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The map label for this gene is luxQ [H]

Identifier: 116622396

GI number: 116622396

Start: 4161619

End: 4163451

Strand: Direct

Name: luxQ [H]

Synonym: Acid_3290

Alternate gene names: 116622396

Gene position: 4161619-4163451 (Clockwise)

Preceding gene: 116622395

Following gene: 116622397

Centisome position: 41.76

GC content: 58.76

Gene sequence:

>1833_bases
ATGATACAGCGCGTCAGGCTGGTCATCGGGCTTCGAGGTTCGCTTGCCGCCGATCAGACGGCAAGAATGTTGCACGTTCT
CCTCGCAACTCTTCTCCTGTGGATGGCAGCGGGTTTCGTCTCCACGATACCGTTCGCTCCGATGAGCTTCCCACGGATAT
TCAATTCGCTCGTCCTGGAAGTGTGTTACGCCACCGCACTGGTGTTGCTCCGGCTCGGTCACTTTCGGCGCGCCAGTCGG
GCCTATCTCGCAGGCACTTGGATCTGGGCAACGCTCGTCTGCTCTTCCTACGGGGGTGTACGCAGCCCGGGAGCGCTGCT
CTACGTGTCCATGCCAGCCTCGGCGGCATGGCTGCTCGGATCCACAGCCGCCATAAGGACAGCGGGTGGATGCCTGCTCA
GCGCGTTGGTATTCACGGTTCTGGAGATGACGCATGGTCTTCCTCTCCAGCGTATGGCAACGCCGCTCGGGACCTGGAAC
ATCGTCGTTCAAGCCGTCCTGATCAATGCCATCCCGGTGGGAGAGATCATCGGCAGGCTGCGGGAGACGCTTCAGGAATT
ACAGCGGCATCAGCAGCACCTTGCGTCGCTGGTTGATCAACGCACGCAGCAAGTTGTTGAGGCGCGCGACCAGGCGGAAT
CCGCCAACCGGGCCAAGAGCGCCTTCCTGGCCAATATGAGCCACGAACTTCGTACGCCCCTCAGTGTCATACTGGCATCT
TCCGACCTCCTGAACGAGAGTGACCCAACACCCGATCAGCGTGAAGACATCGCCAGGATCAGCCACAGCGGCAAGCATCT
CCTGGGACTGATCGATGACGTGCTGGATGTCGCCAAAATCGAGGCTGGCAAAGAGGATCTAGCAATCGCAGCCAGCGATT
TGATCTCCACGGTGCGAACGGTCGTTGAAATGATGCGCGTACGGGCGGAGGAGAAGTGCCTCTCGCTCGTTTACTATCAA
GCTCCTGATGTTCCGCGCTACGTTCGCGTAGATGCACCGAAATTGCGGCAAATTCTCATTAACCTGCTCGGCAATGCCAT
CAAGTTCACAAGAAAGGGAACCGTAAAGCTACAGTTGAGCGCCAAGACCGGTGCCGAACCCGGGCTCGCCCGCTTTTCTT
TCGATATTGAGGACAGCGGAGTGGGGATGCCACAACATCACTTAGGCCGCATATTCGAGCCGTTCGAGGTGAGCAATCCT
GGCCCACAGACGGGCACAGGCCTAGGCCTGACAATTACTCAGCGATTTGTAGAACTGATGGGCGGGACGCTGGTGGTTAA
GAGTGACGTGGGTCGAGGATCACGTTTTGAGGTCGAACTGCCGCTGGAACTGGCAAAGGAGTCGGAGACTTACGGCGCAG
AACTGGCACCAGGGCACGCCTTCATCCTGGAATCGGGCCAACCGGAGTGGCGCGTTCTGATTGTCGAAGACGACCTTGAA
AGCGCCACGGTCTTGCGGAAGATGCTCACTCGCGCAGGATTTCAGGTGAGAGTTGCGGACAATGGAGCACTCGGAATAGA
GGCTTTCCAGGAGTGGCGGCCGCACTTTATCTGGATGGACCTGGATCTAGCCGAGGCGAGTGGCACGGAAGCGACACGGC
GGATTCGCCTGTTGGACGGAGGAGCGGACGTTAAAATCGCCGCCATTACCGCGGCTGCGGATGCTTCGGACCGTGACGAA
GTAATGCACGCCGGCTTTGACGACTTCACTTTCAAGCCATTTCGCCAGACAACAATCTTCTTCTGCATAGCGCGCCACCT
GGGTGTGCGCTATGCGTCTTCGGAAGGGGCAGGAAATGAGTCGCGGCAGCAAGCCGGGGGTCGTCCGGGGTGA

