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The map label for this gene is metC [H]

Identifier: 116622356

GI number: 116622356

Start: 4113873

End: 4115048

Strand: Direct

Name: metC [H]

Synonym: Acid_3250

Alternate gene names: 116622356

Gene position: 4113873-4115048 (Clockwise)

Preceding gene: 116622355

Following gene: 116622359

Centisome position: 41.28

GC content: 66.75

Gene sequence:

>1176_bases
TTGAAGATCCATACCCAGGCAGTTCACACAGGCGACCGCCGCAAGCCGGGCGCCCATACCCCGGTTACCACCCCGATCCA
CCTCGCCACCAGTTATTTTTACGACTCGATGGAGCAGTTGGACCGTGTCTTCGCGGACCAGGAGAAGGGCTACTGCTACG
CCCGTCACGACAACCCCTCCACCGGCGCACTCGAAGAACTGATGTGCGTGCTGGAAGCGGGCGATGCCGCGCTGGCGTGC
GCGAGCGGCATGGCCGCGCTCCACACCGCCATCGCCGCCGCGCTCACCGACCGCCGCCGCTCCATCGTCGCCGCCAGCGC
CATGTACGGCGCCACCGTCGGCCTGCTGATGAACGTGTTCGAACCCGCCGGCGTCAGCGTCCGCTTCGCCGATGTCTGCG
ATCTCGAGGGACTGCGTAAGGTGGTCGCCGAAGCGCAGCCCGGCTGCATCGTGATGGAGACCATCTCCAACCCGCTGCTG
CGCGTCGGCGAAATCGATCGCATCGCCGAAATCGCCCGCGAGGCCGGCGCGGCCCTGGTGGTCGATCATACCTTCGCCAC
GCCGCTGCTGGCGCGCCCGCTGGAACTCGGCGCGCACTTCAGCGTCCACAGCGTCACCAAGTATCTGGCCGGCCATGGCG
ACGTGCTCGGCGGCGTGGTTGTCACCAACAAGGATCACGCCGAAATTCTGCGCGCGCTCGGCCGCACCATCGGCCCCGTT
CTCGGCCCCTTCGAAAGCTACCTCACCATGCGCGGCATCAAGACTTTCCCGCTGCGCATGGAGCGGCAGTGCGCCAACGC
ATGCCGTGTGGCCTCCTGGCTCGCCGCCCACCCGCGAGTGGAGCGCGTCTTTTTTACGGGAGATCCGCAGCACCCCGATG
CGGCGGCCATTCGCCGCTTGTTTCCCGAAGGCCTCTACGGCGCCATGATGAGCTTCGAGATCCGCGACGCGGGCAGGGAA
GAGATCTTCCGCTTCATGGACGCGCTCAAGATGATCGTGCGCGCCACCTCGCTCGGCGACGTCCACACCATGATGCTCTA
CCCCGTCATGAGCTCCCACCGCGAGCTCTCGCCCAAGCACCGCCTGCGGATGGGCATCCGCGACAACCTCGTGCGCCTCT
CCACCGGCATCGAAGCGGCCGAGGACATCATCGCCGACCTGGAACAGGCGCTGTAG

Upstream 100 bases:

>100_bases
CGCGCTTGCCGATCAAATTCGCGACCAGCTCCTGGCCCAGGGCATCATCCTCGAGGACACCAAGAGCGGGGTTCGCTGGA
AAAGGAAATAGGTTTCAGGT

Downstream 100 bases:

>100_bases
TCACCGCTTCGGGTGCGACTTCGTGCTGCCTTCCGTCAGGCCGAGCGCCCAGCGGATGGCTTCGAAGTACATCTTCTGAA
TGTCGGGATCGTCCCAGCTC

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKIHTQAVHTGDRRKPGAHTPVTTPIHLATSYFYDSMEQLDRVFADQEKGYCYARHDNPSTGALEELMCVLEAGDAALAC
ASGMAALHTAIAAALTDRRRSIVAASAMYGATVGLLMNVFEPAGVSVRFADVCDLEGLRKVVAEAQPGCIVMETISNPLL
RVGEIDRIAEIAREAGAALVVDHTFATPLLARPLELGAHFSVHSVTKYLAGHGDVLGGVVVTNKDHAEILRALGRTIGPV
LGPFESYLTMRGIKTFPLRMERQCANACRVASWLAAHPRVERVFFTGDPQHPDAAAIRRLFPEGLYGAMMSFEIRDAGRE
EIFRFMDALKMIVRATSLGDVHTMMLYPVMSSHRELSPKHRLRMGIRDNLVRLSTGIEAAEDIIADLEQAL

Sequences:

