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The map label for this gene is aroE [H]

Identifier: 116622630

GI number: 116622630

Start: 4468608

End: 4469465

Strand: Reverse

Name: aroE [H]

Synonym: Acid_3529

Alternate gene names: 116622630

Gene position: 4469465-4468608 (Counterclockwise)

Preceding gene: 116622631

Following gene: 116622619

Centisome position: 44.85

GC content: 67.6

Gene sequence:

>858_bases
ATGCCCGCGAACTTCAAGGCGGAACTTGTCGCCTGCTTCGGCCAGCCTGTCGCGGAGAATCCGACGGGCGCGATGCAGGA
AGCCGCCTTTCGCGCGATGGGCCTGAACTGGCGGTACCTCACCGTCGAGGTGTCACCCGAGAATCTCGCCGACGCCATCC
GCGGCGCCCGCGCCTTCGGCATGCGGGGCCTCAATCTCACTATTCCGCACAAGGTCGCGGTGATTCCGCTGTTGGACGAA
ATCGCACCCGATGCCGCCGTCATCGGCGCCGTGAACACAGTGCGCTTCGATGGCCGCCGGCTCATCGGCGAAAACACCGA
TGGCAAGGGCTTCCTTCGCGGTGTCCGCGTGGATGCCGGCTTGGATCCCAGGGGCAAGCGCGCCATCGTGCTCGGAGCCG
GCGGCGCCGCGCGCGCCATCGTCACCGAACTGGCGCTCGCCGGCGTCGATGATCTCCTCGTCGTCAACCGCTCCGCCGAG
CGCGCCTGGCGCATGACGGAAGAGATCGCCATCCGGACGAAGCACCACATCCGCTGCCAGCCGTGGCGCGGCACCTATCG
CGTCCCCGCCGACACCGACATCCTGGTAAACGCTACGTCGATCGGCCTCTACCCCGATGTGGACGCGATGCCGCCGGTGG
ACCTGCGCGAAGCGCAACCCGGATTGCTGGTCTGCGACGCGGTTTTCAATCCGCCCGAGACCCGCCTCCTGGCCGCCGCC
CGCGAACTCGGCCTGCCAACCCTTGACGGCCTCTCCATGCTCGTCTATCAAGGCGTCATCGGCTGCCGCCTCTGGACCGG
CCAGGATCCCCCGGAAGACGTCATGAAGCATGCCCTCCGACAGGCGTTGGGCCTCTGA

Upstream 100 bases:

>100_bases
GATCTGCCCGCCGTCAATCAGCAGGTCACGGCCAAGAGCCTGAAGCCGCTCGAGGTCACCACCACGGAATCCAAGCCGGC
GCCCGTGGTCCCGTAGCAAG

Downstream 100 bases:

>100_bases
CCCTCGTGTACTACTATGCGCCCTAACGAACTACCTTTTCCACACCCGAGCCCGGTTCCGAGCCGTGACCGTCAGGGAGC
GGTCGCTAATTTGGCATTGT

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPANFKAELVACFGQPVAENPTGAMQEAAFRAMGLNWRYLTVEVSPENLADAIRGARAFGMRGLNLTIPHKVAVIPLLDE
IAPDAAVIGAVNTVRFDGRRLIGENTDGKGFLRGVRVDAGLDPRGKRAIVLGAGGAARAIVTELALAGVDDLLVVNRSAE
RAWRMTEEIAIRTKHHIRCQPWRGTYRVPADTDILVNATSIGLYPDVDAMPPVDLREAQPGLLVCDAVFNPPETRLLAAA
RELGLPTLDGLSMLVYQGVIGCRLWTGQDPPEDVMKHALRQALGL

Sequences:

>Translated_285_residues
MPANFKAELVACFGQPVAENPTGAMQEAAFRAMGLNWRYLTVEVSPENLADAIRGARAFGMRGLNLTIPHKVAVIPLLDE
IAPDAAVIGAVNTVRFDGRRLIGENTDGKGFLRGVRVDAGLDPRGKRAIVLGAGGAARAIVTELALAGVDDLLVVNRSAE
RAWRMTEEIAIRTKHHIRCQPWRGTYRVPADTDILVNATSIGLYPDVDAMPPVDLREAQPGLLVCDAVFNPPETRLLAAA
RELGLPTLDGLSMLVYQGVIGCRLWTGQDPPEDVMKHALRQALGL
>Mature_284_residues
PANFKAELVACFGQPVAENPTGAMQEAAFRAMGLNWRYLTVEVSPENLADAIRGARAFGMRGLNLTIPHKVAVIPLLDEI
APDAAVIGAVNTVRFDGRRLIGENTDGKGFLRGVRVDAGLDPRGKRAIVLGAGGAARAIVTELALAGVDDLLVVNRSAER
AWRMTEEIAIRTKHHIRCQPWRGTYRVPADTDILVNATSIGLYPDVDAMPPVDLREAQPGLLVCDAVFNPPETRLLAAAR
ELGLPTLDGLSMLVYQGVIGCRLWTGQDPPEDVMKHALRQALGL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=286, Percent_Identity=33.2167832167832, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789675, Length=279, Percent_Identity=29.7491039426523, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320332, Length=277, Percent_Identity=25.9927797833935, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 30711; Mature: 30580

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPANFKAELVACFGQPVAENPTGAMQEAAFRAMGLNWRYLTVEVSPENLADAIRGARAFG
CCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHC
MRGLNLTIPHKVAVIPLLDEIAPDAAVIGAVNTVRFDGRRLIGENTDGKGFLRGVRVDAG
CCCCEEECCCEEEEEEHHHHHCCCCEEEECEEEEEECCEEEECCCCCCCCEEEEEEECCC
LDPRGKRAIVLGAGGAARAIVTELALAGVDDLLVVNRSAERAWRMTEEIAIRTKHHIRCQ
CCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEE
PWRGTYRVPADTDILVNATSIGLYPDVDAMPPVDLREAQPGLLVCDAVFNPPETRLLAAA
CCCCCEECCCCCEEEEEEEEECCCCCCCCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHH
RELGLPTLDGLSMLVYQGVIGCRLWTGQDPPEDVMKHALRQALGL
HHHCCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PANFKAELVACFGQPVAENPTGAMQEAAFRAMGLNWRYLTVEVSPENLADAIRGARAFG
CCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHC
MRGLNLTIPHKVAVIPLLDEIAPDAAVIGAVNTVRFDGRRLIGENTDGKGFLRGVRVDAG
CCCCEEECCCEEEEEEHHHHHCCCCEEEECEEEEEECCEEEECCCCCCCCEEEEEEECCC
LDPRGKRAIVLGAGGAARAIVTELALAGVDDLLVVNRSAERAWRMTEEIAIRTKHHIRCQ
CCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEE
PWRGTYRVPADTDILVNATSIGLYPDVDAMPPVDLREAQPGLLVCDAVFNPPETRLLAAA
CCCCCEECCCCCEEEEEEEEECCCCCCCCCCCCCHHCCCCCEEEEECCCCCCHHHHHHHH
RELGLPTLDGLSMLVYQGVIGCRLWTGQDPPEDVMKHALRQALGL
HHHCCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]