Upstream 100 bases:

>100_bases
TGTTTCACCGAAGTCCGCGGAATTCTGTATCATCAATAGTTAATGCGTTGACTCGGGGCTTAAGGGAGGATTTTTGAGGT
TTAGGCGCTACCTCTCGGGG

Downstream 100 bases:

>100_bases
GTTTTGTGCGGTGCTTCACCAAGCCCCTTATCTAAAGCGATACCTCCAACTGCGAACCTCCTCCTTTCCACCTTATTATT
TTCGTACTTCGACCCCGATT

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MIQRVRLVIGLRGSLAADQTARMLHVLLATLLLWMAAGFVSTIPFAPMSFPRIFNSLVLEVCYATALVLLRLGHFRRASR
AYLAGTWIWATLVCSSYGGVRSPGALLYVSMPASAAWLLGSTAAIRTAGGCLLSALVFTVLEMTHGLPLQRMATPLGTWN
IVVQAVLINAIPVGEIIGRLRETLQELQRHQQHLASLVDQRTQQVVEARDQAESANRAKSAFLANMSHELRTPLSVILAS
SDLLNESDPTPDQREDIARISHSGKHLLGLIDDVLDVAKIEAGKEDLAIAASDLISTVRTVVEMMRVRAEEKCLSLVYYQ
APDVPRYVRVDAPKLRQILINLLGNAIKFTRKGTVKLQLSAKTGAEPGLARFSFDIEDSGVGMPQHHLGRIFEPFEVSNP
GPQTGTGLGLTITQRFVELMGGTLVVKSDVGRGSRFEVELPLELAKESETYGAELAPGHAFILESGQPEWRVLIVEDDLE
SATVLRKMLTRAGFQVRVADNGALGIEAFQEWRPHFIWMDLDLAEASGTEATRRIRLLDGGADVKIAAITAAADASDRDE
VMHAGFDDFTFKPFRQTTIFFCIARHLGVRYASSEGAGNESRQQAGGRPG

Sequences:

>Translated_610_residues
MIQRVRLVIGLRGSLAADQTARMLHVLLATLLLWMAAGFVSTIPFAPMSFPRIFNSLVLEVCYATALVLLRLGHFRRASR
AYLAGTWIWATLVCSSYGGVRSPGALLYVSMPASAAWLLGSTAAIRTAGGCLLSALVFTVLEMTHGLPLQRMATPLGTWN
IVVQAVLINAIPVGEIIGRLRETLQELQRHQQHLASLVDQRTQQVVEARDQAESANRAKSAFLANMSHELRTPLSVILAS
SDLLNESDPTPDQREDIARISHSGKHLLGLIDDVLDVAKIEAGKEDLAIAASDLISTVRTVVEMMRVRAEEKCLSLVYYQ
APDVPRYVRVDAPKLRQILINLLGNAIKFTRKGTVKLQLSAKTGAEPGLARFSFDIEDSGVGMPQHHLGRIFEPFEVSNP
GPQTGTGLGLTITQRFVELMGGTLVVKSDVGRGSRFEVELPLELAKESETYGAELAPGHAFILESGQPEWRVLIVEDDLE
SATVLRKMLTRAGFQVRVADNGALGIEAFQEWRPHFIWMDLDLAEASGTEATRRIRLLDGGADVKIAAITAAADASDRDE
VMHAGFDDFTFKPFRQTTIFFCIARHLGVRYASSEGAGNESRQQAGGRPG
>Mature_610_residues
MIQRVRLVIGLRGSLAADQTARMLHVLLATLLLWMAAGFVSTIPFAPMSFPRIFNSLVLEVCYATALVLLRLGHFRRASR
AYLAGTWIWATLVCSSYGGVRSPGALLYVSMPASAAWLLGSTAAIRTAGGCLLSALVFTVLEMTHGLPLQRMATPLGTWN
IVVQAVLINAIPVGEIIGRLRETLQELQRHQQHLASLVDQRTQQVVEARDQAESANRAKSAFLANMSHELRTPLSVILAS
SDLLNESDPTPDQREDIARISHSGKHLLGLIDDVLDVAKIEAGKEDLAIAASDLISTVRTVVEMMRVRAEEKCLSLVYYQ
APDVPRYVRVDAPKLRQILINLLGNAIKFTRKGTVKLQLSAKTGAEPGLARFSFDIEDSGVGMPQHHLGRIFEPFEVSNP
GPQTGTGLGLTITQRFVELMGGTLVVKSDVGRGSRFEVELPLELAKESETYGAELAPGHAFILESGQPEWRVLIVEDDLE
SATVLRKMLTRAGFQVRVADNGALGIEAFQEWRPHFIWMDLDLAEASGTEATRRIRLLDGGADVKIAAITAAADASDRDE
VMHAGFDDFTFKPFRQTTIFFCIARHLGVRYASSEGAGNESRQQAGGRPG

