHHHHHHHHHHHHHHHHHHHECCCCEEECCCCCEEEEEEECCCCHHHHHHHHH
RTLMEKGPSRISPFFIPATIINLAAGQVSIRTGAKGPNSAVATACTTGAHAIGDAFKLIQ
HHHHHCCCCCCCCEEHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHH
RRAADAMICGGTEAAITPLGVAGFCAMRAMSTRNQDPERASRPWDRDRDGFVIGEGGGIL
HHCCCEEEECCCCHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEECCCCEE
ILEERESALRRGAPIVAEIVGYGMSSDAYHLSAPLEDGDGILRVMRNALDDAGLVPEQIE
EECCHHHHHHCCCCHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHH
YLNAHATSTPLGDRGEACAIMRLFGETPRRLAVSSTKSMTGHLLGGSGSLEAGLAVLAIR
HHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEEEE
DQVAPPTINLENRDPEIWLDLVPKCARPLPITYAMSNSFGFGGTNGCLIFHSHSI
CCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure 
GLERRVVVTGVGLISPVGIGTENTWKAITAGKSGIASITQFDATDYDCQIAGEVKGFDP
CCCCEEEEEECCHHCCCCCCCCCCCEEEECCCCCCCHHEECCCCCCCEEEECCCCCCCC
TNWIERKDVKKLGRFAQFAVAASQMALTDAGLKIDETNAERVGVLIGAGIGGFEVIEREY
CCHHHHHHHHHHHHHHHHHHHHHHHHHECCCCEEECCCCCEEEEEEECCCCHHHHHHHHH
RTLMEKGPSRISPFFIPATIINLAAGQVSIRTGAKGPNSAVATACTTGAHAIGDAFKLIQ
HHHHHCCCCCCCCEEHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHH
RRAADAMICGGTEAAITPLGVAGFCAMRAMSTRNQDPERASRPWDRDRDGFVIGEGGGIL
HHCCCEEEECCCCHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEECCCCEE
ILEERESALRRGAPIVAEIVGYGMSSDAYHLSAPLEDGDGILRVMRNALDDAGLVPEQIE
EECCHHHHHHCCCCHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHH
YLNAHATSTPLGDRGEACAIMRLFGETPRRLAVSSTKSMTGHLLGGSGSLEAGLAVLAIR
HHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEEEE
DQVAPPTINLENRDPEIWLDLVPKCARPLPITYAMSNSFGFGGTNGCLIFHSHSI
CCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]