>Translated_391_residues
MKIHTQAVHTGDRRKPGAHTPVTTPIHLATSYFYDSMEQLDRVFADQEKGYCYARHDNPSTGALEELMCVLEAGDAALAC
ASGMAALHTAIAAALTDRRRSIVAASAMYGATVGLLMNVFEPAGVSVRFADVCDLEGLRKVVAEAQPGCIVMETISNPLL
RVGEIDRIAEIAREAGAALVVDHTFATPLLARPLELGAHFSVHSVTKYLAGHGDVLGGVVVTNKDHAEILRALGRTIGPV
LGPFESYLTMRGIKTFPLRMERQCANACRVASWLAAHPRVERVFFTGDPQHPDAAAIRRLFPEGLYGAMMSFEIRDAGRE
EIFRFMDALKMIVRATSLGDVHTMMLYPVMSSHRELSPKHRLRMGIRDNLVRLSTGIEAAEDIIADLEQAL
>Mature_391_residues
MKIHTQAVHTGDRRKPGAHTPVTTPIHLATSYFYDSMEQLDRVFADQEKGYCYARHDNPSTGALEELMCVLEAGDAALAC
ASGMAALHTAIAAALTDRRRSIVAASAMYGATVGLLMNVFEPAGVSVRFADVCDLEGLRKVVAEAQPGCIVMETISNPLL
RVGEIDRIAEIAREAGAALVVDHTFATPLLARPLELGAHFSVHSVTKYLAGHGDVLGGVVVTNKDHAEILRALGRTIGPV
LGPFESYLTMRGIKTFPLRMERQCANACRVASWLAAHPRVERVFFTGDPQHPDAAAIRRLFPEGLYGAMMSFEIRDAGRE
EIFRFMDALKMIVRATSLGDVHTMMLYPVMSSHRELSPKHRLRMGIRDNLVRLSTGIEAAEDIIADLEQAL

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=390, Percent_Identity=33.8461538461538, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI299473759, Length=390, Percent_Identity=32.0512820512821, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI25453487, Length=389, Percent_Identity=30.3341902313625, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1790375, Length=396, Percent_Identity=34.8484848484849, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1789383, Length=399, Percent_Identity=26.3157894736842, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71980708, Length=379, Percent_Identity=32.1899736147757, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17560056, Length=394, Percent_Identity=34.2639593908629, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17538055, Length=391, Percent_Identity=33.5038363171356, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319307, Length=396, Percent_Identity=32.5757575757576, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323333, Length=433, Percent_Identity=31.8706697459584, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321254, Length=414, Percent_Identity=28.9855072463768, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=407, Percent_Identity=27.2727272727273, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321170, Length=312, Percent_Identity=24.6794871794872, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922554, Length=392, Percent_Identity=33.1632653061224, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42686; Mature: 42686

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHTQAVHTGDRRKPGAHTPVTTPIHLATSYFYDSMEQLDRVFADQEKGYCYARHDNPS
CCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
TGALEELMCVLEAGDAALACASGMAALHTAIAAALTDRRRSIVAASAMYGATVGLLMNVF
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPAGVSVRFADVCDLEGLRKVVAEAQPGCIVMETISNPLLRVGEIDRIAEIAREAGAALV
CCCCCEEEEHHHHCHHHHHHHHHCCCCCEEEEHHHCCCHHHHCCHHHHHHHHHHCCCEEE
VDHTFATPLLARPLELGAHFSVHSVTKYLAGHGDVLGGVVVTNKDHAEILRALGRTIGPV
EECHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCEEEECCCHHHHHHHHHHHHHHH
LGPFESYLTMRGIKTFPLRMERQCANACRVASWLAAHPRVERVFFTGDPQHPDAAAIRRL
HCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
FPEGLYGAMMSFEIRDAGREEIFRFMDALKMIVRATSLGDVHTMMLYPVMSSHRELSPKH
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHH
RLRMGIRDNLVRLSTGIEAAEDIIADLEQAL
HHHHCHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIHTQAVHTGDRRKPGAHTPVTTPIHLATSYFYDSMEQLDRVFADQEKGYCYARHDNPS
CCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
TGALEELMCVLEAGDAALACASGMAALHTAIAAALTDRRRSIVAASAMYGATVGLLMNVF
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPAGVSVRFADVCDLEGLRKVVAEAQPGCIVMETISNPLLRVGEIDRIAEIAREAGAALV
CCCCCEEEEHHHHCHHHHHHHHHCCCCCEEEEHHHCCCHHHHCCHHHHHHHHHHCCCEEE
VDHTFATPLLARPLELGAHFSVHSVTKYLAGHGDVLGGVVVTNKDHAEILRALGRTIGPV
EECHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCEEEECCCHHHHHHHHHHHHHHH
LGPFESYLTMRGIKTFPLRMERQCANACRVASWLAAHPRVERVFFTGDPQHPDAAAIRRL
HCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
FPEGLYGAMMSFEIRDAGREEIFRFMDALKMIVRATSLGDVHTMMLYPVMSSHRELSPKH
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHH
RLRMGIRDNLVRLSTGIEAAEDIIADLEQAL
HHHHCHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]