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=373, Percent_Identity=33.5120643431635, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI48994928, Length=373, Percent_Identity=30.8310991957105, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1789149, Length=268, Percent_Identity=38.0597014925373, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788713, Length=373, Percent_Identity=30.5630026809651, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI145693157, Length=263, Percent_Identity=34.2205323193916, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=28.6852589641434, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=29.9212598425197, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=26.5060240963855, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=29.004329004329, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=30.2521008403361, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=28.5046728971963, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=23.6607142857143, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1786783, Length=229, Percent_Identity=25.764192139738, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=26.4069264069264, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66594; Mature: 66594

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQRVRLVIGLRGSLAADQTARMLHVLLATLLLWMAAGFVSTIPFAPMSFPRIFNSLVLE
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VCYATALVLLRLGHFRRASRAYLAGTWIWATLVCSSYGGVRSPGALLYVSMPASAAWLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHC
STAAIRTAGGCLLSALVFTVLEMTHGLPLQRMATPLGTWNIVVQAVLINAIPVGEIIGRL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHH
RETLQELQRHQQHLASLVDQRTQQVVEARDQAESANRAKSAFLANMSHELRTPLSVILAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SDLLNESDPTPDQREDIARISHSGKHLLGLIDDVLDVAKIEAGKEDLAIAASDLISTVRT
HHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VVEMMRVRAEEKCLSLVYYQAPDVPRYVRVDAPKLRQILINLLGNAIKFTRKGTVKLQLS
HHHHHHHHHHHHHHHHHEECCCCCCCEEECCCHHHHHHHHHHHHHHHEEECCCEEEEEEE
AKTGAEPGLARFSFDIEDSGVGMPQHHLGRIFEPFEVSNPGPQTGTGLGLTITQRFVELM
CCCCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GGTLVVKSDVGRGSRFEVELPLELAKESETYGAELAPGHAFILESGQPEWRVLIVEDDLE
CCEEEEEECCCCCCEEEEECCHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCH
SATVLRKMLTRAGFQVRVADNGALGIEAFQEWRPHFIWMDLDLAEASGTEATRRIRLLDG
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCEEEEEEEEECCCCCCCHHEEEEEEEC
GADVKIAAITAAADASDRDEVMHAGFDDFTFKPFRQTTIFFCIARHLGVRYASSEGAGNE
CCCEEEEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCC
SRQQAGGRPG
HHHHCCCCCC
>Mature Secondary Structure
MIQRVRLVIGLRGSLAADQTARMLHVLLATLLLWMAAGFVSTIPFAPMSFPRIFNSLVLE
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VCYATALVLLRLGHFRRASRAYLAGTWIWATLVCSSYGGVRSPGALLYVSMPASAAWLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHC
STAAIRTAGGCLLSALVFTVLEMTHGLPLQRMATPLGTWNIVVQAVLINAIPVGEIIGRL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHH
RETLQELQRHQQHLASLVDQRTQQVVEARDQAESANRAKSAFLANMSHELRTPLSVILAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SDLLNESDPTPDQREDIARISHSGKHLLGLIDDVLDVAKIEAGKEDLAIAASDLISTVRT
HHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VVEMMRVRAEEKCLSLVYYQAPDVPRYVRVDAPKLRQILINLLGNAIKFTRKGTVKLQLS
HHHHHHHHHHHHHHHHHEECCCCCCCEEECCCHHHHHHHHHHHHHHHEEECCCEEEEEEE
AKTGAEPGLARFSFDIEDSGVGMPQHHLGRIFEPFEVSNPGPQTGTGLGLTITQRFVELM
CCCCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GGTLVVKSDVGRGSRFEVELPLELAKESETYGAELAPGHAFILESGQPEWRVLIVEDDLE
CCEEEEEECCCCCCEEEEECCHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCH
SATVLRKMLTRAGFQVRVADNGALGIEAFQEWRPHFIWMDLDLAEASGTEATRRIRLLDG
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCEEEEEEEEECCCCCCCHHEEEEEEEC
GADVKIAAITAAADASDRDEVMHAGFDDFTFKPFRQTTIFFCIARHLGVRYASSEGAGNE
CCCEEEEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCC
SRQQAGGRPG
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]