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The map label for this gene is gcd [H]

Identifier: 116622342

GI number: 116622342

Start: 4096371

End: 4098608

Strand: Direct

Name: gcd [H]

Synonym: Acid_3236

Alternate gene names: 116622342

Gene position: 4096371-4098608 (Clockwise)

Preceding gene: 116622338

Following gene: 116622343

Centisome position: 41.1

GC content: 66.62

Gene sequence:

>2238_bases
ATGCTTCGAGTCTCCGTCGTAGTCGCCCTGTGCGCCATCGCCGCCGCCGCTCAGACCCGCCCCGCCTGGGATGGTTCCTT
CTCCGCCGCTCAAGCCGGCCGCGGCCGCGCCGCTTATCGCGAAAATTGCGCGCGCTGCCACGGGGCGGAGTTGGCCGGCG
CCGAAAGCTCGCCTCCTCTTACCGGCGCCGGCTTCCTGGCACAATGGACCGGCAAGAGCGCGGCCGACCTCCTGGACCGC
ACCCGCCGCACCATGCCCACCGATAATCCCGGCGGCCTCCCCGCTCGCCAGTATGCGGATATCGTCGCGTACCTTCTTTC
CACCAATGGCTTCCGCCCCGGCGCACGCGACCTCGGCGGTGCCGCGGCCGTGACCCCATCCGCCCGCACAGCGGAATGGC
GCTATTACGGCGCCGACGCGGGCAGCACGAAGTATTCGCCGCTCGAACAGATCAACGCCTCTAATGTCGGCAAGCTGCAC
ATCGCCTGGTCATGGAACGCGCAGAATTTCGGAGCTCAGCCCGAGTTCAATTGGGAGGCCACGCCGCTGATGGTGGGCGG
CCGCCTCTTCGTCACCGCCGGCACGCGCCGCGACGTCGTAGCGTTAGACGCCGCCACCGGCGAGACGCTCTGGATGTACC
GCCTGGACGAAGGCGCGCGCGGCGCCGCCGCCGCGCGCCGCAACAATCGCGGACTGGCCTACTGGACCGATGGTCACGAC
GAACGCATTGTGCTCATTTCACCCGGCTACCAGTTGGTCGCGCTCGATGCGCGCACCGGCCGCGAGATTACAACCTTCGG
CAAAAGCGGAGTGGTCGATCTCTGGGAGGGACTGGACCGCGCCGAGGTCAAGCCCGGCGAGATCGGTTCCTCGTCGCCCG
CGATCGTCGTGCGCGACGTAGTGGTCGTGGGTGCCGCCCTGCAGGCGGGAATCGCGCCGCGCTCGAAGAAGAACGTCCCC
GGCTATATTCGCGGCTACGACGTTCGCACCGGCAAACGCCTCTGGACCTTCCGCACCATCCCGCAGCCCGGCGAGTTCGG
CCATGACACGTGGGAGAACGGCTCGTGGGAATACACCGGCAATACCGGCGCATGGGGACCGCTCAGCGCCGATGAAGAGC
TCGGCTATGTTTACGTCCCGGTGGAGACGCCCACCGGCGATTTTTACGGCGGACACCGTCTCGGCAACAATCTCTTCGGC
GAGAGCCTCGTCTGCCTGGATGCCCGCACTGGACGCCGCGTCTGGCACTTTCAGTTGGTGCATCACGGCATTTGGGATTG
GGACCCGCCCACCGCACCCACCCTGCTCGATATCACGGTGGACGGGCGCCGCATTAAGGCCGTCGCGCAGATCACCAAGC
AGGCCTGGGTCTATGTCTTCGATCGCGTGACCGGCAAACCGGTGTGGCCCATCGAGGAGCGTCCCGTGCCGCAATCGGAC
GTTCCCGGCGAGCGCACTTCGCCTACCCAGCCCTTTCCCTCCAAGCCGGCCGCGTTCGATAAGCAGGGCTTCACGCTGGA
CGACCTGATCGATTTCACGCCCGAGCTGAAGGCCGAGGCTCTGAAGATCGCTTCCCAATACCGGCTTGGCCCAATGTTCA
TGCCTCCCTCCGTCGCCGGTGCGGGCGGCAGGAAGGCCACCATCACGCTGCCCTCGCCGACCGGCGGCGCCAACTGGCAG
GGCGGAGCCGCCGACCCGGAGACCGGCATGCTCTACGTTTCCTCCGTCACCTTCGCGGCGCCCGTCTCCCTCGCGCGCGA
CACCCGCCGTACCGATATGGACTACCTCGGCCAATACGGCTTCGCGCACATCGGGCCGCAGGGGCTGCCGCTCGCCAAAC
CGCCATGGGGACGCATTACCGCGATTGATCTCAATACCGGCGAACATGCCTGGACCACGCCCAACGGCAGCACGCCGGAG
TTCGTGAAGAATCATCCCGCGCTGCGCGGCATCGACCTCGGCCGGACCGGCAACCCCGAGCACGCGCCGATCCTCGTGAC
CAAATCGCTGCTCTTCACCGCCGACGGCGGCGGCATGTACGCCATGCCTCCCGGCGCCGGCGGTCCCATGTTCCGCGCCG
TGGATAAGCGGAGTGGCAAAGTACTTCACGAAATGAAGCTCCCGGCTAATGTCACCGGTGTCCCGATGACTTACATGATG
GATGGAGTACAGTACCTGGTGATGGCGATCGGCGCTCCCGGCGTCCCAGCCGAGTTAATCGCGTTGACCGTGCAGTAA

Upstream 100 bases:

>100_bases
AAGTATTCCCCCAACTAACGGCACAACTGCGCCTCAACGAGCCGCGCTGTCGGTCGCACGTTCAAAACAATCTCTGAATT
TCGCTAGAGTAGTGAGACCA

Downstream 100 bases:

>100_bases
GCGTGATCTGATCGCGCTCAACATGAGGCTGGCAGCCTCAATACACGAAGCTCGCCTTCGTCGGAACGTGCTCGTTGCCG
GCCATCCCGCCCGGAGTCAC

Product: quinoprotein glucose dehydrogenase

Products: NA

Alternate protein names: Glucose dehydrogenase [pyrroloquinoline-quinone] [H]

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MLRVSVVVALCAIAAAAQTRPAWDGSFSAAQAGRGRAAYRENCARCHGAELAGAESSPPLTGAGFLAQWTGKSAADLLDR
TRRTMPTDNPGGLPARQYADIVAYLLSTNGFRPGARDLGGAAAVTPSARTAEWRYYGADAGSTKYSPLEQINASNVGKLH
IAWSWNAQNFGAQPEFNWEATPLMVGGRLFVTAGTRRDVVALDAATGETLWMYRLDEGARGAAAARRNNRGLAYWTDGHD
ERIVLISPGYQLVALDARTGREITTFGKSGVVDLWEGLDRAEVKPGEIGSSSPAIVVRDVVVVGAALQAGIAPRSKKNVP
GYIRGYDVRTGKRLWTFRTIPQPGEFGHDTWENGSWEYTGNTGAWGPLSADEELGYVYVPVETPTGDFYGGHRLGNNLFG
ESLVCLDARTGRRVWHFQLVHHGIWDWDPPTAPTLLDITVDGRRIKAVAQITKQAWVYVFDRVTGKPVWPIEERPVPQSD
VPGERTSPTQPFPSKPAAFDKQGFTLDDLIDFTPELKAEALKIASQYRLGPMFMPPSVAGAGGRKATITLPSPTGGANWQ
GGAADPETGMLYVSSVTFAAPVSLARDTRRTDMDYLGQYGFAHIGPQGLPLAKPPWGRITAIDLNTGEHAWTTPNGSTPE
FVKNHPALRGIDLGRTGNPEHAPILVTKSLLFTADGGGMYAMPPGAGGPMFRAVDKRSGKVLHEMKLPANVTGVPMTYMM
DGVQYLVMAIGAPGVPAELIALTVQ

Sequences:

>Translated_745_residues
MLRVSVVVALCAIAAAAQTRPAWDGSFSAAQAGRGRAAYRENCARCHGAELAGAESSPPLTGAGFLAQWTGKSAADLLDR
TRRTMPTDNPGGLPARQYADIVAYLLSTNGFRPGARDLGGAAAVTPSARTAEWRYYGADAGSTKYSPLEQINASNVGKLH
IAWSWNAQNFGAQPEFNWEATPLMVGGRLFVTAGTRRDVVALDAATGETLWMYRLDEGARGAAAARRNNRGLAYWTDGHD
ERIVLISPGYQLVALDARTGREITTFGKSGVVDLWEGLDRAEVKPGEIGSSSPAIVVRDVVVVGAALQAGIAPRSKKNVP
GYIRGYDVRTGKRLWTFRTIPQPGEFGHDTWENGSWEYTGNTGAWGPLSADEELGYVYVPVETPTGDFYGGHRLGNNLFG
ESLVCLDARTGRRVWHFQLVHHGIWDWDPPTAPTLLDITVDGRRIKAVAQITKQAWVYVFDRVTGKPVWPIEERPVPQSD
VPGERTSPTQPFPSKPAAFDKQGFTLDDLIDFTPELKAEALKIASQYRLGPMFMPPSVAGAGGRKATITLPSPTGGANWQ
GGAADPETGMLYVSSVTFAAPVSLARDTRRTDMDYLGQYGFAHIGPQGLPLAKPPWGRITAIDLNTGEHAWTTPNGSTPE
FVKNHPALRGIDLGRTGNPEHAPILVTKSLLFTADGGGMYAMPPGAGGPMFRAVDKRSGKVLHEMKLPANVTGVPMTYMM
DGVQYLVMAIGAPGVPAELIALTVQ
>Mature_745_residues
MLRVSVVVALCAIAAAAQTRPAWDGSFSAAQAGRGRAAYRENCARCHGAELAGAESSPPLTGAGFLAQWTGKSAADLLDR
TRRTMPTDNPGGLPARQYADIVAYLLSTNGFRPGARDLGGAAAVTPSARTAEWRYYGADAGSTKYSPLEQINASNVGKLH
IAWSWNAQNFGAQPEFNWEATPLMVGGRLFVTAGTRRDVVALDAATGETLWMYRLDEGARGAAAARRNNRGLAYWTDGHD
ERIVLISPGYQLVALDARTGREITTFGKSGVVDLWEGLDRAEVKPGEIGSSSPAIVVRDVVVVGAALQAGIAPRSKKNVP
GYIRGYDVRTGKRLWTFRTIPQPGEFGHDTWENGSWEYTGNTGAWGPLSADEELGYVYVPVETPTGDFYGGHRLGNNLFG
ESLVCLDARTGRRVWHFQLVHHGIWDWDPPTAPTLLDITVDGRRIKAVAQITKQAWVYVFDRVTGKPVWPIEERPVPQSD
VPGERTSPTQPFPSKPAAFDKQGFTLDDLIDFTPELKAEALKIASQYRLGPMFMPPSVAGAGGRKATITLPSPTGGANWQ
GGAADPETGMLYVSSVTFAAPVSLARDTRRTDMDYLGQYGFAHIGPQGLPLAKPPWGRITAIDLNTGEHAWTTPNGSTPE
FVKNHPALRGIDLGRTGNPEHAPILVTKSLLFTADGGGMYAMPPGAGGPMFRAVDKRSGKVLHEMKLPANVTGVPMTYMM
DGVQYLVMAIGAPGVPAELIALTVQ

Specific function: GDH is probably involved in energy conservation rather than in sugar metabolism [H]

COG id: COG4993

COG function: function code G; Glucose dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial PQQ dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786316, Length=651, Percent_Identity=29.8003072196621, Blast_Score=239, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017511
- InterPro:   IPR019556
- InterPro:   IPR019551
- InterPro:   IPR018391
- InterPro:   IPR002372
- InterPro:   IPR011047
- InterPro:   IPR001479 [H]

Pfam domain/function: PF01011 PQQ; PF10535 PQQ_C; PF10527 PQQ_N [H]

EC number: =1.1.5.2 [H]

Molecular weight: Translated: 80031; Mature: 80031

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVSVVVALCAIAAAAQTRPAWDGSFSAAQAGRGRAAYRENCARCHGAELAGAESSPPL
CEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
TGAGFLAQWTGKSAADLLDRTRRTMPTDNPGGLPARQYADIVAYLLSTNGFRPGARDLGG
CCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCCC
AAAVTPSARTAEWRYYGADAGSTKYSPLEQINASNVGKLHIAWSWNAQNFGAQPEFNWEA
CEEECCCCCCCEEEEECCCCCCCCCCHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCC
TPLMVGGRLFVTAGTRRDVVALDAATGETLWMYRLDEGARGAAAARRNNRGLAYWTDGHD
CEEEECCEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHCCCCCEEEEECCCC
ERIVLISPGYQLVALDARTGREITTFGKSGVVDLWEGLDRAEVKPGEIGSSSPAIVVRDV
CEEEEECCCCEEEEEECCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEHH
VVVGAALQAGIAPRSKKNVPGYIRGYDVRTGKRLWTFRTIPQPGEFGHDTWENGSWEYTG
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCEEECC
NTGAWGPLSADEELGYVYVPVETPTGDFYGGHRLGNNLFGESLVCLDARTGRRVWHFQLV
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCEEEEECCCCCEEEEEEEE
HHGIWDWDPPTAPTLLDITVDGRRIKAVAQITKQAWVYVFDRVTGKPVWPIEERPVPQSD
CCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCC
VPGERTSPTQPFPSKPAAFDKQGFTLDDLIDFTPELKAEALKIASQYRLGPMFMPPSVAG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEECCCCCCC
AGGRKATITLPSPTGGANWQGGAADPETGMLYVSSVTFAAPVSLARDTRRTDMDYLGQYG
CCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCHHHHHCCC
FAHIGPQGLPLAKPPWGRITAIDLNTGEHAWTTPNGSTPEFVKNHPALRGIDLGRTGNPE
CCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCCHHHHHCCCCEEEEECCCCCCCC
HAPILVTKSLLFTADGGGMYAMPPGAGGPMFRAVDKRSGKVLHEMKLPANVTGVPMTYMM
CCEEEEEEEEEEEECCCCEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
DGVQYLVMAIGAPGVPAELIALTVQ
HHHHHHHHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure
MLRVSVVVALCAIAAAAQTRPAWDGSFSAAQAGRGRAAYRENCARCHGAELAGAESSPPL
CEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
TGAGFLAQWTGKSAADLLDRTRRTMPTDNPGGLPARQYADIVAYLLSTNGFRPGARDLGG
CCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCCC
AAAVTPSARTAEWRYYGADAGSTKYSPLEQINASNVGKLHIAWSWNAQNFGAQPEFNWEA
CEEECCCCCCCEEEEECCCCCCCCCCHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCC
TPLMVGGRLFVTAGTRRDVVALDAATGETLWMYRLDEGARGAAAARRNNRGLAYWTDGHD
CEEEECCEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHCCCCCEEEEECCCC
ERIVLISPGYQLVALDARTGREITTFGKSGVVDLWEGLDRAEVKPGEIGSSSPAIVVRDV
CEEEEECCCCEEEEEECCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEHH
VVVGAALQAGIAPRSKKNVPGYIRGYDVRTGKRLWTFRTIPQPGEFGHDTWENGSWEYTG
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCEEECC
NTGAWGPLSADEELGYVYVPVETPTGDFYGGHRLGNNLFGESLVCLDARTGRRVWHFQLV
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCEEEEECCCCCEEEEEEEE
HHGIWDWDPPTAPTLLDITVDGRRIKAVAQITKQAWVYVFDRVTGKPVWPIEERPVPQSD
CCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCC
VPGERTSPTQPFPSKPAAFDKQGFTLDDLIDFTPELKAEALKIASQYRLGPMFMPPSVAG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEECCCCCCC
AGGRKATITLPSPTGGANWQGGAADPETGMLYVSSVTFAAPVSLARDTRRTDMDYLGQYG
CCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCHHHHHCCC
FAHIGPQGLPLAKPPWGRITAIDLNTGEHAWTTPNGSTPEFVKNHPALRGIDLGRTGNPE
CCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCCHHHHHCCCCEEEEECCCCCCCC
HAPILVTKSLLFTADGGGMYAMPPGAGGPMFRAVDKRSGKVLHEMKLPANVTGVPMTYMM
CCEEEEEEEEEEEECCCCEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
DGVQYLVMAIGAPGVPAELIALTVQ
HHHHHHHHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2228962; 8419307; 8202364; 9278503; 8509415; 8554505 [H]