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The map label for this gene is yhdN [H]

Identifier: 116622375

GI number: 116622375

Start: 4135609

End: 4136592

Strand: Direct

Name: yhdN [H]

Synonym: Acid_3269

Alternate gene names: 116622375

Gene position: 4135609-4136592 (Clockwise)

Preceding gene: 116622374

Following gene: 116622376

Centisome position: 41.5

GC content: 63.11

Gene sequence:

>984_bases
ATGACATTACGGACACTGGGTCAGACCGATTTGAAGATCACACCGATTGGAATCGGAGCTTGGGCAATCGGCGGGGGAAA
GTGGGAATTCGCGTGGGGTCATCAGGATGACGCGCAATCGGTCGCCGCCATCCGCGCAGCCCTCGATCGCGGCATGAACT
GGATCGATACCGCGGCCGTGTACGGGCTCGGACATTCGGAGACCGTGGTGGCCCGCGCTATCGCGGGGCTCACGCAGCGC
CCCCACGTGTTCACGAAATGCAGCCTGGTGTGGGATGACTCCGGAAAGATCTCGCATAACCTGCAGGCCGCTTCCATCCG
GTGCGAATGTGAAGCCAGCTTGAAACGGCTGGAAGTCGATGCGATCGACCTCTATCAGATTCACTGGCCGGCCTGGAACG
GAGCTCCGGAAAGCGCGTCGCCGGGGTCGATCGAAGAGGCCGTCGGCGCGATGGAAAGACTCAGGGCCGAAGGCAAGATC
CGTCACATTGGAGTTTCGAATTTCAATGCCCGCCAGCTCCAGCGCGCCATGGACGTGGCCCCGATTACGTCCCTCCAACC
GCCCTATTCGCTGCTCGCGACCGATGTAGAGACGTCGGTCCTGCCCTTCGCCCTGAAACACCGGATCGGTGTCATCGTTT
ACTCTCCCATGGCGTCCGGCCTGCTCACCGGCGCGATGACGCGCGAACGGATCGCCGCCCTTCCCGACGACGACTGGCGC
AAGCGCAGCGCGAATTTCCAGGAGCCCATGCTCTCGCGCAATCTGCGGCTGGTGGAGAAGCTGGGCGCGGTCGGACGGCG
CTACAACGTGACGCCCGCGCAGATAGCGATCGCGTGGACGCTGCGCAATCCCGCGGTGACGGGCGCAATCATCGGTGTTC
GCAGCGCCGAACAGGTTCAGGGAATTGCCGGAGCCGCCGACGTTCAGCTCAGCGCCGACGATATGTCGGATATCGAAAAA
GCGCTGCCGATGCAGGCGGCCTGA

Upstream 100 bases:

>100_bases
TCCGGGCTCACGAAATCTTTCAATCGGCCCCGCCGATTTTCGCATCCTTTGCGGCACGGAGGTTCCGTATGGGACCCGGC
GCAGGGAGAGGAGACCCGAC

Downstream 100 bases:

>100_bases
CCCGTGAGATTGGAAAAGCTCTCCCGGCTCGCGGCGGTTGCGGCTGCGATTCTGCTGATGGCTGCCGGAACCAGCGATCG
TGACCGCATTCCCGCCGCGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTLRTLGQTDLKITPIGIGAWAIGGGKWEFAWGHQDDAQSVAAIRAALDRGMNWIDTAAVYGLGHSETVVARAIAGLTQR
PHVFTKCSLVWDDSGKISHNLQAASIRCECEASLKRLEVDAIDLYQIHWPAWNGAPESASPGSIEEAVGAMERLRAEGKI
RHIGVSNFNARQLQRAMDVAPITSLQPPYSLLATDVETSVLPFALKHRIGVIVYSPMASGLLTGAMTRERIAALPDDDWR
KRSANFQEPMLSRNLRLVEKLGAVGRRYNVTPAQIAIAWTLRNPAVTGAIIGVRSAEQVQGIAGAADVQLSADDMSDIEK
ALPMQAA

Sequences:

