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The map label for this gene is nanT [H]

Identifier: 116621822

GI number: 116621822

Start: 3427419

End: 3428609

Strand: Reverse

Name: nanT [H]

Synonym: Acid_2704

Alternate gene names: 116621822

Gene position: 3428609-3427419 (Counterclockwise)

Preceding gene: 116621823

Following gene: 116621821

Centisome position: 34.4

GC content: 64.15

Gene sequence:

>1191_bases
ATGAAATCCGAGGGCAACGATCATCGCGCAGCATTACTCGCAGGCTATCTGGGCTGGACCCTGGACGCGTTCGACTTCTT
CCTGGTGGTCTTCTGCCTGACCGCGATCGGCCGCGAGTTCCAACAATCCGACGCGACGATGGCGCTGGCGATCACGATCA
CGCTCGCCTTCCGCCCGCTCGGTGCGATTATCTTCGGACTGCTCGCGGATCGCTACGGCAGGCGTCTGCCGCTCATGCTG
AACCTGGTCTTCTACTCAATCGTCGAAGTGGCCTCCGGCTTGGCGCCAAACTTCAGAACCTTCCTCATTCTGCGCGCCCT
CTTCGGCATCGGTATGGGCGGCGAGTGGGGCGTGGGCGCATCGCTCGCCATGGAGAAAGTGCCTCCGAAACTCCGCGGGC
TGCTCAGCGGATTTCTACAGCAGGGCTACGCCACCGGCTACCTGCTGGCCGCGATCTGCTACTTCCTTCTCTTCGAGCGC
TTCGGCTGGCGGCCTCTGTTCTTCCTCGGCGGCTTGCCCGCGCTGCTCGCTATCTTCGTCCGCGCGCGCGTGAAGGAGAG
CGAGGTCTGGCGGAAGACGAAGCACGATAGCTGGGGCCAACTGATGCGCGCTATCGTCTCGCATTGGAAACTCTTTTTCT
ACCTCGTCTTCCTGATGATGGCGATGAATTTCGCCGCCCACGGCACCCAGGATATGTACCCGACCTTCCTCGAGCGGCAG
TGGCATTTCGGCGTCGGCATGCGCGCGGGCGTCACCGGAGGCTCTATGATCGGCGCCATCATCGGCGGCACGCTCGTGGG
GTGGATCTCGGATAAAGTCGGACGCCGCCGCGCCATGATCGGCGCGCTCCTGCTCGCGACCCTCGTGGTCCCATTGTGGG
CCTTTGCGCCCTCCGTGCCGCTGCTCGTGCTCGGCGCATTTCTCATGCAATTCCTGGTGCAGGGCGCCTGGGGCGTGGTG
CCGGCGCACCTCGCCGAACTCTCGCCCGACGCGGTGCGCGGGTTCCTGCCCGGCTTCGGCTACCAGTGCGGCGTACTATT
GGCGAGCGCTGTGACTTATATTGAAGCTGTGTTCGCCCATCGAACCAGTTACGCGATTGCCATGGCAGGGACGGCGGCGA
CCGTTTTCCTGCTGGCGGCGCTGGCCACGGCCTTAGGGTCCGAGCGCCGCGCGACCGTCTTTGGCGAGTGA

Upstream 100 bases:

>100_bases
CTGGGCCGTCGTCCCCGCGCTCGCCACCCCGCGCCGCGAACCGCGACCGTGAGGGAGCGCTCTCGTAACGGTTCGTCCCC
GGCGTGAGACAGTAGCATTA

Downstream 100 bases:

>100_bases
CCCAGGACATCGGGGACATCCGCGCGGCCATCGAAGAGTTCCTCCGCGGAGCGCGCCAACCGGCGCTGCTCGAACCCGGC
GAAGAACTGCTGCCGCTCAC

Product: major facilitator transporter

Products: NA

Alternate protein names: Sialic acid permease [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKSEGNDHRAALLAGYLGWTLDAFDFFLVVFCLTAIGREFQQSDATMALAITITLAFRPLGAIIFGLLADRYGRRLPLML
NLVFYSIVEVASGLAPNFRTFLILRALFGIGMGGEWGVGASLAMEKVPPKLRGLLSGFLQQGYATGYLLAAICYFLLFER
FGWRPLFFLGGLPALLAIFVRARVKESEVWRKTKHDSWGQLMRAIVSHWKLFFYLVFLMMAMNFAAHGTQDMYPTFLERQ
WHFGVGMRAGVTGGSMIGAIIGGTLVGWISDKVGRRRAMIGALLLATLVVPLWAFAPSVPLLVLGAFLMQFLVQGAWGVV
PAHLAELSPDAVRGFLPGFGYQCGVLLASAVTYIEAVFAHRTSYAIAMAGTAATVFLLAALATALGSERRATVFGE

Sequences:

>Translated_396_residues
MKSEGNDHRAALLAGYLGWTLDAFDFFLVVFCLTAIGREFQQSDATMALAITITLAFRPLGAIIFGLLADRYGRRLPLML
NLVFYSIVEVASGLAPNFRTFLILRALFGIGMGGEWGVGASLAMEKVPPKLRGLLSGFLQQGYATGYLLAAICYFLLFER
FGWRPLFFLGGLPALLAIFVRARVKESEVWRKTKHDSWGQLMRAIVSHWKLFFYLVFLMMAMNFAAHGTQDMYPTFLERQ
WHFGVGMRAGVTGGSMIGAIIGGTLVGWISDKVGRRRAMIGALLLATLVVPLWAFAPSVPLLVLGAFLMQFLVQGAWGVV
PAHLAELSPDAVRGFLPGFGYQCGVLLASAVTYIEAVFAHRTSYAIAMAGTAATVFLLAALATALGSERRATVFGE
>Mature_396_residues
MKSEGNDHRAALLAGYLGWTLDAFDFFLVVFCLTAIGREFQQSDATMALAITITLAFRPLGAIIFGLLADRYGRRLPLML
NLVFYSIVEVASGLAPNFRTFLILRALFGIGMGGEWGVGASLAMEKVPPKLRGLLSGFLQQGYATGYLLAAICYFLLFER
FGWRPLFFLGGLPALLAIFVRARVKESEVWRKTKHDSWGQLMRAIVSHWKLFFYLVFLMMAMNFAAHGTQDMYPTFLERQ
WHFGVGMRAGVTGGSMIGAIIGGTLVGWISDKVGRRRAMIGALLLATLVVPLWAFAPSVPLLVLGAFLMQFLVQGAWGVV
PAHLAELSPDAVRGFLPGFGYQCGVLLASAVTYIEAVFAHRTSYAIAMAGTAATVFLLAALATALGSERRATVFGE

Specific function: May be a sugar-cation symporter involved in sialic acid uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter family. Sialic acid transporter (TC 2.A.1.12.1) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082404, Length=391, Percent_Identity=27.8772378516624, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87082231, Length=185, Percent_Identity=39.4594594594595, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790550, Length=377, Percent_Identity=24.4031830238727, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788292, Length=322, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789941, Length=389, Percent_Identity=29.305912596401, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788942, Length=375, Percent_Identity=24.8, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI32564663, Length=174, Percent_Identity=31.0344827586207, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17542342, Length=140, Percent_Identity=36.4285714285714, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322632, Length=416, Percent_Identity=29.3269230769231, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004742
- InterPro:   IPR005828 [H]

Pfam domain/function: PF07690 MFS_1; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 43204; Mature: 43204

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA