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The map label for this gene is pepP [H]

Identifier: 116622638

GI number: 116622638

Start: 4481802

End: 4483211

Strand: Reverse

Name: pepP [H]

Synonym: Acid_3537

Alternate gene names: 116622638

Gene position: 4483211-4481802 (Counterclockwise)

Preceding gene: 116622641

Following gene: 116622637

Centisome position: 44.99

GC content: 62.34

Gene sequence:

>1410_bases
ATGCATTATTTCGCCCTCCTCCTCATTGGTCTGCCGCTGGCCGGACAGCCCGTGTTCACCGACGTCTTTCCGCGCGACGA
ATATGCGGCTCGCCGCGCGCGCGTGATGGCGAAACTGGGCGACGGCGTTGCCATCATTCAGGGCACAACGGAGCGCCCCG
GAGAACAGCCGCTCCGCCAGGCCAACCAGTTCTTCTACATCTCGGGCGTCGTGGAACCGCGCGCGATCCTCATCGTCGAT
GGCAAAACGCACATCTCCACGCTCTTCCTGAATCCGCGCAACGAACGCCGCGAGACCATGATGTTCGGGCCCGGTCTCTA
CCCCGGCGAGGACGCGGTGCGCTCCACCGGCATCGAAGCCGTCCTGCAGCGCAGCGAGTTTCAATCGGCGCTCGAGGCGA
TCGCCAAAGAAGGCCGCACCATCTACACGCCTTTCCGGCCCGAAGTGCTGGGATGCGCCTCCGCCAGCGACCCCATCGCG
CTCGCCCGCGCCACAAAGAGCGATCCCTGGGATGGACGCGCCTCGCGCGAGGAGGCCTTCATCGAACATGTCAAAGCGGC
CGCCCCGAAATCCGCAATCGAAAATCTCGATCCGATTCTCGACGAGTTGCGCGGCACCAAGAGCCCGCGCGAAATCGCCA
TCATTCGCGAGGCCACCCGCATCGCCGGACTCGGCATCATCGAGGCCATGCGCGACGCCCGCCCCGGCATGAAGGAGTAC
GAGCTGCAGGCCGACGCCGAGTACGTCTTCAAGAAGTACGGCGCCTACGGTCCCAGTTACTTCGCCCTGATCGCCACCGG
CGAGAACACCTGGTACTCGCACTATCACAAGAACACCCGCGCGCTCGACGCCGGCGACCTGGTGCAGTTCGATTACGCGC
CCGATTTCAAATACTATTCCAGCGATGTCACGCGTGTCTTTCCCGCCGGAGGGAAATTCTCTCCGCGCCAGCGCGAGTTC
TATACGATTTATCTGCGCCTCTACCAGGCATTGATGACTTCGATCCAGGTACACGCGCGCCCCGCCGACATCATTAAACA
CGCCGTCGTCAAAATGGACACCGTAATGTCCAAATTCACCTTCACCGACGCCACCATCAAGCAGGCTGCCACCACGTTCG
TGGAGCGGTATCGCAACAGCCGCGCCAATTCGCTCGGCCACAGTGTCGGCATGGAAGTCCACGATGTCCGCAACCCGACC
GACACCCTGGAGCCCGGACAGATCTTCACCATCGAGCCCGCCATGCTGATCCCGGCCGAACACGTCGGCATCCGCCTGGA
AGACATGATCCTCATCACCGAGTCCGGCTACGAGAACCTCTCCGCGTTTGTGCCGGTGGAGATCGCCGATATCGAAAAGA
TGATGACCCGCCACGGCCTCAGCGACGCGCAGGTACAGCTCAAGAAATAG

Upstream 100 bases:

>100_bases
CGGTGCTCTGAGTCGTAGTTGCCATGGTGGATACTCTTATTATATCGTAGCGTCACCGAATTTAAGTAAGCGCTTTCAGA
GTGCATCGGGAAAAACTTAC

Downstream 100 bases:

>100_bases
TGGCAGTAGCCATTCCACTTAGCCGCTTCGGTTAGTCGGATTTACTTCTAAGAAACGGATTAGAAACCATTGCCGGGCTG
CTCAACCGGATGTATACTCC

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MHYFALLLIGLPLAGQPVFTDVFPRDEYAARRARVMAKLGDGVAIIQGTTERPGEQPLRQANQFFYISGVVEPRAILIVD
GKTHISTLFLNPRNERRETMMFGPGLYPGEDAVRSTGIEAVLQRSEFQSALEAIAKEGRTIYTPFRPEVLGCASASDPIA
LARATKSDPWDGRASREEAFIEHVKAAAPKSAIENLDPILDELRGTKSPREIAIIREATRIAGLGIIEAMRDARPGMKEY
ELQADAEYVFKKYGAYGPSYFALIATGENTWYSHYHKNTRALDAGDLVQFDYAPDFKYYSSDVTRVFPAGGKFSPRQREF
YTIYLRLYQALMTSIQVHARPADIIKHAVVKMDTVMSKFTFTDATIKQAATTFVERYRNSRANSLGHSVGMEVHDVRNPT
DTLEPGQIFTIEPAMLIPAEHVGIRLEDMILITESGYENLSAFVPVEIADIEKMMTRHGLSDAQVQLKK

Sequences:

>Translated_469_residues
MHYFALLLIGLPLAGQPVFTDVFPRDEYAARRARVMAKLGDGVAIIQGTTERPGEQPLRQANQFFYISGVVEPRAILIVD
GKTHISTLFLNPRNERRETMMFGPGLYPGEDAVRSTGIEAVLQRSEFQSALEAIAKEGRTIYTPFRPEVLGCASASDPIA
LARATKSDPWDGRASREEAFIEHVKAAAPKSAIENLDPILDELRGTKSPREIAIIREATRIAGLGIIEAMRDARPGMKEY
ELQADAEYVFKKYGAYGPSYFALIATGENTWYSHYHKNTRALDAGDLVQFDYAPDFKYYSSDVTRVFPAGGKFSPRQREF
YTIYLRLYQALMTSIQVHARPADIIKHAVVKMDTVMSKFTFTDATIKQAATTFVERYRNSRANSLGHSVGMEVHDVRNPT
DTLEPGQIFTIEPAMLIPAEHVGIRLEDMILITESGYENLSAFVPVEIADIEKMMTRHGLSDAQVQLKK
>Mature_469_residues
MHYFALLLIGLPLAGQPVFTDVFPRDEYAARRARVMAKLGDGVAIIQGTTERPGEQPLRQANQFFYISGVVEPRAILIVD
GKTHISTLFLNPRNERRETMMFGPGLYPGEDAVRSTGIEAVLQRSEFQSALEAIAKEGRTIYTPFRPEVLGCASASDPIA
LARATKSDPWDGRASREEAFIEHVKAAAPKSAIENLDPILDELRGTKSPREIAIIREATRIAGLGIIEAMRDARPGMKEY
ELQADAEYVFKKYGAYGPSYFALIATGENTWYSHYHKNTRALDAGDLVQFDYAPDFKYYSSDVTRVFPAGGKFSPRQREF
YTIYLRLYQALMTSIQVHARPADIIKHAVVKMDTVMSKFTFTDATIKQAATTFVERYRNSRANSLGHSVGMEVHDVRNPT
DTLEPGQIFTIEPAMLIPAEHVGIRLEDMILITESGYENLSAFVPVEIADIEKMMTRHGLSDAQVQLKK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=465, Percent_Identity=26.0215053763441, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI149589008, Length=449, Percent_Identity=25.6124721603563, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI260593665, Length=344, Percent_Identity=26.1627906976744, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI260593663, Length=333, Percent_Identity=23.7237237237237, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1789275, Length=459, Percent_Identity=30.9368191721133, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI1788728, Length=252, Percent_Identity=28.968253968254, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=501, Percent_Identity=24.750499001996, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71989583, Length=282, Percent_Identity=24.468085106383, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320922, Length=469, Percent_Identity=25.7995735607676, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321118, Length=461, Percent_Identity=23.644251626898, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920384, Length=399, Percent_Identity=25.5639097744361, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI21357079, Length=453, Percent_Identity=27.5938189845475, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 52438; Mature: 52438

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYFALLLIGLPLAGQPVFTDVFPRDEYAARRARVMAKLGDGVAIIQGTTERPGEQPLRQ
CHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
ANQFFYISGVVEPRAILIVDGKTHISTLFLNPRNERRETMMFGPGLYPGEDAVRSTGIEA
CCCEEEEEEECCCEEEEEECCCCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHH
VLQRSEFQSALEAIAKEGRTIYTPFRPEVLGCASASDPIALARATKSDPWDGRASREEAF
HHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCHHHHH
IEHVKAAAPKSAIENLDPILDELRGTKSPREIAIIREATRIAGLGIIEAMRDARPGMKEY
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHH
ELQADAEYVFKKYGAYGPSYFALIATGENTWYSHYHKNTRALDAGDLVQFDYAPDFKYYS
HHHCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCEEEECCCCCCHHHC
SDVTRVFPAGGKFSPRQREFYTIYLRLYQALMTSIQVHARPADIIKHAVVKMDTVMSKFT
CCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FTDATIKQAATTFVERYRNSRANSLGHSVGMEVHDVRNPTDTLEPGQIFTIEPAMLIPAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEECCCEECCHH
HVGIRLEDMILITESGYENLSAFVPVEIADIEKMMTRHGLSDAQVQLKK
HCCEEEEEEEEEECCCCCCCCEECCEEHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MHYFALLLIGLPLAGQPVFTDVFPRDEYAARRARVMAKLGDGVAIIQGTTERPGEQPLRQ
CHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
ANQFFYISGVVEPRAILIVDGKTHISTLFLNPRNERRETMMFGPGLYPGEDAVRSTGIEA
CCCEEEEEEECCCEEEEEECCCCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHH
VLQRSEFQSALEAIAKEGRTIYTPFRPEVLGCASASDPIALARATKSDPWDGRASREEAF
HHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCHHHHH
IEHVKAAAPKSAIENLDPILDELRGTKSPREIAIIREATRIAGLGIIEAMRDARPGMKEY
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHH
ELQADAEYVFKKYGAYGPSYFALIATGENTWYSHYHKNTRALDAGDLVQFDYAPDFKYYS
HHHCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCEEEECCCCCCHHHC
SDVTRVFPAGGKFSPRQREFYTIYLRLYQALMTSIQVHARPADIIKHAVVKMDTVMSKFT
CCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FTDATIKQAATTFVERYRNSRANSLGHSVGMEVHDVRNPTDTLEPGQIFTIEPAMLIPAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEECCCEECCHH
HVGIRLEDMILITESGYENLSAFVPVEIADIEKMMTRHGLSDAQVQLKK
HCCEEEEEEEEEECCCCCCCCEECCEEHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]