>Translated_327_residues
MTLRTLGQTDLKITPIGIGAWAIGGGKWEFAWGHQDDAQSVAAIRAALDRGMNWIDTAAVYGLGHSETVVARAIAGLTQR
PHVFTKCSLVWDDSGKISHNLQAASIRCECEASLKRLEVDAIDLYQIHWPAWNGAPESASPGSIEEAVGAMERLRAEGKI
RHIGVSNFNARQLQRAMDVAPITSLQPPYSLLATDVETSVLPFALKHRIGVIVYSPMASGLLTGAMTRERIAALPDDDWR
KRSANFQEPMLSRNLRLVEKLGAVGRRYNVTPAQIAIAWTLRNPAVTGAIIGVRSAEQVQGIAGAADVQLSADDMSDIEK
ALPMQAA
>Mature_326_residues
TLRTLGQTDLKITPIGIGAWAIGGGKWEFAWGHQDDAQSVAAIRAALDRGMNWIDTAAVYGLGHSETVVARAIAGLTQRP
HVFTKCSLVWDDSGKISHNLQAASIRCECEASLKRLEVDAIDLYQIHWPAWNGAPESASPGSIEEAVGAMERLRAEGKIR
HIGVSNFNARQLQRAMDVAPITSLQPPYSLLATDVETSVLPFALKHRIGVIVYSPMASGLLTGAMTRERIAALPDDDWRK
RSANFQEPMLSRNLRLVEKLGAVGRRYNVTPAQIAIAWTLRNPAVTGAIIGVRSAEQVQGIAGAADVQLSADDMSDIEKA
LPMQAA

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=337, Percent_Identity=27.299703264095, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4504825, Length=334, Percent_Identity=27.2455089820359, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI27436962, Length=337, Percent_Identity=26.1127596439169, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI27436964, Length=337, Percent_Identity=26.1127596439169, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI27436966, Length=337, Percent_Identity=26.1127596439169, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI223718702, Length=296, Percent_Identity=28.7162162162162, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI27436971, Length=338, Percent_Identity=26.6272189349112, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI41152114, Length=299, Percent_Identity=27.4247491638796, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI41327764, Length=278, Percent_Identity=28.7769784172662, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI223718708, Length=138, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788070, Length=331, Percent_Identity=33.8368580060423, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI87081735, Length=326, Percent_Identity=30.3680981595092, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788081, Length=311, Percent_Identity=28.6173633440514, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789199, Length=349, Percent_Identity=26.0744985673352, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789375, Length=342, Percent_Identity=24.5614035087719, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082198, Length=301, Percent_Identity=27.2425249169435, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994888, Length=323, Percent_Identity=25.6965944272446, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786400, Length=242, Percent_Identity=24.3801652892562, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212645785, Length=305, Percent_Identity=24.5901639344262, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17564128, Length=335, Percent_Identity=28.6567164179104, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17550248, Length=317, Percent_Identity=23.0283911671924, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=340, Percent_Identity=26.1764705882353, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323998, Length=344, Percent_Identity=22.6744186046512, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640980, Length=356, Percent_Identity=24.1573033707865, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45549126, Length=353, Percent_Identity=24.3626062322946, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646155, Length=229, Percent_Identity=29.6943231441048, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35350; Mature: 35219

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRTLGQTDLKITPIGIGAWAIGGGKWEFAWGHQDDAQSVAAIRAALDRGMNWIDTAAV
CCCCCCCCCCEEEEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH
YGLGHSETVVARAIAGLTQRPHVFTKCSLVWDDSGKISHNLQAASIRCECEASLKRLEVD
HCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEEEEEEEHHHHHHEECC
AIDLYQIHWPAWNGAPESASPGSIEEAVGAMERLRAEGKIRHIGVSNFNARQLQRAMDVA
EEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCC
PITSLQPPYSLLATDVETSVLPFALKHRIGVIVYSPMASGLLTGAMTRERIAALPDDDWR
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHH
KRSANFQEPMLSRNLRLVEKLGAVGRRYNVTPAQIAIAWTLRNPAVTGAIIGVRSAEQVQ
HHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCEEEEEECCCHHHHH
GIAGAADVQLSADDMSDIEKALPMQAA
CCCCCCEEEECCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TLRTLGQTDLKITPIGIGAWAIGGGKWEFAWGHQDDAQSVAAIRAALDRGMNWIDTAAV
CCCCCCCCCEEEEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH
YGLGHSETVVARAIAGLTQRPHVFTKCSLVWDDSGKISHNLQAASIRCECEASLKRLEVD
HCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEEEEEEEHHHHHHEECC
AIDLYQIHWPAWNGAPESASPGSIEEAVGAMERLRAEGKIRHIGVSNFNARQLQRAMDVA
EEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCC
PITSLQPPYSLLATDVETSVLPFALKHRIGVIVYSPMASGLLTGAMTRERIAALPDDDWR
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHH
KRSANFQEPMLSRNLRLVEKLGAVGRRYNVTPAQIAIAWTLRNPAVTGAIIGVRSAEQVQ
HHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCEEEEEECCCHHHHH
GIAGAADVQLSADDMSDIEKALPMQAA
CCCCCCEEEECCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]